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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIO
Full Name:
Triple functional domain protein
Alias:
EC 2.7.11.1; ERBB1; PTPRF interacting protein; PTPRF-interacting protein; Triple functional domain (PTPRF interacting)
Type:
Apoptosis; Guanine nucleotide exchange factor, misc.; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; Trio family
Mass (Da):
346900
Number AA:
3097
UniProt ID:
O75962
International Prot ID:
IPI00657953
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005089
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y75
I
L
K
E
K
V
A
Y
L
S
G
G
R
D
K
Site 2
T89
K
R
G
G
P
I
L
T
F
P
A
R
S
N
H
Site 3
S116
S
Y
L
A
C
I
P
S
E
E
V
C
K
R
G
Site 4
S133
V
I
V
D
M
R
G
S
K
W
D
S
I
K
P
Site 5
S137
M
R
G
S
K
W
D
S
I
K
P
L
L
K
I
Site 6
T170
N
F
W
Q
K
Q
R
T
N
F
G
S
S
K
F
Site 7
S174
K
Q
R
T
N
F
G
S
S
K
F
E
F
E
T
Site 8
T181
S
S
K
F
E
F
E
T
N
M
V
S
L
E
G
Site 9
S185
E
F
E
T
N
M
V
S
L
E
G
L
T
K
V
Site 10
S196
L
T
K
V
V
D
P
S
Q
L
T
P
E
F
D
Site 11
Y208
E
F
D
G
C
L
E
Y
N
H
E
E
W
I
E
Site 12
Y223
I
R
V
A
F
E
D
Y
I
S
N
A
T
H
M
Site 13
S232
S
N
A
T
H
M
L
S
R
L
E
E
L
Q
D
Site 14
S261
R
N
M
I
E
E
H
S
Q
L
K
K
K
V
I
Site 15
S288
K
L
L
Q
R
I
Q
S
S
E
S
F
P
K
K
Site 16
S291
Q
R
I
Q
S
S
E
S
F
P
K
K
N
S
G
Site 17
T313
N
L
L
P
K
V
S
T
M
L
D
R
L
H
S
Site 18
S320
T
M
L
D
R
L
H
S
T
R
Q
H
L
H
Q
Site 19
S366
N
K
G
L
F
L
N
S
Y
T
E
I
G
T
S
Site 20
Y367
K
G
L
F
L
N
S
Y
T
E
I
G
T
S
H
Site 21
T368
G
L
F
L
N
S
Y
T
E
I
G
T
S
H
P
Site 22
S373
S
Y
T
E
I
G
T
S
H
P
H
A
M
E
L
Site 23
Y414
R
L
V
E
S
G
H
Y
A
S
Q
Q
I
R
Q
Site 24
S448
S
T
L
L
D
M
S
S
I
F
H
Q
K
A
E
Site 25
Y457
F
H
Q
K
A
E
K
Y
M
S
N
V
D
S
W
Site 26
S475
C
G
E
V
D
L
P
S
E
L
Q
D
L
E
D
Site 27
Y491
I
H
H
H
Q
G
I
Y
E
H
I
T
L
A
Y
Site 28
T495
Q
G
I
Y
E
H
I
T
L
A
Y
S
E
V
S
Site 29
S502
T
L
A
Y
S
E
V
S
Q
D
G
K
S
L
L
Site 30
S507
E
V
S
Q
D
G
K
S
L
L
D
K
L
Q
R
Site 31
T517
D
K
L
Q
R
P
L
T
P
G
S
S
D
S
L
Site 32
S520
Q
R
P
L
T
P
G
S
S
D
S
L
T
A
S
Site 33
S521
R
P
L
T
P
G
S
S
D
S
L
T
A
S
A
Site 34
S523
L
T
P
G
S
S
D
S
L
T
A
S
A
N
Y
Site 35
T525
P
G
S
S
D
S
L
T
A
S
A
N
Y
S
K
Site 36
S527
S
S
D
S
L
T
A
S
A
N
Y
S
K
A
V
Site 37
S591
N
H
G
E
A
F
L
S
K
H
T
G
V
G
K
Site 38
S599
K
H
T
G
V
G
K
S
L
H
R
A
R
A
L
Site 39
Y646
E
C
D
P
E
E
I
Y
Q
A
A
H
Q
L
E
Site 40
Y699
K
E
L
L
D
D
V
Y
A
E
S
V
E
A
V
Site 41
S702
L
D
D
V
Y
A
E
S
V
E
A
V
Q
D
L
Site 42
T720
F
G
Q
Q
Q
Q
T
T
L
Q
V
T
V
N
V
Site 43
T724
Q
Q
T
T
L
Q
V
T
V
N
V
I
K
E
G
Site 44
S741
L
I
Q
Q
L
R
D
S
A
I
S
S
N
K
T
Site 45
S744
Q
L
R
D
S
A
I
S
S
N
K
T
P
H
N
Site 46
S745
L
R
D
S
A
I
S
S
N
K
T
P
H
N
S
Site 47
T748
S
A
I
S
S
N
K
T
P
H
N
S
S
I
N
Site 48
S769
Q
Q
L
D
E
A
Q
S
Q
M
E
E
L
F
Q
Site 49
S800
R
D
A
I
D
I
I
S
D
L
E
S
W
N
D
Site 50
S804
D
I
I
S
D
L
E
S
W
N
D
E
L
S
Q
Site 51
T818
Q
Q
M
N
D
F
D
T
E
D
L
T
I
A
E
Site 52
T822
D
F
D
T
E
D
L
T
I
A
E
Q
R
L
Q
Site 53
Y855
Q
G
Q
D
L
L
Q
Y
V
N
E
V
Q
A
S
Site 54
Y980
A
M
L
Q
A
N
H
Y
D
M
D
M
I
R
D
Site 55
S1025
K
T
S
E
Q
V
C
S
V
L
E
S
L
E
Q
Site 56
S1029
Q
V
C
S
V
L
E
S
L
E
Q
E
Y
K
R
Site 57
Y1034
L
E
S
L
E
Q
E
Y
K
R
E
E
D
W
C
Site 58
S1051
A
D
K
L
G
P
N
S
E
T
D
H
V
T
P
Site 59
T1053
K
L
G
P
N
S
E
T
D
H
V
T
P
M
I
Site 60
T1057
N
S
E
T
D
H
V
T
P
M
I
S
K
H
L
Site 61
T1075
E
A
F
L
K
A
C
T
L
A
R
R
N
A
D
Site 62
Y1087
N
A
D
V
F
L
K
Y
L
H
R
N
S
V
N
Site 63
T1128
N
R
V
L
H
Y
W
T
M
R
K
R
R
L
D
Site 64
Y1140
R
L
D
Q
C
Q
Q
Y
V
V
F
E
R
S
A
Site 65
Y1161
I
H
D
N
G
E
F
Y
L
S
T
H
T
S
T
Site 66
S1163
D
N
G
E
F
Y
L
S
T
H
T
S
T
G
S
Site 67
T1164
N
G
E
F
Y
L
S
T
H
T
S
T
G
S
S
Site 68
T1166
E
F
Y
L
S
T
H
T
S
T
G
S
S
I
Q
Site 69
S1167
F
Y
L
S
T
H
T
S
T
G
S
S
I
Q
H
Site 70
S1171
T
H
T
S
T
G
S
S
I
Q
H
T
Q
E
L
Site 71
T1175
T
G
S
S
I
Q
H
T
Q
E
L
L
K
E
H
Site 72
T1188
E
H
E
E
F
Q
I
T
A
K
Q
T
K
E
R
Site 73
Y1228
V
T
A
V
D
K
R
Y
R
D
F
S
L
R
M
Site 74
S1232
D
K
R
Y
R
D
F
S
L
R
M
E
K
Y
R
Site 75
Y1238
F
S
L
R
M
E
K
Y
R
T
S
L
E
K
A
Site 76
T1240
L
R
M
E
K
Y
R
T
S
L
E
K
A
L
G
Site 77
S1241
R
M
E
K
Y
R
T
S
L
E
K
A
L
G
I
Site 78
S1250
E
K
A
L
G
I
S
S
D
S
N
K
S
S
K
Site 79
S1252
A
L
G
I
S
S
D
S
N
K
S
S
K
S
L
Site 80
S1255
I
S
S
D
S
N
K
S
S
K
S
L
Q
L
D
Site 81
S1256
S
S
D
S
N
K
S
S
K
S
L
Q
L
D
I
Site 82
S1258
D
S
N
K
S
S
K
S
L
Q
L
D
I
I
P
Site 83
S1271
I
P
A
S
I
P
G
S
E
V
K
L
R
D
A
Site 84
S1289
L
N
E
E
K
R
K
S
A
R
R
K
E
F
I
Site 85
T1303
I
M
A
E
L
I
Q
T
E
K
A
Y
V
R
D
Site 86
Y1307
L
I
Q
T
E
K
A
Y
V
R
D
L
R
E
C
Site 87
Y1318
L
R
E
C
M
D
T
Y
L
W
E
M
T
S
G
Site 88
S1324
T
Y
L
W
E
M
T
S
G
V
E
E
I
P
P
Site 89
Y1362
F
L
K
E
L
E
K
Y
E
Q
L
P
E
D
V
Site 90
Y1386
K
F
Q
M
Y
V
T
Y
C
K
N
K
P
D
S
Site 91
S1393
Y
C
K
N
K
P
D
S
T
Q
L
I
L
E
H
Site 92
T1394
C
K
N
K
P
D
S
T
Q
L
I
L
E
H
A
Site 93
S1403
L
I
L
E
H
A
G
S
Y
F
D
E
I
Q
Q
Site 94
Y1404
I
L
E
H
A
G
S
Y
F
D
E
I
Q
Q
R
Site 95
S1417
Q
R
H
G
L
A
N
S
I
S
S
Y
L
I
K
Site 96
Y1421
L
A
N
S
I
S
S
Y
L
I
K
P
V
Q
R
Site 97
T1430
I
K
P
V
Q
R
I
T
K
Y
Q
L
L
L
K
Site 98
Y1432
P
V
Q
R
I
T
K
Y
Q
L
L
L
K
E
L
Site 99
S1459
D
G
L
E
V
M
L
S
V
P
K
R
A
N
D
Site 100
S1482
G
F
D
E
N
I
E
S
Q
G
E
L
I
L
Q
Site 101
S1491
G
E
L
I
L
Q
E
S
F
Q
V
W
D
P
K
Site 102
T1499
F
Q
V
W
D
P
K
T
L
I
R
K
G
R
E
Site 103
S1519
F
E
M
S
L
V
F
S
K
E
V
K
D
S
S
Site 104
S1525
F
S
K
E
V
K
D
S
S
G
R
S
K
Y
L
Site 105
S1526
S
K
E
V
K
D
S
S
G
R
S
K
Y
L
Y
Site 106
S1529
V
K
D
S
S
G
R
S
K
Y
L
Y
K
S
K
Site 107
Y1531
D
S
S
G
R
S
K
Y
L
Y
K
S
K
L
F
Site 108
Y1533
S
G
R
S
K
Y
L
Y
K
S
K
L
F
T
S
Site 109
S1535
R
S
K
Y
L
Y
K
S
K
L
F
T
S
E
L
Site 110
T1545
F
T
S
E
L
G
V
T
E
H
V
E
G
D
P
Site 111
T1562
F
A
L
W
V
G
R
T
P
T
S
D
N
K
I
Site 112
T1564
L
W
V
G
R
T
P
T
S
D
N
K
I
V
L
Site 113
S1565
W
V
G
R
T
P
T
S
D
N
K
I
V
L
K
Site 114
S1574
D
S
Q
G
D
G
S
S
Q
P
D
T
I
S
I
Site 115
T1610
E
P
I
H
I
P
K
T
A
P
A
T
R
Q
K
Site 116
S1627
R
D
G
E
D
L
D
S
Q
G
D
G
S
S
Q
Site 117
S1632
L
D
S
Q
G
D
G
S
S
Q
P
D
T
I
S
Site 118
S1633
D
S
Q
G
D
G
S
S
Q
P
D
T
I
S
I
Site 119
T1637
D
G
S
S
Q
P
D
T
I
S
I
A
S
R
T
Site 120
S1639
S
S
Q
P
D
T
I
S
I
A
S
R
T
S
Q
Site 121
S1645
I
S
I
A
S
R
T
S
Q
N
T
L
D
S
D
Site 122
T1648
A
S
R
T
S
Q
N
T
L
D
S
D
K
L
S
Site 123
S1651
T
S
Q
N
T
L
D
S
D
K
L
S
G
G
C
Site 124
S1655
T
L
D
S
D
K
L
S
G
G
C
E
L
T
V
Site 125
T1676
A
C
N
S
N
E
L
T
I
R
R
G
Q
T
V
Site 126
T1682
L
T
I
R
R
G
Q
T
V
E
V
L
E
R
P
Site 127
T1700
P
D
W
C
L
V
R
T
T
D
R
S
P
A
A
Site 128
T1701
D
W
C
L
V
R
T
T
D
R
S
P
A
A
E
Site 129
S1704
L
V
R
T
T
D
R
S
P
A
A
E
G
L
V
Site 130
S1721
G
S
L
C
I
A
H
S
R
S
S
M
E
M
E
Site 131
S1724
C
I
A
H
S
R
S
S
M
E
M
E
G
I
F
Site 132
S1736
G
I
F
N
H
K
D
S
L
S
V
S
S
N
D
Site 133
S1738
F
N
H
K
D
S
L
S
V
S
S
N
D
A
S
Site 134
S1740
H
K
D
S
L
S
V
S
S
N
D
A
S
P
P
Site 135
S1741
K
D
S
L
S
V
S
S
N
D
A
S
P
P
A
Site 136
S1745
S
V
S
S
N
D
A
S
P
P
A
S
V
A
S
Site 137
S1749
N
D
A
S
P
P
A
S
V
A
S
L
Q
P
H
Site 138
S1763
H
M
I
G
A
Q
S
S
P
G
P
K
R
P
G
Site 139
T1772
G
P
K
R
P
G
N
T
L
R
K
W
L
T
S
Site 140
T1778
N
T
L
R
K
W
L
T
S
P
V
R
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T
C
I
A
V
N
D
Site 293
S2769
V
N
D
M
G
S
A
S
S
S
A
S
L
R
V
Site 294
S2771
D
M
G
S
A
S
S
S
A
S
L
R
V
L
G
Site 295
S2773
G
S
A
S
S
S
A
S
L
R
V
L
G
P
G
Site 296
S2794
T
W
K
D
N
F
D
S
F
Y
S
E
V
A
E
Site 297
Y2796
K
D
N
F
D
S
F
Y
S
E
V
A
E
L
G
Site 298
S2808
E
L
G
R
G
R
F
S
V
V
K
K
C
D
Q
Site 299
T2838
L
M
K
R
D
Q
V
T
H
E
L
G
I
L
Q
Site 300
S2886
D
C
V
V
R
W
G
S
L
T
E
G
K
I
R
Site 301
T2888
V
V
R
W
G
S
L
T
E
G
K
I
R
A
H
Site 302
S2926
E
N
I
L
V
D
E
S
L
A
K
P
T
I
K
Site 303
Y2948
V
Q
L
N
T
T
Y
Y
I
H
Q
L
L
G
N
Site 304
T2972
L
G
N
P
V
S
L
T
S
D
T
W
S
V
G
Site 305
S2973
G
N
P
V
S
L
T
S
D
T
W
S
V
G
V
Site 306
S2996
V
S
P
F
L
D
D
S
V
E
E
T
C
L
N
Site 307
Y3015
D
F
S
F
P
D
D
Y
F
K
G
V
S
Q
K
Site 308
S3020
D
D
Y
F
K
G
V
S
Q
K
A
K
E
F
V
Site 309
S3040
E
D
P
A
K
R
P
S
A
A
L
A
L
Q
E
Site 310
T3058
Q
A
G
N
G
R
S
T
G
V
L
D
T
S
R
Site 311
T3063
R
S
T
G
V
L
D
T
S
R
L
T
S
F
I
Site 312
S3064
S
T
G
V
L
D
T
S
R
L
T
S
F
I
E
Site 313
T3067
V
L
D
T
S
R
L
T
S
F
I
E
R
R
K
Site 314
S3068
L
D
T
S
R
L
T
S
F
I
E
R
R
K
H
Site 315
S3084
N
D
V
R
P
I
R
S
I
K
N
F
L
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation