KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
AKAP3
Full Name:
A-kinase anchor protein 3
Alias:
A-kinase anchor protein 110 kDa;Cancer/testis antigen 82;Fibrous sheath protein of 95 kDa;Fibrousheathin I;Fibrousheathin-1;Protein kinase A-anchoring protein 3;Sperm oocyte-binding protein
Type:
Adapter/scaffold protein
Mass (Da):
94736
Number AA:
853
UniProt ID:
O75969
International Prot ID:
IPI00290854
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001669
Uniprot
OncoNet
Molecular Function:
GO:0051018
PhosphoSite+
KinaseNET
Biological Process:
GO:0007340
GO:0006928
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
G
V
C
K
V
D
V
Y
S
P
G
D
N
Q
A
Site 2
S21
V
C
K
V
D
V
Y
S
P
G
D
N
Q
A
Q
Site 3
T34
A
Q
D
W
K
M
D
T
S
T
D
P
V
R
V
Site 4
S35
Q
D
W
K
M
D
T
S
T
D
P
V
R
V
L
Site 5
T36
D
W
K
M
D
T
S
T
D
P
V
R
V
L
S
Site 6
S43
T
D
P
V
R
V
L
S
W
L
R
R
D
L
E
Site 7
S52
L
R
R
D
L
E
K
S
T
A
E
F
Q
D
V
Site 8
S66
V
R
F
K
P
G
E
S
F
G
G
E
T
S
N
Site 9
S72
E
S
F
G
G
E
T
S
N
S
G
D
P
H
K
Site 10
S74
F
G
G
E
T
S
N
S
G
D
P
H
K
G
F
Site 11
Y85
H
K
G
F
S
V
D
Y
Y
N
T
T
T
K
G
Site 12
Y86
K
G
F
S
V
D
Y
Y
N
T
T
T
K
G
T
Site 13
T89
S
V
D
Y
Y
N
T
T
T
K
G
T
P
E
R
Site 14
T93
Y
N
T
T
T
K
G
T
P
E
R
L
H
F
E
Site 15
S119
R
A
Q
L
G
N
G
S
S
V
D
E
V
S
F
Site 16
S120
A
Q
L
G
N
G
S
S
V
D
E
V
S
F
Y
Site 17
S125
G
S
S
V
D
E
V
S
F
Y
A
N
R
L
T
Site 18
Y127
S
V
D
E
V
S
F
Y
A
N
R
L
T
N
L
Site 19
Y156
G
S
E
N
K
C
V
Y
Q
S
L
Y
M
G
N
Site 20
Y160
K
C
V
Y
Q
S
L
Y
M
G
N
E
P
T
P
Site 21
T166
L
Y
M
G
N
E
P
T
P
T
K
S
L
S
K
Site 22
T168
M
G
N
E
P
T
P
T
K
S
L
S
K
I
A
Site 23
S170
N
E
P
T
P
T
K
S
L
S
K
I
A
S
E
Site 24
S172
P
T
P
T
K
S
L
S
K
I
A
S
E
L
V
Site 25
S176
K
S
L
S
K
I
A
S
E
L
V
N
E
T
V
Site 26
T182
A
S
E
L
V
N
E
T
V
S
A
C
S
R
N
Site 27
S184
E
L
V
N
E
T
V
S
A
C
S
R
N
A
A
Site 28
S198
A
P
D
K
A
P
G
S
G
D
R
V
S
G
S
Site 29
S203
P
G
S
G
D
R
V
S
G
S
S
Q
S
P
P
Site 30
S205
S
G
D
R
V
S
G
S
S
Q
S
P
P
N
L
Site 31
S206
G
D
R
V
S
G
S
S
Q
S
P
P
N
L
K
Site 32
S208
R
V
S
G
S
S
Q
S
P
P
N
L
K
Y
K
Site 33
Y214
Q
S
P
P
N
L
K
Y
K
S
T
L
K
I
K
Site 34
S216
P
P
N
L
K
Y
K
S
T
L
K
I
K
E
S
Site 35
T217
P
N
L
K
Y
K
S
T
L
K
I
K
E
S
T
Site 36
S236
G
P
D
D
K
P
P
S
K
K
S
F
F
Y
K
Site 37
S239
D
K
P
P
S
K
K
S
F
F
Y
K
E
V
F
Site 38
Y242
P
S
K
K
S
F
F
Y
K
E
V
F
E
S
R
Site 39
Y253
F
E
S
R
N
G
D
Y
A
R
E
G
G
R
F
Site 40
T278
Q
E
R
P
D
D
F
T
A
S
V
S
E
G
I
Site 41
S280
R
P
D
D
F
T
A
S
V
S
E
G
I
M
T
Site 42
S282
D
D
F
T
A
S
V
S
E
G
I
M
T
Y
A
Site 43
S331
K
H
A
K
E
V
V
S
D
L
I
D
S
F
L
Site 44
T347
N
L
H
S
V
T
G
T
L
M
T
D
T
Q
F
Site 45
S367
R
T
V
F
S
H
G
S
Q
K
A
T
D
I
M
Site 46
T371
S
H
G
S
Q
K
A
T
D
I
M
D
A
M
L
Site 47
Y382
D
A
M
L
R
K
L
Y
N
V
M
F
A
K
K
Site 48
S403
K
A
Q
D
K
A
E
S
Y
S
L
I
S
M
K
Site 49
Y404
A
Q
D
K
A
E
S
Y
S
L
I
S
M
K
G
Site 50
S405
Q
D
K
A
E
S
Y
S
L
I
S
M
K
G
M
Site 51
S426
N
V
N
F
A
M
K
S
E
T
K
L
R
E
K
Site 52
T428
N
F
A
M
K
S
E
T
K
L
R
E
K
M
Y
Site 53
Y435
T
K
L
R
E
K
M
Y
S
E
P
K
S
E
E
Site 54
S436
K
L
R
E
K
M
Y
S
E
P
K
S
E
E
E
Site 55
S440
K
M
Y
S
E
P
K
S
E
E
E
T
C
A
K
Site 56
T444
E
P
K
S
E
E
E
T
C
A
K
T
L
G
E
Site 57
T459
H
I
I
K
E
G
L
T
L
W
H
K
S
Q
Q
Site 58
S464
G
L
T
L
W
H
K
S
Q
Q
K
E
C
K
S
Site 59
S471
S
Q
Q
K
E
C
K
S
L
G
F
Q
H
A
A
Site 60
T484
A
A
F
E
A
P
N
T
Q
R
K
P
A
S
D
Site 61
S490
N
T
Q
R
K
P
A
S
D
I
S
F
E
Y
P
Site 62
S493
R
K
P
A
S
D
I
S
F
E
Y
P
E
D
I
Site 63
Y496
A
S
D
I
S
F
E
Y
P
E
D
I
G
N
L
Site 64
S504
P
E
D
I
G
N
L
S
L
P
P
Y
P
P
E
Site 65
Y508
G
N
L
S
L
P
P
Y
P
P
E
K
P
E
N
Site 66
Y518
E
K
P
E
N
F
M
Y
D
S
D
S
W
A
K
Site 67
S520
P
E
N
F
M
Y
D
S
D
S
W
A
K
D
L
Site 68
S522
N
F
M
Y
D
S
D
S
W
A
K
D
L
I
V
Site 69
S549
G
G
R
R
D
A
R
S
F
V
E
A
A
G
T
Site 70
T556
S
F
V
E
A
A
G
T
T
N
F
P
A
N
E
Site 71
S571
P
P
V
A
P
D
E
S
C
L
K
S
A
P
I
Site 72
S575
P
D
E
S
C
L
K
S
A
P
I
V
G
D
Q
Site 73
S592
A
E
K
K
D
L
R
S
V
F
F
N
F
I
R
Site 74
S603
N
F
I
R
N
L
L
S
E
T
I
F
K
R
D
Site 75
S612
T
I
F
K
R
D
Q
S
P
E
P
K
V
P
E
Site 76
S635
L
C
E
R
P
L
A
S
S
P
P
R
L
Y
E
Site 77
S636
C
E
R
P
L
A
S
S
P
P
R
L
Y
E
D
Site 78
Y641
A
S
S
P
P
R
L
Y
E
D
D
E
T
P
G
Site 79
T646
R
L
Y
E
D
D
E
T
P
G
A
L
S
G
L
Site 80
S659
G
L
T
K
M
A
V
S
Q
I
D
G
H
M
S
Site 81
S691
I
A
K
S
C
D
A
S
L
A
E
L
G
D
D
Site 82
S700
A
E
L
G
D
D
K
S
G
D
A
S
R
L
T
Site 83
S704
D
D
K
S
G
D
A
S
R
L
T
S
A
F
P
Site 84
T707
S
G
D
A
S
R
L
T
S
A
F
P
D
S
L
Site 85
S708
G
D
A
S
R
L
T
S
A
F
P
D
S
L
Y
Site 86
Y715
S
A
F
P
D
S
L
Y
E
C
L
P
A
K
G
Site 87
S725
L
P
A
K
G
T
G
S
A
E
A
V
L
Q
N
Site 88
T744
I
H
N
E
M
R
G
T
S
G
Q
P
P
E
G
Site 89
S745
H
N
E
M
R
G
T
S
G
Q
P
P
E
G
C
Site 90
T756
P
E
G
C
A
A
P
T
V
I
V
S
N
H
N
Site 91
T767
S
N
H
N
L
T
D
T
V
Q
N
K
Q
L
Q
Site 92
Y791
E
L
N
V
P
I
L
Y
F
A
G
D
D
E
G
Site 93
S807
Q
E
K
L
L
Q
L
S
A
A
A
V
D
K
G
Site 94
S823
S
V
G
E
V
L
Q
S
V
L
R
Y
E
K
E
Site 95
T841
N
E
A
V
G
N
V
T
P
L
Q
L
L
D
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation