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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLY
Full Name:
SAM and SH3 domain-containing protein 3
Alias:
753P9; CXorf9; SAM and SH3 domain containing 3; SH3 protein expressed in lymphocytes; SH3D6C
Type:
Adapter/scaffold protein
Mass (Da):
41595
Number AA:
380
UniProt ID:
O75995
International Prot ID:
IPI00004504
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
L
R
R
K
P
S
N
A
S
E
K
E
P
Site 2
S10
R
R
K
P
S
N
A
S
E
K
E
P
T
Q
K
Site 3
T15
N
A
S
E
K
E
P
T
Q
K
K
K
L
S
L
Site 4
S21
P
T
Q
K
K
K
L
S
L
Q
R
S
S
S
F
Site 5
S25
K
K
L
S
L
Q
R
S
S
S
F
K
D
F
A
Site 6
S26
K
L
S
L
Q
R
S
S
S
F
K
D
F
A
K
Site 7
S27
L
S
L
Q
R
S
S
S
F
K
D
F
A
K
S
Site 8
S34
S
F
K
D
F
A
K
S
K
P
S
S
P
V
V
Site 9
S37
D
F
A
K
S
K
P
S
S
P
V
V
S
E
K
Site 10
S38
F
A
K
S
K
P
S
S
P
V
V
S
E
K
E
Site 11
S42
K
P
S
S
P
V
V
S
E
K
E
F
N
L
D
Site 12
S57
D
N
I
P
E
D
D
S
G
V
P
T
P
E
D
Site 13
T61
E
D
D
S
G
V
P
T
P
E
D
A
G
K
S
Site 14
S68
T
P
E
D
A
G
K
S
G
K
K
L
G
K
K
Site 15
S81
K
K
W
R
A
V
I
S
R
T
M
N
R
K
M
Site 16
T83
W
R
A
V
I
S
R
T
M
N
R
K
M
G
K
Site 17
S97
K
M
M
V
K
A
L
S
E
E
M
A
D
T
L
Site 18
T103
L
S
E
E
M
A
D
T
L
E
E
G
S
A
S
Site 19
S108
A
D
T
L
E
E
G
S
A
S
P
T
S
P
D
Site 20
S110
T
L
E
E
G
S
A
S
P
T
S
P
D
Y
S
Site 21
T112
E
E
G
S
A
S
P
T
S
P
D
Y
S
L
D
Site 22
S113
E
G
S
A
S
P
T
S
P
D
Y
S
L
D
S
Site 23
Y116
A
S
P
T
S
P
D
Y
S
L
D
S
P
G
P
Site 24
S117
S
P
T
S
P
D
Y
S
L
D
S
P
G
P
E
Site 25
S120
S
P
D
Y
S
L
D
S
P
G
P
E
K
M
A
Site 26
S131
E
K
M
A
L
A
F
S
E
Q
E
E
H
E
L
Site 27
S142
E
H
E
L
P
V
L
S
R
Q
A
S
T
G
S
Site 28
S146
P
V
L
S
R
Q
A
S
T
G
S
E
L
C
S
Site 29
T147
V
L
S
R
Q
A
S
T
G
S
E
L
C
S
P
Site 30
S149
S
R
Q
A
S
T
G
S
E
L
C
S
P
S
P
Site 31
S153
S
T
G
S
E
L
C
S
P
S
P
G
S
G
S
Site 32
S155
G
S
E
L
C
S
P
S
P
G
S
G
S
F
G
Site 33
S158
L
C
S
P
S
P
G
S
G
S
F
G
E
E
P
Site 34
S160
S
P
S
P
G
S
G
S
F
G
E
E
P
P
A
Site 35
Y170
E
E
P
P
A
P
Q
Y
T
G
P
F
C
G
R
Site 36
T182
C
G
R
A
R
V
H
T
D
F
T
P
S
P
Y
Site 37
T185
A
R
V
H
T
D
F
T
P
S
P
Y
D
H
D
Site 38
S187
V
H
T
D
F
T
P
S
P
Y
D
H
D
S
L
Site 39
Y189
T
D
F
T
P
S
P
Y
D
H
D
S
L
K
L
Site 40
S193
P
S
P
Y
D
H
D
S
L
K
L
Q
K
G
D
Site 41
S243
A
V
G
H
A
R
P
S
R
R
Q
S
K
G
K
Site 42
S247
A
R
P
S
R
R
Q
S
K
G
K
R
P
K
P
Site 43
T256
G
K
R
P
K
P
K
T
L
H
E
L
L
E
R
Site 44
T272
G
L
E
E
H
T
S
T
L
L
L
N
G
Y
Q
Site 45
Y278
S
T
L
L
L
N
G
Y
Q
T
L
E
D
F
K
Site 46
T280
L
L
L
N
G
Y
Q
T
L
E
D
F
K
E
L
Site 47
T290
D
F
K
E
L
R
E
T
H
L
N
E
L
N
I
Site 48
Y316
A
A
E
L
L
L
D
Y
D
T
G
S
E
E
A
Site 49
T318
E
L
L
L
D
Y
D
T
G
S
E
E
A
E
E
Site 50
S320
L
L
D
Y
D
T
G
S
E
E
A
E
E
G
A
Site 51
S329
E
A
E
E
G
A
E
S
S
Q
E
P
V
A
H
Site 52
S330
A
E
E
G
A
E
S
S
Q
E
P
V
A
H
T
Site 53
S349
K
V
D
I
P
R
D
S
G
C
F
E
G
S
E
Site 54
S355
D
S
G
C
F
E
G
S
E
S
G
R
D
D
A
Site 55
S357
G
C
F
E
G
S
E
S
G
R
D
D
A
E
L
Site 56
T367
D
D
A
E
L
A
G
T
E
E
Q
L
Q
G
L
Site 57
S375
E
E
Q
L
Q
G
L
S
L
A
G
A
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation