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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WFS1
Full Name:
Wolframin
Alias:
DFNA14; DFNA38; DFNA6; DIDMOAD; WFS; Wolfram syndrome 1
Type:
Endoplasmic reticulum
Mass (Da):
100287
Number AA:
890
UniProt ID:
O76024
International Prot ID:
IPI00008711
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030425
GO:0030176
Uniprot
OncoNet
Molecular Function:
GO:0051117
PhosphoSite+
KinaseNET
Biological Process:
GO:0006983
GO:0032469
GO:0042593
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
D
S
N
T
A
P
L
G
P
Site 2
T5
_
_
_
M
D
S
N
T
A
P
L
G
P
S
C
Site 3
S11
N
T
A
P
L
G
P
S
C
P
Q
P
P
P
A
Site 4
T30
A
R
S
R
L
N
A
T
A
S
L
E
Q
E
R
Site 5
S32
S
R
L
N
A
T
A
S
L
E
Q
E
R
S
E
Site 6
S38
A
S
L
E
Q
E
R
S
E
R
P
R
A
P
G
Site 7
T77
S
R
E
R
A
D
G
T
G
P
T
K
G
D
M
Site 8
T104
A
G
D
P
K
A
Q
T
E
V
G
K
H
Y
L
Site 9
Y110
Q
T
E
V
G
K
H
Y
L
Q
L
A
G
D
T
Site 10
S123
D
T
D
E
E
L
N
S
C
T
A
V
D
W
L
Site 11
T156
L
A
D
R
R
G
I
T
S
E
N
E
R
E
V
Site 12
S157
A
D
R
R
G
I
T
S
E
N
E
R
E
V
R
Site 13
S167
E
R
E
V
R
Q
L
S
S
E
T
D
L
E
R
Site 14
Y184
R
K
A
A
L
V
M
Y
W
K
L
N
P
K
K
Site 15
S222
Q
P
G
P
V
P
K
S
L
Q
K
Q
R
R
M
Site 16
S235
R
M
L
E
R
L
V
S
S
E
S
K
N
Y
I
Site 17
S236
M
L
E
R
L
V
S
S
E
S
K
N
Y
I
A
Site 18
S238
E
R
L
V
S
S
E
S
K
N
Y
I
A
L
D
Site 19
Y241
V
S
S
E
S
K
N
Y
I
A
L
D
D
F
V
Site 20
S262
A
K
G
V
I
P
S
S
L
F
L
Q
D
D
E
Site 21
S278
D
D
E
L
A
G
K
S
P
E
D
L
P
L
R
Site 22
T376
K
A
W
E
N
F
R
T
L
T
D
L
L
L
R
Site 23
T378
W
E
N
F
R
T
L
T
D
L
L
L
R
F
E
Site 24
S446
F
T
V
T
S
Y
L
S
L
S
T
H
A
E
P
Site 25
S448
V
T
S
Y
L
S
L
S
T
H
A
E
P
Y
T
Site 26
Y454
L
S
T
H
A
E
P
Y
T
R
R
A
L
A
T
Site 27
T455
S
T
H
A
E
P
Y
T
R
R
A
L
A
T
E
Site 28
Y480
S
M
P
L
N
W
P
Y
L
K
V
L
G
Q
T
Site 29
S619
W
W
T
K
A
S
F
S
V
V
G
M
V
K
S
Site 30
S626
S
V
V
G
M
V
K
S
L
T
R
S
S
M
V
Site 31
T628
V
G
M
V
K
S
L
T
R
S
S
M
V
K
L
Site 32
Y660
R
S
E
G
M
K
V
Y
N
S
T
L
T
W
Q
Site 33
Y669
S
T
L
T
W
Q
Q
Y
G
A
L
C
G
P
R
Site 34
T681
G
P
R
A
W
K
E
T
N
M
A
R
T
Q
I
Site 35
T699
H
L
E
G
H
R
V
T
W
T
G
R
F
K
Y
Site 36
T701
E
G
H
R
V
T
W
T
G
R
F
K
Y
V
R
Site 37
Y706
T
W
T
G
R
F
K
Y
V
R
V
T
D
I
D
Site 38
T710
R
F
K
Y
V
R
V
T
D
I
D
N
S
A
E
Site 39
S715
R
V
T
D
I
D
N
S
A
E
S
A
I
N
M
Site 40
Y739
R
C
L
Y
G
E
A
Y
P
A
C
S
P
G
N
Site 41
S743
G
E
A
Y
P
A
C
S
P
G
N
T
S
T
A
Site 42
S748
A
C
S
P
G
N
T
S
T
A
E
E
E
L
C
Site 43
Y773
H
I
K
K
F
D
R
Y
K
F
E
I
T
V
G
Site 44
T778
D
R
Y
K
F
E
I
T
V
G
M
P
F
S
S
Site 45
S784
I
T
V
G
M
P
F
S
S
G
A
D
G
S
R
Site 46
S785
T
V
G
M
P
F
S
S
G
A
D
G
S
R
S
Site 47
S790
F
S
S
G
A
D
G
S
R
S
R
E
E
D
D
Site 48
S792
S
G
A
D
G
S
R
S
R
E
E
D
D
V
T
Site 49
T799
S
R
E
E
D
D
V
T
K
D
I
V
L
R
A
Site 50
S812
R
A
S
S
E
F
K
S
V
L
L
S
L
R
Q
Site 51
S855
L
N
C
M
A
Q
L
S
P
T
R
R
H
V
K
Site 52
T870
I
E
H
D
W
R
S
T
V
H
G
A
V
K
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation