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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLPX
Full Name:
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Alias:
ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial; ClpX caseinolytic peptidase X; ClpX caseinolytic protease X; Energy-dependent regulato
Type:
Mitochondrial
Mass (Da):
69224
Number AA:
633
UniProt ID:
O76031
International Prot ID:
IPI00008728
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009841
GO:0005743
GO:0042645
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0016504
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
GO:0051603
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
A
S
A
Q
R
G
I
S
G
G
R
I
H
M
S
Site 2
S36
S
G
G
R
I
H
M
S
V
L
G
R
L
G
T
Site 3
S56
L
Q
R
A
P
L
R
S
F
T
E
T
P
A
Y
Site 4
T58
R
A
P
L
R
S
F
T
E
T
P
A
Y
F
A
Site 5
T60
P
L
R
S
F
T
E
T
P
A
Y
F
A
S
K
Site 6
Y63
S
F
T
E
T
P
A
Y
F
A
S
K
D
G
I
Site 7
S66
E
T
P
A
Y
F
A
S
K
D
G
I
S
K
D
Site 8
S71
F
A
S
K
D
G
I
S
K
D
G
S
G
D
G
Site 9
S75
D
G
I
S
K
D
G
S
G
D
G
N
K
K
S
Site 10
S82
S
G
D
G
N
K
K
S
A
S
E
G
S
S
K
Site 11
S84
D
G
N
K
K
S
A
S
E
G
S
S
K
K
S
Site 12
S87
K
K
S
A
S
E
G
S
S
K
K
S
G
S
G
Site 13
S88
K
S
A
S
E
G
S
S
K
K
S
G
S
G
N
Site 14
S91
S
E
G
S
S
K
K
S
G
S
G
N
S
G
K
Site 15
S93
G
S
S
K
K
S
G
S
G
N
S
G
K
G
G
Site 16
T117
D
L
C
T
H
V
E
T
F
V
S
S
T
R
F
Site 17
S120
T
H
V
E
T
F
V
S
S
T
R
F
V
K
C
Site 18
S121
H
V
E
T
F
V
S
S
T
R
F
V
K
C
E
Site 19
S138
H
H
F
F
V
V
L
S
E
A
D
S
K
K
S
Site 20
S142
V
V
L
S
E
A
D
S
K
K
S
I
I
K
E
Site 21
S145
S
E
A
D
S
K
K
S
I
I
K
E
P
E
S
Site 22
S152
S
I
I
K
E
P
E
S
A
A
E
A
V
K
L
Site 23
Y175
P
P
K
K
I
Y
N
Y
L
D
K
Y
V
V
G
Site 24
S184
D
K
Y
V
V
G
Q
S
F
A
K
K
V
L
S
Site 25
Y195
K
V
L
S
V
A
V
Y
N
H
Y
K
R
I
Y
Site 26
Y198
S
V
A
V
Y
N
H
Y
K
R
I
Y
N
N
I
Site 27
Y202
Y
N
H
Y
K
R
I
Y
N
N
I
P
A
N
L
Site 28
S220
A
E
V
E
K
Q
T
S
L
T
P
R
E
L
E
Site 29
T222
V
E
K
Q
T
S
L
T
P
R
E
L
E
I
R
Site 30
Y235
I
R
R
R
E
D
E
Y
R
F
T
K
L
L
Q
Site 31
T238
R
E
D
E
Y
R
F
T
K
L
L
Q
I
A
G
Site 32
S277
R
G
G
E
V
L
D
S
S
H
D
D
I
K
L
Site 33
S278
G
G
E
V
L
D
S
S
H
D
D
I
K
L
E
Site 34
S287
D
D
I
K
L
E
K
S
N
I
L
L
L
G
P
Site 35
Y327
T
T
L
T
Q
A
G
Y
V
G
E
D
I
E
S
Site 36
Y345
K
L
L
Q
D
A
N
Y
N
V
E
K
A
Q
Q
Site 37
S365
D
E
V
D
K
I
G
S
V
P
G
I
H
Q
L
Site 38
T407
S
R
K
L
R
G
E
T
V
Q
V
D
T
T
N
Site 39
S431
N
G
L
D
R
I
I
S
R
R
K
N
E
K
Y
Site 40
Y438
S
R
R
K
N
E
K
Y
L
G
F
G
T
P
S
Site 41
T443
E
K
Y
L
G
F
G
T
P
S
N
L
G
K
G
Site 42
S445
Y
L
G
F
G
T
P
S
N
L
G
K
G
R
R
Site 43
S463
A
A
D
L
A
N
R
S
G
E
S
N
T
H
Q
Site 44
T513
L
H
S
L
D
E
K
T
L
V
Q
I
L
T
E
Site 45
Y529
R
N
A
V
I
P
Q
Y
Q
A
L
F
S
M
D
Site 46
T543
D
K
C
E
L
N
V
T
E
D
A
L
K
A
I
Site 47
T559
R
L
A
L
E
R
K
T
G
A
R
G
L
R
S
Site 48
Y602
E
G
K
K
E
P
G
Y
I
R
A
P
T
K
E
Site 49
T607
P
G
Y
I
R
A
P
T
K
E
S
S
E
E
E
Site 50
S610
I
R
A
P
T
K
E
S
S
E
E
E
Y
D
S
Site 51
S611
R
A
P
T
K
E
S
S
E
E
E
Y
D
S
G
Site 52
Y615
K
E
S
S
E
E
E
Y
D
S
G
V
E
E
E
Site 53
S617
S
S
E
E
E
Y
D
S
G
V
E
E
E
G
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation