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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEBL
Full Name:
Nebulette
Alias:
Actin-binding Z-disk protein; LNEBL
Type:
Actin binding protein
Mass (Da):
116453
Number AA:
1014
UniProt ID:
O76041
International Prot ID:
IPI00844035
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0008307
PhosphoSite+
KinaseNET
Biological Process:
GO:0030832
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
F
E
D
I
K
D
E
T
E
E
E
K
I
G
E
Site 2
S38
K
P
V
I
E
D
L
S
M
E
L
A
R
K
C
Site 3
T46
M
E
L
A
R
K
C
T
E
L
I
S
D
I
R
Site 4
S50
R
K
C
T
E
L
I
S
D
I
R
Y
K
E
E
Site 5
Y54
E
L
I
S
D
I
R
Y
K
E
E
F
K
K
S
Site 6
T66
K
K
S
K
D
K
C
T
F
V
T
D
S
P
M
Site 7
S71
K
C
T
F
V
T
D
S
P
M
L
N
H
V
K
Site 8
S85
K
N
I
G
A
F
I
S
E
A
K
Y
K
G
T
Site 9
Y89
A
F
I
S
E
A
K
Y
K
G
T
I
K
A
D
Site 10
S98
G
T
I
K
A
D
L
S
N
S
L
Y
K
R
M
Site 11
S100
I
K
A
D
L
S
N
S
L
Y
K
R
M
P
A
Site 12
Y102
A
D
L
S
N
S
L
Y
K
R
M
P
A
T
I
Site 13
Y126
Q
L
Q
S
E
V
A
Y
K
Q
K
H
D
A
A
Site 14
Y139
A
A
K
G
F
S
D
Y
A
H
M
K
E
P
P
Site 15
S162
N
K
H
Q
S
N
I
S
Y
R
K
D
V
Q
D
Site 16
T170
Y
R
K
D
V
Q
D
T
H
T
Y
S
A
E
L
Site 17
T172
K
D
V
Q
D
T
H
T
Y
S
A
E
L
D
R
Site 18
S174
V
Q
D
T
H
T
Y
S
A
E
L
D
R
P
D
Site 19
T186
R
P
D
I
K
M
A
T
Q
I
S
K
I
I
S
Site 20
S193
T
Q
I
S
K
I
I
S
N
A
E
Y
K
K
G
Site 21
Y197
K
I
I
S
N
A
E
Y
K
K
G
Q
G
I
M
Site 22
S227
V
E
A
S
K
L
S
S
Q
I
K
Y
K
E
K
Site 23
Y231
K
L
S
S
Q
I
K
Y
K
E
K
F
D
N
E
Site 24
Y246
M
K
D
K
K
H
H
Y
N
P
L
E
S
A
S
Site 25
S253
Y
N
P
L
E
S
A
S
F
R
Q
N
Q
L
A
Site 26
Y269
T
L
A
S
N
V
K
Y
K
K
D
I
Q
N
M
Site 27
S281
Q
N
M
H
D
P
V
S
D
L
P
N
L
L
F
Site 28
S296
L
D
H
V
L
K
A
S
K
M
L
S
G
R
E
Site 29
S300
L
K
A
S
K
M
L
S
G
R
E
Y
K
K
L
Site 30
Y304
K
M
L
S
G
R
E
Y
K
K
L
F
E
E
N
Site 31
S335
K
G
N
A
V
L
Q
S
Q
V
K
Y
K
E
E
Site 32
Y339
V
L
Q
S
Q
V
K
Y
K
E
E
Y
E
K
N
Site 33
Y343
Q
V
K
Y
K
E
E
Y
E
K
N
K
G
K
P
Site 34
T357
P
M
L
E
F
V
E
T
P
S
Y
Q
A
S
K
Site 35
S359
L
E
F
V
E
T
P
S
Y
Q
A
S
K
E
A
Site 36
Y360
E
F
V
E
T
P
S
Y
Q
A
S
K
E
A
Q
Site 37
S363
E
T
P
S
Y
Q
A
S
K
E
A
Q
K
M
Q
Site 38
Y375
K
M
Q
S
E
K
V
Y
K
E
D
F
E
K
E
Site 39
S388
K
E
I
K
G
R
S
S
L
D
L
D
K
T
P
Site 40
T394
S
S
L
D
L
D
K
T
P
E
F
L
H
V
K
Site 41
Y402
P
E
F
L
H
V
K
Y
I
T
N
L
L
R
E
Site 42
S429
G
K
G
M
E
L
N
S
E
V
L
D
I
Q
R
Site 43
S441
I
Q
R
A
K
R
A
S
E
M
A
S
E
K
E
Site 44
S445
K
R
A
S
E
M
A
S
E
K
E
Y
K
K
D
Site 45
Y449
E
M
A
S
E
K
E
Y
K
K
D
L
E
S
I
Site 46
S455
E
Y
K
K
D
L
E
S
I
I
K
G
K
G
M
Site 47
T468
G
M
Q
A
G
T
D
T
L
E
M
Q
H
A
K
Site 48
Y486
E
I
A
S
E
K
D
Y
K
R
D
L
E
T
E
Site 49
T492
D
Y
K
R
D
L
E
T
E
I
K
G
K
G
M
Site 50
S502
K
G
K
G
M
Q
V
S
T
D
T
L
D
V
Q
Site 51
T505
G
M
Q
V
S
T
D
T
L
D
V
Q
R
A
K
Site 52
S515
V
Q
R
A
K
K
A
S
E
M
A
S
Q
K
Q
Site 53
S519
K
K
A
S
E
M
A
S
Q
K
Q
Y
K
K
D
Site 54
Y523
E
M
A
S
Q
K
Q
Y
K
K
D
L
E
N
E
Site 55
S539
K
G
K
G
M
Q
V
S
M
D
I
P
D
I
L
Site 56
S552
I
L
R
A
K
R
T
S
E
I
Y
S
Q
R
K
Site 57
Y555
A
K
R
T
S
E
I
Y
S
Q
R
K
Y
K
D
Site 58
S556
K
R
T
S
E
I
Y
S
Q
R
K
Y
K
D
E
Site 59
Y560
E
I
Y
S
Q
R
K
Y
K
D
E
A
E
K
M
Site 60
S569
D
E
A
E
K
M
L
S
N
Y
S
T
I
A
D
Site 61
T573
K
M
L
S
N
Y
S
T
I
A
D
T
P
E
I
Site 62
T577
N
Y
S
T
I
A
D
T
P
E
I
Q
R
I
K
Site 63
T585
P
E
I
Q
R
I
K
T
T
Q
Q
N
I
S
A
Site 64
Y595
Q
N
I
S
A
V
F
Y
K
K
E
V
G
A
G
Site 65
S608
A
G
T
A
V
K
D
S
P
E
I
E
R
V
K
Site 66
Y626
Q
N
I
S
S
V
K
Y
K
E
E
I
K
H
A
Site 67
S637
I
K
H
A
T
A
I
S
D
P
P
E
L
K
R
Site 68
Y657
K
N
I
S
N
L
Q
Y
K
E
Q
N
Y
K
A
Site 69
T665
K
E
Q
N
Y
K
A
T
P
V
S
M
T
P
E
Site 70
S668
N
Y
K
A
T
P
V
S
M
T
P
E
I
E
R
Site 71
T670
K
A
T
P
V
S
M
T
P
E
I
E
R
V
R
Site 72
S684
R
R
N
Q
E
Q
L
S
A
V
K
Y
K
G
E
Site 73
Y688
E
Q
L
S
A
V
K
Y
K
G
E
L
Q
R
G
Site 74
T696
K
G
E
L
Q
R
G
T
A
I
S
D
P
P
E
Site 75
S699
L
Q
R
G
T
A
I
S
D
P
P
E
L
K
R
Site 76
Y718
Q
K
N
I
S
N
V
Y
Y
R
G
Q
L
G
R
Site 77
Y719
K
N
I
S
N
V
Y
Y
R
G
Q
L
G
R
A
Site 78
T727
R
G
Q
L
G
R
A
T
T
L
S
V
T
P
E
Site 79
T728
G
Q
L
G
R
A
T
T
L
S
V
T
P
E
M
Site 80
S730
L
G
R
A
T
T
L
S
V
T
P
E
M
E
R
Site 81
T732
R
A
T
T
L
S
V
T
P
E
M
E
R
V
K
Site 82
S747
K
N
Q
E
N
I
S
S
V
K
Y
T
Q
D
H
Site 83
Y750
E
N
I
S
S
V
K
Y
T
Q
D
H
K
Q
M
Site 84
T751
N
I
S
S
V
K
Y
T
Q
D
H
K
Q
M
K
Site 85
S762
K
Q
M
K
G
R
P
S
L
I
L
D
T
P
A
Site 86
T767
R
P
S
L
I
L
D
T
P
A
M
R
H
V
K
Site 87
Y785
N
H
I
S
M
V
K
Y
H
E
D
F
E
K
T
Site 88
T798
K
T
K
G
R
G
F
T
P
V
V
D
D
P
V
Site 89
T806
P
V
V
D
D
P
V
T
E
R
V
R
K
N
T
Site 90
T813
T
E
R
V
R
K
N
T
Q
V
V
S
D
A
A
Site 91
Y821
Q
V
V
S
D
A
A
Y
K
G
V
H
P
H
I
Site 92
T846
V
D
L
K
V
W
R
T
D
P
G
S
I
F
D
Site 93
S850
V
W
R
T
D
P
G
S
I
F
D
L
D
P
L
Site 94
S863
P
L
E
D
N
I
Q
S
R
S
L
H
M
L
S
Site 95
S865
E
D
N
I
Q
S
R
S
L
H
M
L
S
E
K
Site 96
S870
S
R
S
L
H
M
L
S
E
K
A
S
H
Y
R
Site 97
Y876
L
S
E
K
A
S
H
Y
R
R
H
W
S
R
S
Site 98
S881
S
H
Y
R
R
H
W
S
R
S
H
S
S
S
T
Site 99
S883
Y
R
R
H
W
S
R
S
H
S
S
S
T
F
G
Site 100
S885
R
H
W
S
R
S
H
S
S
S
T
F
G
T
G
Site 101
S886
H
W
S
R
S
H
S
S
S
T
F
G
T
G
L
Site 102
S887
W
S
R
S
H
S
S
S
T
F
G
T
G
L
G
Site 103
T888
S
R
S
H
S
S
S
T
F
G
T
G
L
G
D
Site 104
T891
H
S
S
S
T
F
G
T
G
L
G
D
D
R
S
Site 105
S898
T
G
L
G
D
D
R
S
E
I
S
E
I
Y
P
Site 106
Y904
R
S
E
I
S
E
I
Y
P
S
F
S
C
C
S
Site 107
S908
S
E
I
Y
P
S
F
S
C
C
S
E
V
T
R
Site 108
S911
Y
P
S
F
S
C
C
S
E
V
T
R
P
S
D
Site 109
S917
C
S
E
V
T
R
P
S
D
E
G
A
P
V
L
Site 110
S931
L
P
G
A
Y
Q
Q
S
H
S
Q
G
Y
G
Y
Site 111
Y938
S
H
S
Q
G
Y
G
Y
M
H
Q
T
S
V
S
Site 112
T942
G
Y
G
Y
M
H
Q
T
S
V
S
S
M
R
S
Site 113
S946
M
H
Q
T
S
V
S
S
M
R
S
M
Q
H
S
Site 114
S949
T
S
V
S
S
M
R
S
M
Q
H
S
P
N
L
Site 115
S953
S
M
R
S
M
Q
H
S
P
N
L
R
T
Y
R
Site 116
T958
Q
H
S
P
N
L
R
T
Y
R
A
M
Y
D
Y
Site 117
Y959
H
S
P
N
L
R
T
Y
R
A
M
Y
D
Y
S
Site 118
Y963
L
R
T
Y
R
A
M
Y
D
Y
S
A
Q
D
E
Site 119
Y965
T
Y
R
A
M
Y
D
Y
S
A
Q
D
E
D
E
Site 120
S974
A
Q
D
E
D
E
V
S
F
R
D
G
D
Y
I
Site 121
Y993
P
I
D
D
G
W
M
Y
G
T
V
Q
R
T
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation