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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF8
Full Name:
E3 ubiquitin-protein ligase RNF8
Alias:
EC 6.3.2.-; KIAA0646; KIAA0646, ubiquitin ligase protein RNF8; RING finger protein 8
Type:
Transcription, coactivator/corepressor; Ligase; Histone-binding protein; DNA repair; EC 6.3.2.-; Ubiquitin conjugating system
Mass (Da):
55518
Number AA:
485
UniProt ID:
O76064
International Prot ID:
IPI00022561
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005634
GO:0000151
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0042393
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0006302
GO:0033522
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
G
D
R
A
G
G
R
S
W
C
L
R
R
V
G
Site 2
Y48
G
R
G
F
G
V
T
Y
Q
L
V
S
K
I
C
Site 3
T75
Q
N
P
E
G
Q
W
T
I
M
D
N
K
S
L
Site 4
Y98
R
L
E
P
L
R
V
Y
S
I
H
Q
G
D
Y
Site 5
S99
L
E
P
L
R
V
Y
S
I
H
Q
G
D
Y
I
Site 6
Y105
Y
S
I
H
Q
G
D
Y
I
Q
L
G
V
P
L
Site 7
Y120
E
N
K
E
N
A
E
Y
E
Y
E
V
T
E
E
Site 8
Y122
K
E
N
A
E
Y
E
Y
E
V
T
E
E
D
W
Site 9
T125
A
E
Y
E
Y
E
V
T
E
E
D
W
E
T
I
Site 10
T131
V
T
E
E
D
W
E
T
I
Y
P
C
L
S
P
Site 11
Y133
E
E
D
W
E
T
I
Y
P
C
L
S
P
K
N
Site 12
S137
E
T
I
Y
P
C
L
S
P
K
N
D
Q
M
I
Site 13
T152
E
K
N
K
E
L
R
T
K
R
K
F
S
L
D
Site 14
S157
L
R
T
K
R
K
F
S
L
D
E
L
A
G
P
Site 15
S174
E
G
P
S
N
L
K
S
K
I
N
K
V
S
C
Site 16
S183
I
N
K
V
S
C
E
S
G
Q
P
V
K
S
Q
Site 17
S189
E
S
G
Q
P
V
K
S
Q
G
K
G
E
V
A
Site 18
S197
Q
G
K
G
E
V
A
S
T
P
S
D
N
L
D
Site 19
T198
G
K
G
E
V
A
S
T
P
S
D
N
L
D
P
Site 20
T215
T
A
L
E
P
S
K
T
T
G
A
P
I
Y
P
Site 21
Y221
K
T
T
G
A
P
I
Y
P
G
F
P
K
V
T
Site 22
S237
V
H
H
E
Q
K
A
S
N
S
S
A
S
Q
R
Site 23
S239
H
E
Q
K
A
S
N
S
S
A
S
Q
R
S
L
Site 24
S242
K
A
S
N
S
S
A
S
Q
R
S
L
Q
M
F
Site 25
S245
N
S
S
A
S
Q
R
S
L
Q
M
F
K
V
T
Site 26
S297
Q
E
L
Q
D
L
Q
S
Q
L
C
A
E
Q
A
Site 27
T316
R
V
E
Q
L
E
K
T
F
Q
E
E
E
Q
H
Site 28
S357
L
M
E
E
L
N
R
S
K
K
D
F
E
A
I
Site 29
T375
K
N
K
E
L
E
Q
T
K
E
E
K
E
K
M
Site 30
S446
I
C
R
K
D
I
K
S
K
T
Y
S
L
V
L
Site 31
T448
R
K
D
I
K
S
K
T
Y
S
L
V
L
D
N
Site 32
S450
D
I
K
S
K
T
Y
S
L
V
L
D
N
C
I
Site 33
S466
K
M
V
N
N
L
S
S
E
V
K
E
R
R
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation