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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE5A
Full Name:
cGMP-specific 3',5'-cyclic phosphodiesterase
Alias:
CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase; CN5A; PDE5; phosphodiesterase 5A, cGMP-specific
Type:
Nucleotide Metabolism - purine; EC 3.1.4.35; Phosphodiesterase; EC 3.1.4.17
Mass (Da):
100013
Number AA:
875
UniProt ID:
O76074
International Prot ID:
IPI00294595
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0047555
GO:0030553
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
Q
Q
Q
R
D
Q
D
S
V
E
A
W
L
D
D
Site 2
Y44
H
W
D
F
T
F
S
Y
F
V
R
K
A
T
R
Site 3
T50
S
Y
F
V
R
K
A
T
R
E
M
V
N
A
W
Site 4
T64
W
F
A
E
R
V
H
T
I
P
V
C
K
E
G
Site 5
T76
K
E
G
I
R
G
H
T
E
S
C
S
C
P
L
Site 6
S78
G
I
R
G
H
T
E
S
C
S
C
P
L
Q
Q
Site 7
S80
R
G
H
T
E
S
C
S
C
P
L
Q
Q
S
P
Site 8
S86
C
S
C
P
L
Q
Q
S
P
R
A
D
N
S
V
Site 9
S92
Q
S
P
R
A
D
N
S
V
P
G
T
P
T
R
Site 10
T96
A
D
N
S
V
P
G
T
P
T
R
K
I
S
A
Site 11
S102
G
T
P
T
R
K
I
S
A
S
E
F
D
R
P
Site 12
S104
P
T
R
K
I
S
A
S
E
F
D
R
P
L
R
Site 13
S123
K
D
S
E
G
T
V
S
F
L
S
D
S
E
K
Site 14
S126
E
G
T
V
S
F
L
S
D
S
E
K
K
E
Q
Site 15
S128
T
V
S
F
L
S
D
S
E
K
K
E
Q
M
P
Site 16
T137
K
K
E
Q
M
P
L
T
P
P
R
F
D
H
D
Site 17
S150
H
D
E
G
D
Q
C
S
R
L
L
E
L
V
K
Site 18
S202
S
N
D
K
F
L
I
S
R
L
F
D
V
A
E
Site 19
S211
L
F
D
V
A
E
G
S
T
L
E
E
V
S
N
Site 20
Y246
P
L
N
I
K
D
A
Y
E
D
P
R
F
N
A
Site 21
Y261
E
V
D
Q
I
T
G
Y
K
T
Q
S
I
L
C
Site 22
T263
D
Q
I
T
G
Y
K
T
Q
S
I
L
C
M
P
Site 23
S289
A
Q
A
I
N
K
K
S
G
N
G
G
T
F
T
Site 24
T294
K
K
S
G
N
G
G
T
F
T
E
K
D
E
K
Site 25
T296
S
G
N
G
G
T
F
T
E
K
D
E
K
D
F
Site 26
Y320
V
L
H
N
A
Q
L
Y
E
T
S
L
L
E
N
Site 27
S346
L
I
F
E
E
Q
Q
S
L
E
V
I
L
K
K
Site 28
S379
V
D
E
D
C
S
D
S
F
S
S
V
F
H
M
Site 29
S394
E
C
E
E
L
E
K
S
S
D
T
L
T
R
E
Site 30
T399
E
K
S
S
D
T
L
T
R
E
H
D
A
N
K
Site 31
Y409
H
D
A
N
K
I
N
Y
M
Y
A
Q
Y
V
K
Site 32
Y411
A
N
K
I
N
Y
M
Y
A
Q
Y
V
K
N
T
Site 33
Y414
I
N
Y
M
Y
A
Q
Y
V
K
N
T
M
E
P
Site 34
S428
P
L
N
I
P
D
V
S
K
D
K
R
F
P
W
Site 35
T436
K
D
K
R
F
P
W
T
T
E
N
T
G
N
V
Site 36
T454
C
I
R
S
L
L
C
T
P
I
K
N
G
K
K
Site 37
Y509
G
I
Q
N
T
Q
M
Y
E
A
V
E
R
A
M
Site 38
S531
E
V
L
S
Y
H
A
S
A
A
E
E
E
T
R
Site 39
T557
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
Site 40
S560
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
Site 41
S562
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
Site 42
S663
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
Site 43
Y664
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
P
Site 44
Y676
E
H
P
L
A
Q
L
Y
C
H
S
I
M
E
H
Site 45
S702
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
Site 46
Y709
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
Site 47
T711
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
Site 48
T712
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
Site 49
Y728
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
Site 50
T784
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
Site 51
S815
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
Site 52
S869
K
M
L
I
N
G
E
S
G
Q
A
K
R
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation