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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DFFB
Full Name:
DNA fragmentation factor subunit beta
Alias:
Caspase-activated deoxyribonuclease;Caspase-activated nuclease;DNA fragmentation factor 40 kDa subunit
Type:
Mass (Da):
39110
Number AA:
338
UniProt ID:
O76075
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
L
Q
K
P
K
S
V
K
L
R
A
L
R
Site 2
S15
V
K
L
R
A
L
R
S
P
R
K
F
G
V
A
Site 3
S25
K
F
G
V
A
G
R
S
C
Q
E
V
L
R
K
Site 4
S44
F
Q
L
P
E
R
G
S
R
L
C
L
Y
E
D
Site 5
Y49
R
G
S
R
L
C
L
Y
E
D
G
T
E
L
T
Site 6
T53
L
C
L
Y
E
D
G
T
E
L
T
E
D
Y
F
Site 7
T56
Y
E
D
G
T
E
L
T
E
D
Y
F
P
S
V
Site 8
Y59
G
T
E
L
T
E
D
Y
F
P
S
V
P
D
N
Site 9
S62
L
T
E
D
Y
F
P
S
V
P
D
N
A
E
L
Site 10
Y81
L
G
Q
A
W
Q
G
Y
V
S
D
I
R
R
F
Site 11
S83
Q
A
W
Q
G
Y
V
S
D
I
R
R
F
L
S
Site 12
S90
S
D
I
R
R
F
L
S
A
F
H
E
P
Q
V
Site 13
S127
A
D
L
L
H
N
V
S
Q
N
I
A
A
E
T
Site 14
S147
P
W
F
E
G
L
E
S
R
F
Q
S
K
S
G
Site 15
S151
G
L
E
S
R
F
Q
S
K
S
G
Y
L
R
Y
Site 16
S153
E
S
R
F
Q
S
K
S
G
Y
L
R
Y
S
C
Site 17
Y155
R
F
Q
S
K
S
G
Y
L
R
Y
S
C
E
S
Site 18
Y158
S
K
S
G
Y
L
R
Y
S
C
E
S
R
I
R
Site 19
S159
K
S
G
Y
L
R
Y
S
C
E
S
R
I
R
S
Site 20
S162
Y
L
R
Y
S
C
E
S
R
I
R
S
Y
L
R
Site 21
S166
S
C
E
S
R
I
R
S
Y
L
R
E
V
S
S
Site 22
Y167
C
E
S
R
I
R
S
Y
L
R
E
V
S
S
Y
Site 23
S172
R
S
Y
L
R
E
V
S
S
Y
P
S
T
V
G
Site 24
S173
S
Y
L
R
E
V
S
S
Y
P
S
T
V
G
A
Site 25
Y174
Y
L
R
E
V
S
S
Y
P
S
T
V
G
A
E
Site 26
S176
R
E
V
S
S
Y
P
S
T
V
G
A
E
A
Q
Site 27
T177
E
V
S
S
Y
P
S
T
V
G
A
E
A
Q
E
Site 28
S192
E
F
L
R
V
L
G
S
M
C
Q
R
L
R
S
Site 29
S205
R
S
M
Q
Y
N
G
S
Y
F
D
R
G
A
K
Site 30
Y206
S
M
Q
Y
N
G
S
Y
F
D
R
G
A
K
G
Site 31
S215
D
R
G
A
K
G
G
S
R
L
C
T
P
E
G
Site 32
T219
K
G
G
S
R
L
C
T
P
E
G
W
F
S
C
Site 33
S234
Q
G
P
F
D
M
D
S
C
L
S
R
H
S
I
Site 34
S240
D
S
C
L
S
R
H
S
I
N
P
Y
S
N
R
Site 35
Y244
S
R
H
S
I
N
P
Y
S
N
R
E
S
R
I
Site 36
S245
R
H
S
I
N
P
Y
S
N
R
E
S
R
I
L
Site 37
S249
N
P
Y
S
N
R
E
S
R
I
L
F
S
T
W
Site 38
S254
R
E
S
R
I
L
F
S
T
W
N
L
D
H
I
Site 39
T267
H
I
I
E
K
K
R
T
I
I
P
T
L
V
E
Site 40
T271
K
K
R
T
I
I
P
T
L
V
E
A
I
K
E
Site 41
Y288
G
R
E
V
D
W
E
Y
F
Y
G
L
L
F
T
Site 42
Y290
E
V
D
W
E
Y
F
Y
G
L
L
F
T
S
E
Site 43
S319
H
K
L
N
C
D
P
S
R
I
Y
K
P
Q
T
Site 44
Y322
N
C
D
P
S
R
I
Y
K
P
Q
T
R
L
K
Site 45
T326
S
R
I
Y
K
P
Q
T
R
L
K
R
K
Q
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation