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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOM3Z
Full Name:
Protein Dom3Z
Alias:
Dom-3 homolog Z
Type:
Mass (Da):
44929
Number AA:
396
UniProt ID:
O77932
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
D
P
R
G
T
K
R
G
A
E
K
T
Site 2
T13
T
K
R
G
A
E
K
T
E
V
A
E
P
R
N
Site 3
S28
K
L
P
R
P
A
P
S
L
P
T
D
P
A
L
Site 4
Y36
L
P
T
D
P
A
L
Y
S
G
P
F
P
F
Y
Site 5
S37
P
T
D
P
A
L
Y
S
G
P
F
P
F
Y
R
Site 6
Y43
Y
S
G
P
F
P
F
Y
R
R
P
S
E
L
G
Site 7
S47
F
P
F
Y
R
R
P
S
E
L
G
C
F
S
L
Site 8
S53
P
S
E
L
G
C
F
S
L
D
A
Q
R
Q
Y
Site 9
Y60
S
L
D
A
Q
R
Q
Y
H
G
D
A
R
A
L
Site 10
Y69
G
D
A
R
A
L
R
Y
Y
S
P
P
P
T
N
Site 11
Y70
D
A
R
A
L
R
Y
Y
S
P
P
P
T
N
G
Site 12
S71
A
R
A
L
R
Y
Y
S
P
P
P
T
N
G
P
Site 13
T75
R
Y
Y
S
P
P
P
T
N
G
P
G
P
N
F
Site 14
Y88
N
F
D
L
R
D
G
Y
P
D
R
Y
Q
P
R
Site 15
Y92
R
D
G
Y
P
D
R
Y
Q
P
R
D
E
E
V
Site 16
T140
G
H
L
T
K
L
L
T
T
P
Y
E
R
Q
E
Site 17
T141
H
L
T
K
L
L
T
T
P
Y
E
R
Q
E
G
Site 18
Y143
T
K
L
L
T
T
P
Y
E
R
Q
E
G
W
Q
Site 19
S154
E
G
W
Q
L
A
A
S
R
F
Q
G
T
L
Y
Site 20
Y161
S
R
F
Q
G
T
L
Y
L
S
E
V
E
T
P
Site 21
S163
F
Q
G
T
L
Y
L
S
E
V
E
T
P
N
A
Site 22
T167
L
Y
L
S
E
V
E
T
P
N
A
R
A
Q
R
Site 23
Y186
P
L
L
R
E
L
M
Y
M
G
Y
K
F
E
Q
Site 24
Y194
M
G
Y
K
F
E
Q
Y
M
C
A
D
K
P
G
Site 25
S202
M
C
A
D
K
P
G
S
S
P
D
P
S
G
E
Site 26
S203
C
A
D
K
P
G
S
S
P
D
P
S
G
E
V
Site 27
S207
P
G
S
S
P
D
P
S
G
E
V
N
T
N
V
Site 28
T238
F
S
G
E
V
D
C
T
D
P
Q
A
P
S
T
Site 29
T245
T
D
P
Q
A
P
S
T
Q
P
P
T
C
Y
V
Site 30
T249
A
P
S
T
Q
P
P
T
C
Y
V
E
L
K
T
Site 31
Y251
S
T
Q
P
P
T
C
Y
V
E
L
K
T
S
K
Site 32
S262
K
T
S
K
E
M
H
S
P
G
Q
W
R
S
F
Site 33
Y270
P
G
Q
W
R
S
F
Y
R
H
K
L
L
K
W
Site 34
S302
N
P
D
G
F
V
S
S
L
K
T
F
P
T
M
Site 35
T308
S
S
L
K
T
F
P
T
M
K
M
F
E
Y
V
Site 36
Y314
P
T
M
K
M
F
E
Y
V
R
N
D
R
D
G
Site 37
S354
P
R
L
V
H
L
F
S
W
E
P
G
G
P
V
Site 38
T362
W
E
P
G
G
P
V
T
V
S
V
H
Q
D
A
Site 39
S364
P
G
G
P
V
T
V
S
V
H
Q
D
A
P
Y
Site 40
Y371
S
V
H
Q
D
A
P
Y
A
F
L
P
I
W
Y
Site 41
S388
A
M
T
Q
D
L
P
S
P
P
K
T
P
S
P
Site 42
T392
D
L
P
S
P
P
K
T
P
S
P
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation