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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRPM2
Full Name:
Transient receptor potential cation channel subfamily M member 2
Alias:
EREG1; Estrogen-responsive element-associated 1; KNP3; Long transient receptor potential channel 2; LTRPC2; LTrpC-2; NUDT9H; NUDT9L1; Transient receptor cation channel M2; Transient receptor potential cation channel, subfamily M, member 2; TrpC7
Type:
EC 3.6.1.13; Membrane protein, integral; Channel, calcium; Hydrolase; Transporter
Mass (Da):
171200
Number AA:
UniProt ID:
O94759
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0047631
GO:0005262
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
S
A
L
R
K
A
G
S
E
Q
E
E
G
F
E
Site 2
T25
E
G
L
P
R
R
V
T
D
L
G
M
V
S
N
Site 3
S31
V
T
D
L
G
M
V
S
N
L
R
R
S
N
S
Site 4
S36
M
V
S
N
L
R
R
S
N
S
S
L
F
K
S
Site 5
S38
S
N
L
R
R
S
N
S
S
L
F
K
S
W
R
Site 6
S39
N
L
R
R
S
N
S
S
L
F
K
S
W
R
L
Site 7
S43
S
N
S
S
L
F
K
S
W
R
L
Q
C
P
F
Site 8
S58
G
N
N
D
K
Q
E
S
L
S
S
W
I
P
E
Site 9
S61
D
K
Q
E
S
L
S
S
W
I
P
E
N
I
K
Site 10
Y74
I
K
K
K
E
C
V
Y
F
V
E
S
S
K
L
Site 11
S78
E
C
V
Y
F
V
E
S
S
K
L
S
D
A
G
Site 12
T107
E
E
A
T
K
P
H
T
F
Q
G
T
Q
W
D
Site 13
Y142
L
S
Q
K
V
K
K
Y
V
R
V
S
Q
D
T
Site 14
S146
V
K
K
Y
V
R
V
S
Q
D
T
P
S
S
V
Site 15
T149
Y
V
R
V
S
Q
D
T
P
S
S
V
I
Y
H
Site 16
S151
R
V
S
Q
D
T
P
S
S
V
I
Y
H
L
M
Site 17
S152
V
S
Q
D
T
P
S
S
V
I
Y
H
L
M
T
Site 18
Y155
D
T
P
S
S
V
I
Y
H
L
M
T
Q
H
W
Site 19
S188
N
M
K
P
R
L
K
S
I
F
R
R
G
L
V
Site 20
S226
G
E
A
V
R
D
F
S
L
S
S
S
Y
K
E
Site 21
S228
A
V
R
D
F
S
L
S
S
S
Y
K
E
G
E
Site 22
S230
R
D
F
S
L
S
S
S
Y
K
E
G
E
L
I
Site 23
T246
I
G
V
A
T
W
G
T
V
H
R
R
E
G
L
Site 24
Y264
T
G
S
F
P
A
E
Y
I
L
D
E
D
G
Q
Site 25
T275
E
D
G
Q
G
N
L
T
C
L
D
S
N
H
S
Site 26
T291
F
I
L
V
D
D
G
T
H
G
Q
Y
G
V
E
Site 27
Y295
D
D
G
T
H
G
Q
Y
G
V
E
I
P
L
R
Site 28
S310
T
R
L
E
K
F
I
S
E
Q
T
K
E
R
G
Site 29
T339
G
G
P
G
T
L
H
T
I
D
N
A
T
T
N
Site 30
T344
L
H
T
I
D
N
A
T
T
N
G
T
P
C
V
Site 31
T348
D
N
A
T
T
N
G
T
P
C
V
V
V
E
G
Site 32
T393
F
F
Q
E
M
F
E
T
F
T
E
S
R
I
V
Site 33
T395
Q
E
M
F
E
T
F
T
E
S
R
I
V
E
W
Site 34
T417
V
R
R
R
Q
L
L
T
V
F
R
E
G
K
D
Site 35
S443
A
L
L
K
A
S
R
S
Q
D
H
F
G
H
E
Site 36
T489
S
D
L
H
P
T
M
T
A
A
L
I
S
N
K
Site 37
T518
K
E
F
V
T
W
D
T
L
L
Y
L
Y
E
N
Site 38
Y521
V
T
W
D
T
L
L
Y
L
Y
E
N
L
D
P
Site 39
Y523
W
D
T
L
L
Y
L
Y
E
N
L
D
P
S
C
Site 40
S529
L
Y
E
N
L
D
P
S
C
L
F
H
S
K
L
Site 41
T573
R
E
L
L
G
D
F
T
Q
P
L
Y
P
R
P
Site 42
Y577
G
D
F
T
Q
P
L
Y
P
R
P
R
H
N
D
Site 43
S603
K
L
N
V
Q
G
V
S
L
R
S
L
Y
K
R
Site 44
S606
V
Q
G
V
S
L
R
S
L
Y
K
R
S
S
G
Site 45
Y608
G
V
S
L
R
S
L
Y
K
R
S
S
G
H
V
Site 46
S612
R
S
L
Y
K
R
S
S
G
H
V
T
F
T
M
Site 47
T616
K
R
S
S
G
H
V
T
F
T
M
D
P
I
R
Site 48
T618
S
S
G
H
V
T
F
T
M
D
P
I
R
D
L
Site 49
S663
S
K
I
L
K
E
L
S
K
E
E
E
D
T
D
Site 50
T669
L
S
K
E
E
E
D
T
D
S
S
E
E
M
L
Site 51
S671
K
E
E
E
D
T
D
S
S
E
E
M
L
A
L
Site 52
Y682
M
L
A
L
A
E
E
Y
E
H
R
A
I
G
V
Site 53
Y694
I
G
V
F
T
E
C
Y
R
K
D
E
E
R
A
Site 54
S709
Q
K
L
L
T
R
V
S
E
A
W
G
K
T
T
Site 55
S731
A
K
D
M
K
F
V
S
H
G
G
I
Q
A
F
Site 56
T768
L
A
F
P
L
L
L
T
G
L
I
S
F
R
E
Site 57
T783
K
R
L
Q
D
V
G
T
P
A
A
R
A
R
A
Site 58
Y849
E
E
M
R
Q
L
F
Y
D
P
D
E
C
G
L
Site 59
Y863
L
M
K
K
A
A
L
Y
F
S
D
F
W
N
K
Site 60
T1001
E
H
C
S
P
N
G
T
D
P
Y
K
P
K
C
Site 61
Y1004
S
P
N
G
T
D
P
Y
K
P
K
C
P
E
S
Site 62
S1011
Y
K
P
K
C
P
E
S
D
A
T
Q
Q
R
P
Site 63
T1014
K
C
P
E
S
D
A
T
Q
Q
R
P
A
F
P
Site 64
T1101
I
K
R
V
V
L
K
T
P
A
K
R
H
K
Q
Site 65
S1123
N
E
E
A
A
L
L
S
W
E
I
Y
L
K
E
Site 66
Y1127
A
L
L
S
W
E
I
Y
L
K
E
N
Y
L
Q
Site 67
Y1132
E
I
Y
L
K
E
N
Y
L
Q
N
R
Q
F
Q
Site 68
S1170
D
L
D
P
L
K
R
S
G
S
M
E
Q
R
L
Site 69
S1172
D
P
L
K
R
S
G
S
M
E
Q
R
L
A
S
Site 70
S1179
S
M
E
Q
R
L
A
S
L
E
E
Q
V
A
Q
Site 71
S1201
I
V
R
T
L
R
A
S
G
F
S
S
E
A
D
Site 72
S1205
L
R
A
S
G
F
S
S
E
A
D
V
P
T
L
Site 73
T1211
S
S
E
A
D
V
P
T
L
A
S
Q
K
A
A
Site 74
T1231
E
P
G
G
R
K
K
T
E
E
P
G
D
S
Y
Site 75
S1237
K
T
E
E
P
G
D
S
Y
H
V
N
A
R
H
Site 76
Y1238
T
E
E
P
G
D
S
Y
H
V
N
A
R
H
L
Site 77
Y1247
V
N
A
R
H
L
L
Y
P
N
C
P
V
T
R
Site 78
T1253
L
Y
P
N
C
P
V
T
R
F
P
V
P
N
E
Site 79
Y1271
W
E
T
E
F
L
I
Y
D
P
P
F
Y
T
A
Site 80
Y1276
L
I
Y
D
P
P
F
Y
T
A
E
R
K
D
A
Site 81
S1297
G
D
T
L
E
P
L
S
T
I
Q
Y
N
V
V
Site 82
T1298
D
T
L
E
P
L
S
T
I
Q
Y
N
V
V
D
Site 83
Y1301
E
P
L
S
T
I
Q
Y
N
V
V
D
G
L
R
Site 84
S1312
D
G
L
R
D
R
R
S
F
H
G
P
Y
T
V
Site 85
Y1317
R
R
S
F
H
G
P
Y
T
V
Q
A
G
L
P
Site 86
T1318
R
S
F
H
G
P
Y
T
V
Q
A
G
L
P
L
Site 87
S1338
T
G
L
R
G
R
G
S
L
S
C
F
G
P
N
Site 88
S1340
L
R
G
R
G
S
L
S
C
F
G
P
N
H
T
Site 89
T1347
S
C
F
G
P
N
H
T
L
Y
P
M
V
T
R
Site 90
Y1349
F
G
P
N
H
T
L
Y
P
M
V
T
R
W
R
Site 91
S1367
D
G
A
I
C
R
K
S
I
K
K
M
L
E
V
Site 92
S1391
H
W
A
L
P
G
G
S
R
E
P
G
E
M
L
Site 93
S1413
L
R
Q
E
H
W
P
S
F
E
N
L
L
K
C
Site 94
S1462
V
E
L
N
R
L
N
S
N
L
H
A
C
D
S
Site 95
S1469
S
N
L
H
A
C
D
S
G
A
S
I
R
W
Q
Site 96
Y1485
V
D
R
R
I
P
L
Y
A
N
H
K
T
L
L
Site 97
T1490
P
L
Y
A
N
H
K
T
L
L
Q
K
A
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation