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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP1
Full Name:
Ubiquitin carboxyl-terminal hydrolase 1
Alias:
Deubiquitinating enzyme 1; EC 3.1.2.15; Ubiquitin carboxyl-terminal hydrolase 1; Ubiquitin specific peptidase 1; Ubiquitin thioesterase 1; Ubiquitin thiolesterase 1; UBP; UBP1
Type:
EC 3.1.2.15; Ubiquitin conjugating system; Protease
Mass (Da):
88207
Number AA:
785
UniProt ID:
O94782
International Prot ID:
IPI00304379
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0005515
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0016579
GO:0006282
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
P
G
V
I
P
S
E
S
N
G
L
S
R
Site 2
S9
P
G
V
I
P
S
E
S
N
G
L
S
R
G
S
Site 3
S13
P
S
E
S
N
G
L
S
R
G
S
P
S
K
K
Site 4
S16
S
N
G
L
S
R
G
S
P
S
K
K
N
R
L
Site 5
S18
G
L
S
R
G
S
P
S
K
K
N
R
L
S
L
Site 6
S24
P
S
K
K
N
R
L
S
L
K
F
F
Q
K
K
Site 7
T33
K
F
F
Q
K
K
E
T
K
R
A
L
D
F
T
Site 8
T40
T
K
R
A
L
D
F
T
D
S
Q
E
N
E
E
Site 9
S42
R
A
L
D
F
T
D
S
Q
E
N
E
E
K
A
Site 10
S50
Q
E
N
E
E
K
A
S
E
Y
R
A
S
E
I
Site 11
S55
K
A
S
E
Y
R
A
S
E
I
D
Q
V
V
P
Site 12
S67
V
V
P
A
A
Q
S
S
P
I
N
C
E
K
R
Site 13
S117
K
H
L
F
N
I
I
S
R
K
K
E
A
L
K
Site 14
S139
K
G
N
C
K
E
D
S
L
A
S
Y
E
L
I
Site 15
Y143
K
E
D
S
L
A
S
Y
E
L
I
C
S
L
Q
Site 16
S162
S
V
E
Q
L
Q
A
S
F
L
L
N
P
E
K
Site 17
T184
Q
P
R
R
L
L
N
T
L
R
E
L
N
P
M
Site 18
Y192
L
R
E
L
N
P
M
Y
E
G
Y
L
Q
H
D
Site 19
S248
E
E
M
N
G
I
N
S
I
E
M
D
S
M
R
Site 20
S253
I
N
S
I
E
M
D
S
M
R
H
S
E
D
F
Site 21
S257
E
M
D
S
M
R
H
S
E
D
F
K
E
K
L
Site 22
S273
K
G
N
G
K
R
K
S
D
T
E
F
G
N
M
Site 23
T275
N
G
K
R
K
S
D
T
E
F
G
N
M
K
K
Site 24
S287
M
K
K
K
V
K
L
S
K
E
H
Q
S
L
E
Site 25
S292
K
L
S
K
E
H
Q
S
L
E
E
N
Q
R
Q
Site 26
T300
L
E
E
N
Q
R
Q
T
R
S
K
R
K
A
T
Site 27
S302
E
N
Q
R
Q
T
R
S
K
R
K
A
T
S
D
Site 28
T307
T
R
S
K
R
K
A
T
S
D
T
L
E
S
P
Site 29
S308
R
S
K
R
K
A
T
S
D
T
L
E
S
P
P
Site 30
T310
K
R
K
A
T
S
D
T
L
E
S
P
P
K
I
Site 31
S313
A
T
S
D
T
L
E
S
P
P
K
I
I
P
K
Site 32
Y321
P
P
K
I
I
P
K
Y
I
S
E
N
E
S
P
Site 33
S323
K
I
I
P
K
Y
I
S
E
N
E
S
P
R
P
Site 34
S327
K
Y
I
S
E
N
E
S
P
R
P
S
Q
K
K
Site 35
S331
E
N
E
S
P
R
P
S
Q
K
K
S
R
V
K
Site 36
S335
P
R
P
S
Q
K
K
S
R
V
K
I
N
W
L
Site 37
S344
V
K
I
N
W
L
K
S
A
T
K
Q
P
S
I
Site 38
T346
I
N
W
L
K
S
A
T
K
Q
P
S
I
L
S
Site 39
S350
K
S
A
T
K
Q
P
S
I
L
S
K
F
C
S
Site 40
S353
T
K
Q
P
S
I
L
S
K
F
C
S
L
G
K
Site 41
S387
E
D
L
G
K
C
E
S
D
N
T
T
N
G
C
Site 42
T390
G
K
C
E
S
D
N
T
T
N
G
C
G
L
E
Site 43
T391
K
C
E
S
D
N
T
T
N
G
C
G
L
E
S
Site 44
S398
T
N
G
C
G
L
E
S
P
G
N
T
V
T
P
Site 45
T402
G
L
E
S
P
G
N
T
V
T
P
V
N
V
N
Site 46
T404
E
S
P
G
N
T
V
T
P
V
N
V
N
E
V
Site 47
T447
C
L
E
C
E
S
L
T
E
R
R
E
D
F
Q
Site 48
S457
R
E
D
F
Q
D
I
S
V
P
V
Q
E
D
E
Site 49
S466
P
V
Q
E
D
E
L
S
K
V
E
E
S
S
E
Site 50
S471
E
L
S
K
V
E
E
S
S
E
I
S
P
E
P
Site 51
S475
V
E
E
S
S
E
I
S
P
E
P
K
T
E
M
Site 52
T480
E
I
S
P
E
P
K
T
E
M
K
T
L
R
W
Site 53
T484
E
P
K
T
E
M
K
T
L
R
W
A
I
S
Q
Site 54
S490
K
T
L
R
W
A
I
S
Q
F
A
S
V
E
R
Site 55
Y504
R
I
V
G
E
D
K
Y
F
C
E
N
C
H
H
Site 56
Y512
F
C
E
N
C
H
H
Y
T
E
A
E
R
S
L
Site 57
S518
H
Y
T
E
A
E
R
S
L
L
F
D
K
M
P
Site 58
T529
D
K
M
P
E
V
I
T
I
H
L
K
C
F
A
Site 59
Y545
S
G
L
E
F
D
C
Y
G
G
G
L
S
K
I
Site 60
S563
L
L
T
P
L
K
L
S
L
E
E
W
S
T
K
Site 61
T569
L
S
L
E
E
W
S
T
K
P
T
N
D
S
Y
Site 62
T572
E
E
W
S
T
K
P
T
N
D
S
Y
G
L
F
Site 63
S575
S
T
K
P
T
N
D
S
Y
G
L
F
A
V
V
Site 64
S590
M
H
S
G
I
T
I
S
S
G
H
Y
T
A
S
Site 65
S591
H
S
G
I
T
I
S
S
G
H
Y
T
A
S
V
Site 66
T595
T
I
S
S
G
H
Y
T
A
S
V
K
V
T
D
Site 67
S597
S
S
G
H
Y
T
A
S
V
K
V
T
D
L
N
Site 68
S605
V
K
V
T
D
L
N
S
L
E
L
D
K
G
N
Site 69
S645
N
Y
N
D
E
E
V
S
I
R
V
G
G
N
T
Site 70
T652
S
I
R
V
G
G
N
T
Q
P
S
K
V
L
N
Site 71
S674
G
L
L
G
G
Q
K
S
K
A
D
Y
E
L
Y
Site 72
Y678
G
Q
K
S
K
A
D
Y
E
L
Y
N
K
A
S
Site 73
Y681
S
K
A
D
Y
E
L
Y
N
K
A
S
N
P
D
Site 74
S685
Y
E
L
Y
N
K
A
S
N
P
D
K
V
A
S
Site 75
S701
A
F
A
E
N
R
N
S
E
T
S
D
T
T
G
Site 76
S704
E
N
R
N
S
E
T
S
D
T
T
G
T
H
E
Site 77
T706
R
N
S
E
T
S
D
T
T
G
T
H
E
S
D
Site 78
S712
D
T
T
G
T
H
E
S
D
R
N
K
E
S
S
Site 79
S719
S
D
R
N
K
E
S
S
D
Q
T
G
I
N
I
Site 80
T722
N
K
E
S
S
D
Q
T
G
I
N
I
S
G
F
Site 81
S734
S
G
F
E
N
K
I
S
Y
V
V
Q
S
L
K
Site 82
Y735
G
F
E
N
K
I
S
Y
V
V
Q
S
L
K
E
Site 83
S739
K
I
S
Y
V
V
Q
S
L
K
E
Y
E
G
K
Site 84
Y743
V
V
Q
S
L
K
E
Y
E
G
K
W
L
L
F
Site 85
S753
K
W
L
L
F
D
D
S
E
V
K
V
T
E
E
Site 86
T758
D
D
S
E
V
K
V
T
E
E
K
D
F
L
N
Site 87
S766
E
E
K
D
F
L
N
S
L
S
P
S
T
S
P
Site 88
S768
K
D
F
L
N
S
L
S
P
S
T
S
P
T
S
Site 89
S770
F
L
N
S
L
S
P
S
T
S
P
T
S
T
P
Site 90
T771
L
N
S
L
S
P
S
T
S
P
T
S
T
P
Y
Site 91
S772
N
S
L
S
P
S
T
S
P
T
S
T
P
Y
L
Site 92
T774
L
S
P
S
T
S
P
T
S
T
P
Y
L
L
F
Site 93
S775
S
P
S
T
S
P
T
S
T
P
Y
L
L
F
Y
Site 94
T776
P
S
T
S
P
T
S
T
P
Y
L
L
F
Y
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation