KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SLIT2
Full Name:
Slit homolog 2 protein
Alias:
SLIL2; SLIL3; Slit 2; Slit-2
Type:
Extracellular matrix
Mass (Da):
169870
Number AA:
1529
UniProt ID:
O94813
International Prot ID:
IPI00006288
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0002042
GO:0006935
GO:0008347
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
Q
A
C
P
A
Q
C
S
C
S
G
S
T
V
D
Site 2
S48
C
H
G
L
A
L
R
S
V
P
R
N
I
P
R
Site 3
T57
P
R
N
I
P
R
N
T
E
R
L
D
L
N
G
Site 4
T71
G
N
N
I
T
R
I
T
K
T
D
F
A
G
L
Site 5
T73
N
I
T
R
I
T
K
T
D
F
A
G
L
R
H
Site 6
S92
Q
L
M
E
N
K
I
S
T
I
E
R
G
A
F
Site 7
S135
K
L
Y
R
L
D
L
S
E
N
Q
I
Q
A
I
Site 8
Y160
I
K
N
L
Q
L
D
Y
N
Q
I
S
C
I
E
Site 9
T181
L
R
D
L
E
V
L
T
L
N
N
N
N
I
T
Site 10
T203
N
H
M
P
K
L
R
T
F
R
L
H
S
N
N
Site 11
Y233
Q
R
P
R
V
G
L
Y
T
Q
C
M
G
P
S
Site 12
T234
R
P
R
V
G
L
Y
T
Q
C
M
G
P
S
H
Site 13
T292
D
C
R
G
K
G
L
T
E
I
P
T
N
L
P
Site 14
T296
K
G
L
T
E
I
P
T
N
L
P
E
T
I
T
Site 15
T311
E
I
R
L
E
Q
N
T
I
K
V
I
P
P
G
Site 16
S321
V
I
P
P
G
A
F
S
P
Y
K
K
L
R
R
Site 17
S332
K
L
R
R
I
D
L
S
N
N
Q
I
S
E
L
Site 18
S352
Q
G
L
R
S
L
N
S
L
V
L
Y
G
N
K
Site 19
S402
L
H
N
L
N
L
L
S
L
Y
D
N
K
L
Q
Site 20
Y404
N
L
N
L
L
S
L
Y
D
N
K
L
Q
T
I
Site 21
Y444
H
L
K
W
L
A
D
Y
L
H
T
N
P
I
E
Site 22
S453
H
T
N
P
I
E
T
S
G
A
R
C
T
S
P
Site 23
T458
E
T
S
G
A
R
C
T
S
P
R
R
L
A
N
Site 24
S459
T
S
G
A
R
C
T
S
P
R
R
L
A
N
K
Site 25
S473
K
R
I
G
Q
I
K
S
K
K
F
R
C
S
A
Site 26
S479
K
S
K
K
F
R
C
S
A
K
E
Q
Y
F
I
Site 27
Y484
R
C
S
A
K
E
Q
Y
F
I
P
G
T
E
D
Site 28
T489
E
Q
Y
F
I
P
G
T
E
D
Y
R
S
K
L
Site 29
Y492
F
I
P
G
T
E
D
Y
R
S
K
L
S
G
D
Site 30
S494
P
G
T
E
D
Y
R
S
K
L
S
G
D
C
F
Site 31
S520
E
G
T
T
V
D
C
S
N
Q
K
L
N
K
I
Site 32
Y534
I
P
E
H
I
P
Q
Y
T
A
E
L
R
L
N
Site 33
S566
Q
L
R
K
I
N
F
S
N
N
K
I
T
D
I
Site 34
T590
G
V
N
E
I
L
L
T
S
N
R
L
E
N
V
Site 35
S591
V
N
E
I
L
L
T
S
N
R
L
E
N
V
Q
Site 36
S607
K
M
F
K
G
L
E
S
L
K
T
L
M
L
R
Site 37
T610
K
G
L
E
S
L
K
T
L
M
L
R
S
N
R
Site 38
T619
M
L
R
S
N
R
I
T
C
V
G
N
D
S
F
Site 39
T644
L
Y
D
N
Q
I
T
T
V
A
P
G
A
F
D
Site 40
T686
L
R
K
K
R
I
V
T
G
N
P
R
C
Q
K
Site 41
Y695
N
P
R
C
Q
K
P
Y
F
L
K
E
I
P
I
Site 42
S720
D
D
G
N
D
D
N
S
C
S
P
L
S
R
C
Site 43
S722
G
N
D
D
N
S
C
S
P
L
S
R
C
P
T
Site 44
S725
D
N
S
C
S
P
L
S
R
C
P
T
E
C
T
Site 45
T729
S
P
L
S
R
C
P
T
E
C
T
C
L
D
T
Site 46
T757
K
G
I
P
R
D
V
T
E
L
Y
L
D
G
N
Site 47
Y760
P
R
D
V
T
E
L
Y
L
D
G
N
Q
F
T
Site 48
T767
Y
L
D
G
N
Q
F
T
L
V
P
K
E
L
S
Site 49
Y776
V
P
K
E
L
S
N
Y
K
H
L
T
L
I
D
Site 50
T780
L
S
N
Y
K
H
L
T
L
I
D
L
S
N
N
Site 51
S790
D
L
S
N
N
R
I
S
T
L
S
N
Q
S
F
Site 52
T791
L
S
N
N
R
I
S
T
L
S
N
Q
S
F
S
Site 53
S793
N
N
R
I
S
T
L
S
N
Q
S
F
S
N
M
Site 54
S796
I
S
T
L
S
N
Q
S
F
S
N
M
T
Q
L
Site 55
T820
L
R
C
I
P
P
R
T
F
D
G
L
K
S
L
Site 56
S826
R
T
F
D
G
L
K
S
L
R
L
L
S
L
H
Site 57
S831
L
K
S
L
R
L
L
S
L
H
G
N
D
I
S
Site 58
Y878
S
D
W
V
K
S
E
Y
K
E
P
G
I
A
R
Site 59
T900
A
D
K
L
L
L
T
T
P
S
K
K
F
T
C
Site 60
S902
K
L
L
L
T
T
P
S
K
K
F
T
C
Q
G
Site 61
T906
T
T
P
S
K
K
F
T
C
Q
G
P
V
D
V
Site 62
S935
K
N
D
G
T
C
N
S
D
P
V
D
F
Y
R
Site 63
Y941
N
S
D
P
V
D
F
Y
R
C
T
C
P
Y
G
Site 64
Y1020
C
V
D
G
I
N
N
Y
T
C
L
C
P
P
E
Site 65
Y1028
T
C
L
C
P
P
E
Y
T
G
E
L
C
E
E
Site 66
T1056
H
D
S
K
C
I
L
T
P
K
G
F
K
C
D
Site 67
T1122
P
P
M
V
L
P
R
T
S
P
C
D
N
F
D
Site 68
S1123
P
M
V
L
P
R
T
S
P
C
D
N
F
D
C
Site 69
Y1151
I
C
Q
C
L
P
G
Y
Q
G
E
K
C
E
K
Site 70
S1161
E
K
C
E
K
L
V
S
V
N
F
I
N
K
E
Site 71
Y1170
N
F
I
N
K
E
S
Y
L
Q
I
P
S
A
K
Site 72
S1175
E
S
Y
L
Q
I
P
S
A
K
V
R
P
Q
T
Site 73
T1182
S
A
K
V
R
P
Q
T
N
I
T
L
Q
I
A
Site 74
S1194
Q
I
A
T
D
E
D
S
G
I
L
L
Y
K
G
Site 75
Y1199
E
D
S
G
I
L
L
Y
K
G
D
K
D
H
I
Site 76
S1218
Y
R
G
R
V
R
A
S
Y
D
T
G
S
H
P
Site 77
Y1219
R
G
R
V
R
A
S
Y
D
T
G
S
H
P
A
Site 78
T1221
R
V
R
A
S
Y
D
T
G
S
H
P
A
S
A
Site 79
S1223
R
A
S
Y
D
T
G
S
H
P
A
S
A
I
Y
Site 80
S1227
D
T
G
S
H
P
A
S
A
I
Y
S
V
E
T
Site 81
S1231
H
P
A
S
A
I
Y
S
V
E
T
I
N
D
G
Site 82
S1255
L
D
Q
S
L
S
L
S
V
D
G
G
N
P
K
Site 83
S1268
P
K
I
I
T
N
L
S
K
Q
S
T
L
N
F
Site 84
T1272
T
N
L
S
K
Q
S
T
L
N
F
D
S
P
L
Site 85
S1277
Q
S
T
L
N
F
D
S
P
L
Y
V
G
G
M
Site 86
Y1280
L
N
F
D
S
P
L
Y
V
G
G
M
P
G
K
Site 87
S1288
V
G
G
M
P
G
K
S
N
V
A
S
L
R
Q
Site 88
S1292
P
G
K
S
N
V
A
S
L
R
Q
A
P
G
Q
Site 89
Y1312
H
G
C
I
R
N
L
Y
I
N
S
E
L
Q
D
Site 90
T1345
K
K
V
C
A
H
G
T
C
Q
P
S
S
Q
A
Site 91
S1350
H
G
T
C
Q
P
S
S
Q
A
G
F
T
C
E
Site 92
T1371
G
P
L
C
D
Q
R
T
N
D
P
C
L
G
N
Site 93
S1429
K
H
G
K
C
R
L
S
G
L
G
Q
P
Y
C
Site 94
Y1435
L
S
G
L
G
Q
P
Y
C
E
C
S
S
G
Y
Site 95
S1439
G
Q
P
Y
C
E
C
S
S
G
Y
T
G
D
S
Site 96
S1446
S
S
G
Y
T
G
D
S
C
D
R
E
I
S
C
Site 97
S1452
D
S
C
D
R
E
I
S
C
R
G
E
R
I
R
Site 98
Y1461
R
G
E
R
I
R
D
Y
Y
Q
K
Q
Q
G
Y
Site 99
Y1462
G
E
R
I
R
D
Y
Y
Q
K
Q
Q
G
Y
A
Site 100
S1497
Q
C
C
G
P
L
R
S
K
R
R
K
Y
S
F
Site 101
Y1502
L
R
S
K
R
R
K
Y
S
F
E
C
T
D
G
Site 102
S1503
R
S
K
R
R
K
Y
S
F
E
C
T
D
G
S
Site 103
T1507
R
K
Y
S
F
E
C
T
D
G
S
S
F
V
D
Site 104
S1510
S
F
E
C
T
D
G
S
S
F
V
D
E
V
E
Site 105
S1511
F
E
C
T
D
G
S
S
F
V
D
E
V
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation