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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF294
Full Name:
RING finger protein 160
Alias:
C21orf10; C21orf98; FLJ11053; KIAA0714; RING finger 160; Ring finger protein 160; RNF160; Zinc finger 294; ZN294
Type:
Unknown function
Mass (Da):
200526
Number AA:
1766
UniProt ID:
O94822
International Prot ID:
IPI00783835
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
T
K
G
N
L
R
P
S
N
S
G
R
A
A
E
Site 2
S18
G
N
L
R
P
S
N
S
G
R
A
A
E
L
L
Site 3
T40
P
G
F
I
G
F
G
T
S
Q
S
D
L
G
Y
Site 4
Y47
T
S
Q
S
D
L
G
Y
V
P
A
I
Q
G
A
Site 5
S59
Q
G
A
E
E
I
D
S
L
V
D
S
D
F
R
Site 6
S63
E
I
D
S
L
V
D
S
D
F
R
M
V
L
R
Site 7
S73
R
M
V
L
R
K
L
S
K
K
D
V
T
T
K
Site 8
T89
K
A
M
Q
E
F
G
T
M
C
T
E
R
D
T
Site 9
T96
T
M
C
T
E
R
D
T
E
T
V
K
G
V
L
Site 10
T98
C
T
E
R
D
T
E
T
V
K
G
V
L
P
Y
Site 11
S114
P
R
I
F
C
K
I
S
L
D
H
D
R
R
V
Site 12
T125
D
R
R
V
R
E
A
T
Q
Q
A
F
E
K
L
Site 13
Y143
V
K
K
Q
L
A
P
Y
L
K
S
L
M
G
Y
Site 14
S177
F
E
A
A
F
P
P
S
K
Q
P
E
A
I
A
Site 15
T191
A
F
C
K
D
E
I
T
S
V
L
Q
D
H
L
Site 16
T202
Q
D
H
L
I
K
E
T
P
D
T
L
S
D
P
Site 17
T205
L
I
K
E
T
P
D
T
L
S
D
P
Q
T
V
Site 18
S207
K
E
T
P
D
T
L
S
D
P
Q
T
V
P
E
Site 19
T211
D
T
L
S
D
P
Q
T
V
P
E
E
E
R
E
Site 20
Y222
E
E
R
E
A
K
F
Y
R
V
V
T
C
S
L
Site 21
S246
L
P
D
N
E
L
D
S
L
E
E
K
F
K
S
Site 22
S253
S
L
E
E
K
F
K
S
L
L
S
Q
N
K
F
Site 23
S256
E
K
F
K
S
L
L
S
Q
N
K
F
W
K
Y
Site 24
Y263
S
Q
N
K
F
W
K
Y
G
K
H
S
V
P
Q
Site 25
S298
K
E
E
A
S
K
V
S
P
S
V
L
L
S
I
Site 26
S300
E
A
S
K
V
S
P
S
V
L
L
S
I
D
D
Site 27
S339
L
H
V
N
A
K
K
S
V
F
P
K
L
S
T
Site 28
S345
K
S
V
F
P
K
L
S
T
V
I
R
E
G
G
Site 29
T346
S
V
F
P
K
L
S
T
V
I
R
E
G
G
R
Site 30
S373
F
I
S
K
L
P
Q
S
I
T
N
P
K
L
D
Site 31
T375
S
K
L
P
Q
S
I
T
N
P
K
L
D
F
F
Site 32
S394
T
S
L
V
A
G
L
S
T
E
R
T
K
T
S
Site 33
T395
S
L
V
A
G
L
S
T
E
R
T
K
T
S
S
Site 34
T398
A
G
L
S
T
E
R
T
K
T
S
S
S
E
S
Site 35
T400
L
S
T
E
R
T
K
T
S
S
S
E
S
S
A
Site 36
S401
S
T
E
R
T
K
T
S
S
S
E
S
S
A
V
Site 37
S402
T
E
R
T
K
T
S
S
S
E
S
S
A
V
I
Site 38
S403
E
R
T
K
T
S
S
S
E
S
S
A
V
I
S
Site 39
S405
T
K
T
S
S
S
E
S
S
A
V
I
S
A
F
Site 40
S406
K
T
S
S
S
E
S
S
A
V
I
S
A
F
F
Site 41
T463
L
F
N
H
L
A
E
T
L
S
S
W
E
A
K
Site 42
S465
N
H
L
A
E
T
L
S
S
W
E
A
K
A
D
Site 43
S466
H
L
A
E
T
L
S
S
W
E
A
K
A
D
T
Site 44
T479
D
T
E
K
D
E
K
T
A
H
N
L
E
N
V
Site 45
S511
E
P
E
A
D
V
E
S
V
L
G
V
S
N
L
Site 46
S527
Q
V
L
Q
K
P
K
S
S
L
K
S
S
K
K
Site 47
S528
V
L
Q
K
P
K
S
S
L
K
S
S
K
K
K
Site 48
S531
K
P
K
S
S
L
K
S
S
K
K
K
N
G
K
Site 49
S532
P
K
S
S
L
K
S
S
K
K
K
N
G
K
V
Site 50
S548
F
A
D
E
I
L
E
S
N
K
E
N
E
K
C
Site 51
S557
K
E
N
E
K
C
V
S
S
E
G
E
K
I
E
Site 52
S558
E
N
E
K
C
V
S
S
E
G
E
K
I
E
G
Site 53
T569
K
I
E
G
W
E
L
T
T
E
P
S
L
T
H
Site 54
S573
W
E
L
T
T
E
P
S
L
T
H
N
S
S
G
Site 55
T575
L
T
T
E
P
S
L
T
H
N
S
S
G
L
L
Site 56
S578
E
P
S
L
T
H
N
S
S
G
L
L
S
P
L
Site 57
S579
P
S
L
T
H
N
S
S
G
L
L
S
P
L
R
Site 58
S583
H
N
S
S
G
L
L
S
P
L
R
K
K
P
L
Site 59
Y604
L
A
D
I
S
I
N
Y
V
N
E
R
K
S
E
Site 60
S610
N
Y
V
N
E
R
K
S
E
Q
H
L
R
F
L
Site 61
S618
E
Q
H
L
R
F
L
S
T
L
L
D
S
F
S
Site 62
T619
Q
H
L
R
F
L
S
T
L
L
D
S
F
S
S
Site 63
S625
S
T
L
L
D
S
F
S
S
S
R
V
F
K
M
Site 64
T706
K
K
V
L
D
D
L
T
K
V
D
L
K
W
N
Site 65
S714
K
V
D
L
K
W
N
S
L
L
K
I
I
E
K
Site 66
S726
I
E
K
A
C
P
S
S
D
K
H
A
L
V
T
Site 67
T733
S
D
K
H
A
L
V
T
P
W
L
K
G
D
I
Site 68
S759
L
C
N
E
D
L
E
S
R
V
S
S
E
S
H
Site 69
S762
E
D
L
E
S
R
V
S
S
E
S
H
F
S
E
Site 70
S763
D
L
E
S
R
V
S
S
E
S
H
F
S
E
R
Site 71
S765
E
S
R
V
S
S
E
S
H
F
S
E
R
W
T
Site 72
S768
V
S
S
E
S
H
F
S
E
R
W
T
L
L
S
Site 73
Y786
S
Q
H
V
K
N
D
Y
L
I
G
D
V
Y
V
Site 74
T807
L
H
E
T
L
F
K
T
K
K
L
S
E
A
E
Site 75
S811
L
F
K
T
K
K
L
S
E
A
E
S
S
D
S
Site 76
S815
K
K
L
S
E
A
E
S
S
D
S
S
V
S
F
Site 77
S816
K
L
S
E
A
E
S
S
D
S
S
V
S
F
I
Site 78
S818
S
E
A
E
S
S
D
S
S
V
S
F
I
C
D
Site 79
S819
E
A
E
S
S
D
S
S
V
S
F
I
C
D
V
Site 80
S821
E
S
S
D
S
S
V
S
F
I
C
D
V
A
Y
Site 81
T861
C
A
Q
S
K
E
K
T
H
L
P
D
F
L
I
Site 82
T886
V
N
L
L
V
H
Q
T
D
S
S
Y
K
E
S
Site 83
S888
L
L
V
H
Q
T
D
S
S
Y
K
E
S
T
F
Site 84
S889
L
V
H
Q
T
D
S
S
Y
K
E
S
T
F
L
Site 85
Y890
V
H
Q
T
D
S
S
Y
K
E
S
T
F
L
H
Site 86
S893
T
D
S
S
Y
K
E
S
T
F
L
H
L
S
A
Site 87
T894
D
S
S
Y
K
E
S
T
F
L
H
L
S
A
L
Site 88
S899
E
S
T
F
L
H
L
S
A
L
W
L
K
N
Q
Site 89
S910
L
K
N
Q
V
Q
A
S
S
L
D
I
N
S
L
Site 90
S911
K
N
Q
V
Q
A
S
S
L
D
I
N
S
L
Q
Site 91
T930
A
V
D
D
L
L
N
T
L
L
E
S
E
D
S
Site 92
S952
G
S
V
M
P
N
D
S
E
W
E
K
M
R
Q
Site 93
S976
P
L
L
E
G
R
L
S
L
N
Y
E
C
F
K
Site 94
Y979
E
G
R
L
S
L
N
Y
E
C
F
K
T
D
F
Site 95
T993
F
K
E
Q
D
I
K
T
L
P
S
H
L
C
T
Site 96
S996
Q
D
I
K
T
L
P
S
H
L
C
T
S
A
L
Site 97
T1016
L
I
A
L
R
K
E
T
V
L
E
N
N
E
L
Site 98
S1081
L
Q
L
L
F
N
R
S
R
E
H
G
T
L
W
Site 99
S1100
A
K
L
I
L
S
R
S
I
S
S
D
E
V
K
Site 100
S1102
L
I
L
S
R
S
I
S
S
D
E
V
K
P
H
Site 101
S1103
I
L
S
R
S
I
S
S
D
E
V
K
P
H
Y
Site 102
Y1110
S
D
E
V
K
P
H
Y
K
R
K
E
S
F
F
Site 103
S1115
P
H
Y
K
R
K
E
S
F
F
P
L
T
E
G
Site 104
T1120
K
E
S
F
F
P
L
T
E
G
N
L
H
T
I
Site 105
S1135
Q
S
L
C
P
F
L
S
K
E
E
K
K
E
F
Site 106
T1161
T
K
K
D
L
C
S
T
N
G
G
F
G
H
L
Site 107
T1177
I
F
N
S
C
L
Q
T
K
S
I
D
D
G
E
Site 108
S1179
N
S
C
L
Q
T
K
S
I
D
D
G
E
L
L
Site 109
S1195
G
I
L
K
I
I
I
S
W
K
K
E
H
E
D
Site 110
S1207
H
E
D
I
F
L
F
S
C
N
L
S
E
A
S
Site 111
S1214
S
C
N
L
S
E
A
S
P
E
V
L
G
V
N
Site 112
S1237
L
F
L
K
Y
C
S
S
P
L
A
E
S
E
W
Site 113
S1305
N
L
P
V
N
L
I
S
E
W
K
E
F
F
S
Site 114
S1312
S
E
W
K
E
F
F
S
Q
G
I
H
S
L
L
Site 115
S1334
T
G
E
N
K
D
V
S
E
T
S
F
Q
N
A
Site 116
S1337
N
K
D
V
S
E
T
S
F
Q
N
A
M
L
K
Site 117
T1351
K
P
M
C
E
T
L
T
Y
I
S
K
E
Q
L
Site 118
Y1352
P
M
C
E
T
L
T
Y
I
S
K
E
Q
L
L
Site 119
S1360
I
S
K
E
Q
L
L
S
H
K
L
P
A
R
L
Site 120
T1373
R
L
V
A
D
Q
K
T
N
L
P
E
Y
L
Q
Site 121
Y1378
Q
K
T
N
L
P
E
Y
L
Q
T
L
L
N
T
Site 122
Y1415
L
M
P
E
L
P
Q
Y
D
Q
D
N
L
K
S
Site 123
S1422
Y
D
Q
D
N
L
K
S
Y
G
D
E
E
E
E
Site 124
S1433
E
E
E
E
P
A
L
S
P
P
A
A
L
M
S
Site 125
S1493
T
F
F
K
A
A
S
S
Q
L
R
A
L
Y
S
Site 126
Y1499
S
S
Q
L
R
A
L
Y
S
M
Y
L
R
K
T
Site 127
S1500
S
Q
L
R
A
L
Y
S
M
Y
L
R
K
T
K
Site 128
Y1502
L
R
A
L
Y
S
M
Y
L
R
K
T
K
S
L
Site 129
T1506
Y
S
M
Y
L
R
K
T
K
S
L
N
K
L
L
Site 130
S1508
M
Y
L
R
K
T
K
S
L
N
K
L
L
Y
H
Site 131
Y1514
K
S
L
N
K
L
L
Y
H
L
F
R
L
M
P
Site 132
Y1526
L
M
P
E
N
P
T
Y
A
E
T
A
V
E
V
Site 133
T1540
V
P
N
K
D
P
K
T
F
F
T
E
E
L
Q
Site 134
T1543
K
D
P
K
T
F
F
T
E
E
L
Q
L
S
I
Site 135
S1549
F
T
E
E
L
Q
L
S
I
R
E
T
T
M
L
Site 136
T1554
Q
L
S
I
R
E
T
T
M
L
P
Y
H
I
P
Site 137
Y1558
R
E
T
T
M
L
P
Y
H
I
P
H
L
A
C
Site 138
T1598
F
N
I
V
D
R
F
T
S
K
Y
V
S
S
V
Site 139
S1603
R
F
T
S
K
Y
V
S
S
V
L
S
F
Q
E
Site 140
S1613
L
S
F
Q
E
I
S
S
V
Q
T
S
T
Q
L
Site 141
S1617
E
I
S
S
V
Q
T
S
T
Q
L
F
N
G
M
Site 142
T1625
T
Q
L
F
N
G
M
T
V
K
A
R
A
T
T
Site 143
T1631
M
T
V
K
A
R
A
T
T
R
E
V
M
A
T
Site 144
T1632
T
V
K
A
R
A
T
T
R
E
V
M
A
T
Y
Site 145
S1660
P
S
N
Y
P
L
G
S
I
I
V
E
S
G
K
Site 146
Y1686
W
M
L
Q
L
S
T
Y
L
T
H
Q
N
G
S
Site 147
T1688
L
Q
L
S
T
Y
L
T
H
Q
N
G
S
I
M
Site 148
Y1727
S
V
I
H
G
F
N
Y
S
L
P
K
K
A
C
Site 149
Y1747
K
F
H
S
A
C
L
Y
K
W
F
T
S
S
N
Site 150
T1751
A
C
L
Y
K
W
F
T
S
S
N
K
S
T
C
Site 151
T1757
F
T
S
S
N
K
S
T
C
P
L
C
R
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation