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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDHD2
Full Name:
Phospholipase DDHD2
Alias:
DDHD domain containing 2; DDHD domain-containing protein 2; KIAA0725; SAM, WWE and DDHD domain-containing protein 1; SAMWD1
Type:
Hydrolase; EC 3.1.1.-
Mass (Da):
81013
Number AA:
711
UniProt ID:
O94830
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0016787
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
S
V
Q
S
Q
Q
E
Q
L
S
Q
Site 2
S12
Q
S
Q
Q
E
Q
L
S
Q
S
D
P
S
P
S
Site 3
S14
Q
Q
E
Q
L
S
Q
S
D
P
S
P
S
P
N
Site 4
S17
Q
L
S
Q
S
D
P
S
P
S
P
N
S
C
S
Site 5
S19
S
Q
S
D
P
S
P
S
P
N
S
C
S
S
F
Site 6
S22
D
P
S
P
S
P
N
S
C
S
S
F
E
L
I
Site 7
S24
S
P
S
P
N
S
C
S
S
F
E
L
I
D
M
Site 8
S25
P
S
P
N
S
C
S
S
F
E
L
I
D
M
D
Site 9
Y37
D
M
D
A
G
S
L
Y
E
P
V
S
P
H
W
Site 10
S64
I
P
F
N
S
E
D
S
Q
Q
L
E
E
A
Y
Site 11
Y71
S
Q
Q
L
E
E
A
Y
S
S
G
K
G
C
N
Site 12
S72
Q
Q
L
E
E
A
Y
S
S
G
K
G
C
N
G
Site 13
S73
Q
L
E
E
A
Y
S
S
G
K
G
C
N
G
R
Site 14
Y89
V
P
T
D
G
G
R
Y
D
V
H
L
G
E
R
Site 15
Y99
H
L
G
E
R
M
R
Y
A
V
Y
W
D
E
L
Site 16
T114
A
S
E
V
R
R
C
T
W
F
Y
K
G
D
K
Site 17
Y117
V
R
R
C
T
W
F
Y
K
G
D
K
D
N
K
Site 18
Y125
K
G
D
K
D
N
K
Y
V
P
Y
S
E
S
F
Site 19
Y128
K
D
N
K
Y
V
P
Y
S
E
S
F
S
Q
V
Site 20
S129
D
N
K
Y
V
P
Y
S
E
S
F
S
Q
V
L
Site 21
S131
K
Y
V
P
Y
S
E
S
F
S
Q
V
L
E
E
Site 22
S133
V
P
Y
S
E
S
F
S
Q
V
L
E
E
T
Y
Site 23
S155
E
W
K
K
K
L
E
S
P
N
R
E
I
I
I
Site 24
Y172
N
P
K
L
M
V
H
Y
Q
P
V
A
G
S
D
Site 25
S178
H
Y
Q
P
V
A
G
S
D
D
W
G
S
T
P
Site 26
S183
A
G
S
D
D
W
G
S
T
P
T
E
Q
G
R
Site 27
T184
G
S
D
D
W
G
S
T
P
T
E
Q
G
R
P
Site 28
T186
D
D
W
G
S
T
P
T
E
Q
G
R
P
R
T
Site 29
T193
T
E
Q
G
R
P
R
T
V
K
R
G
V
E
N
Site 30
S243
Q
C
V
N
D
F
R
S
V
S
L
N
L
L
Q
Site 31
S245
V
N
D
F
R
S
V
S
L
N
L
L
Q
T
H
Site 32
S274
F
L
P
V
N
W
H
S
P
L
H
S
T
G
V
Site 33
S278
N
W
H
S
P
L
H
S
T
G
V
D
V
D
L
Site 34
T289
D
V
D
L
Q
R
I
T
L
P
S
I
N
R
L
Site 35
S292
L
Q
R
I
T
L
P
S
I
N
R
L
R
H
F
Site 36
T300
I
N
R
L
R
H
F
T
N
D
T
I
L
D
V
Site 37
T322
Y
C
Q
T
I
V
D
T
V
A
S
E
M
N
R
Site 38
Y331
A
S
E
M
N
R
I
Y
T
L
F
L
Q
R
N
Site 39
T332
S
E
M
N
R
I
Y
T
L
F
L
Q
R
N
P
Site 40
S346
P
D
F
K
G
G
V
S
I
A
G
H
S
L
G
Site 41
S367
I
L
T
N
Q
K
D
S
L
G
D
I
D
S
E
Site 42
S373
D
S
L
G
D
I
D
S
E
K
D
S
L
N
I
Site 43
S377
D
I
D
S
E
K
D
S
L
N
I
V
M
D
Q
Site 44
T387
I
V
M
D
Q
G
D
T
P
T
L
E
E
D
L
Site 45
T389
M
D
Q
G
D
T
P
T
L
E
E
D
L
K
K
Site 46
Y440
P
R
K
K
I
L
N
Y
F
S
T
R
K
N
S
Site 47
S442
K
K
I
L
N
Y
F
S
T
R
K
N
S
M
G
Site 48
T443
K
I
L
N
Y
F
S
T
R
K
N
S
M
G
I
Site 49
S447
Y
F
S
T
R
K
N
S
M
G
I
K
R
P
A
Site 50
S459
R
P
A
P
Q
P
A
S
G
A
N
I
P
K
E
Site 51
S467
G
A
N
I
P
K
E
S
E
F
C
S
S
S
N
Site 52
S471
P
K
E
S
E
F
C
S
S
S
N
T
R
N
G
Site 53
S472
K
E
S
E
F
C
S
S
S
N
T
R
N
G
D
Site 54
S473
E
S
E
F
C
S
S
S
N
T
R
N
G
D
Y
Site 55
T475
E
F
C
S
S
S
N
T
R
N
G
D
Y
L
D
Site 56
Y480
S
N
T
R
N
G
D
Y
L
D
V
G
I
G
Q
Site 57
Y492
I
G
Q
V
S
V
K
Y
P
R
L
I
Y
K
P
Site 58
Y525
L
K
R
I
D
P
N
Y
R
F
P
T
C
K
G
Site 59
S583
R
E
G
L
T
R
M
S
M
D
L
K
N
N
L
Site 60
S593
L
K
N
N
L
L
G
S
L
R
M
A
W
K
S
Site 61
S600
S
L
R
M
A
W
K
S
F
T
R
A
P
Y
P
Site 62
T602
R
M
A
W
K
S
F
T
R
A
P
Y
P
A
L
Site 63
Y606
K
S
F
T
R
A
P
Y
P
A
L
Q
A
S
E
Site 64
S612
P
Y
P
A
L
Q
A
S
E
T
P
E
E
T
E
Site 65
T614
P
A
L
Q
A
S
E
T
P
E
E
T
E
A
E
Site 66
S624
E
T
E
A
E
P
E
S
T
S
E
K
P
S
D
Site 67
S626
E
A
E
P
E
S
T
S
E
K
P
S
D
V
N
Site 68
S630
E
S
T
S
E
K
P
S
D
V
N
T
E
E
T
Site 69
T634
E
K
P
S
D
V
N
T
E
E
T
S
V
A
V
Site 70
Y661
N
G
G
Q
R
I
D
Y
V
L
Q
E
K
P
I
Site 71
S670
L
Q
E
K
P
I
E
S
F
N
E
Y
L
F
A
Site 72
Y674
P
I
E
S
F
N
E
Y
L
F
A
L
Q
S
H
Site 73
Y684
A
L
Q
S
H
L
C
Y
W
E
S
E
D
T
V
Site 74
T690
C
Y
W
E
S
E
D
T
V
L
L
V
L
K
E
Site 75
T701
V
L
K
E
I
Y
Q
T
Q
G
I
F
L
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation