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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TOX4
Full Name:
TOX high mobility group box family member 4
Alias:
C14orf92; CN092; Epidermal Langerhans cell protein LCP1; KIAA0737; LCP1
Type:
Mass (Da):
66195
Number AA:
621
UniProt ID:
O94842
International Prot ID:
IPI00006586
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003677
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0010468
GO:0019219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
F
P
G
G
N
D
N
Y
L
T
I
T
G
P
S
Site 2
T12
G
G
N
D
N
Y
L
T
I
T
G
P
S
H
P
Site 3
S22
G
P
S
H
P
F
L
S
G
A
E
T
F
H
T
Site 4
T26
P
F
L
S
G
A
E
T
F
H
T
P
S
L
G
Site 5
T29
S
G
A
E
T
F
H
T
P
S
L
G
D
E
E
Site 6
S31
A
E
T
F
H
T
P
S
L
G
D
E
E
F
E
Site 7
S43
E
F
E
I
P
P
I
S
L
D
S
D
P
S
L
Site 8
S53
S
D
P
S
L
A
V
S
D
V
V
G
H
F
D
Site 9
S66
F
D
D
L
A
D
P
S
S
S
Q
D
G
S
F
Site 10
S67
D
D
L
A
D
P
S
S
S
Q
D
G
S
F
S
Site 11
S68
D
L
A
D
P
S
S
S
Q
D
G
S
F
S
A
Site 12
S72
P
S
S
S
Q
D
G
S
F
S
A
Q
Y
G
V
Site 13
S74
S
S
Q
D
G
S
F
S
A
Q
Y
G
V
Q
T
Site 14
Y77
D
G
S
F
S
A
Q
Y
G
V
Q
T
L
D
M
Site 15
S117
H
S
I
G
T
Q
Y
S
A
N
P
P
V
T
I
Site 16
T132
D
V
P
M
T
D
M
T
S
G
L
M
G
H
S
Site 17
T143
M
G
H
S
Q
L
T
T
I
D
Q
S
E
L
S
Site 18
S147
Q
L
T
T
I
D
Q
S
E
L
S
S
Q
L
G
Site 19
S150
T
I
D
Q
S
E
L
S
S
Q
L
G
L
S
L
Site 20
S151
I
D
Q
S
E
L
S
S
Q
L
G
L
S
L
G
Site 21
S168
T
I
L
P
P
A
Q
S
P
E
D
R
L
S
T
Site 22
S174
Q
S
P
E
D
R
L
S
T
T
P
S
P
T
S
Site 23
T175
S
P
E
D
R
L
S
T
T
P
S
P
T
S
S
Site 24
T176
P
E
D
R
L
S
T
T
P
S
P
T
S
S
L
Site 25
S178
D
R
L
S
T
T
P
S
P
T
S
S
L
H
E
Site 26
T180
L
S
T
T
P
S
P
T
S
S
L
H
E
D
G
Site 27
S181
S
T
T
P
S
P
T
S
S
L
H
E
D
G
V
Site 28
S182
T
T
P
S
P
T
S
S
L
H
E
D
G
V
E
Site 29
S197
D
F
R
R
Q
L
P
S
Q
K
T
V
V
V
E
Site 30
T200
R
Q
L
P
S
Q
K
T
V
V
V
E
A
G
K
Site 31
S228
N
E
P
Q
K
P
V
S
A
Y
A
L
F
F
R
Site 32
T237
Y
A
L
F
F
R
D
T
Q
A
A
I
K
G
Q
Site 33
T249
K
G
Q
N
P
N
A
T
F
G
E
V
S
K
I
Site 34
S259
E
V
S
K
I
V
A
S
M
W
D
S
L
G
E
Site 35
S263
I
V
A
S
M
W
D
S
L
G
E
E
Q
K
Q
Site 36
Y272
G
E
E
Q
K
Q
V
Y
K
R
K
T
E
A
A
Site 37
T276
K
Q
V
Y
K
R
K
T
E
A
A
K
K
E
Y
Site 38
Y283
T
E
A
A
K
K
E
Y
L
K
A
L
A
A
Y
Site 39
Y290
Y
L
K
A
L
A
A
Y
K
D
N
Q
E
C
Q
Site 40
T299
D
N
Q
E
C
Q
A
T
V
E
T
V
E
L
D
Site 41
S311
E
L
D
P
A
P
P
S
Q
T
P
S
P
P
P
Site 42
T313
D
P
A
P
P
S
Q
T
P
S
P
P
P
M
A
Site 43
S315
A
P
P
S
Q
T
P
S
P
P
P
M
A
T
V
Site 44
T321
P
S
P
P
P
M
A
T
V
D
P
A
S
P
A
Site 45
S331
P
A
S
P
A
P
A
S
I
E
P
P
A
L
S
Site 46
Y350
V
N
S
T
L
S
S
Y
V
A
N
Q
A
S
S
Site 47
S356
S
Y
V
A
N
Q
A
S
S
G
A
G
G
Q
P
Site 48
S377
I
T
K
Q
M
L
P
S
S
I
T
M
S
Q
G
Site 49
S378
T
K
Q
M
L
P
S
S
I
T
M
S
Q
G
G
Site 50
S382
L
P
S
S
I
T
M
S
Q
G
G
M
V
T
V
Site 51
T393
M
V
T
V
I
P
A
T
V
V
T
S
R
G
L
Site 52
S406
G
L
Q
L
G
Q
T
S
T
A
T
I
Q
P
S
Site 53
T407
L
Q
L
G
Q
T
S
T
A
T
I
Q
P
S
Q
Site 54
T409
L
G
Q
T
S
T
A
T
I
Q
P
S
Q
Q
A
Site 55
S413
S
T
A
T
I
Q
P
S
Q
Q
A
Q
I
V
T
Site 56
S495
P
P
P
L
Q
I
K
S
V
P
L
P
T
L
K
Site 57
T506
P
T
L
K
M
Q
T
T
L
V
P
P
T
V
E
Site 58
T511
Q
T
T
L
V
P
P
T
V
E
S
S
P
E
R
Site 59
S514
L
V
P
P
T
V
E
S
S
P
E
R
P
M
N
Site 60
S515
V
P
P
T
V
E
S
S
P
E
R
P
M
N
N
Site 61
S523
P
E
R
P
M
N
N
S
P
E
A
H
T
V
E
Site 62
S533
A
H
T
V
E
A
P
S
P
E
T
I
C
E
M
Site 63
S550
D
V
V
P
E
V
E
S
P
S
Q
M
D
V
E
Site 64
S552
V
P
E
V
E
S
P
S
Q
M
D
V
E
L
V
Site 65
S567
S
G
S
P
V
A
L
S
P
Q
P
R
C
V
R
Site 66
S575
P
Q
P
R
C
V
R
S
G
C
E
N
P
P
I
Site 67
Y591
S
K
D
W
D
N
E
Y
C
S
N
E
C
V
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation