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Updated November 2019
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Protein Info
Short Name:
SORBS2
Full Name:
Sorbin and SH3 domain-containing protein 2
Alias:
Arg/Abl-interacting protein 2
Type:
Mass (Da):
71899
Number AA:
645
UniProt ID:
O94875
International Prot ID:
IPI00061793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030018
GO:0015629
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008093
GO:0005200
GO:0008307
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
Y
Y
Q
R
P
F
S
P
S
A
Y
S
L
P
Site 2
S11
Y
Q
R
P
F
S
P
S
A
Y
S
L
P
A
S
Site 3
Y13
R
P
F
S
P
S
A
Y
S
L
P
A
S
L
N
Site 4
S14
P
F
S
P
S
A
Y
S
L
P
A
S
L
N
S
Site 5
S30
I
V
M
Q
H
G
T
S
L
D
S
T
D
T
Y
Site 6
S33
Q
H
G
T
S
L
D
S
T
D
T
Y
P
Q
H
Site 7
T34
H
G
T
S
L
D
S
T
D
T
Y
P
Q
H
A
Site 8
T36
T
S
L
D
S
T
D
T
Y
P
Q
H
A
Q
S
Site 9
Y37
S
L
D
S
T
D
T
Y
P
Q
H
A
Q
S
L
Site 10
S43
T
Y
P
Q
H
A
Q
S
L
D
G
T
T
S
S
Site 11
T47
H
A
Q
S
L
D
G
T
T
S
S
S
I
P
L
Site 12
T48
A
Q
S
L
D
G
T
T
S
S
S
I
P
L
Y
Site 13
S49
Q
S
L
D
G
T
T
S
S
S
I
P
L
Y
R
Site 14
S50
S
L
D
G
T
T
S
S
S
I
P
L
Y
R
S
Site 15
S51
L
D
G
T
T
S
S
S
I
P
L
Y
R
S
S
Site 16
Y55
T
S
S
S
I
P
L
Y
R
S
S
E
E
E
K
Site 17
S57
S
S
I
P
L
Y
R
S
S
E
E
E
K
R
V
Site 18
S58
S
I
P
L
Y
R
S
S
E
E
E
K
R
V
T
Site 19
T65
S
E
E
E
K
R
V
T
V
I
K
A
P
H
Y
Site 20
Y72
T
V
I
K
A
P
H
Y
P
G
I
G
P
V
D
Site 21
S81
G
I
G
P
V
D
E
S
G
I
P
T
A
I
R
Site 22
T85
V
D
E
S
G
I
P
T
A
I
R
T
T
V
D
Site 23
T89
G
I
P
T
A
I
R
T
T
V
D
R
P
K
D
Site 24
T90
I
P
T
A
I
R
T
T
V
D
R
P
K
D
W
Site 25
Y98
V
D
R
P
K
D
W
Y
K
T
M
F
K
Q
I
Site 26
T100
R
P
K
D
W
Y
K
T
M
F
K
Q
I
H
M
Site 27
T115
V
H
K
P
D
D
D
T
D
M
Y
N
T
P
Y
Site 28
Y118
P
D
D
D
T
D
M
Y
N
T
P
Y
T
Y
N
Site 29
T120
D
D
T
D
M
Y
N
T
P
Y
T
Y
N
A
G
Site 30
Y122
T
D
M
Y
N
T
P
Y
T
Y
N
A
G
L
Y
Site 31
Y129
Y
T
Y
N
A
G
L
Y
N
P
P
Y
S
A
Q
Site 32
Y133
A
G
L
Y
N
P
P
Y
S
A
Q
S
H
P
A
Site 33
S134
G
L
Y
N
P
P
Y
S
A
Q
S
H
P
A
A
Site 34
T143
Q
S
H
P
A
A
K
T
Q
T
Y
R
P
L
S
Site 35
T145
H
P
A
A
K
T
Q
T
Y
R
P
L
S
K
S
Site 36
Y146
P
A
A
K
T
Q
T
Y
R
P
L
S
K
S
H
Site 37
S150
T
Q
T
Y
R
P
L
S
K
S
H
S
D
N
S
Site 38
S152
T
Y
R
P
L
S
K
S
H
S
D
N
S
P
N
Site 39
S154
R
P
L
S
K
S
H
S
D
N
S
P
N
A
F
Site 40
S157
S
K
S
H
S
D
N
S
P
N
A
F
K
D
A
Site 41
S165
P
N
A
F
K
D
A
S
S
P
V
P
P
P
H
Site 42
S166
N
A
F
K
D
A
S
S
P
V
P
P
P
H
V
Site 43
S186
P
L
R
P
R
D
R
S
S
T
E
K
H
D
W
Site 44
S187
L
R
P
R
D
R
S
S
T
E
K
H
D
W
D
Site 45
T188
R
P
R
D
R
S
S
T
E
K
H
D
W
D
P
Site 46
T202
P
P
D
R
K
V
D
T
R
K
F
R
S
E
P
Site 47
S207
V
D
T
R
K
F
R
S
E
P
R
S
I
F
E
Site 48
S211
K
F
R
S
E
P
R
S
I
F
E
Y
E
P
G
Site 49
Y215
E
P
R
S
I
F
E
Y
E
P
G
K
S
S
I
Site 50
S220
F
E
Y
E
P
G
K
S
S
I
L
Q
H
E
R
Site 51
S230
L
Q
H
E
R
P
A
S
L
Y
Q
S
S
I
D
Site 52
Y232
H
E
R
P
A
S
L
Y
Q
S
S
I
D
R
S
Site 53
S234
R
P
A
S
L
Y
Q
S
S
I
D
R
S
L
E
Site 54
S235
P
A
S
L
Y
Q
S
S
I
D
R
S
L
E
R
Site 55
S239
Y
Q
S
S
I
D
R
S
L
E
R
P
M
S
S
Site 56
S245
R
S
L
E
R
P
M
S
S
A
S
M
A
S
D
Site 57
S246
S
L
E
R
P
M
S
S
A
S
M
A
S
D
F
Site 58
S248
E
R
P
M
S
S
A
S
M
A
S
D
F
R
K
Site 59
S251
M
S
S
A
S
M
A
S
D
F
R
K
R
R
K
Site 60
S259
D
F
R
K
R
R
K
S
E
P
A
V
G
P
P
Site 61
S273
P
R
G
L
G
D
Q
S
A
S
R
T
S
P
G
Site 62
S275
G
L
G
D
Q
S
A
S
R
T
S
P
G
R
V
Site 63
T277
G
D
Q
S
A
S
R
T
S
P
G
R
V
D
L
Site 64
S278
D
Q
S
A
S
R
T
S
P
G
R
V
D
L
P
Site 65
S287
G
R
V
D
L
P
G
S
S
T
T
L
T
K
S
Site 66
S288
R
V
D
L
P
G
S
S
T
T
L
T
K
S
F
Site 67
T290
D
L
P
G
S
S
T
T
L
T
K
S
F
T
S
Site 68
T292
P
G
S
S
T
T
L
T
K
S
F
T
S
S
S
Site 69
S294
S
S
T
T
L
T
K
S
F
T
S
S
S
P
S
Site 70
T296
T
T
L
T
K
S
F
T
S
S
S
P
S
S
P
Site 71
S297
T
L
T
K
S
F
T
S
S
S
P
S
S
P
S
Site 72
S298
L
T
K
S
F
T
S
S
S
P
S
S
P
S
R
Site 73
S299
T
K
S
F
T
S
S
S
P
S
S
P
S
R
A
Site 74
S301
L
Q
H
E
R
P
A
S
L
Y
Q
S
S
I
D
Site 75
S302
F
T
S
S
S
P
S
S
P
S
R
A
G
G
D
Site 76
S304
S
S
S
P
S
S
P
S
R
A
K
G
G
D
D
Site 77
S312
R
A
K
G
G
D
D
S
K
I
C
P
S
L
C
Site 78
S317
D
D
S
K
I
C
P
S
L
C
S
Y
S
G
L
Site 79
S320
K
I
C
P
S
L
C
S
Y
S
G
L
N
G
N
Site 80
Y321
I
C
P
S
L
C
S
Y
S
G
L
N
G
N
P
Site 81
S322
C
P
S
L
C
S
Y
S
G
L
N
G
N
P
S
Site 82
S329
S
G
L
N
G
N
P
S
S
E
L
D
Y
C
S
Site 83
S330
D
F
R
K
R
R
K
S
E
P
A
V
G
P
P
Site 84
Y334
N
P
S
S
E
L
D
Y
C
S
T
Y
R
Q
H
Site 85
S336
S
S
E
L
D
Y
C
S
T
Y
R
Q
H
L
D
Site 86
T337
S
E
L
D
Y
C
S
T
Y
R
Q
H
L
D
V
Site 87
S348
H
L
D
V
P
R
D
S
P
R
A
I
S
F
K
Site 88
S353
R
D
S
P
R
A
I
S
F
K
N
G
W
Q
M
Site 89
S369
R
Q
N
A
E
I
W
S
S
T
E
E
T
V
S
Site 90
S370
L
T
K
S
F
T
S
S
S
P
S
S
P
S
R
Site 91
T374
I
W
S
S
T
E
E
T
V
S
P
K
I
K
S
Site 92
S376
S
S
T
E
E
T
V
S
P
K
I
K
S
R
S
Site 93
S383
S
R
A
K
D
R
E
S
P
R
S
Y
S
S
T
Site 94
S394
L
L
N
D
D
C
D
S
F
P
D
P
K
V
K
Site 95
S402
F
P
D
P
K
V
K
S
E
S
M
G
S
L
L
Site 96
S404
D
P
K
V
K
S
E
S
M
G
S
L
L
C
E
Site 97
S407
V
K
S
E
S
M
G
S
L
L
C
E
E
D
S
Site 98
S414
S
L
L
C
E
E
D
S
K
E
S
C
P
M
A
Site 99
S424
S
C
P
M
A
W
G
S
P
Y
V
P
E
V
R
Site 100
Y426
P
M
A
W
G
S
P
Y
V
P
E
V
R
S
N
Site 101
S432
P
Y
V
P
E
V
R
S
N
G
R
S
R
I
R
Site 102
S436
E
V
R
S
N
G
R
S
R
I
R
H
R
S
A
Site 103
S442
R
S
R
I
R
H
R
S
A
R
N
A
P
G
F
Site 104
Y453
A
P
G
F
L
K
M
Y
K
K
M
H
R
I
N
Site 105
Y480
V
K
S
R
I
L
Q
Y
E
S
E
Q
Q
H
K
Site 106
S494
K
D
L
L
R
A
W
S
Q
C
S
T
E
E
V
Site 107
S497
L
R
A
W
S
Q
C
S
T
E
E
V
P
R
D
Site 108
T498
R
A
W
S
Q
C
S
T
E
E
V
P
R
D
M
Site 109
T508
V
P
R
D
M
V
P
T
R
I
S
E
F
E
K
Site 110
S511
D
M
V
P
T
R
I
S
E
F
E
K
L
I
Q
Site 111
S522
K
L
I
Q
K
S
K
S
M
P
N
L
G
D
D
Site 112
S532
N
L
G
D
D
M
L
S
P
V
T
L
E
P
P
Site 113
T535
D
D
M
L
S
P
V
T
L
E
P
P
Q
N
G
Site 114
S550
L
C
P
K
R
R
F
S
I
E
Y
L
L
E
E
Site 115
Y553
K
R
R
F
S
I
E
Y
L
L
E
E
E
N
Q
Site 116
S561
L
L
E
E
E
N
Q
S
G
P
P
A
R
G
R
Site 117
S573
R
G
R
R
G
C
Q
S
N
A
L
V
P
I
H
Site 118
S585
P
I
H
I
E
V
T
S
D
E
Q
P
R
A
H
Site 119
S596
P
R
A
H
V
E
F
S
D
S
D
Q
D
G
V
Site 120
S598
A
H
V
E
F
S
D
S
D
Q
D
G
V
V
S
Site 121
S605
S
D
Q
D
G
V
V
S
D
H
S
D
Y
I
H
Site 122
S608
D
G
V
V
S
D
H
S
D
Y
I
H
L
E
G
Site 123
Y610
V
V
S
D
H
S
D
Y
I
H
L
E
G
S
S
Site 124
S616
D
Y
I
H
L
E
G
S
S
F
C
S
E
S
D
Site 125
S617
Y
I
H
L
E
G
S
S
F
C
S
E
S
D
F
Site 126
S620
L
E
G
S
S
F
C
S
E
S
D
F
D
H
F
Site 127
S622
G
S
S
F
C
S
E
S
D
F
D
H
F
S
F
Site 128
S628
E
S
D
F
D
H
F
S
F
T
S
S
E
S
F
Site 129
T630
D
F
D
H
F
S
F
T
S
S
E
S
F
Y
G
Site 130
S631
F
D
H
F
S
F
T
S
S
E
S
F
Y
G
S
Site 131
S632
D
H
F
S
F
T
S
S
E
S
F
Y
G
S
S
Site 132
S634
F
S
F
T
S
S
E
S
F
Y
G
S
S
H
H
Site 133
Y636
F
T
S
S
E
S
F
Y
G
S
S
H
H
H
H
Site 134
Y665
K
G
R
C
P
A
S
Y
T
R
F
T
T
M
L
Site 135
T669
P
A
S
Y
T
R
F
T
T
M
L
K
H
E
R
Site 136
T670
A
S
Y
T
R
F
T
T
M
L
K
H
E
R
A
Site 137
T682
E
R
A
R
H
E
N
T
E
E
P
R
R
Q
E
Site 138
S702
S
K
L
A
F
L
V
S
P
V
P
F
R
R
K
Site 139
S712
P
F
R
R
K
K
N
S
A
P
K
K
Q
T
E
Site 140
S726
E
K
A
K
C
K
A
S
V
F
E
A
L
D
S
Site 141
S750
K
A
E
K
K
R
G
S
L
P
D
N
S
I
L
Site 142
S755
R
G
S
L
P
D
N
S
I
L
H
R
L
I
S
Site 143
S773
P
D
V
P
E
R
N
S
S
L
R
A
L
R
R
Site 144
S774
D
V
P
E
R
N
S
S
L
R
A
L
R
R
S
Site 145
S781
S
L
R
A
L
R
R
S
P
L
H
Q
P
L
H
Site 146
S811
D
C
G
R
M
P
R
S
A
S
F
Q
D
V
D
Site 147
S813
G
R
M
P
R
S
A
S
F
Q
D
V
D
T
A
Site 148
T819
A
S
F
Q
D
V
D
T
A
N
S
S
C
H
H
Site 149
S838
G
A
L
Q
D
R
E
S
P
R
S
Y
S
S
T
Site 150
S841
Q
D
R
E
S
P
R
S
Y
S
S
T
L
T
D
Site 151
Y842
D
R
E
S
P
R
S
Y
S
S
T
L
T
D
M
Site 152
S843
R
E
S
P
R
S
Y
S
S
T
L
T
D
M
G
Site 153
T845
S
P
R
S
Y
S
S
T
L
T
D
M
G
R
S
Site 154
T847
R
S
Y
S
S
T
L
T
D
M
G
R
S
A
P
Site 155
S852
T
L
T
D
M
G
R
S
A
P
R
E
R
R
G
Site 156
T860
A
P
R
E
R
R
G
T
P
E
K
E
K
L
P
Site 157
S879
Y
D
F
K
A
Q
T
S
K
E
L
S
F
K
K
Site 158
S883
A
Q
T
S
K
E
L
S
F
K
K
G
D
T
V
Site 159
T889
L
S
F
K
K
G
D
T
V
Y
I
L
R
K
I
Site 160
Y891
F
K
K
G
D
T
V
Y
I
L
R
K
I
D
Q
Site 161
Y901
R
K
I
D
Q
N
W
Y
E
G
E
H
H
G
R
Site 162
S915
R
V
G
I
F
P
I
S
Y
V
E
K
L
T
P
Site 163
Y916
V
G
I
F
P
I
S
Y
V
E
K
L
T
P
P
Site 164
T921
I
S
Y
V
E
K
L
T
P
P
E
K
A
Q
P
Site 165
Y947
I
G
E
A
I
A
K
Y
N
F
N
A
D
T
N
Site 166
T953
K
Y
N
F
N
A
D
T
N
V
E
L
S
L
R
Site 167
S958
A
D
T
N
V
E
L
S
L
R
K
G
D
R
V
Site 168
Y976
K
R
V
D
Q
N
W
Y
E
G
K
I
P
G
T
Site 169
T983
Y
E
G
K
I
P
G
T
N
R
Q
G
I
F
P
Site 170
S992
R
Q
G
I
F
P
V
S
Y
V
E
V
V
K
K
Site 171
Y993
Q
G
I
F
P
V
S
Y
V
E
V
V
K
K
N
Site 172
T1001
V
E
V
V
K
K
N
T
K
G
A
E
D
Y
P
Site 173
Y1007
N
T
K
G
A
E
D
Y
P
D
P
P
I
P
H
Site 174
S1015
P
D
P
P
I
P
H
S
Y
S
S
D
R
I
H
Site 175
S1017
P
P
I
P
H
S
Y
S
S
D
R
I
H
S
L
Site 176
S1018
P
I
P
H
S
Y
S
S
D
R
I
H
S
L
S
Site 177
S1023
Y
S
S
D
R
I
H
S
L
S
S
N
K
P
Q
Site 178
S1025
S
D
R
I
H
S
L
S
S
N
K
P
Q
R
P
Site 179
Y1050
G
E
P
F
Q
A
L
Y
N
Y
T
P
R
N
E
Site 180
Y1052
P
F
Q
A
L
Y
N
Y
T
P
R
N
E
D
E
Site 181
T1053
F
Q
A
L
Y
N
Y
T
P
R
N
E
D
E
L
Site 182
S1065
D
E
L
E
L
R
E
S
D
V
I
D
V
M
E
Site 183
T1082
D
D
G
W
F
V
G
T
S
R
R
T
K
F
F
Site 184
T1086
F
V
G
T
S
R
R
T
K
F
F
G
T
F
P
Site 185
T1091
R
R
T
K
F
F
G
T
F
P
G
N
Y
V
K
Site 186
Y1096
F
G
T
F
P
G
N
Y
V
K
R
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation