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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FARP2
Full Name:
FERM, RhoGEF and pleckstrin domain-containing protein 2
Alias:
FGD1-related Cdc42-GEF; FIR; FRG; PLEKHC3
Type:
Intracellular, Extrinsic membrane, Cytoplasm, Cytoskeleton protein
Mass (Da):
119888
Number AA:
1054
UniProt ID:
O94887
International Prot ID:
IPI00744221
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0008092
PhosphoSite+
KinaseNET
Biological Process:
GO:0016601
GO:0016322
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
G
E
I
E
G
T
Y
R
V
L
Q
T
A
Site 2
Y8
M
G
E
I
E
G
T
Y
R
V
L
Q
T
A
G
Site 3
S27
A
Q
T
P
V
G
V
S
T
L
E
P
G
Q
T
Site 4
T28
Q
T
P
V
G
V
S
T
L
E
P
G
Q
T
L
Site 5
T34
S
T
L
E
P
G
Q
T
L
L
P
R
M
Q
E
Site 6
T54
R
V
K
L
L
D
N
T
M
E
I
F
D
I
E
Site 7
Y84
L
N
L
V
E
C
D
Y
F
G
M
E
F
Q
N
Site 8
Y135
P
G
Q
L
Q
E
E
Y
T
R
Y
L
F
A
L
Site 9
Y138
L
Q
E
E
Y
T
R
Y
L
F
A
L
Q
L
K
Site 10
T154
D
L
L
E
E
R
L
T
C
A
D
T
T
A
A
Site 11
Y175
L
Q
S
E
I
G
D
Y
D
E
T
L
D
R
E
Site 12
T178
E
I
G
D
Y
D
E
T
L
D
R
E
H
L
K
Site 13
Y189
E
H
L
K
V
N
E
Y
L
P
G
Q
Q
H
C
Site 14
T211
H
Q
K
H
V
G
Q
T
P
A
E
S
D
F
Q
Site 15
S215
V
G
Q
T
P
A
E
S
D
F
Q
V
L
E
I
Site 16
S237
G
I
R
F
H
M
A
S
D
R
E
G
T
K
I
Site 17
T242
M
A
S
D
R
E
G
T
K
I
Q
L
A
V
S
Site 18
T264
Q
G
T
T
K
I
N
T
F
N
W
S
K
V
R
Site 19
S274
W
S
K
V
R
K
L
S
F
K
R
K
R
F
L
Site 20
T295
V
H
G
P
Y
Q
D
T
L
E
F
L
L
G
S
Site 21
S336
K
A
K
A
V
F
F
S
R
G
S
S
F
R
Y
Site 22
S339
A
V
F
F
S
R
G
S
S
F
R
Y
S
G
R
Site 23
S340
V
F
F
S
R
G
S
S
F
R
Y
S
G
R
T
Site 24
Y343
S
R
G
S
S
F
R
Y
S
G
R
T
Q
K
Q
Site 25
S344
R
G
S
S
F
R
Y
S
G
R
T
Q
K
Q
L
Site 26
T347
S
F
R
Y
S
G
R
T
Q
K
Q
L
V
D
Y
Site 27
Y354
T
Q
K
Q
L
V
D
Y
F
K
D
S
G
M
K
Site 28
Y365
S
G
M
K
R
I
P
Y
E
R
R
H
S
K
T
Site 29
S370
I
P
Y
E
R
R
H
S
K
T
H
T
S
V
R
Site 30
T372
Y
E
R
R
H
S
K
T
H
T
S
V
R
A
L
Site 31
T374
R
R
H
S
K
T
H
T
S
V
R
A
L
T
A
Site 32
S375
R
H
S
K
T
H
T
S
V
R
A
L
T
A
D
Site 33
T380
H
T
S
V
R
A
L
T
A
D
L
P
K
Q
S
Site 34
S387
T
A
D
L
P
K
Q
S
I
S
F
P
E
G
L
Site 35
S389
D
L
P
K
Q
S
I
S
F
P
E
G
L
R
T
Site 36
T396
S
F
P
E
G
L
R
T
P
A
S
P
S
S
A
Site 37
S399
E
G
L
R
T
P
A
S
P
S
S
A
N
A
F
Site 38
S401
L
R
T
P
A
S
P
S
S
A
N
A
F
Y
S
Site 39
S402
R
T
P
A
S
P
S
S
A
N
A
F
Y
S
L
Site 40
Y407
P
S
S
A
N
A
F
Y
S
L
S
P
S
T
L
Site 41
S410
A
N
A
F
Y
S
L
S
P
S
T
L
V
P
S
Site 42
S425
G
L
P
E
F
K
D
S
S
S
S
L
T
D
P
Site 43
S426
L
P
E
F
K
D
S
S
S
S
L
T
D
P
Q
Site 44
S427
P
E
F
K
D
S
S
S
S
L
T
D
P
Q
V
Site 45
S428
E
F
K
D
S
S
S
S
L
T
D
P
Q
V
S
Site 46
T430
K
D
S
S
S
S
L
T
D
P
Q
V
S
Y
V
Site 47
S435
S
L
T
D
P
Q
V
S
Y
V
K
S
P
A
A
Site 48
Y436
L
T
D
P
Q
V
S
Y
V
K
S
P
A
A
E
Site 49
S439
P
Q
V
S
Y
V
K
S
P
A
A
E
R
R
S
Site 50
S446
S
P
A
A
E
R
R
S
G
A
V
A
G
G
P
Site 51
T455
A
V
A
G
G
P
D
T
P
S
A
Q
P
L
G
Site 52
S457
A
G
G
P
D
T
P
S
A
Q
P
L
G
P
P
Site 53
S473
L
Q
P
G
P
G
L
S
T
K
S
P
Q
P
S
Site 54
T474
Q
P
G
P
G
L
S
T
K
S
P
Q
P
S
P
Site 55
S476
G
P
G
L
S
T
K
S
P
Q
P
S
P
S
S
Site 56
S480
S
T
K
S
P
Q
P
S
P
S
S
R
K
S
P
Site 57
S482
K
S
P
Q
P
S
P
S
S
R
K
S
P
L
S
Site 58
S483
S
P
Q
P
S
P
S
S
R
K
S
P
L
S
L
Site 59
S486
P
S
P
S
S
R
K
S
P
L
S
L
S
P
A
Site 60
S489
S
S
R
K
S
P
L
S
L
S
P
A
F
Q
V
Site 61
S491
R
K
S
P
L
S
L
S
P
A
F
Q
V
P
L
Site 62
S505
L
G
P
A
E
Q
G
S
S
P
L
L
S
P
V
Site 63
S506
G
P
A
E
Q
G
S
S
P
L
L
S
P
V
L
Site 64
S510
Q
G
S
S
P
L
L
S
P
V
L
S
D
A
G
Site 65
T546
I
V
K
E
I
L
A
T
E
R
T
Y
L
K
D
Site 66
Y587
F
S
N
I
D
P
I
Y
E
F
H
R
G
F
L
Site 67
S608
L
A
L
W
E
G
P
S
K
A
H
T
K
G
S
Site 68
T612
E
G
P
S
K
A
H
T
K
G
S
H
Q
R
I
Site 69
S615
S
K
A
H
T
K
G
S
H
Q
R
I
G
D
I
Site 70
S635
R
Q
L
K
E
F
T
S
Y
F
Q
R
H
D
E
Site 71
Y636
Q
L
K
E
F
T
S
Y
F
Q
R
H
D
E
V
Site 72
Y699
L
R
R
L
C
G
H
Y
S
P
G
H
H
D
Y
Site 73
Y706
Y
S
P
G
H
H
D
Y
A
D
C
H
D
A
L
Site 74
T766
E
G
C
L
H
K
L
T
K
K
G
L
Q
Q
R
Site 75
S786
S
D
M
L
L
Y
T
S
K
G
V
A
G
T
S
Site 76
S793
S
K
G
V
A
G
T
S
H
F
R
I
R
G
L
Site 77
S811
Q
G
M
L
V
E
E
S
D
N
E
W
S
V
P
Site 78
S835
K
T
I
V
V
A
A
S
T
R
L
E
K
E
K
Site 79
S856
S
A
I
Q
A
A
K
S
G
G
D
T
A
P
A
Site 80
T860
A
A
K
S
G
G
D
T
A
P
A
L
P
G
R
Site 81
T868
A
P
A
L
P
G
R
T
V
C
T
R
P
P
R
Site 82
T871
L
P
G
R
T
V
C
T
R
P
P
R
S
P
N
Site 83
S876
V
C
T
R
P
P
R
S
P
N
E
V
S
L
E
Site 84
S881
P
R
S
P
N
E
V
S
L
E
Q
E
S
E
D
Site 85
S896
D
A
R
G
V
R
S
S
L
E
G
H
G
Q
H
Site 86
S918
V
C
W
Y
R
N
T
S
V
S
R
A
D
H
S
Site 87
S920
W
Y
R
N
T
S
V
S
R
A
D
H
S
A
A
Site 88
S925
S
V
S
R
A
D
H
S
A
A
V
E
N
Q
L
Site 89
Y935
V
E
N
Q
L
S
G
Y
L
L
R
K
F
K
N
Site 90
Y968
Y
K
T
H
Q
D
D
Y
P
L
A
S
L
P
L
Site 91
S972
Q
D
D
Y
P
L
A
S
L
P
L
L
G
Y
S
Site 92
S981
P
L
L
G
Y
S
V
S
I
P
R
E
A
D
G
Site 93
Y993
A
D
G
I
H
K
D
Y
V
F
K
L
Q
F
K
Site 94
Y1004
L
Q
F
K
S
H
V
Y
F
F
R
A
E
S
K
Site 95
Y1012
F
F
R
A
E
S
K
Y
T
F
E
R
W
M
E
Site 96
T1013
F
R
A
E
S
K
Y
T
F
E
R
W
M
E
V
Site 97
S1033
S
S
A
G
R
A
P
S
I
V
Q
D
G
P
Q
Site 98
S1042
V
Q
D
G
P
Q
P
S
S
G
L
E
G
M
V
Site 99
S1043
Q
D
G
P
Q
P
S
S
G
L
E
G
M
V
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation