KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KLHL18
Full Name:
Kelch-like protein 18
Alias:
Type:
Mass (Da):
63638
Number AA:
574
UniProt ID:
O94889
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
E
D
L
V
H
F
S
V
S
E
L
P
S
R
Site 2
S18
D
L
V
H
F
S
V
S
E
L
P
S
R
G
Y
Site 3
S22
F
S
V
S
E
L
P
S
R
G
Y
G
V
M
E
Site 4
Y25
S
E
L
P
S
R
G
Y
G
V
M
E
E
I
R
Site 5
T41
Q
G
K
L
C
D
V
T
L
K
I
G
D
H
K
Site 6
S50
K
I
G
D
H
K
F
S
A
H
R
I
V
L
A
Site 7
T129
S
I
K
D
A
C
C
T
F
L
R
E
R
L
H
Site 8
S171
H
Q
H
F
V
E
V
S
M
S
E
E
F
L
A
Site 9
S197
R
D
E
L
N
V
K
S
E
E
Q
V
F
E
A
Site 10
Y211
A
A
L
A
W
V
R
Y
D
R
E
Q
R
G
P
Site 11
Y219
D
R
E
Q
R
G
P
Y
L
P
E
L
L
S
N
Site 12
S238
L
C
R
P
Q
F
L
S
D
R
V
Q
Q
D
D
Site 13
Y263
L
V
D
E
A
K
D
Y
H
L
M
P
E
R
R
Site 14
T278
P
H
L
P
A
F
R
T
R
P
R
C
C
T
S
Site 15
T284
R
T
R
P
R
C
C
T
S
I
A
G
L
I
Y
Site 16
T323
W
E
R
C
R
P
M
T
T
A
R
S
R
V
G
Site 17
T324
E
R
C
R
P
M
T
T
A
R
S
R
V
G
V
Site 18
S351
Y
D
G
Q
L
R
L
S
T
V
E
A
Y
N
P
Site 19
T352
D
G
Q
L
R
L
S
T
V
E
A
Y
N
P
E
Site 20
T362
A
Y
N
P
E
T
D
T
W
T
R
V
G
S
M
Site 21
T364
N
P
E
T
D
T
W
T
R
V
G
S
M
N
S
Site 22
S368
D
T
W
T
R
V
G
S
M
N
S
K
R
S
A
Site 23
S371
T
R
V
G
S
M
N
S
K
R
S
A
M
G
T
Site 24
T378
S
K
R
S
A
M
G
T
V
V
L
D
G
Q
I
Site 25
Y391
Q
I
Y
V
C
G
G
Y
D
G
N
S
S
L
S
Site 26
S395
C
G
G
Y
D
G
N
S
S
L
S
S
V
E
T
Site 27
S396
G
G
Y
D
G
N
S
S
L
S
S
V
E
T
Y
Site 28
S398
Y
D
G
N
S
S
L
S
S
V
E
T
Y
S
P
Site 29
S399
D
G
N
S
S
L
S
S
V
E
T
Y
S
P
E
Site 30
T402
S
S
L
S
S
V
E
T
Y
S
P
E
T
D
K
Site 31
Y403
S
L
S
S
V
E
T
Y
S
P
E
T
D
K
W
Site 32
S404
L
S
S
V
E
T
Y
S
P
E
T
D
K
W
T
Site 33
T411
S
P
E
T
D
K
W
T
V
V
T
S
M
S
S
Site 34
S415
D
K
W
T
V
V
T
S
M
S
S
N
R
S
A
Site 35
S417
W
T
V
V
T
S
M
S
S
N
R
S
A
A
G
Site 36
S421
T
S
M
S
S
N
R
S
A
A
G
V
T
V
F
Site 37
Y433
T
V
F
E
G
R
I
Y
V
S
G
G
H
D
G
Site 38
S474
R
C
R
H
G
A
A
S
L
G
S
K
M
F
V
Site 39
S492
Y
D
G
S
G
F
L
S
I
A
E
M
Y
S
S
Site 40
T512
C
L
I
V
P
M
H
T
R
R
S
R
V
S
L
Site 41
S515
V
P
M
H
T
R
R
S
R
V
S
L
V
A
S
Site 42
S518
H
T
R
R
S
R
V
S
L
V
A
S
C
G
R
Site 43
S522
S
R
V
S
L
V
A
S
C
G
R
L
Y
A
V
Site 44
S536
V
G
G
Y
D
G
Q
S
N
L
S
S
V
E
M
Site 45
S540
D
G
Q
S
N
L
S
S
V
E
M
Y
D
P
E
Site 46
Y544
N
L
S
S
V
E
M
Y
D
P
E
T
D
C
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation