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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TOX
Full Name:
Thymocyte selection-associated high mobility group box protein TOX
Alias:
KIAA0808; Thymocyte selection-associated high mobility group box; Thymus high mobility group box protein TOX; TOX1
Type:
DNA binding protein
Mass (Da):
57513
Number AA:
526
UniProt ID:
O94900
International Prot ID:
IPI00006065
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
D
A
P
C
L
G
P
S
P
C
L
D
P
Y
Y
Site 2
Y30
P
S
P
C
L
D
P
Y
Y
C
N
K
F
D
G
Site 3
Y31
S
P
C
L
D
P
Y
Y
C
N
K
F
D
G
E
Site 4
Y41
K
F
D
G
E
N
M
Y
M
S
M
T
E
P
S
Site 5
S43
D
G
E
N
M
Y
M
S
M
T
E
P
S
Q
D
Site 6
S48
Y
M
S
M
T
E
P
S
Q
D
Y
V
P
A
S
Site 7
Y51
M
T
E
P
S
Q
D
Y
V
P
A
S
Q
S
Y
Site 8
S55
S
Q
D
Y
V
P
A
S
Q
S
Y
P
G
P
S
Site 9
S57
D
Y
V
P
A
S
Q
S
Y
P
G
P
S
L
E
Site 10
Y58
Y
V
P
A
S
Q
S
Y
P
G
P
S
L
E
S
Site 11
S62
S
Q
S
Y
P
G
P
S
L
E
S
E
D
F
N
Site 12
T74
D
F
N
I
P
P
I
T
P
P
S
L
P
D
H
Site 13
S82
P
P
S
L
P
D
H
S
L
V
H
L
N
E
V
Site 14
Y93
L
N
E
V
E
S
G
Y
H
S
L
C
H
P
M
Site 15
T119
N
M
D
L
P
E
I
T
V
S
N
M
L
G
Q
Site 16
S121
D
L
P
E
I
T
V
S
N
M
L
G
Q
D
G
Site 17
T129
N
M
L
G
Q
D
G
T
L
L
S
N
S
I
S
Site 18
S132
G
Q
D
G
T
L
L
S
N
S
I
S
V
M
P
Site 19
T147
D
I
R
N
P
E
G
T
Q
Y
S
S
H
P
Q
Site 20
Y149
R
N
P
E
G
T
Q
Y
S
S
H
P
Q
M
A
Site 21
S150
N
P
E
G
T
Q
Y
S
S
H
P
Q
M
A
A
Site 22
S198
L
G
L
N
M
G
G
S
N
V
P
H
N
S
P
Site 23
S204
G
S
N
V
P
H
N
S
P
S
P
P
G
S
K
Site 24
S206
N
V
P
H
N
S
P
S
P
P
G
S
K
S
A
Site 25
S210
N
S
P
S
P
P
G
S
K
S
A
T
P
S
P
Site 26
S212
P
S
P
P
G
S
K
S
A
T
P
S
P
S
S
Site 27
T214
P
P
G
S
K
S
A
T
P
S
P
S
S
S
V
Site 28
S216
G
S
K
S
A
T
P
S
P
S
S
S
V
H
E
Site 29
S218
K
S
A
T
P
S
P
S
S
S
V
H
E
D
E
Site 30
S219
S
A
T
P
S
P
S
S
S
V
H
E
D
E
G
Site 31
S220
A
T
P
S
P
S
S
S
V
H
E
D
E
G
D
Site 32
T229
H
E
D
E
G
D
D
T
S
K
I
N
G
G
E
Site 33
S230
E
D
E
G
D
D
T
S
K
I
N
G
G
E
K
Site 34
S241
G
G
E
K
R
P
A
S
D
M
G
K
K
P
K
Site 35
T249
D
M
G
K
K
P
K
T
P
K
K
K
K
K
K
Site 36
S266
N
E
P
Q
K
P
V
S
A
Y
A
L
F
F
R
Site 37
T275
Y
A
L
F
F
R
D
T
Q
A
A
I
K
G
Q
Site 38
T287
K
G
Q
N
P
N
A
T
F
G
E
V
S
K
I
Site 39
S331
Q
L
A
A
Y
R
A
S
L
V
S
K
S
Y
S
Site 40
S334
A
Y
R
A
S
L
V
S
K
S
Y
S
E
P
V
Site 41
S336
R
A
S
L
V
S
K
S
Y
S
E
P
V
D
V
Site 42
Y337
A
S
L
V
S
K
S
Y
S
E
P
V
D
V
K
Site 43
S338
S
L
V
S
K
S
Y
S
E
P
V
D
V
K
T
Site 44
T345
S
E
P
V
D
V
K
T
S
Q
P
P
Q
L
I
Site 45
S346
E
P
V
D
V
K
T
S
Q
P
P
Q
L
I
N
Site 46
S354
Q
P
P
Q
L
I
N
S
K
P
S
V
F
H
G
Site 47
S357
Q
L
I
N
S
K
P
S
V
F
H
G
P
S
Q
Site 48
S363
P
S
V
F
H
G
P
S
Q
A
H
S
A
L
Y
Site 49
S367
H
G
P
S
Q
A
H
S
A
L
Y
L
S
S
H
Site 50
Y370
S
Q
A
H
S
A
L
Y
L
S
S
H
Y
H
Q
Site 51
T386
P
G
M
N
P
H
L
T
A
M
H
P
S
L
P
Site 52
S391
H
L
T
A
M
H
P
S
L
P
R
N
I
A
P
Site 53
S424
P
P
P
P
L
Q
I
S
P
P
L
H
Q
H
L
Site 54
T440
M
Q
Q
H
Q
P
L
T
M
Q
Q
P
L
G
N
Site 55
S455
Q
L
P
M
Q
V
Q
S
A
L
H
S
P
T
M
Site 56
S459
Q
V
Q
S
A
L
H
S
P
T
M
Q
Q
G
F
Site 57
T467
P
T
M
Q
Q
G
F
T
L
Q
P
D
Y
Q
T
Site 58
Y472
G
F
T
L
Q
P
D
Y
Q
T
I
I
N
P
T
Site 59
Y492
V
V
T
Q
A
M
E
Y
V
R
S
G
C
R
N
Site 60
S495
Q
A
M
E
Y
V
R
S
G
C
R
N
P
P
P
Site 61
Y511
P
V
D
W
N
N
D
Y
C
S
S
G
G
M
Q
Site 62
S513
D
W
N
N
D
Y
C
S
S
G
G
M
Q
R
D
Site 63
T526
R
D
K
A
L
Y
L
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation