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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DKK1
Full Name:
Dickkopf-related protein 1
Alias:
SK
Type:
Mass (Da):
28672
Number AA:
266
UniProt ID:
O94907
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
T
L
N
S
V
L
N
S
N
A
I
K
N
L
P
Site 2
Y68
S
A
A
P
G
I
L
Y
P
G
G
N
K
Y
Q
Site 3
Y74
L
Y
P
G
G
N
K
Y
Q
T
I
D
N
Y
Q
Site 4
T76
P
G
G
N
K
Y
Q
T
I
D
N
Y
Q
P
Y
Site 5
Y80
K
Y
Q
T
I
D
N
Y
Q
P
Y
P
C
A
E
Site 6
Y83
T
I
D
N
Y
Q
P
Y
P
C
A
E
D
E
E
Site 7
T93
A
E
D
E
E
C
G
T
D
E
Y
C
A
S
P
Site 8
Y96
E
E
C
G
T
D
E
Y
C
A
S
P
T
R
G
Site 9
S99
G
T
D
E
Y
C
A
S
P
T
R
G
G
D
A
Site 10
Y132
A
M
C
C
P
G
N
Y
C
K
N
G
I
C
V
Site 11
T153
F
R
G
E
I
E
E
T
I
T
E
S
F
G
N
Site 12
T155
G
E
I
E
E
T
I
T
E
S
F
G
N
D
H
Site 13
S157
I
E
E
T
I
T
E
S
F
G
N
D
H
S
T
Site 14
S163
E
S
F
G
N
D
H
S
T
L
D
G
Y
S
R
Site 15
T164
S
F
G
N
D
H
S
T
L
D
G
Y
S
R
R
Site 16
Y168
D
H
S
T
L
D
G
Y
S
R
R
T
T
L
S
Site 17
S169
H
S
T
L
D
G
Y
S
R
R
T
T
L
S
S
Site 18
T172
L
D
G
Y
S
R
R
T
T
L
S
S
K
M
Y
Site 19
T173
D
G
Y
S
R
R
T
T
L
S
S
K
M
Y
H
Site 20
S175
Y
S
R
R
T
T
L
S
S
K
M
Y
H
T
K
Site 21
S176
S
R
R
T
T
L
S
S
K
M
Y
H
T
K
G
Site 22
Y179
T
T
L
S
S
K
M
Y
H
T
K
G
Q
E
G
Site 23
S187
H
T
K
G
Q
E
G
S
V
C
L
R
S
S
D
Site 24
S192
E
G
S
V
C
L
R
S
S
D
C
A
S
G
L
Site 25
S197
L
R
S
S
D
C
A
S
G
L
C
C
A
R
H
Site 26
S228
T
K
H
R
R
K
G
S
H
G
L
E
I
F
Q
Site 27
S255
Q
K
D
H
H
Q
A
S
N
S
S
R
L
H
T
Site 28
S257
D
H
H
Q
A
S
N
S
S
R
L
H
T
C
Q
Site 29
S258
H
H
Q
A
S
N
S
S
R
L
H
T
C
Q
R
Site 30
T262
S
N
S
S
R
L
H
T
C
Q
R
H
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation