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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LPHN1
Full Name:
Latrophilin-1
Alias:
Calcium-independent alpha-latrotoxin receptor 1; CIRL1; KIAA0821; LEC2; Lectomedin-2; LHN1
Type:
Receptor, G protein-coupled
Mass (Da):
162717
Number AA:
1474
UniProt ID:
O94910
International Prot ID:
IPI00183445
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0005529
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
T
S
A
T
Q
G
L
S
R
A
G
L
P
F
G
Site 2
Y44
R
E
L
A
C
E
G
Y
P
I
E
L
R
C
P
Site 3
Y63
I
M
V
E
N
A
N
Y
G
R
T
D
D
K
I
Site 4
T100
S
Q
R
C
N
N
R
T
Q
C
V
V
V
A
G
Site 5
Y121
P
C
P
G
T
Y
K
Y
L
E
V
Q
Y
D
C
Site 6
Y126
Y
K
Y
L
E
V
Q
Y
D
C
V
P
Y
K
V
Site 7
Y131
V
Q
Y
D
C
V
P
Y
K
V
E
Q
K
V
F
Site 8
S152
Q
K
V
L
E
P
T
S
T
H
E
S
E
H
Q
Site 9
T153
K
V
L
E
P
T
S
T
H
E
S
E
H
Q
S
Site 10
S156
E
P
T
S
T
H
E
S
E
H
Q
S
G
A
W
Site 11
T186
W
I
P
Y
R
T
D
T
L
T
E
Y
A
S
W
Site 12
T188
P
Y
R
T
D
T
L
T
E
Y
A
S
W
E
D
Site 13
Y190
R
T
D
T
L
T
E
Y
A
S
W
E
D
Y
V
Site 14
S192
D
T
L
T
E
Y
A
S
W
E
D
Y
V
A
A
Site 15
Y196
E
Y
A
S
W
E
D
Y
V
A
A
R
H
T
T
Site 16
T202
D
Y
V
A
A
R
H
T
T
T
Y
R
L
P
N
Site 17
T203
Y
V
A
A
R
H
T
T
T
Y
R
L
P
N
R
Site 18
Y205
A
A
R
H
T
T
T
Y
R
L
P
N
R
V
D
Site 19
T214
L
P
N
R
V
D
G
T
G
F
V
V
Y
D
G
Site 20
Y236
R
T
R
N
I
V
K
Y
D
L
R
T
R
I
K
Site 21
T240
I
V
K
Y
D
L
R
T
R
I
K
S
G
E
T
Site 22
S244
D
L
R
T
R
I
K
S
G
E
T
V
I
N
T
Site 23
Y254
T
V
I
N
T
A
N
Y
H
D
T
S
P
Y
R
Site 24
T266
P
Y
R
W
G
G
K
T
D
I
D
L
A
V
D
Site 25
Y281
E
N
G
L
W
V
I
Y
A
T
E
G
N
N
G
Site 26
S293
N
N
G
R
L
V
V
S
Q
L
N
P
Y
T
L
Site 27
Y298
V
V
S
Q
L
N
P
Y
T
L
R
F
E
G
T
Site 28
T299
V
S
Q
L
N
P
Y
T
L
R
F
E
G
T
W
Site 29
Y310
E
G
T
W
E
T
G
Y
D
K
R
S
A
S
N
Site 30
S314
E
T
G
Y
D
K
R
S
A
S
N
A
F
M
V
Site 31
S316
G
Y
D
K
R
S
A
S
N
A
F
M
V
C
G
Site 32
Y332
L
Y
V
L
R
S
V
Y
V
D
D
D
S
E
A
Site 33
S337
S
V
Y
V
D
D
D
S
E
A
A
G
N
R
V
Site 34
Y346
A
A
G
N
R
V
D
Y
A
F
N
T
N
A
N
Site 35
S359
A
N
R
E
E
P
V
S
L
T
F
P
N
P
Y
Site 36
T361
R
E
E
P
V
S
L
T
F
P
N
P
Y
Q
F
Site 37
Y366
S
L
T
F
P
N
P
Y
Q
F
I
S
S
V
D
Site 38
S370
P
N
P
Y
Q
F
I
S
S
V
D
Y
N
P
R
Site 39
Y374
Q
F
I
S
S
V
D
Y
N
P
R
D
N
Q
L
Site 40
Y382
N
P
R
D
N
Q
L
Y
V
W
N
N
Y
F
V
Site 41
S393
N
Y
F
V
V
R
Y
S
L
E
F
G
P
P
D
Site 42
S402
E
F
G
P
P
D
P
S
A
G
P
A
T
S
P
Site 43
T407
D
P
S
A
G
P
A
T
S
P
P
L
S
T
T
Site 44
S408
P
S
A
G
P
A
T
S
P
P
L
S
T
T
T
Site 45
S412
P
A
T
S
P
P
L
S
T
T
T
T
A
R
P
Site 46
T416
P
P
L
S
T
T
T
T
A
R
P
T
P
L
T
Site 47
T420
T
T
T
T
A
R
P
T
P
L
T
S
T
A
S
Site 48
T423
T
A
R
P
T
P
L
T
S
T
A
S
P
A
A
Site 49
S424
A
R
P
T
P
L
T
S
T
A
S
P
A
A
T
Site 50
T425
R
P
T
P
L
T
S
T
A
S
P
A
A
T
T
Site 51
T431
S
T
A
S
P
A
A
T
T
P
L
R
R
A
P
Site 52
T432
T
A
S
P
A
A
T
T
P
L
R
R
A
P
L
Site 53
T441
L
R
R
A
P
L
T
T
H
P
V
G
A
I
N
Site 54
T458
G
P
D
L
P
P
A
T
A
P
V
P
S
T
R
Site 55
S463
P
A
T
A
P
V
P
S
T
R
R
P
P
A
P
Site 56
T464
A
T
A
P
V
P
S
T
R
R
P
P
A
P
N
Site 57
S475
P
A
P
N
L
H
V
S
P
E
L
F
C
E
P
Site 58
T493
R
R
V
Q
W
P
A
T
Q
Q
G
M
L
V
E
Site 59
S530
N
P
R
G
P
D
L
S
N
C
T
S
P
W
V
Site 60
S534
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Site 61
S546
Q
V
A
Q
K
I
K
S
G
E
N
A
A
N
I
Site 62
T561
A
S
E
L
A
R
H
T
R
G
S
I
Y
A
G
Site 63
S564
L
A
R
H
T
R
G
S
I
Y
A
G
D
V
S
Site 64
Y566
R
H
T
R
G
S
I
Y
A
G
D
V
S
S
S
Site 65
S572
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
Site 66
S573
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
Site 67
S598
L
R
P
I
E
R
E
S
A
G
K
N
Y
N
K
Site 68
T612
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
Site 69
Y616
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
Site 70
S635
L
R
P
E
A
L
E
S
W
K
D
M
N
A
T
Site 71
Y702
L
V
F
P
Q
E
E
Y
P
R
K
N
S
I
Q
Site 72
S707
E
E
Y
P
R
K
N
S
I
Q
L
S
A
K
T
Site 73
S711
R
K
N
S
I
Q
L
S
A
K
T
I
K
Q
N
Site 74
T714
S
I
Q
L
S
A
K
T
I
K
Q
N
S
R
N
Site 75
S739
N
N
L
G
L
F
L
S
T
E
N
A
T
V
K
Site 76
S771
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
R
Site 77
S776
A
A
S
I
N
K
E
S
S
R
V
F
L
M
D
Site 78
Y807
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Site 79
Y815
S
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
Site 80
T829
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
Site 81
T831
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
Site 82
Y851
L
M
A
H
R
E
I
Y
Q
G
R
I
N
E
L
Site 83
T890
C
F
L
R
G
L
Q
T
D
R
N
T
I
H
K
Site 84
T894
G
L
Q
T
D
R
N
T
I
H
K
N
L
C
I
Site 85
S958
L
L
V
E
V
F
E
S
E
Y
S
R
T
K
Y
Site 86
Y960
V
E
V
F
E
S
E
Y
S
R
T
K
Y
Y
Y
Site 87
S961
E
V
F
E
S
E
Y
S
R
T
K
Y
Y
Y
L
Site 88
T963
F
E
S
E
Y
S
R
T
K
Y
Y
Y
L
G
G
Site 89
Y965
S
E
Y
S
R
T
K
Y
Y
Y
L
G
G
Y
C
Site 90
Y966
E
Y
S
R
T
K
Y
Y
Y
L
G
G
Y
C
F
Site 91
Y967
Y
S
R
T
K
Y
Y
Y
L
G
G
Y
C
F
P
Site 92
Y986
G
I
A
A
A
I
D
Y
R
S
Y
G
T
E
K
Site 93
S988
A
A
A
I
D
Y
R
S
Y
G
T
E
K
A
C
Site 94
Y989
A
A
I
D
Y
R
S
Y
G
T
E
K
A
C
W
Site 95
S1032
T
L
H
K
M
I
R
S
S
S
V
L
K
P
D
Site 96
S1033
L
H
K
M
I
R
S
S
S
V
L
K
P
D
S
Site 97
S1034
H
K
M
I
R
S
S
S
V
L
K
P
D
S
S
Site 98
S1040
S
S
V
L
K
P
D
S
S
R
L
D
N
I
K
Site 99
S1041
S
V
L
K
P
D
S
S
R
L
D
N
I
K
S
Site 100
Y1116
S
K
C
L
R
H
S
Y
C
C
I
R
S
P
P
Site 101
S1121
H
S
Y
C
C
I
R
S
P
P
G
G
T
H
G
Site 102
T1126
I
R
S
P
P
G
G
T
H
G
S
L
K
T
S
Site 103
S1129
P
P
G
G
T
H
G
S
L
K
T
S
A
M
R
Site 104
T1132
G
T
H
G
S
L
K
T
S
A
M
R
S
N
T
Site 105
S1133
T
H
G
S
L
K
T
S
A
M
R
S
N
T
R
Site 106
S1137
L
K
T
S
A
M
R
S
N
T
R
Y
Y
T
G
Site 107
T1139
T
S
A
M
R
S
N
T
R
Y
Y
T
G
T
Q
Site 108
Y1141
A
M
R
S
N
T
R
Y
Y
T
G
T
Q
S
R
Site 109
Y1142
M
R
S
N
T
R
Y
Y
T
G
T
Q
S
R
I
Site 110
T1143
R
S
N
T
R
Y
Y
T
G
T
Q
S
R
I
R
Site 111
T1145
N
T
R
Y
Y
T
G
T
Q
S
R
I
R
R
M
Site 112
S1147
R
Y
Y
T
G
T
Q
S
R
I
R
R
M
W
N
Site 113
T1156
I
R
R
M
W
N
D
T
V
R
K
Q
T
E
S
Site 114
T1161
N
D
T
V
R
K
Q
T
E
S
S
F
M
A
G
Site 115
S1163
T
V
R
K
Q
T
E
S
S
F
M
A
G
D
I
Site 116
S1164
V
R
K
Q
T
E
S
S
F
M
A
G
D
I
N
Site 117
S1172
F
M
A
G
D
I
N
S
T
P
T
L
N
R
G
Site 118
T1173
M
A
G
D
I
N
S
T
P
T
L
N
R
G
T
Site 119
T1175
G
D
I
N
S
T
P
T
L
N
R
G
T
M
G
Site 120
T1180
T
P
T
L
N
R
G
T
M
G
N
H
L
L
T
Site 121
T1187
T
M
G
N
H
L
L
T
N
P
V
L
Q
P
R
Site 122
T1197
V
L
Q
P
R
G
G
T
S
P
Y
N
T
L
I
Site 123
S1198
L
Q
P
R
G
G
T
S
P
Y
N
T
L
I
A
Site 124
T1202
G
G
T
S
P
Y
N
T
L
I
A
E
S
V
G
Site 125
S1207
Y
N
T
L
I
A
E
S
V
G
F
N
P
S
S
Site 126
S1213
E
S
V
G
F
N
P
S
S
P
P
V
F
N
S
Site 127
S1214
S
V
G
F
N
P
S
S
P
P
V
F
N
S
P
Site 128
S1220
S
S
P
P
V
F
N
S
P
G
S
Y
R
E
P
Site 129
S1223
P
V
F
N
S
P
G
S
Y
R
E
P
K
H
P
Site 130
Y1224
V
F
N
S
P
G
S
Y
R
E
P
K
H
P
L
Site 131
T1241
R
E
A
C
G
M
D
T
L
P
L
N
G
N
F
Site 132
Y1252
N
G
N
F
N
N
S
Y
S
L
R
S
G
D
F
Site 133
S1253
G
N
F
N
N
S
Y
S
L
R
S
G
D
F
P
Site 134
S1296
V
H
N
N
L
R
G
S
S
S
A
A
K
G
P
Site 135
S1297
H
N
N
L
R
G
S
S
S
A
A
K
G
P
P
Site 136
S1298
N
N
L
R
G
S
S
S
A
A
K
G
P
P
P
Site 137
Y1337
R
A
E
I
E
L
L
Y
K
A
L
E
E
P
L
Site 138
S1351
L
L
L
P
R
A
Q
S
V
L
Y
Q
S
D
L
Site 139
Y1354
P
R
A
Q
S
V
L
Y
Q
S
D
L
D
E
S
Site 140
S1356
A
Q
S
V
L
Y
Q
S
D
L
D
E
S
E
S
Site 141
S1363
S
D
L
D
E
S
E
S
C
T
A
E
D
G
A
Site 142
T1365
L
D
E
S
E
S
C
T
A
E
D
G
A
T
S
Site 143
T1371
C
T
A
E
D
G
A
T
S
R
P
L
S
S
P
Site 144
S1372
T
A
E
D
G
A
T
S
R
P
L
S
S
P
P
Site 145
S1376
G
A
T
S
R
P
L
S
S
P
P
G
R
D
S
Site 146
S1377
A
T
S
R
P
L
S
S
P
P
G
R
D
S
L
Site 147
S1383
S
S
P
P
G
R
D
S
L
Y
A
S
G
A
N
Site 148
Y1385
P
P
G
R
D
S
L
Y
A
S
G
A
N
L
R
Site 149
S1387
G
R
D
S
L
Y
A
S
G
A
N
L
R
D
S
Site 150
S1394
S
G
A
N
L
R
D
S
P
S
Y
P
D
S
S
Site 151
S1396
A
N
L
R
D
S
P
S
Y
P
D
S
S
P
E
Site 152
Y1397
N
L
R
D
S
P
S
Y
P
D
S
S
P
E
G
Site 153
S1400
D
S
P
S
Y
P
D
S
S
P
E
G
P
S
E
Site 154
S1401
S
P
S
Y
P
D
S
S
P
E
G
P
S
E
A
Site 155
S1406
D
S
S
P
E
G
P
S
E
A
L
P
P
P
P
Site 156
Y1423
P
P
G
P
P
E
I
Y
Y
T
S
R
P
P
A
Site 157
Y1424
P
G
P
P
E
I
Y
Y
T
S
R
P
P
A
L
Site 158
T1425
G
P
P
E
I
Y
Y
T
S
R
P
P
A
L
V
Site 159
S1426
P
P
E
I
Y
Y
T
S
R
P
P
A
L
V
A
Site 160
Y1440
A
R
N
P
L
Q
G
Y
Y
Q
V
R
R
P
S
Site 161
Y1441
R
N
P
L
Q
G
Y
Y
Q
V
R
R
P
S
H
Site 162
S1447
Y
Y
Q
V
R
R
P
S
H
E
G
Y
L
A
A
Site 163
Y1451
R
R
P
S
H
E
G
Y
L
A
A
P
G
L
E
Site 164
S1473
G
Q
M
Q
L
V
T
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation