KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PCF11
Full Name:
Pre-mRNA cleavage complex 2 protein Pcf11
Alias:
KIAA0824; PCF11, cleavage and polyadenylation factor subunit,; PCFB; Pre-mRNA cleavage complex II protein Pcf11
Type:
Enzyme, misc.
Mass (Da):
173050
Number AA:
1555
UniProt ID:
O94913
International Prot ID:
IPI00016387
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005849
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006379
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
S
E
Q
T
P
A
E
A
G
A
A
Site 2
Y22
R
E
D
A
C
R
D
Y
Q
S
S
L
E
D
L
Site 3
S25
A
C
R
D
Y
Q
S
S
L
E
D
L
T
F
N
Site 4
T30
Q
S
S
L
E
D
L
T
F
N
S
K
P
H
I
Site 5
S33
L
E
D
L
T
F
N
S
K
P
H
I
N
M
L
Site 6
S68
Q
T
A
K
A
P
S
S
E
K
L
P
V
M
Y
Site 7
Y88
V
K
N
V
G
R
E
Y
L
T
A
F
T
K
N
Site 8
S114
V
D
E
N
T
R
K
S
L
F
K
L
R
S
T
Site 9
S120
K
S
L
F
K
L
R
S
T
W
D
E
I
F
P
Site 10
T121
S
L
F
K
L
R
S
T
W
D
E
I
F
P
L
Site 11
S140
A
L
D
V
R
V
N
S
L
D
P
A
W
P
I
Site 12
S158
P
P
N
V
N
T
S
S
I
H
V
N
P
K
F
Site 13
S169
N
P
K
F
L
N
K
S
P
E
E
P
S
T
P
Site 14
S174
N
K
S
P
E
E
P
S
T
P
G
T
V
V
S
Site 15
T175
K
S
P
E
E
P
S
T
P
G
T
V
V
S
S
Site 16
T178
E
E
P
S
T
P
G
T
V
V
S
S
P
S
I
Site 17
S181
S
T
P
G
T
V
V
S
S
P
S
I
S
T
P
Site 18
S182
T
P
G
T
V
V
S
S
P
S
I
S
T
P
P
Site 19
S184
G
T
V
V
S
S
P
S
I
S
T
P
P
I
V
Site 20
S186
V
V
S
S
P
S
I
S
T
P
P
I
V
P
D
Site 21
T187
V
S
S
P
S
I
S
T
P
P
I
V
P
D
I
Site 22
T199
P
D
I
Q
K
N
L
T
Q
E
Q
L
I
R
Q
Site 23
S239
A
Q
L
A
V
S
L
S
V
Q
Q
E
T
S
N
Site 24
S245
L
S
V
Q
Q
E
T
S
N
L
G
P
G
S
A
Site 25
S251
T
S
N
L
G
P
G
S
A
P
S
K
L
H
V
Site 26
S254
L
G
P
G
S
A
P
S
K
L
H
V
S
Q
I
Site 27
S276
P
H
Q
V
P
V
Q
S
E
K
S
R
P
G
P
Site 28
S279
V
P
V
Q
S
E
K
S
R
P
G
P
S
L
Q
Site 29
S303
D
P
R
L
N
R
I
S
Q
H
S
H
G
K
D
Site 30
S306
L
N
R
I
S
Q
H
S
H
G
K
D
Q
S
H
Site 31
S312
H
S
H
G
K
D
Q
S
H
R
K
E
F
L
M
Site 32
T321
R
K
E
F
L
M
N
T
L
N
Q
S
D
T
K
Site 33
T327
N
T
L
N
Q
S
D
T
K
T
S
K
T
I
P
Site 34
T329
L
N
Q
S
D
T
K
T
S
K
T
I
P
S
E
Site 35
T332
S
D
T
K
T
S
K
T
I
P
S
E
K
L
N
Site 36
S335
K
T
S
K
T
I
P
S
E
K
L
N
S
S
K
Site 37
S340
I
P
S
E
K
L
N
S
S
K
Q
E
K
S
K
Site 38
S341
P
S
E
K
L
N
S
S
K
Q
E
K
S
K
S
Site 39
S346
N
S
S
K
Q
E
K
S
K
S
G
E
K
I
T
Site 40
S348
S
K
Q
E
K
S
K
S
G
E
K
I
T
K
K
Site 41
S362
K
E
L
D
Q
L
D
S
K
S
K
S
K
S
K
Site 42
S364
L
D
Q
L
D
S
K
S
K
S
K
S
K
S
P
Site 43
S366
Q
L
D
S
K
S
K
S
K
S
K
S
P
S
P
Site 44
S368
D
S
K
S
K
S
K
S
K
S
P
S
P
L
K
Site 45
S370
K
S
K
S
K
S
K
S
P
S
P
L
K
N
K
Site 46
S372
K
S
K
S
K
S
P
S
P
L
K
N
K
L
S
Site 47
S379
S
P
L
K
N
K
L
S
H
T
K
D
L
K
N
Site 48
S389
K
D
L
K
N
Q
E
S
E
S
M
R
L
S
D
Site 49
S391
L
K
N
Q
E
S
E
S
M
R
L
S
D
M
N
Site 50
S395
E
S
E
S
M
R
L
S
D
M
N
K
R
D
P
Site 51
T412
K
K
H
L
Q
D
K
T
D
G
K
D
D
D
V
Site 52
T425
D
V
K
E
K
R
K
T
A
E
K
K
D
K
D
Site 53
S437
D
K
D
E
H
M
K
S
S
E
H
R
L
A
G
Site 54
S445
S
E
H
R
L
A
G
S
R
N
K
I
I
N
G
Site 55
T459
G
I
V
Q
K
Q
D
T
I
T
E
E
S
E
K
Site 56
T461
V
Q
K
Q
D
T
I
T
E
E
S
E
K
Q
G
Site 57
T469
E
E
S
E
K
Q
G
T
K
P
G
R
S
S
T
Site 58
S474
Q
G
T
K
P
G
R
S
S
T
R
K
R
S
R
Site 59
S475
G
T
K
P
G
R
S
S
T
R
K
R
S
R
S
Site 60
T476
T
K
P
G
R
S
S
T
R
K
R
S
R
S
R
Site 61
S480
R
S
S
T
R
K
R
S
R
S
R
S
P
K
S
Site 62
S482
S
T
R
K
R
S
R
S
R
S
P
K
S
R
S
Site 63
S484
R
K
R
S
R
S
R
S
P
K
S
R
S
P
I
Site 64
S487
S
R
S
R
S
P
K
S
R
S
P
I
I
H
S
Site 65
S489
S
R
S
P
K
S
R
S
P
I
I
H
S
P
K
Site 66
S494
E
S
E
S
M
R
L
S
D
M
N
K
R
D
P
Site 67
S502
P
K
R
R
D
R
R
S
P
K
R
R
Q
R
S
Site 68
S509
S
P
K
R
R
Q
R
S
M
S
P
T
S
T
P
Site 69
S511
K
R
R
Q
R
S
M
S
P
T
S
T
P
K
A
Site 70
T513
R
Q
R
S
M
S
P
T
S
T
P
K
A
G
K
Site 71
S514
Q
R
S
M
S
P
T
S
T
P
K
A
G
K
I
Site 72
T515
R
S
M
S
P
T
S
T
P
K
A
G
K
I
R
Site 73
S524
K
A
G
K
I
R
Q
S
G
A
K
Q
S
H
M
Site 74
S529
R
Q
S
G
A
K
Q
S
H
M
E
E
F
T
P
Site 75
T535
Q
S
H
M
E
E
F
T
P
P
S
R
E
D
R
Site 76
S538
M
E
E
F
T
P
P
S
R
E
D
R
N
A
K
Site 77
S547
E
D
R
N
A
K
R
S
T
K
Q
D
I
R
D
Site 78
T548
D
R
N
A
K
R
S
T
K
Q
D
I
R
D
P
Site 79
T561
D
P
R
R
M
K
K
T
E
E
E
R
P
Q
E
Site 80
T570
E
E
R
P
Q
E
T
T
N
Q
H
S
T
K
S
Site 81
S593
S
R
S
P
I
I
H
S
P
K
R
R
D
R
R
Site 82
S599
K
S
A
K
R
W
K
S
G
W
E
E
N
K
S
Site 83
S606
S
G
W
E
E
N
K
S
L
Q
Q
V
D
E
H
Site 84
S614
L
Q
Q
V
D
E
H
S
K
P
P
H
L
R
H
Site 85
S624
P
H
L
R
H
R
E
S
W
S
S
T
K
G
I
Site 86
S626
L
R
H
R
E
S
W
S
S
T
K
G
I
L
S
Site 87
S627
R
H
R
E
S
W
S
S
T
K
G
I
L
S
P
Site 88
T628
H
R
E
S
W
S
S
T
K
G
I
L
S
P
R
Site 89
S633
S
S
T
K
G
I
L
S
P
R
A
P
K
Q
Q
Site 90
S645
K
Q
Q
Q
H
R
L
S
V
D
A
N
L
Q
I
Site 91
T657
L
Q
I
P
K
E
L
T
L
A
S
K
R
E
L
Site 92
S660
P
K
E
L
T
L
A
S
K
R
E
L
L
Q
K
Site 93
T668
K
R
E
L
L
Q
K
T
S
E
R
L
A
S
G
Site 94
S669
R
E
L
L
Q
K
T
S
E
R
L
A
S
G
E
Site 95
S674
K
T
S
E
R
L
A
S
G
E
I
T
Q
D
D
Site 96
Y695
Q
I
R
Q
L
F
Q
Y
Q
E
G
V
R
E
E
Site 97
S705
G
V
R
E
E
Q
R
S
P
F
N
D
R
F
P
Site 98
Y718
F
P
L
K
R
P
R
Y
E
D
S
D
K
P
F
Site 99
S721
K
R
P
R
Y
E
D
S
D
K
P
F
V
D
S
Site 100
S728
S
D
K
P
F
V
D
S
P
A
S
R
F
A
G
Site 101
S731
P
F
V
D
S
P
A
S
R
F
A
G
L
D
T
Site 102
T738
S
R
F
A
G
L
D
T
N
Q
R
L
T
A
L
Site 103
T743
L
D
T
N
Q
R
L
T
A
L
A
E
D
R
P
Site 104
S756
R
P
L
F
D
G
P
S
R
P
S
V
A
R
D
Site 105
S759
F
D
G
P
S
R
P
S
V
A
R
D
G
P
T
Site 106
T766
S
V
A
R
D
G
P
T
K
M
I
F
E
G
P
Site 107
S777
F
E
G
P
N
K
L
S
P
R
I
D
G
P
P
Site 108
T785
P
R
I
D
G
P
P
T
P
A
S
L
R
F
D
Site 109
S788
D
G
P
P
T
P
A
S
L
R
F
D
G
S
P
Site 110
S794
A
S
L
R
F
D
G
S
P
G
Q
M
G
G
G
Site 111
T830
G
P
P
G
P
V
G
T
P
L
R
F
E
G
P
Site 112
S851
G
G
F
R
F
E
G
S
P
G
L
R
F
E
G
Site 113
S859
P
G
L
R
F
E
G
S
P
G
G
L
R
F
E
Site 114
S963
F
E
G
P
H
G
Q
S
V
A
G
L
R
F
E
Site 115
S1012
G
M
R
F
E
G
P
S
V
P
G
G
G
L
R
Site 116
S1047
D
G
Q
P
G
Q
P
S
L
L
P
R
F
D
G
Site 117
T1066
P
G
P
R
F
E
R
T
P
G
Q
P
G
P
Q
Site 118
T1114
I
P
L
G
L
Q
G
T
R
F
D
N
H
P
S
Site 119
S1121
T
R
F
D
N
H
P
S
Q
R
L
E
S
V
S
Site 120
S1126
H
P
S
Q
R
L
E
S
V
S
F
N
Q
T
G
Site 121
S1128
S
Q
R
L
E
S
V
S
F
N
Q
T
G
P
Y
Site 122
T1132
E
S
V
S
F
N
Q
T
G
P
Y
N
D
P
P
Site 123
Y1135
S
F
N
Q
T
G
P
Y
N
D
P
P
G
N
A
Site 124
S1147
G
N
A
F
N
A
P
S
Q
G
L
Q
F
Q
R
Site 125
S1161
R
H
E
Q
I
F
D
S
P
Q
G
P
N
F
N
Site 126
S1177
P
H
G
P
G
N
Q
S
F
S
N
P
L
N
R
Site 127
S1179
G
P
G
N
Q
S
F
S
N
P
L
N
R
A
S
Site 128
S1186
S
N
P
L
N
R
A
S
G
H
Y
F
D
E
K
Site 129
Y1189
L
N
R
A
S
G
H
Y
F
D
E
K
N
L
Q
Site 130
S1198
D
E
K
N
L
Q
S
S
Q
F
G
N
F
G
N
Site 131
Y1259
S
G
A
L
P
K
A
Y
P
D
N
H
L
S
Q
Site 132
S1265
A
Y
P
D
N
H
L
S
Q
V
D
V
N
E
L
Site 133
S1285
K
T
G
I
L
K
L
S
Q
T
D
S
A
T
T
Site 134
T1287
G
I
L
K
L
S
Q
T
D
S
A
T
T
Q
V
Site 135
S1289
L
K
L
S
Q
T
D
S
A
T
T
Q
V
S
E
Site 136
T1291
L
S
Q
T
D
S
A
T
T
Q
V
S
E
V
T
Site 137
T1319
D
Q
D
V
P
D
L
T
N
F
T
V
E
E
L
Site 138
T1322
V
P
D
L
T
N
F
T
V
E
E
L
K
Q
R
Site 139
Y1330
V
E
E
L
K
Q
R
Y
D
S
V
I
N
R
L
Site 140
S1332
E
L
K
Q
R
Y
D
S
V
I
N
R
L
Y
T
Site 141
Y1338
D
S
V
I
N
R
L
Y
T
G
I
Q
C
Y
S
Site 142
T1352
S
C
G
M
R
F
T
T
S
Q
T
D
V
Y
A
Site 143
Y1358
T
T
S
Q
T
D
V
Y
A
D
H
L
D
W
H
Site 144
Y1366
A
D
H
L
D
W
H
Y
R
Q
N
R
T
E
K
Site 145
S1376
N
R
T
E
K
D
V
S
R
K
V
T
H
R
R
Site 146
T1380
K
D
V
S
R
K
V
T
H
R
R
W
Y
Y
S
Site 147
S1406
D
L
E
E
R
A
K
S
Q
F
F
E
K
V
H
Site 148
T1420
H
E
E
V
V
L
K
T
Q
E
A
A
K
E
K
Site 149
S1431
A
K
E
K
E
F
Q
S
V
P
A
G
P
A
G
Site 150
S1442
G
P
A
G
A
V
E
S
C
E
I
C
Q
E
Q
Site 151
Y1479
K
I
Y
H
P
S
C
Y
E
D
Y
Q
N
T
S
Site 152
Y1482
H
P
S
C
Y
E
D
Y
Q
N
T
S
S
F
D
Site 153
T1485
C
Y
E
D
Y
Q
N
T
S
S
F
D
C
T
P
Site 154
S1487
E
D
Y
Q
N
T
S
S
F
D
C
T
P
S
P
Site 155
T1491
N
T
S
S
F
D
C
T
P
S
P
S
K
T
P
Site 156
S1493
S
S
F
D
C
T
P
S
P
S
K
T
P
V
E
Site 157
S1495
F
D
C
T
P
S
P
S
K
T
P
V
E
N
P
Site 158
T1497
C
T
P
S
P
S
K
T
P
V
E
N
P
L
N
Site 159
S1520
E
L
Q
E
P
C
D
S
P
K
V
K
E
E
R
Site 160
T1530
V
K
E
E
R
I
D
T
P
P
A
C
T
E
E
Site 161
S1538
P
P
A
C
T
E
E
S
I
A
T
P
S
E
I
Site 162
T1541
C
T
E
E
S
I
A
T
P
S
E
I
K
T
E
Site 163
T1547
A
T
P
S
E
I
K
T
E
N
D
T
V
E
S
Site 164
T1551
E
I
K
T
E
N
D
T
V
E
S
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation