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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRYL
Full Name:
Protein furry homolog-like
Alias:
ALL1-fused gene from chromosome 4p12; DKFZp686E205; FRY-like; Furry-like; KIAA0826
Type:
Transcription regulation
Mass (Da):
339598
Number AA:
3013
UniProt ID:
O94915
International Prot ID:
IPI00159652
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
P
D
V
K
P
G
E
Y
V
I
K
S
L
F
A
Site 2
S45
E
P
L
E
K
L
L
S
R
S
L
Q
R
G
E
Site 3
S47
L
E
K
L
L
S
R
S
L
Q
R
G
E
D
L
Site 4
S62
Q
F
D
Q
L
I
S
S
M
S
S
V
A
E
H
Site 5
T77
C
L
P
S
L
L
R
T
L
F
D
W
Y
R
R
Site 6
Y82
L
R
T
L
F
D
W
Y
R
R
Q
N
G
T
E
Site 7
T88
W
Y
R
R
Q
N
G
T
E
D
E
S
Y
E
Y
Site 8
S92
Q
N
G
T
E
D
E
S
Y
E
Y
R
P
R
S
Site 9
Y93
N
G
T
E
D
E
S
Y
E
Y
R
P
R
S
S
Site 10
Y95
T
E
D
E
S
Y
E
Y
R
P
R
S
S
T
K
Site 11
S99
S
Y
E
Y
R
P
R
S
S
T
K
S
K
G
D
Site 12
S100
Y
E
Y
R
P
R
S
S
T
K
S
K
G
D
E
Site 13
T101
E
Y
R
P
R
S
S
T
K
S
K
G
D
E
Q
Site 14
S103
R
P
R
S
S
T
K
S
K
G
D
E
Q
Q
R
Site 15
Y114
E
Q
Q
R
E
R
D
Y
L
L
E
R
R
D
L
Site 16
S166
F
K
H
K
E
G
Y
S
G
T
N
T
G
N
V
Site 17
T170
E
G
Y
S
G
T
N
T
G
N
V
H
I
I
A
Site 18
T201
A
V
R
K
K
F
V
T
E
L
K
E
L
R
Q
Site 19
S212
E
L
R
Q
K
E
Q
S
P
H
V
V
Q
S
V
Site 20
Y234
K
F
F
R
V
K
M
Y
P
V
E
D
F
E
A
Site 21
Y252
F
M
Q
E
C
A
Q
Y
F
L
E
V
K
D
K
Site 22
Y297
K
N
F
V
E
M
L
Y
Q
T
T
F
E
L
S
Site 23
T300
V
E
M
L
Y
Q
T
T
F
E
L
S
S
R
K
Site 24
S304
Y
Q
T
T
F
E
L
S
S
R
K
K
H
S
L
Site 25
S310
L
S
S
R
K
K
H
S
L
A
L
Y
P
L
I
Site 26
Y360
R
V
A
L
E
S
L
Y
R
L
L
W
V
Y
V
Site 27
S374
V
I
R
I
K
C
E
S
N
T
V
T
Q
S
R
Site 28
T376
R
I
K
C
E
S
N
T
V
T
Q
S
R
L
M
Site 29
T378
K
C
E
S
N
T
V
T
Q
S
R
L
M
S
I
Site 30
S380
E
S
N
T
V
T
Q
S
R
L
M
S
I
V
S
Site 31
S384
V
T
Q
S
R
L
M
S
I
V
S
A
L
F
P
Site 32
S394
S
A
L
F
P
K
G
S
R
S
V
V
P
R
D
Site 33
S396
L
F
P
K
G
S
R
S
V
V
P
R
D
T
P
Site 34
T402
R
S
V
V
P
R
D
T
P
L
N
I
F
V
K
Site 35
S436
D
L
L
S
V
G
K
S
T
K
T
F
T
I
N
Site 36
T439
S
V
G
K
S
T
K
T
F
T
I
N
P
E
R
Site 37
T441
G
K
S
T
K
T
F
T
I
N
P
E
R
M
N
Site 38
T472
D
G
E
P
P
M
P
T
T
G
V
I
L
P
S
Site 39
T473
G
E
P
P
M
P
T
T
G
V
I
L
P
S
G
Site 40
S479
T
T
G
V
I
L
P
S
G
N
T
L
R
V
K
Site 41
T482
V
I
L
P
S
G
N
T
L
R
V
K
K
I
F
Site 42
T493
K
K
I
F
L
N
K
T
L
T
D
E
E
A
K
Site 43
S517
Q
V
R
K
A
L
D
S
I
L
R
H
L
D
K
Site 44
T533
V
G
R
P
M
C
M
T
S
V
Q
M
S
N
K
Site 45
S538
C
M
T
S
V
Q
M
S
N
K
E
P
E
D
M
Site 46
T547
K
E
P
E
D
M
I
T
G
E
R
K
P
K
I
Site 47
S573
R
L
I
P
D
G
M
S
R
T
D
L
I
E
L
Site 48
S670
H
G
V
A
N
G
A
S
H
P
P
P
L
E
R
Site 49
S678
H
P
P
P
L
E
R
S
P
Y
S
N
V
F
H
Site 50
Y680
P
P
L
E
R
S
P
Y
S
N
V
F
H
V
V
Site 51
S681
P
L
E
R
S
P
Y
S
N
V
F
H
V
V
E
Site 52
T755
L
T
G
A
D
Q
T
T
L
L
Y
C
P
S
S
Site 53
T767
P
S
S
I
D
L
Q
T
L
A
E
W
N
S
S
Site 54
S773
Q
T
L
A
E
W
N
S
S
P
I
S
H
Q
F
Site 55
S774
T
L
A
E
W
N
S
S
P
I
S
H
Q
F
D
Site 56
S777
E
W
N
S
S
P
I
S
H
Q
F
D
V
I
S
Site 57
S804
G
Q
D
P
W
I
I
S
L
S
S
F
L
K
Q
Site 58
S806
D
P
W
I
I
S
L
S
S
F
L
K
Q
E
N
Site 59
S807
P
W
I
I
S
L
S
S
F
L
K
Q
E
N
L
Site 60
S837
Y
T
R
L
Q
L
L
S
P
Q
V
D
I
N
S
Site 61
S844
S
P
Q
V
D
I
N
S
P
I
N
A
K
K
V
Site 62
T853
I
N
A
K
K
V
N
T
T
T
S
S
D
S
Y
Site 63
T855
A
K
K
V
N
T
T
T
S
S
D
S
Y
I
G
Site 64
S857
K
V
N
T
T
T
S
S
D
S
Y
I
G
L
W
Site 65
S859
N
T
T
T
S
S
D
S
Y
I
G
L
W
R
N
Site 66
Y860
T
T
T
S
S
D
S
Y
I
G
L
W
R
N
Y
Site 67
S878
C
C
S
A
A
T
S
S
S
S
T
S
A
G
S
Site 68
S879
C
S
A
A
T
S
S
S
S
T
S
A
G
S
V
Site 69
S880
S
A
A
T
S
S
S
S
T
S
A
G
S
V
R
Site 70
T881
A
A
T
S
S
S
S
T
S
A
G
S
V
R
C
Site 71
S882
A
T
S
S
S
S
T
S
A
G
S
V
R
C
S
Site 72
S885
S
S
S
T
S
A
G
S
V
R
C
S
P
P
E
Site 73
S889
S
A
G
S
V
R
C
S
P
P
E
T
L
A
S
Site 74
T893
V
R
C
S
P
P
E
T
L
A
S
T
P
D
S
Site 75
S896
S
P
P
E
T
L
A
S
T
P
D
S
G
Y
S
Site 76
T897
P
P
E
T
L
A
S
T
P
D
S
G
Y
S
I
Site 77
S900
T
L
A
S
T
P
D
S
G
Y
S
I
D
S
K
Site 78
Y902
A
S
T
P
D
S
G
Y
S
I
D
S
K
I
I
Site 79
S903
S
T
P
D
S
G
Y
S
I
D
S
K
I
I
G
Site 80
S906
D
S
G
Y
S
I
D
S
K
I
I
G
I
P
S
Site 81
S913
S
K
I
I
G
I
P
S
P
S
S
L
F
K
H
Site 82
S916
I
G
I
P
S
P
S
S
L
F
K
H
I
V
P
Site 83
S929
V
P
M
M
R
S
E
S
M
E
I
T
E
S
L
Site 84
S999
D
A
G
V
I
S
H
S
A
S
G
G
L
D
N
Site 85
S1001
G
V
I
S
H
S
A
S
G
G
L
D
N
E
T
Site 86
T1008
S
G
G
L
D
N
E
T
H
F
L
N
N
T
L
Site 87
Y1018
L
N
N
T
L
L
E
Y
V
D
L
T
R
Q
L
Site 88
S1034
E
A
E
N
E
K
D
S
D
T
L
K
D
I
R
Site 89
T1036
E
N
E
K
D
S
D
T
L
K
D
I
R
C
H
Site 90
S1062
V
P
V
H
Q
R
R
S
I
F
P
Q
Q
S
L
Site 91
S1068
R
S
I
F
P
Q
Q
S
L
R
H
S
L
F
M
Site 92
S1072
P
Q
Q
S
L
R
H
S
L
F
M
L
F
S
H
Site 93
S1085
S
H
W
A
G
P
F
S
I
M
F
T
P
L
D
Site 94
T1089
G
P
F
S
I
M
F
T
P
L
D
R
Y
S
D
Site 95
Y1094
M
F
T
P
L
D
R
Y
S
D
R
N
M
Q
I
Site 96
Y1106
M
Q
I
N
R
H
Q
Y
C
A
L
K
A
M
S
Site 97
S1128
V
A
D
N
V
G
L
S
S
D
G
Y
L
Y
K
Site 98
Y1132
V
G
L
S
S
D
G
Y
L
Y
K
W
L
D
N
Site 99
Y1134
L
S
S
D
G
Y
L
Y
K
W
L
D
N
I
L
Site 100
S1143
W
L
D
N
I
L
D
S
L
D
K
K
V
H
Q
Site 101
Y1171
P
D
Q
S
N
L
M
Y
W
A
V
D
R
C
Y
Site 102
Y1178
Y
W
A
V
D
R
C
Y
T
G
S
G
R
V
A
Site 103
T1179
W
A
V
D
R
C
Y
T
G
S
G
R
V
A
A
Site 104
S1181
V
D
R
C
Y
T
G
S
G
R
V
A
A
G
C
Site 105
Y1201
N
V
F
Q
N
R
D
Y
Q
C
D
T
V
M
L
Site 106
S1220
L
F
K
A
A
D
S
S
R
S
I
Y
E
V
A
Site 107
Y1224
A
D
S
S
R
S
I
Y
E
V
A
M
Q
L
L
Site 108
T1250
H
K
L
E
V
Q
R
T
D
G
V
L
S
Q
L
Site 109
S1255
Q
R
T
D
G
V
L
S
Q
L
S
P
L
P
H
Site 110
S1258
D
G
V
L
S
Q
L
S
P
L
P
H
L
Y
S
Site 111
S1265
S
P
L
P
H
L
Y
S
V
S
Y
Y
Q
L
S
Site 112
S1267
L
P
H
L
Y
S
V
S
Y
Y
Q
L
S
E
E
Site 113
Y1268
P
H
L
Y
S
V
S
Y
Y
Q
L
S
E
E
L
Site 114
Y1269
H
L
Y
S
V
S
Y
Y
Q
L
S
E
E
L
A
Site 115
S1272
S
V
S
Y
Y
Q
L
S
E
E
L
A
R
A
Y
Site 116
T1296
E
I
S
Q
R
I
Q
T
A
H
P
A
G
R
Q
Site 117
Y1308
G
R
Q
V
M
L
H
Y
L
L
P
W
M
N
N
Site 118
T1326
V
D
L
K
P
L
P
T
A
R
R
H
D
E
D
Site 119
S1337
H
D
E
D
E
D
D
S
L
K
D
R
E
L
M
Site 120
T1346
K
D
R
E
L
M
V
T
S
R
R
W
L
R
G
Site 121
S1347
D
R
E
L
M
V
T
S
R
R
W
L
R
G
E
Site 122
S1358
L
R
G
E
G
W
G
S
P
Q
A
T
A
M
V
Site 123
T1390
S
E
V
E
N
V
W
T
T
L
A
D
G
W
P
Site 124
S1418
C
G
V
N
S
E
P
S
L
L
P
Y
V
K
K
Site 125
T1435
V
Y
L
G
R
D
K
T
M
Q
L
L
E
E
L
Site 126
S1444
Q
L
L
E
E
L
V
S
E
L
Q
L
T
D
P
Site 127
S1453
L
Q
L
T
D
P
V
S
S
G
V
T
H
M
D
Site 128
T1457
D
P
V
S
S
G
V
T
H
M
D
N
P
P
Y
Site 129
Y1464
T
H
M
D
N
P
P
Y
Y
R
I
T
S
S
Y
Site 130
Y1465
H
M
D
N
P
P
Y
Y
R
I
T
S
S
Y
K
Site 131
T1468
N
P
P
Y
Y
R
I
T
S
S
Y
K
I
P
S
Site 132
S1469
P
P
Y
Y
R
I
T
S
S
Y
K
I
P
S
V
Site 133
Y1471
Y
Y
R
I
T
S
S
Y
K
I
P
S
V
T
S
Site 134
S1475
T
S
S
Y
K
I
P
S
V
T
S
G
T
T
S
Site 135
T1477
S
Y
K
I
P
S
V
T
S
G
T
T
S
S
S
Site 136
S1478
Y
K
I
P
S
V
T
S
G
T
T
S
S
S
N
Site 137
T1480
I
P
S
V
T
S
G
T
T
S
S
S
N
T
M
Site 138
S1482
S
V
T
S
G
T
T
S
S
S
N
T
M
V
A
Site 139
T1486
G
T
T
S
S
S
N
T
M
V
A
P
T
D
G
Site 140
Y1508
K
E
N
I
E
E
S
Y
V
H
L
D
I
Y
S
Site 141
Y1514
S
Y
V
H
L
D
I
Y
S
G
L
N
S
H
L
Site 142
S1530
R
Q
H
H
R
L
E
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E
D
S
T
G
S
I
T
T
E
E
Site 295
T2547
V
L
Q
I
R
D
E
T
P
T
L
E
A
S
L
Site 296
T2549
Q
I
R
D
E
T
P
T
L
E
A
S
L
D
N
Site 297
S2553
E
T
P
T
L
E
A
S
L
D
N
A
N
S
R
Site 298
S2559
A
S
L
D
N
A
N
S
R
L
P
E
D
T
T
Site 299
T2565
N
S
R
L
P
E
D
T
T
S
V
L
K
E
E
Site 300
T2566
S
R
L
P
E
D
T
T
S
V
L
K
E
E
H
Site 301
S2567
R
L
P
E
D
T
T
S
V
L
K
E
E
H
V
Site 302
T2575
V
L
K
E
E
H
V
T
T
F
E
D
E
G
S
Site 303
T2576
L
K
E
E
H
V
T
T
F
E
D
E
G
S
Y
Site 304
S2582
T
T
F
E
D
E
G
S
Y
I
I
Q
E
Q
Q
Site 305
T2603
G
I
L
D
L
E
E
T
E
M
P
E
P
L
A
Site 306
S2613
P
E
P
L
A
P
E
S
Y
P
E
S
V
C
E
Site 307
Y2614
E
P
L
A
P
E
S
Y
P
E
S
V
C
E
E
Site 308
S2617
A
P
E
S
Y
P
E
S
V
C
E
E
D
V
T
Site 309
T2624
S
V
C
E
E
D
V
T
L
A
L
K
E
L
D
Site 310
S2642
E
E
E
E
A
D
F
S
G
L
S
S
Q
D
E
Site 311
S2646
A
D
F
S
G
L
S
S
Q
D
E
E
E
Q
D
Site 312
S2661
G
F
P
E
V
Q
T
S
P
L
P
S
P
F
L
Site 313
S2696
C
H
V
N
Q
M
L
S
D
T
D
G
S
S
A
Site 314
T2698
V
N
Q
M
L
S
D
T
D
G
S
S
A
V
F
Site 315
S2730
E
I
T
N
E
A
V
S
F
L
G
D
S
L
Q
Site 316
T2741
D
S
L
Q
R
I
G
T
K
F
K
S
S
L
E
Site 317
T2788
E
L
Q
E
H
L
D
T
Y
N
V
K
R
E
A
Site 318
Y2789
L
Q
E
H
L
D
T
Y
N
V
K
R
E
A
A
Site 319
T2806
W
L
D
D
C
K
R
T
F
G
A
K
E
D
M
Site 320
Y2814
F
G
A
K
E
D
M
Y
R
I
N
T
D
A
Q
Site 321
T2818
E
D
M
Y
R
I
N
T
D
A
Q
Q
M
E
I
Site 322
S2877
E
E
L
A
Q
L
E
S
I
L
K
E
A
E
S
Site 323
S2884
S
I
L
K
E
A
E
S
A
S
E
N
E
E
I
Site 324
S2894
E
N
E
E
I
D
I
S
K
A
A
Q
T
T
I
Site 325
S2933
A
F
R
S
L
W
P
S
D
I
F
G
S
C
E
Site 326
S2973
I
G
S
N
L
D
M
S
E
A
N
Y
K
L
M
Site 327
Y2977
L
D
M
S
E
A
N
Y
K
L
M
E
L
N
L
Site 328
S2989
L
N
L
E
I
R
E
S
L
R
M
V
Q
S
Y
Site 329
S2995
E
S
L
R
M
V
Q
S
Y
Q
L
L
A
Q
A
Site 330
Y2996
S
L
R
M
V
Q
S
Y
Q
L
L
A
Q
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation