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Updated November 2019
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Protein Info
Short Name:
NFAT5
Full Name:
Nuclear factor of activated T-cells 5
Alias:
KIAA0827; NF-AT5; NFATL1; NFATZ; nuclear factor of activated T cells 5; nuclear factor of activated T-cells 5, tonicity-responsive; OREBP; T cell transcription factor NFAT5; TonE-binding protein; TonEBP; tonicity-responsive enhancer-binding protein
Type:
Transcription factor
Mass (Da):
165763
Number AA:
1531
UniProt ID:
O94916
International Prot ID:
IPI00218771
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007588
GO:0006355
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
S
A
D
L
D
L
E
S
P
K
S
L
Y
S
R
Site 2
S20
L
D
L
E
S
P
K
S
L
Y
S
R
E
S
V
Site 3
Y22
L
E
S
P
K
S
L
Y
S
R
E
S
V
Y
D
Site 4
S23
E
S
P
K
S
L
Y
S
R
E
S
V
Y
D
L
Site 5
S26
K
S
L
Y
S
R
E
S
V
Y
D
L
L
P
K
Site 6
S40
K
E
L
Q
L
P
P
S
R
E
T
S
V
A
S
Site 7
T43
Q
L
P
P
S
R
E
T
S
V
A
S
M
S
Q
Site 8
S44
L
P
P
S
R
E
T
S
V
A
S
M
S
Q
T
Site 9
S47
S
R
E
T
S
V
A
S
M
S
Q
T
S
G
G
Site 10
S49
E
T
S
V
A
S
M
S
Q
T
S
G
G
E
A
Site 11
T51
S
V
A
S
M
S
Q
T
S
G
G
E
A
G
S
Site 12
S58
T
S
G
G
E
A
G
S
P
P
P
A
V
V
A
Site 13
S73
A
D
A
S
S
A
P
S
S
S
S
M
G
G
A
Site 14
S74
D
A
S
S
A
P
S
S
S
S
M
G
G
A
C
Site 15
S75
A
S
S
A
P
S
S
S
S
M
G
G
A
C
S
Site 16
S76
S
S
A
P
S
S
S
S
M
G
G
A
C
S
S
Site 17
S82
S
S
M
G
G
A
C
S
S
F
T
T
S
S
S
Site 18
S83
S
M
G
G
A
C
S
S
F
T
T
S
S
S
P
Site 19
T85
G
G
A
C
S
S
F
T
T
S
S
S
P
T
I
Site 20
T86
G
A
C
S
S
F
T
T
S
S
S
P
T
I
Y
Site 21
S87
A
C
S
S
F
T
T
S
S
S
P
T
I
Y
S
Site 22
S88
C
S
S
F
T
T
S
S
S
P
T
I
Y
S
T
Site 23
S89
S
S
F
T
T
S
S
S
P
T
I
Y
S
T
S
Site 24
T91
F
T
T
S
S
S
P
T
I
Y
S
T
S
V
T
Site 25
Y93
T
S
S
S
P
T
I
Y
S
T
S
V
T
D
S
Site 26
S94
S
S
S
P
T
I
Y
S
T
S
V
T
D
S
K
Site 27
S96
S
P
T
I
Y
S
T
S
V
T
D
S
K
A
M
Site 28
T98
T
I
Y
S
T
S
V
T
D
S
K
A
M
Q
V
Site 29
S100
Y
S
T
S
V
T
D
S
K
A
M
Q
V
E
S
Site 30
S110
M
Q
V
E
S
C
S
S
A
V
G
V
S
N
R
Site 31
S115
C
S
S
A
V
G
V
S
N
R
G
V
S
E
K
Site 32
S120
G
V
S
N
R
G
V
S
E
K
Q
L
T
S
N
Site 33
T125
G
V
S
E
K
Q
L
T
S
N
T
V
Q
Q
H
Site 34
S134
N
T
V
Q
Q
H
P
S
T
P
K
R
H
T
V
Site 35
T135
T
V
Q
Q
H
P
S
T
P
K
R
H
T
V
L
Site 36
T140
P
S
T
P
K
R
H
T
V
L
Y
I
S
P
P
Site 37
Y143
P
K
R
H
T
V
L
Y
I
S
P
P
P
E
D
Site 38
S145
R
H
T
V
L
Y
I
S
P
P
P
E
D
L
L
Site 39
S158
L
L
D
N
S
R
M
S
C
Q
D
E
G
C
G
Site 40
S173
L
E
S
E
Q
S
C
S
M
W
M
E
D
S
P
Site 41
S184
E
D
S
P
S
N
F
S
N
M
S
T
S
S
Y
Site 42
S187
P
S
N
F
S
N
M
S
T
S
S
Y
N
D
N
Site 43
T188
S
N
F
S
N
M
S
T
S
S
Y
N
D
N
T
Site 44
Y191
S
N
M
S
T
S
S
Y
N
D
N
T
E
V
P
Site 45
T195
T
S
S
Y
N
D
N
T
E
V
P
R
K
S
R
Site 46
S201
N
T
E
V
P
R
K
S
R
K
R
N
P
K
Q
Site 47
Y235
D
S
A
K
A
P
H
Y
V
L
S
Q
L
T
T
Site 48
S238
K
A
P
H
Y
V
L
S
Q
L
T
T
D
N
K
Site 49
T242
Y
V
L
S
Q
L
T
T
D
N
K
G
N
S
K
Site 50
S248
T
T
D
N
K
G
N
S
K
A
G
N
G
T
L
Site 51
S266
K
G
T
G
V
K
K
S
P
M
L
C
G
Q
Y
Site 52
Y273
S
P
M
L
C
G
Q
Y
P
V
K
S
E
G
K
Site 53
S277
C
G
Q
Y
P
V
K
S
E
G
K
E
L
K
I
Site 54
T290
K
I
V
V
Q
P
E
T
Q
H
R
A
R
Y
L
Site 55
Y296
E
T
Q
H
R
A
R
Y
L
T
E
G
S
R
G
Site 56
T298
Q
H
R
A
R
Y
L
T
E
G
S
R
G
S
V
Site 57
S304
L
T
E
G
S
R
G
S
V
K
D
R
T
Q
Q
Site 58
T309
R
G
S
V
K
D
R
T
Q
Q
G
F
P
T
V
Site 59
T315
R
T
Q
Q
G
F
P
T
V
K
L
E
G
H
N
Site 60
S335
Q
V
F
V
G
N
D
S
G
R
V
K
P
H
G
Site 61
Y344
R
V
K
P
H
G
F
Y
Q
A
C
R
V
T
G
Site 62
T350
F
Y
Q
A
C
R
V
T
G
R
N
T
T
P
C
Site 63
T354
C
R
V
T
G
R
N
T
T
P
C
K
E
V
D
Site 64
T355
R
V
T
G
R
N
T
T
P
C
K
E
V
D
I
Site 65
T366
E
V
D
I
E
G
T
T
V
I
E
V
G
L
D
Site 66
S375
I
E
V
G
L
D
P
S
N
N
M
T
L
A
V
Site 67
S404
A
R
I
G
I
A
G
S
K
K
K
S
T
R
A
Site 68
S408
I
A
G
S
K
K
K
S
T
R
A
R
L
V
F
Site 69
S425
N
I
M
R
K
D
G
S
T
L
T
L
Q
T
P
Site 70
T426
I
M
R
K
D
G
S
T
L
T
L
Q
T
P
S
Site 71
T428
R
K
D
G
S
T
L
T
L
Q
T
P
S
S
P
Site 72
S451
V
P
E
I
L
K
K
S
L
H
S
C
S
V
K
Site 73
S456
K
K
S
L
H
S
C
S
V
K
G
E
E
E
V
Site 74
S483
V
I
F
Q
E
N
V
S
D
E
N
S
W
K
S
Site 75
S487
E
N
V
S
D
E
N
S
W
K
S
E
A
E
I
Site 76
S490
S
D
E
N
S
W
K
S
E
A
E
I
D
M
E
Site 77
T528
S
V
G
I
Y
V
V
T
N
A
G
R
S
H
D
Site 78
T540
S
H
D
V
Q
P
F
T
Y
T
P
D
P
A
A
Site 79
T542
D
V
Q
P
F
T
Y
T
P
D
P
A
A
A
G
Site 80
S561
N
V
K
K
E
I
S
S
P
A
R
P
C
S
F
Site 81
S567
S
S
P
A
R
P
C
S
F
E
E
A
M
K
A
Site 82
S604
I
P
S
S
M
I
K
S
E
D
V
T
P
M
E
Site 83
T608
M
I
K
S
E
D
V
T
P
M
E
V
T
A
E
Site 84
S619
V
T
A
E
K
R
S
S
T
I
F
K
T
T
K
Site 85
T620
T
A
E
K
R
S
S
T
I
F
K
T
T
K
S
Site 86
T624
R
S
S
T
I
F
K
T
T
K
S
V
G
S
T
Site 87
T625
S
S
T
I
F
K
T
T
K
S
V
G
S
T
Q
Site 88
S627
T
I
F
K
T
T
K
S
V
G
S
T
Q
Q
T
Site 89
T634
S
V
G
S
T
Q
Q
T
L
E
N
I
S
N
I
Site 90
S646
S
N
I
A
G
N
G
S
F
S
S
P
S
S
S
Site 91
S648
I
A
G
N
G
S
F
S
S
P
S
S
S
H
L
Site 92
S649
A
G
N
G
S
F
S
S
P
S
S
S
H
L
P
Site 93
S651
N
G
S
F
S
S
P
S
S
S
H
L
P
S
E
Site 94
S652
G
S
F
S
S
P
S
S
S
H
L
P
S
E
N
Site 95
S653
S
F
S
S
P
S
S
S
H
L
P
S
E
N
E
Site 96
S657
P
S
S
S
H
L
P
S
E
N
E
K
Q
Q
Q
Site 97
T674
P
K
A
Y
N
P
E
T
L
T
T
I
Q
T
Q
Site 98
T677
Y
N
P
E
T
L
T
T
I
Q
T
Q
D
I
S
Site 99
T680
E
T
L
T
T
I
Q
T
Q
D
I
S
Q
P
G
Site 100
S684
T
I
Q
T
Q
D
I
S
Q
P
G
T
F
P
A
Site 101
T688
Q
D
I
S
Q
P
G
T
F
P
A
V
S
A
S
Site 102
S693
P
G
T
F
P
A
V
S
A
S
S
Q
L
P
N
Site 103
S695
T
F
P
A
V
S
A
S
S
Q
L
P
N
S
D
Site 104
S696
F
P
A
V
S
A
S
S
Q
L
P
N
S
D
A
Site 105
S701
A
S
S
Q
L
P
N
S
D
A
L
L
Q
Q
A
Site 106
T716
T
Q
F
Q
T
R
E
T
Q
S
R
E
I
L
Q
Site 107
S724
Q
S
R
E
I
L
Q
S
D
G
T
V
V
N
L
Site 108
S732
D
G
T
V
V
N
L
S
Q
L
T
E
A
S
Q
Site 109
S738
L
S
Q
L
T
E
A
S
Q
Q
Q
Q
Q
S
P
Site 110
S744
A
S
Q
Q
Q
Q
Q
S
P
L
Q
E
Q
A
Q
Site 111
T752
P
L
Q
E
Q
A
Q
T
L
Q
Q
Q
I
S
S
Site 112
S758
Q
T
L
Q
Q
Q
I
S
S
N
I
F
P
S
P
Site 113
S764
I
S
S
N
I
F
P
S
P
N
S
V
S
Q
L
Site 114
S767
N
I
F
P
S
P
N
S
V
S
Q
L
Q
N
T
Site 115
S769
F
P
S
P
N
S
V
S
Q
L
Q
N
T
I
Q
Site 116
S782
I
Q
Q
L
Q
A
G
S
F
T
G
S
T
A
S
Site 117
S786
Q
A
G
S
F
T
G
S
T
A
S
G
S
S
G
Site 118
T787
A
G
S
F
T
G
S
T
A
S
G
S
S
G
S
Site 119
S789
S
F
T
G
S
T
A
S
G
S
S
G
S
V
D
Site 120
S791
T
G
S
T
A
S
G
S
S
G
S
V
D
L
V
Site 121
S792
G
S
T
A
S
G
S
S
G
S
V
D
L
V
Q
Site 122
S810
E
A
Q
Q
Q
L
S
S
V
L
F
S
A
P
D
Site 123
S814
Q
L
S
S
V
L
F
S
A
P
D
G
N
E
N
Site 124
S835
A
D
I
F
Q
Q
V
S
Q
I
Q
S
G
V
S
Site 125
S839
Q
Q
V
S
Q
I
Q
S
G
V
S
P
G
M
F
Site 126
S842
S
Q
I
Q
S
G
V
S
P
G
M
F
S
S
T
Site 127
S848
V
S
P
G
M
F
S
S
T
E
P
T
V
H
T
Site 128
T849
S
P
G
M
F
S
S
T
E
P
T
V
H
T
R
Site 129
T852
M
F
S
S
T
E
P
T
V
H
T
R
P
D
N
Site 130
S867
L
L
P
G
R
A
E
S
V
H
P
Q
S
E
N
Site 131
S872
A
E
S
V
H
P
Q
S
E
N
T
L
S
N
Q
Site 132
S877
P
Q
S
E
N
T
L
S
N
Q
Q
Q
Q
Q
Q
Site 133
S918
I
Q
S
E
L
F
P
S
T
A
S
A
N
G
N
Site 134
T919
Q
S
E
L
F
P
S
T
A
S
A
N
G
N
L
Site 135
S929
A
N
G
N
L
Q
Q
S
P
V
Y
Q
Q
T
S
Site 136
Y932
N
L
Q
Q
S
P
V
Y
Q
Q
T
S
H
M
M
Site 137
S936
S
P
V
Y
Q
Q
T
S
H
M
M
S
A
L
S
Site 138
S940
Q
Q
T
S
H
M
M
S
A
L
S
T
N
E
D
Site 139
S956
Q
M
Q
C
E
L
F
S
S
P
P
A
V
S
G
Site 140
S957
M
Q
C
E
L
F
S
S
P
P
A
V
S
G
N
Site 141
S962
F
S
S
P
P
A
V
S
G
N
E
T
S
T
T
Site 142
T966
P
A
V
S
G
N
E
T
S
T
T
T
T
Q
Q
Site 143
T969
S
G
N
E
T
S
T
T
T
T
Q
Q
V
A
T
Site 144
T971
N
E
T
S
T
T
T
T
Q
Q
V
A
T
P
G
Site 145
T976
T
T
T
Q
Q
V
A
T
P
G
T
T
M
F
Q
Site 146
T984
P
G
T
T
M
F
Q
T
S
S
S
G
D
G
E
Site 147
S985
G
T
T
M
F
Q
T
S
S
S
G
D
G
E
E
Site 148
S987
T
M
F
Q
T
S
S
S
G
D
G
E
E
T
G
Site 149
T995
G
D
G
E
E
T
G
T
Q
A
K
Q
I
Q
N
Site 150
S1025
Q
P
Q
V
N
L
F
S
S
T
K
S
M
M
S
Site 151
S1026
P
Q
V
N
L
F
S
S
T
K
S
M
M
S
V
Site 152
S1029
N
L
F
S
S
T
K
S
M
M
S
V
Q
N
S
Site 153
S1032
S
S
T
K
S
M
M
S
V
Q
N
S
G
T
Q
Site 154
S1036
S
M
M
S
V
Q
N
S
G
T
Q
Q
Q
G
N
Site 155
S1054
Q
Q
G
N
E
M
M
S
L
Q
S
G
N
F
L
Site 156
S1067
F
L
Q
Q
S
S
H
S
Q
A
Q
L
F
H
P
Site 157
S1085
I
A
D
A
Q
N
L
S
Q
E
T
Q
G
S
L
Site 158
S1091
L
S
Q
E
T
Q
G
S
L
F
H
S
P
N
P
Site 159
S1095
T
Q
G
S
L
F
H
S
P
N
P
I
V
H
S
Site 160
S1102
S
P
N
P
I
V
H
S
Q
T
S
T
T
S
S
Site 161
T1104
N
P
I
V
H
S
Q
T
S
T
T
S
S
E
Q
Site 162
S1105
P
I
V
H
S
Q
T
S
T
T
S
S
E
Q
M
Site 163
T1106
I
V
H
S
Q
T
S
T
T
S
S
E
Q
M
Q
Site 164
S1109
S
Q
T
S
T
T
S
S
E
Q
M
Q
P
P
M
Site 165
S1137
S
V
P
Q
D
Q
Q
S
T
N
I
F
L
S
Q
Site 166
S1143
Q
S
T
N
I
F
L
S
Q
S
P
M
N
N
L
Site 167
S1145
T
N
I
F
L
S
Q
S
P
M
N
N
L
Q
T
Site 168
T1154
M
N
N
L
Q
T
N
T
V
A
Q
E
A
F
F
Site 169
S1168
F
A
A
P
N
S
I
S
P
L
Q
S
T
S
N
Site 170
S1172
N
S
I
S
P
L
Q
S
T
S
N
S
E
Q
Q
Site 171
S1174
I
S
P
L
Q
S
T
S
N
S
E
Q
Q
A
A
Site 172
S1176
P
L
Q
S
T
S
N
S
E
Q
Q
A
A
F
Q
Site 173
T1193
A
P
I
S
H
I
Q
T
P
M
L
S
Q
E
Q
Site 174
S1197
H
I
Q
T
P
M
L
S
Q
E
Q
A
Q
P
P
Site 175
S1217
Q
P
Q
V
A
L
G
S
L
P
P
N
P
M
P
Site 176
S1226
P
P
N
P
M
P
Q
S
Q
Q
G
T
M
F
Q
Site 177
T1230
M
P
Q
S
Q
Q
G
T
M
F
Q
S
Q
H
S
Site 178
S1243
H
S
I
V
A
M
Q
S
N
S
P
S
Q
E
Q
Site 179
S1245
I
V
A
M
Q
S
N
S
P
S
Q
E
Q
Q
Q
Site 180
S1247
A
M
Q
S
N
S
P
S
Q
E
Q
Q
Q
Q
Q
Site 181
S1271
Q
Q
Q
S
I
L
F
S
N
Q
N
T
M
A
T
Site 182
S1281
N
T
M
A
T
M
A
S
P
K
Q
P
P
P
N
Site 183
S1329
Q
Q
P
M
Q
F
Q
S
Q
S
T
V
S
S
L
Site 184
S1331
P
M
Q
F
Q
S
Q
S
T
V
S
S
L
Q
N
Site 185
T1332
M
Q
F
Q
S
Q
S
T
V
S
S
L
Q
N
P
Site 186
S1335
Q
S
Q
S
T
V
S
S
L
Q
N
P
G
P
T
Site 187
T1342
S
L
Q
N
P
G
P
T
Q
S
E
S
S
Q
T
Site 188
S1344
Q
N
P
G
P
T
Q
S
E
S
S
Q
T
P
L
Site 189
S1346
P
G
P
T
Q
S
E
S
S
Q
T
P
L
F
H
Site 190
S1347
G
P
T
Q
S
E
S
S
Q
T
P
L
F
H
S
Site 191
T1349
T
Q
S
E
S
S
Q
T
P
L
F
H
S
S
P
Site 192
S1355
Q
T
P
L
F
H
S
S
P
Q
I
Q
L
V
Q
Site 193
S1364
Q
I
Q
L
V
Q
G
S
P
S
S
Q
E
Q
Q
Site 194
S1367
L
V
Q
G
S
P
S
S
Q
E
Q
Q
V
T
L
Site 195
T1373
S
S
Q
E
Q
Q
V
T
L
F
L
S
P
A
S
Site 196
T1386
A
S
M
S
A
L
Q
T
S
I
N
Q
Q
D
M
Site 197
S1396
N
Q
Q
D
M
Q
Q
S
P
L
Y
S
P
Q
N
Site 198
Y1399
D
M
Q
Q
S
P
L
Y
S
P
Q
N
N
M
P
Site 199
S1400
M
Q
Q
S
P
L
Y
S
P
Q
N
N
M
P
G
Site 200
S1414
G
I
Q
G
A
T
S
S
P
Q
P
Q
A
T
L
Site 201
T1420
S
S
P
Q
P
Q
A
T
L
F
H
N
T
A
G
Site 202
S1436
T
M
N
Q
L
Q
N
S
P
G
S
S
Q
Q
T
Site 203
S1439
Q
L
Q
N
S
P
G
S
S
Q
Q
T
S
G
M
Site 204
S1440
L
Q
N
S
P
G
S
S
Q
Q
T
S
G
M
F
Site 205
T1443
S
P
G
S
S
Q
Q
T
S
G
M
F
L
F
G
Site 206
S1444
P
G
S
S
Q
Q
T
S
G
M
F
L
F
G
I
Site 207
S1456
F
G
I
Q
N
N
C
S
Q
L
L
T
S
G
P
Site 208
T1460
N
N
C
S
Q
L
L
T
S
G
P
A
T
L
P
Site 209
S1461
N
C
S
Q
L
L
T
S
G
P
A
T
L
P
D
Site 210
S1474
P
D
Q
L
M
A
I
S
Q
P
G
Q
P
Q
N
Site 211
T1488
N
E
G
Q
P
P
V
T
T
L
L
S
Q
Q
M
Site 212
S1492
P
P
V
T
T
L
L
S
Q
Q
M
P
E
N
S
Site 213
S1499
S
Q
Q
M
P
E
N
S
P
L
A
S
S
I
N
Site 214
S1503
P
E
N
S
P
L
A
S
S
I
N
T
N
Q
N
Site 215
S1504
E
N
S
P
L
A
S
S
I
N
T
N
Q
N
I
Site 216
S1519
E
K
I
D
L
L
V
S
L
Q
N
Q
G
N
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation