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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GLCE
Full Name:
D-glucuronyl C5-epimerase
Alias:
EC 5.1.3.-; Glucuronic acid epimerase; Heparan sulfate epimerase; Heparin/heparan sulfate:glucuronic acid C5 epimerase; Heparin/heparan sulfate;glucuronic acid C5 epimerase; HSEPI; KIAA0836; UDP-glucuronic acid epimerase
Type:
EC 5.1.3.-; Isomerase; Glycan Metabolism - heparan sulfate biosynthesis
Mass (Da):
70101
Number AA:
617
UniProt ID:
O94923
International Prot ID:
IPI00433284
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0050379
PhosphoSite+
KinaseNET
Biological Process:
GO:0015012
GO:0030210
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S43
A
I
Q
F
P
R
R
S
S
S
G
F
R
V
D
Site 2
S44
I
Q
F
P
R
R
S
S
S
G
F
R
V
D
G
Site 3
S45
Q
F
P
R
R
S
S
S
G
F
R
V
D
G
F
Site 4
Y64
A
A
S
E
S
N
N
Y
M
N
H
V
A
K
Q
Site 5
S73
N
H
V
A
K
Q
Q
S
E
E
A
F
P
Q
E
Site 6
S97
G
F
N
S
N
V
G
S
K
V
L
G
L
K
Y
Site 7
Y136
P
F
T
W
V
E
K
Y
F
D
V
Y
G
K
V
Site 8
Y140
V
E
K
Y
F
D
V
Y
G
K
V
V
Q
Y
D
Site 9
Y149
K
V
V
Q
Y
D
G
Y
D
R
F
E
F
S
H
Site 10
S155
G
Y
D
R
F
E
F
S
H
S
Y
S
K
V
Y
Site 11
S157
D
R
F
E
F
S
H
S
Y
S
K
V
Y
A
Q
Site 12
S159
F
E
F
S
H
S
Y
S
K
V
Y
A
Q
R
A
Site 13
Y162
S
H
S
Y
S
K
V
Y
A
Q
R
A
P
Y
H
Site 14
Y168
V
Y
A
Q
R
A
P
Y
H
P
D
G
V
F
M
Site 15
Y180
V
F
M
S
F
E
G
Y
N
V
E
V
R
D
R
Site 16
S192
R
D
R
V
K
C
I
S
G
V
E
G
V
P
L
Site 17
S200
G
V
E
G
V
P
L
S
T
Q
W
G
P
Q
G
Site 18
Y208
T
Q
W
G
P
Q
G
Y
F
Y
P
I
Q
I
A
Site 19
S220
Q
I
A
Q
Y
G
L
S
H
Y
S
K
N
L
T
Site 20
T227
S
H
Y
S
K
N
L
T
E
K
P
P
H
I
E
Site 21
Y236
K
P
P
H
I
E
V
Y
E
T
A
E
D
R
D
Site 22
T238
P
H
I
E
V
Y
E
T
A
E
D
R
D
K
N
Site 23
S265
M
A
N
V
A
D
K
S
R
F
T
N
V
K
Q
Site 24
T268
V
A
D
K
S
R
F
T
N
V
K
Q
F
I
A
Site 25
S283
P
E
T
S
E
G
V
S
L
Q
L
G
N
T
K
Site 26
Y338
A
F
K
E
R
D
I
Y
Y
G
I
G
P
R
T
Site 27
Y339
F
K
E
R
D
I
Y
Y
G
I
G
P
R
T
S
Site 28
T345
Y
Y
G
I
G
P
R
T
S
W
S
T
V
T
R
Site 29
S346
Y
G
I
G
P
R
T
S
W
S
T
V
T
R
D
Site 30
S348
I
G
P
R
T
S
W
S
T
V
T
R
D
L
V
Site 31
T349
G
P
R
T
S
W
S
T
V
T
R
D
L
V
T
Site 32
T351
R
T
S
W
S
T
V
T
R
D
L
V
T
D
L
Site 33
T356
T
V
T
R
D
L
V
T
D
L
R
K
G
V
G
Site 34
S365
L
R
K
G
V
G
L
S
N
T
K
A
V
K
P
Site 35
T367
K
G
V
G
L
S
N
T
K
A
V
K
P
T
K
Site 36
T427
G
G
W
P
I
M
V
T
R
K
L
G
E
G
F
Site 37
S436
K
L
G
E
G
F
K
S
L
E
P
G
W
Y
S
Site 38
Y442
K
S
L
E
P
G
W
Y
S
A
M
A
Q
G
Q
Site 39
S443
S
L
E
P
G
W
Y
S
A
M
A
Q
G
Q
A
Site 40
Y458
I
S
T
L
V
R
A
Y
L
L
T
K
D
H
I
Site 41
Y477
A
L
R
A
T
A
P
Y
K
F
L
S
E
Q
H
Site 42
S481
T
A
P
Y
K
F
L
S
E
Q
H
G
V
K
A
Site 43
Y500
K
H
D
W
Y
E
E
Y
P
T
T
P
S
S
F
Site 44
T502
D
W
Y
E
E
Y
P
T
T
P
S
S
F
V
L
Site 45
T503
W
Y
E
E
Y
P
T
T
P
S
S
F
V
L
N
Site 46
S505
E
E
Y
P
T
T
P
S
S
F
V
L
N
G
F
Site 47
S506
E
Y
P
T
T
P
S
S
F
V
L
N
G
F
M
Site 48
S536
K
L
G
K
E
A
R
S
L
Y
E
R
G
M
E
Site 49
Y538
G
K
E
A
R
S
L
Y
E
R
G
M
E
S
L
Site 50
S544
L
Y
E
R
G
M
E
S
L
K
A
M
L
P
L
Site 51
S556
L
P
L
Y
D
T
G
S
G
T
I
Y
D
L
R
Site 52
T558
L
Y
D
T
G
S
G
T
I
Y
D
L
R
H
F
Site 53
Y560
D
T
G
S
G
T
I
Y
D
L
R
H
F
M
L
Site 54
T591
N
Q
L
Q
L
L
S
T
I
D
E
S
P
V
F
Site 55
S595
L
L
S
T
I
D
E
S
P
V
F
K
E
F
V
Site 56
S607
E
F
V
K
R
W
K
S
Y
L
K
G
S
R
A
Site 57
Y608
F
V
K
R
W
K
S
Y
L
K
G
S
R
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation