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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GLS
Full Name:
Glutaminase kidney isoform, mitochondrial
Alias:
EC 3.5.1.2; GLS1; GLSK; Glutaminase, kidney isoform, mitochondrial; K-glutaminase; KIAA0838; L-glutamine amidohydrolase
Type:
Energy Metabolism - nitrogen; EC 3.5.1.2; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Amino Acid Metabolism - arginine and proline; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate; Hydrolase
Mass (Da):
73461
Number AA:
669
UniProt ID:
O94925
International Prot ID:
IPI00289159
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0004359
PhosphoSite+
KinaseNET
Biological Process:
GO:0006543
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
S
P
A
G
V
S
A
T
L
R
R
A
Q
P
L
Site 2
T33
R
R
A
Q
P
L
V
T
L
C
R
R
P
R
G
Site 3
S73
E
P
L
A
R
G
L
S
S
S
P
S
E
I
L
Site 4
S75
L
A
R
G
L
S
S
S
P
S
E
I
L
Q
E
Site 5
S77
R
G
L
S
S
S
P
S
E
I
L
Q
E
L
G
Site 6
S87
L
Q
E
L
G
K
G
S
T
H
P
Q
P
G
V
Site 7
S95
T
H
P
Q
P
G
V
S
P
P
A
A
P
A
A
Site 8
S126
E
G
K
E
L
V
A
S
G
E
N
K
I
K
Q
Site 9
Y145
S
L
E
D
L
L
F
Y
T
I
A
E
G
Q
E
Site 10
S165
K
F
I
T
A
L
K
S
T
G
L
R
T
S
D
Site 11
S171
K
S
T
G
L
R
T
S
D
P
R
L
K
E
C
Site 12
T185
C
M
D
M
L
R
L
T
L
Q
T
T
S
D
G
Site 13
S229
P
D
F
M
S
F
T
S
H
I
D
E
L
Y
E
Site 14
Y235
T
S
H
I
D
E
L
Y
E
S
A
K
K
Q
S
Site 15
S237
H
I
D
E
L
Y
E
S
A
K
K
Q
S
G
G
Site 16
Y249
S
G
G
K
V
A
D
Y
I
P
Q
L
A
K
F
Site 17
T267
L
W
G
V
S
V
C
T
V
D
G
Q
R
H
S
Site 18
S274
T
V
D
G
Q
R
H
S
T
G
D
T
K
V
P
Site 19
T275
V
D
G
Q
R
H
S
T
G
D
T
K
V
P
F
Site 20
T278
Q
R
H
S
T
G
D
T
K
V
P
F
C
L
Q
Site 21
Y304
V
N
D
L
G
T
E
Y
V
H
R
Y
V
G
K
Site 22
Y308
G
T
E
Y
V
H
R
Y
V
G
K
E
P
S
G
Site 23
S314
R
Y
V
G
K
E
P
S
G
L
R
F
N
K
L
Site 24
Y357
N
N
A
E
K
F
D
Y
V
M
Q
F
L
N
K
Site 25
Y370
N
K
M
A
G
N
E
Y
V
G
F
S
N
A
T
Site 26
T377
Y
V
G
F
S
N
A
T
F
Q
S
E
R
E
S
Site 27
S380
F
S
N
A
T
F
Q
S
E
R
E
S
G
D
R
Site 28
S384
T
F
Q
S
E
R
E
S
G
D
R
N
F
A
I
Site 29
Y394
R
N
F
A
I
G
Y
Y
L
K
E
K
K
C
F
Site 30
T443
N
G
G
F
C
P
I
T
G
E
R
V
L
S
P
Site 31
S449
I
T
G
E
R
V
L
S
P
E
A
V
R
N
T
Site 32
T456
S
P
E
A
V
R
N
T
L
S
L
M
H
S
C
Site 33
Y530
S
L
C
N
F
H
N
Y
D
N
L
R
H
F
A
Site 34
S575
A
L
R
R
F
A
L
S
A
M
D
M
E
Q
R
Site 35
Y584
M
D
M
E
Q
R
D
Y
D
S
R
T
A
L
H
Site 36
S586
M
E
Q
R
D
Y
D
S
R
T
A
L
H
V
A
Site 37
T622
P
K
D
R
W
N
N
T
P
M
D
E
A
L
H
Site 38
Y642
V
F
K
I
L
Q
E
Y
Q
V
Q
Y
T
P
Q
Site 39
Y646
L
Q
E
Y
Q
V
Q
Y
T
P
Q
G
D
S
D
Site 40
T647
Q
E
Y
Q
V
Q
Y
T
P
Q
G
D
S
D
N
Site 41
S652
Q
Y
T
P
Q
G
D
S
D
N
G
K
E
N
Q
Site 42
T660
D
N
G
K
E
N
Q
T
V
H
K
N
L
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation