KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TRIM37
Full Name:
E3 ubiquitin-protein ligase TRIM37
Alias:
KIAA0898; MUL; Mulibrey nanism protein; POB1; RING-B-box-coiled-coil protein; TEF3; TRI37; Tripartite motif-containing 37; Tripartite motif-containing protein 37
Type:
Unknown function
Mass (Da):
107887
Number AA:
964
UniProt ID:
O94972
International Prot ID:
IPI00016619
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048471
GO:0005777
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T45
S
C
I
R
R
W
L
T
E
Q
R
A
Q
C
P
Site 2
T73
C
R
W
A
E
E
V
T
Q
Q
L
D
T
L
Q
Site 3
T78
E
V
T
Q
Q
L
D
T
L
Q
L
C
S
L
T
Site 4
S83
L
D
T
L
Q
L
C
S
L
T
K
H
E
E
N
Site 5
T85
T
L
Q
L
C
S
L
T
K
H
E
E
N
E
K
Site 6
T128
G
G
M
H
G
G
H
T
F
K
P
L
A
E
I
Site 7
T141
E
I
Y
E
Q
H
V
T
K
V
N
E
E
V
A
Site 8
S159
R
R
L
M
E
L
I
S
L
V
Q
E
V
E
R
Site 9
T195
M
M
I
A
R
L
D
T
Q
L
K
N
K
L
I
Site 10
T203
Q
L
K
N
K
L
I
T
L
M
G
Q
K
T
S
Site 11
S210
T
L
M
G
Q
K
T
S
L
T
Q
E
T
E
L
Site 12
T212
M
G
Q
K
T
S
L
T
Q
E
T
E
L
L
E
Site 13
S220
Q
E
T
E
L
L
E
S
L
L
Q
E
V
E
H
Site 14
S231
E
V
E
H
Q
L
R
S
C
S
K
S
E
L
I
Site 15
S233
E
H
Q
L
R
S
C
S
K
S
E
L
I
S
K
Site 16
S235
Q
L
R
S
C
S
K
S
E
L
I
S
K
S
S
Site 17
S239
C
S
K
S
E
L
I
S
K
S
S
E
I
L
M
Site 18
S258
V
H
R
K
P
M
A
S
F
V
T
T
P
V
P
Site 19
T269
T
P
V
P
P
D
F
T
S
E
L
V
P
S
Y
Site 20
S270
P
V
P
P
D
F
T
S
E
L
V
P
S
Y
D
Site 21
S278
E
L
V
P
S
Y
D
S
A
T
F
V
L
E
N
Site 22
T288
F
V
L
E
N
F
S
T
L
R
Q
R
A
D
P
Site 23
Y297
R
Q
R
A
D
P
V
Y
S
P
P
L
Q
V
S
Site 24
S298
Q
R
A
D
P
V
Y
S
P
P
L
Q
V
S
G
Site 25
S304
Y
S
P
P
L
Q
V
S
G
L
C
W
R
L
K
Site 26
Y313
L
C
W
R
L
K
V
Y
P
D
G
N
G
V
V
Site 27
Y341
G
L
P
E
T
S
K
Y
E
Y
R
V
E
M
V
Site 28
Y343
P
E
T
S
K
Y
E
Y
R
V
E
M
V
H
Q
Site 29
S365
N
I
I
R
E
F
A
S
D
F
E
V
G
E
C
Site 30
Y375
E
V
G
E
C
W
G
Y
N
R
F
F
R
L
D
Site 31
Y389
D
L
L
A
N
E
G
Y
L
N
P
Q
N
D
T
Site 32
T396
Y
L
N
P
Q
N
D
T
V
I
L
R
F
Q
V
Site 33
S405
I
L
R
F
Q
V
R
S
P
T
F
F
Q
K
S
Site 34
T407
R
F
Q
V
R
S
P
T
F
F
Q
K
S
R
D
Site 35
Y418
K
S
R
D
Q
H
W
Y
I
T
Q
L
E
A
A
Site 36
T427
T
Q
L
E
A
A
Q
T
S
Y
I
Q
Q
I
N
Site 37
T441
N
N
L
K
E
R
L
T
I
E
L
S
R
T
Q
Site 38
S445
E
R
L
T
I
E
L
S
R
T
Q
K
S
R
D
Site 39
T447
L
T
I
E
L
S
R
T
Q
K
S
R
D
L
S
Site 40
S450
E
L
S
R
T
Q
K
S
R
D
L
S
P
P
D
Site 41
S454
T
Q
K
S
R
D
L
S
P
P
D
N
H
L
S
Site 42
S461
S
P
P
D
N
H
L
S
P
Q
N
D
D
A
L
Site 43
S490
E
G
G
P
T
T
A
S
V
R
E
A
K
E
D
Site 44
Y509
E
K
I
Q
N
E
D
Y
H
H
E
L
S
D
G
Site 45
S514
E
D
Y
H
H
E
L
S
D
G
D
L
D
L
D
Site 46
Y524
D
L
D
L
D
L
V
Y
E
D
E
V
N
Q
L
Site 47
S534
E
V
N
Q
L
D
G
S
S
S
S
A
S
S
T
Site 48
S535
V
N
Q
L
D
G
S
S
S
S
A
S
S
T
A
Site 49
S536
N
Q
L
D
G
S
S
S
S
A
S
S
T
A
T
Site 50
S537
Q
L
D
G
S
S
S
S
A
S
S
T
A
T
S
Site 51
S539
D
G
S
S
S
S
A
S
S
T
A
T
S
N
T
Site 52
S540
G
S
S
S
S
A
S
S
T
A
T
S
N
T
E
Site 53
T541
S
S
S
S
A
S
S
T
A
T
S
N
T
E
E
Site 54
T543
S
S
A
S
S
T
A
T
S
N
T
E
E
N
D
Site 55
S544
S
A
S
S
T
A
T
S
N
T
E
E
N
D
I
Site 56
T555
E
N
D
I
D
E
E
T
M
S
G
E
N
D
V
Site 57
S557
D
I
D
E
E
T
M
S
G
E
N
D
V
E
Y
Site 58
Y564
S
G
E
N
D
V
E
Y
N
N
M
E
L
E
E
Site 59
S587
A
A
G
P
A
G
S
S
H
G
Y
V
G
S
S
Site 60
Y590
P
A
G
S
S
H
G
Y
V
G
S
S
S
R
I
Site 61
S593
S
S
H
G
Y
V
G
S
S
S
R
I
S
R
R
Site 62
S594
S
H
G
Y
V
G
S
S
S
R
I
S
R
R
T
Site 63
S595
H
G
Y
V
G
S
S
S
R
I
S
R
R
T
H
Site 64
S598
V
G
S
S
S
R
I
S
R
R
T
H
L
C
S
Site 65
T601
S
S
R
I
S
R
R
T
H
L
C
S
A
A
T
Site 66
S605
S
R
R
T
H
L
C
S
A
A
T
S
S
L
L
Site 67
S630
L
D
L
K
D
R
S
S
I
E
N
L
W
G
L
Site 68
S644
L
Q
P
R
P
P
A
S
L
L
Q
P
T
A
S
Site 69
T649
P
A
S
L
L
Q
P
T
A
S
Y
S
R
K
D
Site 70
S651
S
L
L
Q
P
T
A
S
Y
S
R
K
D
K
D
Site 71
S670
Q
A
M
W
R
V
P
S
D
L
K
M
L
K
R
Site 72
T680
K
M
L
K
R
L
K
T
Q
M
A
E
V
R
C
Site 73
T690
A
E
V
R
C
M
K
T
D
V
K
N
T
L
S
Site 74
S697
T
D
V
K
N
T
L
S
E
I
K
S
S
S
A
Site 75
S701
N
T
L
S
E
I
K
S
S
S
A
A
S
G
D
Site 76
S702
T
L
S
E
I
K
S
S
S
A
A
S
G
D
M
Site 77
S703
L
S
E
I
K
S
S
S
A
A
S
G
D
M
Q
Site 78
S706
I
K
S
S
S
A
A
S
G
D
M
Q
T
S
L
Site 79
S712
A
S
G
D
M
Q
T
S
L
F
S
A
D
Q
A
Site 80
S729
A
A
C
G
T
E
N
S
G
R
L
Q
D
L
G
Site 81
Y749
K
S
S
V
A
N
C
Y
I
R
N
S
T
N
K
Site 82
S753
A
N
C
Y
I
R
N
S
T
N
K
K
S
N
S
Site 83
T754
N
C
Y
I
R
N
S
T
N
K
K
S
N
S
P
Site 84
S758
R
N
S
T
N
K
K
S
N
S
P
K
P
A
R
Site 85
S760
S
T
N
K
K
S
N
S
P
K
P
A
R
S
S
Site 86
S766
N
S
P
K
P
A
R
S
S
V
A
G
S
L
S
Site 87
S767
S
P
K
P
A
R
S
S
V
A
G
S
L
S
L
Site 88
S771
A
R
S
S
V
A
G
S
L
S
L
R
R
A
V
Site 89
S773
S
S
V
A
G
S
L
S
L
R
R
A
V
D
P
Site 90
S784
A
V
D
P
G
E
N
S
R
S
K
G
D
C
Q
Site 91
T792
R
S
K
G
D
C
Q
T
L
S
E
G
S
P
G
Site 92
S794
K
G
D
C
Q
T
L
S
E
G
S
P
G
S
S
Site 93
S797
C
Q
T
L
S
E
G
S
P
G
S
S
Q
S
G
Site 94
S800
L
S
E
G
S
P
G
S
S
Q
S
G
S
R
H
Site 95
S801
S
E
G
S
P
G
S
S
Q
S
G
S
R
H
S
Site 96
S803
G
S
P
G
S
S
Q
S
G
S
R
H
S
S
P
Site 97
S805
P
G
S
S
Q
S
G
S
R
H
S
S
P
R
A
Site 98
S808
S
Q
S
G
S
R
H
S
S
P
R
A
L
I
H
Site 99
S809
Q
S
G
S
R
H
S
S
P
R
A
L
I
H
G
Site 100
T825
I
G
D
I
L
P
K
T
E
D
R
Q
C
K
A
Site 101
T857
E
K
R
R
K
M
V
T
L
G
A
N
A
K
G
Site 102
S893
P
V
L
P
E
G
A
S
A
A
P
E
E
G
M
Site 103
S901
A
A
P
E
E
G
M
S
S
D
S
D
I
E
C
Site 104
S902
A
P
E
E
G
M
S
S
D
S
D
I
E
C
D
Site 105
S904
E
E
G
M
S
S
D
S
D
I
E
C
D
T
E
Site 106
T910
D
S
D
I
E
C
D
T
E
N
E
E
Q
E
E
Site 107
S920
E
E
Q
E
E
H
T
S
V
G
G
F
H
D
S
Site 108
T939
T
Q
P
P
D
E
D
T
H
S
S
F
P
D
G
Site 109
S941
P
P
D
E
D
T
H
S
S
F
P
D
G
E
Q
Site 110
S942
P
D
E
D
T
H
S
S
F
P
D
G
E
Q
I
Site 111
S955
Q
I
G
P
E
D
L
S
F
N
T
D
E
N
S
Site 112
T958
P
E
D
L
S
F
N
T
D
E
N
S
G
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation