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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AP2A2
Full Name:
AP-2 complex subunit alpha-2
Alias:
100 kDa coated vesicle protein C; Adapter-related protein complex 2 alpha-2; Adapter-related protein complex 2 alpha-2 subunit; ADTAB
Type:
Plasma membrane coated pit protein
Mass (Da):
103960
Number AA:
939
UniProt ID:
O94973
International Prot ID:
IPI00016621
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005886
GO:0005905
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0008289
PhosphoSite+
KinaseNET
Biological Process:
GO:0002682
GO:0002697
GO:0002831
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
S
D
I
R
N
C
K
S
K
E
A
E
I
K
R
Site 2
Y53
G
D
K
A
L
D
G
Y
S
K
K
K
Y
V
C
Site 3
Y58
D
G
Y
S
K
K
K
Y
V
C
K
L
L
F
I
Site 4
S85
E
A
V
N
L
L
S
S
N
R
Y
T
E
K
Q
Site 5
Y88
N
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
Site 6
T89
L
L
S
S
N
R
Y
T
E
K
Q
I
G
Y
L
Site 7
S122
A
I
K
N
D
L
A
S
R
N
P
T
F
M
G
Site 8
T160
K
V
L
V
A
G
D
T
M
D
S
V
K
Q
S
Site 9
S167
T
M
D
S
V
K
Q
S
A
A
L
C
L
L
R
Site 10
T213
A
A
T
S
L
I
T
T
L
A
Q
K
N
P
E
Site 11
T224
K
N
P
E
E
F
K
T
S
V
S
L
A
V
S
Site 12
S225
N
P
E
E
F
K
T
S
V
S
L
A
V
S
R
Site 13
S227
E
E
F
K
T
S
V
S
L
A
V
S
R
L
S
Site 14
S231
T
S
V
S
L
A
V
S
R
L
S
R
I
V
T
Site 15
S234
S
L
A
V
S
R
L
S
R
I
V
T
S
A
S
Site 16
T238
S
R
L
S
R
I
V
T
S
A
S
T
D
L
Q
Site 17
Y247
A
S
T
D
L
Q
D
Y
T
Y
Y
F
V
P
A
Site 18
T248
S
T
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
Site 19
Y249
T
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
Site 20
Y250
D
L
Q
D
Y
T
Y
Y
F
V
P
A
P
W
L
Site 21
T285
R
L
T
E
C
L
E
T
I
L
N
K
A
Q
E
Site 22
S296
K
A
Q
E
P
P
K
S
K
K
V
Q
H
S
N
Site 23
S321
S
L
I
I
H
H
D
S
E
P
N
L
L
V
R
Site 24
T342
Q
F
L
Q
H
R
E
T
N
L
R
Y
L
A
L
Site 25
Y346
H
R
E
T
N
L
R
Y
L
A
L
E
S
M
C
Site 26
S357
E
S
M
C
T
L
A
S
S
E
F
S
H
E
A
Site 27
S361
T
L
A
S
S
E
F
S
H
E
A
V
K
T
H
Site 28
T367
F
S
H
E
A
V
K
T
H
I
E
T
V
I
N
Site 29
T378
T
V
I
N
A
L
K
T
E
R
D
V
S
V
R
Site 30
S383
L
K
T
E
R
D
V
S
V
R
Q
R
A
V
D
Site 31
Y393
Q
R
A
V
D
L
L
Y
A
M
C
D
R
S
N
Site 32
S410
Q
I
V
A
E
M
L
S
Y
L
E
T
A
D
Y
Site 33
T414
E
M
L
S
Y
L
E
T
A
D
Y
S
I
R
E
Site 34
Y417
S
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
Site 35
S418
Y
L
E
T
A
D
Y
S
I
R
E
E
I
V
L
Site 36
Y438
A
E
K
Y
A
V
D
Y
T
W
Y
V
D
T
I
Site 37
S516
L
I
A
G
D
P
R
S
S
P
L
I
Q
F
H
Site 38
S517
I
A
G
D
P
R
S
S
P
L
I
Q
F
H
L
Site 39
T536
F
H
L
C
S
V
P
T
R
A
L
L
L
S
T
Site 40
T557
L
F
P
E
V
K
P
T
I
Q
D
V
L
R
S
Site 41
S566
Q
D
V
L
R
S
D
S
Q
L
R
N
A
D
V
Site 42
Y582
L
Q
Q
R
A
V
E
Y
L
R
L
S
T
V
A
Site 43
S609
P
P
F
P
E
R
E
S
S
I
L
A
K
L
K
Site 44
S610
P
F
P
E
R
E
S
S
I
L
A
K
L
K
K
Site 45
T623
K
K
K
K
G
P
S
T
V
T
D
L
E
D
T
Site 46
T625
K
K
G
P
S
T
V
T
D
L
E
D
T
K
R
Site 47
T630
T
V
T
D
L
E
D
T
K
R
D
R
S
V
D
Site 48
S635
E
D
T
K
R
D
R
S
V
D
V
N
G
G
P
Site 49
S648
G
P
E
P
A
P
A
S
T
S
A
V
S
T
P
Site 50
T649
P
E
P
A
P
A
S
T
S
A
V
S
T
P
S
Site 51
S650
E
P
A
P
A
S
T
S
A
V
S
T
P
S
P
Site 52
S653
P
A
S
T
S
A
V
S
T
P
S
P
S
A
D
Site 53
T654
A
S
T
S
A
V
S
T
P
S
P
S
A
D
L
Site 54
S656
T
S
A
V
S
T
P
S
P
S
A
D
L
L
G
Site 55
S677
A
P
A
G
P
P
P
S
S
G
G
S
G
L
L
Site 56
S702
V
A
P
L
A
P
G
S
E
D
N
F
A
R
F
Site 57
S729
L
L
Q
I
G
L
K
S
E
F
R
Q
N
L
G
Site 58
Y742
L
G
R
M
F
I
F
Y
G
N
K
T
S
T
Q
Site 59
T777
Q
T
K
P
V
D
P
T
V
E
G
G
A
Q
V
Site 60
Y808
V
L
N
I
Q
F
R
Y
G
G
T
F
Q
N
V
Site 61
T811
I
Q
F
R
Y
G
G
T
F
Q
N
V
S
V
Q
Site 62
S845
F
Q
R
W
K
Q
L
S
N
P
Q
Q
E
V
Q
Site 63
T919
Q
A
Q
M
Y
R
L
T
L
R
T
S
K
E
A
Site 64
S923
Y
R
L
T
L
R
T
S
K
E
A
V
S
Q
R
Site 65
S928
R
T
S
K
E
A
V
S
Q
R
L
C
E
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation