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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEXIM1
Full Name:
Protein HEXIM1
Alias:
Cardiac lineage protein 1; CLP1; CLP-1; EDG1; Estrogen down-regulated gene 1 protein; Hexamethylene bis-acetamide inducible 1; Hexamethylene bis-acetamide-inducible protein 1; HEXI1; HIS1; MAQ1; Menage a quatre protein 1
Type:
Mass (Da):
40623
Number AA:
359
UniProt ID:
O94992
International Prot ID:
IPI00007941
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0004861
GO:0005515
GO:0017069
PhosphoSite+
KinaseNET
Biological Process:
GO:0045736
GO:0000122
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
E
P
F
L
S
E
Y
Q
H
Q
P
Q
T
S
Site 2
S45
E
R
V
P
E
E
D
S
R
W
Q
S
R
A
F
Site 3
S49
E
E
D
S
R
W
Q
S
R
A
F
P
Q
L
G
Site 4
S66
P
G
P
E
G
E
G
S
L
E
S
Q
P
P
P
Site 5
S69
E
G
E
G
S
L
E
S
Q
P
P
P
L
Q
T
Site 6
T76
S
Q
P
P
P
L
Q
T
Q
A
C
P
E
S
S
Site 7
S83
T
Q
A
C
P
E
S
S
C
L
R
E
G
E
K
Site 8
S97
K
G
Q
N
G
D
D
S
S
A
G
G
D
F
P
Site 9
S98
G
Q
N
G
D
D
S
S
A
G
G
D
F
P
P
Site 10
T112
P
P
A
E
V
E
P
T
P
E
A
E
L
L
A
Site 11
S125
L
A
Q
P
C
H
D
S
E
A
S
K
L
G
A
Site 12
S158
K
K
H
R
R
R
P
S
K
K
K
R
H
W
K
Site 13
Y167
K
K
R
H
W
K
P
Y
Y
K
L
T
W
E
E
Site 14
Y168
K
R
H
W
K
P
Y
Y
K
L
T
W
E
E
K
Site 15
S183
K
K
F
D
E
K
Q
S
L
R
A
S
R
I
R
Site 16
S187
E
K
Q
S
L
R
A
S
R
I
R
A
E
M
F
Site 17
Y203
K
G
Q
P
V
A
P
Y
N
T
T
Q
F
L
M
Site 18
T206
P
V
A
P
Y
N
T
T
Q
F
L
M
D
D
H
Site 19
T222
Q
E
E
P
D
L
K
T
G
L
Y
S
K
R
A
Site 20
Y225
P
D
L
K
T
G
L
Y
S
K
R
A
A
A
K
Site 21
S226
D
L
K
T
G
L
Y
S
K
R
A
A
A
K
S
Site 22
S233
S
K
R
A
A
A
K
S
D
D
T
S
D
D
D
Site 23
T236
A
A
A
K
S
D
D
T
S
D
D
D
F
M
E
Site 24
S237
A
A
K
S
D
D
T
S
D
D
D
F
M
E
E
Site 25
S252
G
G
E
E
D
G
G
S
D
G
M
G
G
D
G
Site 26
S260
D
G
M
G
G
D
G
S
E
F
L
Q
R
D
F
Site 27
S268
E
F
L
Q
R
D
F
S
E
T
Y
E
R
Y
H
Site 28
T270
L
Q
R
D
F
S
E
T
Y
E
R
Y
H
T
E
Site 29
Y271
Q
R
D
F
S
E
T
Y
E
R
Y
H
T
E
S
Site 30
Y274
F
S
E
T
Y
E
R
Y
H
T
E
S
L
Q
N
Site 31
T276
E
T
Y
E
R
Y
H
T
E
S
L
Q
N
M
S
Site 32
S278
Y
E
R
Y
H
T
E
S
L
Q
N
M
S
K
Q
Site 33
S283
T
E
S
L
Q
N
M
S
K
Q
E
L
I
K
E
Site 34
Y291
K
Q
E
L
I
K
E
Y
L
E
L
E
K
C
L
Site 35
S299
L
E
L
E
K
C
L
S
R
M
E
D
E
N
N
Site 36
S312
N
N
R
L
R
L
E
S
K
R
L
G
G
D
D
Site 37
S355
Q
Q
E
R
A
P
L
S
K
F
G
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation