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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SEMA3D
Full Name:
Semaphorin-3D
Alias:
Coll-2; Collapsin 2; SEM3D; Sema domain, immunoglobulin domain (Ig) short basic domain, secreted (semaphorin) 3D; Sema-Z2
Type:
Secreted protein
Mass (Da):
89651
Number AA:
777
UniProt ID:
O95025
International Prot ID:
IPI00028213
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
D
E
R
L
K
A
R
S
Q
D
F
H
L
F
P
Site 2
T48
N
I
P
R
L
K
L
T
Y
K
D
L
L
L
S
Site 3
Y49
I
P
R
L
K
L
T
Y
K
D
L
L
L
S
N
Site 4
T72
S
E
G
L
D
F
Q
T
L
L
L
D
E
E
R
Site 5
S94
K
D
H
I
F
L
L
S
L
V
D
L
N
K
N
Site 6
T126
L
A
G
K
D
A
N
T
E
C
A
N
F
I
R
Site 7
Y138
F
I
R
V
L
Q
P
Y
N
K
T
H
I
Y
V
Site 8
Y144
P
Y
N
K
T
H
I
Y
V
C
G
T
G
A
F
Site 9
T173
D
I
I
F
K
L
D
T
H
N
L
E
S
G
R
Site 10
S178
L
D
T
H
N
L
E
S
G
R
L
K
C
P
F
Site 11
Y199
A
S
V
M
T
D
E
Y
L
Y
S
G
T
A
S
Site 12
S202
M
T
D
E
Y
L
Y
S
G
T
A
S
D
F
L
Site 13
T204
D
E
Y
L
Y
S
G
T
A
S
D
F
L
G
K
Site 14
S206
Y
L
Y
S
G
T
A
S
D
F
L
G
K
D
T
Site 15
T213
S
D
F
L
G
K
D
T
A
F
T
R
S
L
G
Site 16
T216
L
G
K
D
T
A
F
T
R
S
L
G
P
T
H
Site 17
S218
K
D
T
A
F
T
R
S
L
G
P
T
H
D
H
Site 18
T222
F
T
R
S
L
G
P
T
H
D
H
H
Y
I
R
Site 19
Y227
G
P
T
H
D
H
H
Y
I
R
T
D
I
S
E
Site 20
Y236
R
T
D
I
S
E
H
Y
W
L
N
G
A
K
F
Site 21
T252
G
T
F
F
I
P
D
T
Y
N
P
D
D
D
K
Site 22
Y253
T
F
F
I
P
D
T
Y
N
P
D
D
D
K
I
Site 23
Y261
N
P
D
D
D
K
I
Y
F
F
F
R
E
S
S
Site 24
S267
I
Y
F
F
F
R
E
S
S
Q
E
G
S
T
S
Site 25
S268
Y
F
F
F
R
E
S
S
Q
E
G
S
T
S
D
Site 26
S272
R
E
S
S
Q
E
G
S
T
S
D
K
T
I
L
Site 27
S274
S
S
Q
E
G
S
T
S
D
K
T
I
L
S
R
Site 28
T277
E
G
S
T
S
D
K
T
I
L
S
R
V
G
R
Site 29
S280
T
S
D
K
T
I
L
S
R
V
G
R
V
C
K
Site 30
S295
N
D
V
G
G
Q
R
S
L
I
N
K
W
T
T
Site 31
T320
P
G
S
D
G
A
D
T
Y
F
D
E
L
Q
D
Site 32
Y321
G
S
D
G
A
D
T
Y
F
D
E
L
Q
D
I
Site 33
Y329
F
D
E
L
Q
D
I
Y
L
L
P
T
R
D
E
Site 34
Y342
D
E
R
N
P
V
V
Y
G
V
F
T
T
T
S
Site 35
Y360
K
G
S
A
V
C
V
Y
S
M
A
D
I
R
A
Site 36
Y373
R
A
V
F
N
G
P
Y
A
H
K
E
S
A
D
Site 37
Y386
A
D
H
R
W
V
Q
Y
D
G
R
I
P
Y
P
Site 38
Y392
Q
Y
D
G
R
I
P
Y
P
R
P
G
T
C
P
Site 39
T397
I
P
Y
P
R
P
G
T
C
P
S
K
T
Y
D
Site 40
S400
P
R
P
G
T
C
P
S
K
T
Y
D
P
L
I
Site 41
T402
P
G
T
C
P
S
K
T
Y
D
P
L
I
K
S
Site 42
S409
T
Y
D
P
L
I
K
S
T
R
D
F
P
D
D
Site 43
S419
D
F
P
D
D
V
I
S
F
I
K
R
H
S
V
Site 44
Y428
I
K
R
H
S
V
M
Y
K
S
V
Y
P
V
A
Site 45
S430
R
H
S
V
M
Y
K
S
V
Y
P
V
A
G
G
Site 46
T439
Y
P
V
A
G
G
P
T
F
K
R
I
N
V
D
Site 47
Y447
F
K
R
I
N
V
D
Y
R
L
T
Q
I
V
V
Site 48
Y519
S
L
K
Q
Q
Q
L
Y
I
G
S
R
D
G
L
Site 49
S530
R
D
G
L
V
Q
L
S
L
H
R
C
D
T
Y
Site 50
T536
L
S
L
H
R
C
D
T
Y
G
K
A
C
A
D
Site 51
Y537
S
L
H
R
C
D
T
Y
G
K
A
C
A
D
C
Site 52
S560
A
W
D
G
N
A
C
S
R
Y
A
P
T
S
K
Site 53
Y562
D
G
N
A
C
S
R
Y
A
P
T
S
K
R
R
Site 54
S566
C
S
R
Y
A
P
T
S
K
R
R
A
R
R
Q
Site 55
Y577
A
R
R
Q
D
V
K
Y
G
D
P
I
T
Q
C
Site 56
S592
W
D
I
E
D
S
I
S
H
E
T
A
D
E
K
Site 57
S617
F
L
E
C
I
P
K
S
Q
Q
A
T
I
K
W
Site 58
T621
I
P
K
S
Q
Q
A
T
I
K
W
Y
I
Q
R
Site 59
Y625
Q
Q
A
T
I
K
W
Y
I
Q
R
S
G
D
E
Site 60
T646
P
D
E
R
I
I
K
T
E
Y
G
L
L
I
R
Site 61
S654
E
Y
G
L
L
I
R
S
L
Q
K
K
D
S
G
Site 62
S660
R
S
L
Q
K
K
D
S
G
M
Y
Y
C
K
A
Site 63
Y664
K
K
D
S
G
M
Y
Y
C
K
A
Q
E
H
T
Site 64
S709
V
K
D
L
L
A
E
S
R
L
R
Y
K
D
Y
Site 65
Y713
L
A
E
S
R
L
R
Y
K
D
Y
I
Q
I
L
Site 66
Y716
S
R
L
R
Y
K
D
Y
I
Q
I
L
S
S
P
Site 67
S721
K
D
Y
I
Q
I
L
S
S
P
N
F
S
L
D
Site 68
S722
D
Y
I
Q
I
L
S
S
P
N
F
S
L
D
Q
Site 69
S726
I
L
S
S
P
N
F
S
L
D
Q
Y
C
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation