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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZO3
Full Name:
Tight junction protein ZO-3
Alias:
Tight junction protein 3; Tight junction protein 3 (zona occludens 3); TJP3; ZO-3; Zona occludens 3; Zona occludens protein 3; Zonula occludens 3; Zonula occludens protein 3
Type:
Adhesion protein
Mass (Da):
102800
Number AA:
933
UniProt ID:
O95049
International Prot ID:
IPI00293451
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005923
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
I
W
E
Q
H
T
A
T
L
S
K
D
P
R
R
Site 2
S15
E
Q
H
T
A
T
L
S
K
D
P
R
R
G
F
Site 3
S27
R
G
F
G
I
A
I
S
G
G
R
D
R
P
G
Site 4
S36
G
R
D
R
P
G
G
S
M
V
V
S
D
V
V
Site 5
T54
P
A
E
G
R
L
Q
T
G
D
H
I
V
M
V
Site 6
T100
R
R
I
H
L
P
A
T
K
A
S
P
S
S
P
Site 7
S103
H
L
P
A
T
K
A
S
P
S
S
P
G
R
Q
Site 8
S105
P
A
T
K
A
S
P
S
S
P
G
R
Q
D
S
Site 9
S106
A
T
K
A
S
P
S
S
P
G
R
Q
D
S
D
Site 10
S112
S
S
P
G
R
Q
D
S
D
E
D
D
G
P
Q
Site 11
Y130
E
V
D
Q
G
R
G
Y
D
G
D
S
S
S
G
Site 12
S134
G
R
G
Y
D
G
D
S
S
S
G
S
G
R
S
Site 13
S135
R
G
Y
D
G
D
S
S
S
G
S
G
R
S
W
Site 14
S136
G
Y
D
G
D
S
S
S
G
S
G
R
S
W
D
Site 15
S138
D
G
D
S
S
S
G
S
G
R
S
W
D
E
R
Site 16
S141
S
S
S
G
S
G
R
S
W
D
E
R
S
R
R
Site 17
S146
G
R
S
W
D
E
R
S
R
R
P
R
P
G
R
Site 18
S159
G
R
R
G
R
A
G
S
H
G
R
R
S
P
G
Site 19
S164
A
G
S
H
G
R
R
S
P
G
G
G
S
E
A
Site 20
S169
R
R
S
P
G
G
G
S
E
A
N
G
L
A
L
Site 21
S195
V
Q
M
K
P
V
K
S
V
L
V
K
R
R
D
Site 22
S203
V
L
V
K
R
R
D
S
E
E
F
G
V
K
L
Site 23
S222
F
I
K
H
I
T
D
S
G
L
A
A
R
H
R
Site 24
S245
L
Q
I
N
G
V
S
S
Q
N
L
S
L
N
D
Site 25
S249
G
V
S
S
Q
N
L
S
L
N
D
T
R
R
L
Site 26
T253
Q
N
L
S
L
N
D
T
R
R
L
I
E
K
S
Site 27
S260
T
R
R
L
I
E
K
S
E
G
K
L
S
L
L
Site 28
S265
E
K
S
E
G
K
L
S
L
L
V
L
R
D
R
Site 29
S284
V
N
I
P
P
A
V
S
D
S
D
S
S
P
L
Site 30
S286
I
P
P
A
V
S
D
S
D
S
S
P
L
E
E
Site 31
S288
P
A
V
S
D
S
D
S
S
P
L
E
E
G
V
Site 32
S289
A
V
S
D
S
D
S
S
P
L
E
E
G
V
T
Site 33
T296
S
P
L
E
E
G
V
T
M
A
D
E
M
S
S
Site 34
S302
V
T
M
A
D
E
M
S
S
P
P
A
D
I
S
Site 35
S303
T
M
A
D
E
M
S
S
P
P
A
D
I
S
D
Site 36
S309
S
S
P
P
A
D
I
S
D
L
A
S
E
L
S
Site 37
S313
A
D
I
S
D
L
A
S
E
L
S
Q
A
P
P
Site 38
S316
S
D
L
A
S
E
L
S
Q
A
P
P
S
H
I
Site 39
S321
E
L
S
Q
A
P
P
S
H
I
P
P
P
P
R
Site 40
S333
P
P
R
H
A
Q
R
S
P
E
A
S
Q
T
D
Site 41
S337
A
Q
R
S
P
E
A
S
Q
T
D
S
P
V
E
Site 42
T339
R
S
P
E
A
S
Q
T
D
S
P
V
E
S
P
Site 43
S341
P
E
A
S
Q
T
D
S
P
V
E
S
P
R
L
Site 44
S345
Q
T
D
S
P
V
E
S
P
R
L
R
R
E
S
Site 45
S352
S
P
R
L
R
R
E
S
S
V
D
S
R
T
I
Site 46
S353
P
R
L
R
R
E
S
S
V
D
S
R
T
I
S
Site 47
S356
R
R
E
S
S
V
D
S
R
T
I
S
E
P
D
Site 48
T358
E
S
S
V
D
S
R
T
I
S
E
P
D
E
Q
Site 49
S360
S
V
D
S
R
T
I
S
E
P
D
E
Q
R
S
Site 50
S367
S
E
P
D
E
Q
R
S
E
L
P
R
E
S
S
Site 51
S373
R
S
E
L
P
R
E
S
S
Y
D
I
Y
R
V
Site 52
S374
S
E
L
P
R
E
S
S
Y
D
I
Y
R
V
P
Site 53
Y378
R
E
S
S
Y
D
I
Y
R
V
P
S
S
Q
S
Site 54
S382
Y
D
I
Y
R
V
P
S
S
Q
S
M
E
D
R
Site 55
S383
D
I
Y
R
V
P
S
S
Q
S
M
E
D
R
G
Site 56
S385
Y
R
V
P
S
S
Q
S
M
E
D
R
G
Y
S
Site 57
Y391
Q
S
M
E
D
R
G
Y
S
P
D
T
R
V
V
Site 58
S392
S
M
E
D
R
G
Y
S
P
D
T
R
V
V
R
Site 59
T395
D
R
G
Y
S
P
D
T
R
V
V
R
F
L
K
Site 60
S427
V
S
G
V
Q
A
G
S
P
A
D
G
Q
G
I
Site 61
T473
G
E
E
M
E
L
V
T
Q
R
K
Q
D
I
F
Site 62
S491
V
Q
S
R
V
G
D
S
F
Y
I
R
T
H
F
Site 63
Y493
S
R
V
G
D
S
F
Y
I
R
T
H
F
E
L
Site 64
S503
T
H
F
E
L
E
P
S
P
P
S
G
L
G
F
Site 65
S506
E
L
E
P
S
P
P
S
G
L
G
F
T
R
G
Site 66
T521
D
V
F
H
V
L
D
T
L
H
P
G
P
G
Q
Site 67
S529
L
H
P
G
P
G
Q
S
H
A
R
G
G
H
W
Site 68
S557
R
G
I
I
P
N
Q
S
R
A
E
Q
L
A
S
Site 69
S564
S
R
A
E
Q
L
A
S
L
E
A
A
Q
R
A
Site 70
S578
A
V
G
V
G
P
G
S
S
A
G
S
N
A
R
Site 71
S582
G
P
G
S
S
A
G
S
N
A
R
A
E
F
W
Site 72
T601
L
R
R
G
A
K
K
T
T
Q
R
S
R
E
D
Site 73
T602
R
R
G
A
K
K
T
T
Q
R
S
R
E
D
L
Site 74
S605
A
K
K
T
T
Q
R
S
R
E
D
L
S
A
L
Site 75
S610
Q
R
S
R
E
D
L
S
A
L
T
R
Q
G
R
Site 76
Y621
R
Q
G
R
Y
P
P
Y
E
R
V
V
L
R
E
Site 77
T662
D
Q
F
E
I
A
E
T
V
S
R
T
D
S
P
Site 78
S664
F
E
I
A
E
T
V
S
R
T
D
S
P
S
K
Site 79
T666
I
A
E
T
V
S
R
T
D
S
P
S
K
I
I
Site 80
S668
E
T
V
S
R
T
D
S
P
S
K
I
I
K
L
Site 81
S670
V
S
R
T
D
S
P
S
K
I
I
K
L
D
T
Site 82
T693
K
H
A
L
L
D
V
T
P
S
A
I
E
R
L
Site 83
S695
A
L
L
D
V
T
P
S
A
I
E
R
L
N
Y
Site 84
S731
R
Q
W
L
A
P
A
S
R
R
S
T
R
R
L
Site 85
S734
L
A
P
A
S
R
R
S
T
R
R
L
Y
A
Q
Site 86
T735
A
P
A
S
R
R
S
T
R
R
L
Y
A
Q
A
Site 87
Y739
R
R
S
T
R
R
L
Y
A
Q
A
Q
K
L
R
Site 88
S749
A
Q
K
L
R
K
H
S
S
H
L
F
T
A
T
Site 89
S750
Q
K
L
R
K
H
S
S
H
L
F
T
A
T
I
Site 90
T754
K
H
S
S
H
L
F
T
A
T
I
P
L
N
G
Site 91
S763
T
I
P
L
N
G
T
S
D
T
W
Y
Q
E
L
Site 92
T765
P
L
N
G
T
S
D
T
W
Y
Q
E
L
K
A
Site 93
Y767
N
G
T
S
D
T
W
Y
Q
E
L
K
A
I
I
Site 94
S792
A
E
D
Q
L
D
G
S
L
E
D
N
L
D
L
Site 95
S807
P
H
H
G
L
A
D
S
S
A
D
L
S
C
D
Site 96
S808
H
H
G
L
A
D
S
S
A
D
L
S
C
D
S
Site 97
S812
A
D
S
S
A
D
L
S
C
D
S
R
V
N
S
Site 98
S815
S
A
D
L
S
C
D
S
R
V
N
S
D
Y
E
Site 99
S819
S
C
D
S
R
V
N
S
D
Y
E
T
D
G
E
Site 100
Y821
D
S
R
V
N
S
D
Y
E
T
D
G
E
G
G
Site 101
T823
R
V
N
S
D
Y
E
T
D
G
E
G
G
A
Y
Site 102
Y830
T
D
G
E
G
G
A
Y
T
D
G
E
G
Y
T
Site 103
Y836
A
Y
T
D
G
E
G
Y
T
D
G
E
G
G
P
Site 104
Y844
T
D
G
E
G
G
P
Y
T
D
V
D
D
E
P
Site 105
T845
D
G
E
G
G
P
Y
T
D
V
D
D
E
P
P
Site 106
S860
A
P
A
L
A
R
S
S
E
P
V
Q
A
D
E
Site 107
S868
E
P
V
Q
A
D
E
S
Q
S
P
R
D
R
G
Site 108
S870
V
Q
A
D
E
S
Q
S
P
R
D
R
G
R
I
Site 109
S878
P
R
D
R
G
R
I
S
A
H
Q
G
A
Q
V
Site 110
S898
Q
G
Q
W
R
Q
D
S
M
R
T
Y
E
R
E
Site 111
Y902
R
Q
D
S
M
R
T
Y
E
R
E
A
L
K
K
Site 112
S919
M
R
V
H
D
A
E
S
S
D
E
D
G
Y
D
Site 113
S920
R
V
H
D
A
E
S
S
D
E
D
G
Y
D
W
Site 114
Y925
E
S
S
D
E
D
G
Y
D
W
G
P
A
T
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation