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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TREK1
Full Name:
Potassium channel subfamily K member 2
Alias:
KCNK2; TREK; Two pore potassium channel TPKC1
Type:
Channel protein, potassium
Mass (Da):
47093
Number AA:
426
UniProt ID:
O95069
International Prot ID:
IPI00028268
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0015271
GO:0030955
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
L
P
S
A
S
R
E
R
P
G
Y
R
Site 2
Y12
A
S
R
E
R
P
G
Y
R
A
G
V
A
A
P
Site 3
S26
P
D
L
L
D
P
K
S
A
A
Q
N
S
K
P
Site 4
S31
P
K
S
A
A
Q
N
S
K
P
R
L
S
F
S
Site 5
S36
Q
N
S
K
P
R
L
S
F
S
T
K
P
T
V
Site 6
S38
S
K
P
R
L
S
F
S
T
K
P
T
V
L
A
Site 7
T39
K
P
R
L
S
F
S
T
K
P
T
V
L
A
S
Site 8
S50
V
L
A
S
R
V
E
S
D
T
T
I
N
V
M
Site 9
T52
A
S
R
V
E
S
D
T
T
I
N
V
M
K
W
Site 10
T53
S
R
V
E
S
D
T
T
I
N
V
M
K
W
K
Site 11
S90
L
E
Q
P
H
E
I
S
Q
R
T
T
I
V
I
Site 12
T94
H
E
I
S
Q
R
T
T
I
V
I
Q
K
Q
T
Site 13
S107
Q
T
F
I
S
Q
H
S
C
V
N
S
T
E
L
Site 14
S111
S
Q
H
S
C
V
N
S
T
E
L
D
E
L
I
Site 15
S140
G
N
T
S
N
Q
I
S
H
W
D
L
G
S
S
Site 16
S164
T
I
G
F
G
N
I
S
P
R
T
E
G
G
K
Site 17
T167
F
G
N
I
S
P
R
T
E
G
G
K
I
F
C
Site 18
T210
G
I
A
K
V
E
D
T
F
I
K
W
N
V
S
Site 19
S277
G
D
Y
V
A
G
G
S
D
I
E
Y
L
D
F
Site 20
Y281
A
G
G
S
D
I
E
Y
L
D
F
Y
K
P
V
Site 21
S315
G
D
W
L
R
V
I
S
K
K
T
K
E
E
V
Site 22
T343
V
T
A
E
F
K
E
T
R
R
R
L
S
V
E
Site 23
S348
K
E
T
R
R
R
L
S
V
E
I
Y
D
K
F
Site 24
Y352
R
R
L
S
V
E
I
Y
D
K
F
Q
R
A
T
Site 25
T359
Y
D
K
F
Q
R
A
T
S
I
K
R
K
L
S
Site 26
S360
D
K
F
Q
R
A
T
S
I
K
R
K
L
S
A
Site 27
S366
T
S
I
K
R
K
L
S
A
E
L
A
G
N
H
Site 28
T378
G
N
H
N
Q
E
L
T
P
C
R
R
T
L
S
Site 29
T383
E
L
T
P
C
R
R
T
L
S
V
N
H
L
T
Site 30
S385
T
P
C
R
R
T
L
S
V
N
H
L
T
S
E
Site 31
S391
L
S
V
N
H
L
T
S
E
R
D
V
L
P
P
Site 32
Y406
L
L
K
T
E
S
I
Y
L
N
G
L
T
P
H
Site 33
T411
S
I
Y
L
N
G
L
T
P
H
C
A
G
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation