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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBR5
Full Name:
E3 ubiquitin-protein ligase UBR5
Alias:
100 kDa protein; DD5; E3 ubiquitin-protein ligase, HECT domain-containing 1; EDD; EDD1; HHYD; Hyperplastic discs protein homolog; KIAA0896; Progestin-induced protein; Ubiquitin protein ligase E3 component n-recognin 5; Ubiquitin--protein ligase EDD
Type:
Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Nuclear receptor co-regulator
Mass (Da):
309352
Number AA:
2799
UniProt ID:
O95071
International Prot ID:
IPI00026320
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0050847
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
N
D
R
L
R
E
V
S
E
K
L
N
K
Y
N
Site 2
Y32
V
S
E
K
L
N
K
Y
N
L
N
S
H
P
P
Site 3
S73
R
V
C
R
I
G
F
S
V
Q
P
D
R
L
E
Site 4
S90
K
P
D
N
N
D
G
S
K
L
N
S
N
S
G
Site 5
S94
N
D
G
S
K
L
N
S
N
S
G
A
G
R
T
Site 6
S96
G
S
K
L
N
S
N
S
G
A
G
R
T
S
R
Site 7
T101
S
N
S
G
A
G
R
T
S
R
P
G
R
T
S
Site 8
S102
N
S
G
A
G
R
T
S
R
P
G
R
T
S
D
Site 9
T107
R
T
S
R
P
G
R
T
S
D
S
P
W
F
L
Site 10
S108
T
S
R
P
G
R
T
S
D
S
P
W
F
L
S
Site 11
S110
R
P
G
R
T
S
D
S
P
W
F
L
S
G
S
Site 12
S115
S
D
S
P
W
F
L
S
G
S
E
T
L
G
R
Site 13
S117
S
P
W
F
L
S
G
S
E
T
L
G
R
L
A
Site 14
T119
W
F
L
S
G
S
E
T
L
G
R
L
A
G
N
Site 15
T127
L
G
R
L
A
G
N
T
L
G
S
R
W
S
S
Site 16
S130
L
A
G
N
T
L
G
S
R
W
S
S
G
V
G
Site 17
S133
N
T
L
G
S
R
W
S
S
G
V
G
G
S
G
Site 18
S134
T
L
G
S
R
W
S
S
G
V
G
G
S
G
G
Site 19
S139
W
S
S
G
V
G
G
S
G
G
G
S
S
G
R
Site 20
S143
V
G
G
S
G
G
G
S
S
G
R
S
S
A
G
Site 21
S144
G
G
S
G
G
G
S
S
G
R
S
S
A
G
A
Site 22
S147
G
G
G
S
S
G
R
S
S
A
G
A
R
D
S
Site 23
S148
G
G
S
S
G
R
S
S
A
G
A
R
D
S
R
Site 24
S154
S
S
A
G
A
R
D
S
R
R
Q
T
R
V
I
Site 25
T158
A
R
D
S
R
R
Q
T
R
V
I
R
T
G
R
Site 26
T163
R
Q
T
R
V
I
R
T
G
R
D
R
G
S
G
Site 27
S169
R
T
G
R
D
R
G
S
G
L
L
G
S
Q
P
Site 28
S174
R
G
S
G
L
L
G
S
Q
P
Q
P
V
I
P
Site 29
S191
V
I
P
E
E
L
I
S
Q
A
Q
V
V
L
Q
Site 30
S203
V
L
Q
G
K
S
R
S
V
I
I
R
E
L
Q
Site 31
T212
I
I
R
E
L
Q
R
T
N
L
D
V
N
L
A
Site 32
S225
L
A
V
N
N
L
L
S
R
D
D
E
D
G
D
Site 33
T237
D
G
D
D
G
D
D
T
A
S
E
S
Y
L
P
Site 34
S239
D
D
G
D
D
T
A
S
E
S
Y
L
P
G
E
Site 35
S241
G
D
D
T
A
S
E
S
Y
L
P
G
E
D
L
Site 36
S276
A
M
F
S
E
D
I
S
Y
F
G
Y
P
S
F
Site 37
Y277
M
F
S
E
D
I
S
Y
F
G
Y
P
S
F
R
Site 38
Y280
E
D
I
S
Y
F
G
Y
P
S
F
R
R
S
S
Site 39
S282
I
S
Y
F
G
Y
P
S
F
R
R
S
S
L
S
Site 40
S286
G
Y
P
S
F
R
R
S
S
L
S
R
L
G
S
Site 41
S287
Y
P
S
F
R
R
S
S
L
S
R
L
G
S
S
Site 42
S289
S
F
R
R
S
S
L
S
R
L
G
S
S
R
V
Site 43
S294
S
L
S
R
L
G
S
S
R
V
L
L
L
P
L
Site 44
S305
L
L
P
L
E
R
D
S
E
L
L
R
E
R
E
Site 45
S313
E
L
L
R
E
R
E
S
V
L
R
L
R
E
R
Site 46
S327
R
R
W
L
D
G
A
S
F
D
N
E
R
G
S
Site 47
S334
S
F
D
N
E
R
G
S
T
S
K
E
G
E
P
Site 48
T335
F
D
N
E
R
G
S
T
S
K
E
G
E
P
N
Site 49
S336
D
N
E
R
G
S
T
S
K
E
G
E
P
N
L
Site 50
T348
P
N
L
D
K
K
N
T
P
V
Q
S
P
V
S
Site 51
S352
K
K
N
T
P
V
Q
S
P
V
S
L
G
E
D
Site 52
S355
T
P
V
Q
S
P
V
S
L
G
E
D
L
Q
W
Site 53
S386
S
E
L
L
A
V
S
S
K
G
E
L
Y
Q
W
Site 54
Y391
V
S
S
K
G
E
L
Y
Q
W
K
W
S
E
S
Site 55
Y401
K
W
S
E
S
E
P
Y
R
N
A
Q
N
P
S
Site 56
T415
S
L
H
H
P
R
A
T
F
L
G
L
T
N
E
Site 57
T435
S
A
N
S
I
R
A
T
V
A
T
E
N
N
K
Site 58
T438
S
I
R
A
T
V
A
T
E
N
N
K
V
A
T
Site 59
S452
T
W
V
D
E
T
L
S
S
V
A
S
K
L
E
Site 60
S453
W
V
D
E
T
L
S
S
V
A
S
K
L
E
H
Site 61
S456
E
T
L
S
S
V
A
S
K
L
E
H
T
A
Q
Site 62
S518
A
K
N
K
K
P
K
S
S
A
G
I
S
S
M
Site 63
S519
K
N
K
K
P
K
S
S
A
G
I
S
S
M
P
Site 64
S523
P
K
S
S
A
G
I
S
S
M
P
N
I
T
V
Site 65
S524
K
S
S
A
G
I
S
S
M
P
N
I
T
V
G
Site 66
S578
S
C
R
F
Q
L
R
S
P
E
S
L
K
N
M
Site 67
S581
F
Q
L
R
S
P
E
S
L
K
N
M
E
K
A
Site 68
T591
N
M
E
K
A
S
K
T
T
E
A
K
P
E
S
Site 69
S598
T
T
E
A
K
P
E
S
K
Q
E
P
V
K
T
Site 70
T605
S
K
Q
E
P
V
K
T
E
M
G
P
P
P
S
Site 71
S612
T
E
M
G
P
P
P
S
P
A
S
T
C
S
D
Site 72
S615
G
P
P
P
S
P
A
S
T
C
S
D
A
S
S
Site 73
T616
P
P
P
S
P
A
S
T
C
S
D
A
S
S
I
Site 74
S618
P
S
P
A
S
T
C
S
D
A
S
S
I
A
S
Site 75
S621
A
S
T
C
S
D
A
S
S
I
A
S
S
A
S
Site 76
S622
S
T
C
S
D
A
S
S
I
A
S
S
A
S
M
Site 77
S625
S
D
A
S
S
I
A
S
S
A
S
M
P
Y
K
Site 78
S626
D
A
S
S
I
A
S
S
A
S
M
P
Y
K
R
Site 79
S628
S
S
I
A
S
S
A
S
M
P
Y
K
R
R
R
Site 80
Y631
A
S
S
A
S
M
P
Y
K
R
R
R
S
T
P
Site 81
S636
M
P
Y
K
R
R
R
S
T
P
A
P
K
E
E
Site 82
T637
P
Y
K
R
R
R
S
T
P
A
P
K
E
E
E
Site 83
S652
K
V
N
E
E
Q
W
S
L
R
E
V
V
F
V
Site 84
S687
V
K
F
P
G
T
S
S
N
T
N
C
Q
N
S
Site 85
T689
F
P
G
T
S
S
N
T
N
C
Q
N
S
S
G
Site 86
S702
S
G
P
D
A
D
P
S
S
L
L
Q
D
C
R
Site 87
S703
G
P
D
A
D
P
S
S
L
L
Q
D
C
R
L
Site 88
T724
Q
V
V
K
T
G
G
T
P
K
V
P
D
C
F
Site 89
T734
V
P
D
C
F
Q
R
T
P
K
K
L
C
I
P
Site 90
Y768
K
T
G
N
W
V
R
Y
C
I
F
D
L
A
T
Site 91
S787
Q
E
N
N
F
P
T
S
S
I
A
F
L
G
Q
Site 92
S808
I
F
T
A
G
Q
E
S
P
I
I
L
R
D
G
Site 93
T818
I
L
R
D
G
N
G
T
I
Y
P
M
A
K
D
Site 94
Y820
R
D
G
N
G
T
I
Y
P
M
A
K
D
C
M
Site 95
Y885
Q
H
I
L
R
C
D
Y
E
A
C
R
Q
Y
L
Site 96
Y891
D
Y
E
A
C
R
Q
Y
L
M
N
L
E
Q
A
Site 97
S928
N
I
L
H
A
C
V
S
V
C
F
P
T
S
N
Site 98
S934
V
S
V
C
F
P
T
S
N
K
E
T
K
E
E
Site 99
S947
E
E
E
E
A
E
R
S
E
R
N
T
F
A
E
Site 100
T951
A
E
R
S
E
R
N
T
F
A
E
R
L
S
A
Site 101
S971
N
A
I
S
V
V
S
S
N
G
P
G
N
R
A
Site 102
S980
G
P
G
N
R
A
G
S
S
S
S
R
S
L
R
Site 103
S981
P
G
N
R
A
G
S
S
S
S
R
S
L
R
L
Site 104
S982
G
N
R
A
G
S
S
S
S
R
S
L
R
L
R
Site 105
S983
N
R
A
G
S
S
S
S
R
S
L
R
L
R
E
Site 106
S985
A
G
S
S
S
S
R
S
L
R
L
R
E
M
M
Site 107
S995
L
R
E
M
M
R
R
S
L
R
A
A
G
L
G
Site 108
S1009
G
R
H
E
A
G
A
S
S
S
D
H
Q
D
P
Site 109
S1011
H
E
A
G
A
S
S
S
D
H
Q
D
P
V
S
Site 110
S1018
S
D
H
Q
D
P
V
S
P
P
I
A
P
P
S
Site 111
S1025
S
P
P
I
A
P
P
S
W
V
P
D
P
P
A
Site 112
S1062
T
G
T
G
Q
G
P
S
T
S
T
I
P
G
P
Site 113
T1063
G
T
G
Q
G
P
S
T
S
T
I
P
G
P
S
Site 114
S1064
T
G
Q
G
P
S
T
S
T
I
P
G
P
S
T
Site 115
S1070
T
S
T
I
P
G
P
S
T
E
P
S
V
V
E
Site 116
T1071
S
T
I
P
G
P
S
T
E
P
S
V
V
E
S
Site 117
S1074
P
G
P
S
T
E
P
S
V
V
E
S
K
D
R
Site 118
S1078
T
E
P
S
V
V
E
S
K
D
R
K
A
N
A
Site 119
S1107
P
Y
L
R
E
L
L
S
A
K
D
A
R
G
M
Site 120
T1115
A
K
D
A
R
G
M
T
P
F
M
S
A
V
S
Site 121
S1119
R
G
M
T
P
F
M
S
A
V
S
G
R
A
Y
Site 122
T1135
A
A
I
T
I
L
E
T
A
Q
K
I
A
K
A
Site 123
S1145
K
I
A
K
A
E
I
S
S
S
E
K
E
E
D
Site 124
S1147
A
K
A
E
I
S
S
S
E
K
E
E
D
V
F
Site 125
S1168
S
G
T
N
P
D
D
S
P
L
Y
V
L
C
C
Site 126
Y1171
N
P
D
D
S
P
L
Y
V
L
C
C
N
D
T
Site 127
S1227
D
C
K
L
K
R
T
S
P
T
A
Y
C
D
C
Site 128
T1266
L
T
A
T
N
L
V
T
L
P
N
S
R
G
E
Site 129
T1287
V
Q
T
V
A
R
Q
T
V
E
H
C
Q
Y
R
Site 130
Y1293
Q
T
V
E
H
C
Q
Y
R
P
P
R
I
R
E
Site 131
T1306
R
E
D
R
N
R
K
T
A
S
P
E
D
S
D
Site 132
S1308
D
R
N
R
K
T
A
S
P
E
D
S
D
M
P
Site 133
S1312
K
T
A
S
P
E
D
S
D
M
P
D
H
D
L
Site 134
S1347
K
S
M
I
M
F
G
S
Q
E
N
K
D
P
L
Site 135
S1355
Q
E
N
K
D
P
L
S
A
S
S
R
I
G
H
Site 136
S1357
N
K
D
P
L
S
A
S
S
R
I
G
H
L
L
Site 137
Y1370
L
L
P
E
E
Q
V
Y
L
N
Q
Q
S
G
T
Site 138
S1375
Q
V
Y
L
N
Q
Q
S
G
T
I
R
L
D
C
Site 139
T1414
K
E
L
Q
N
K
Y
T
P
G
R
R
E
E
A
Site 140
S1446
L
S
V
E
M
A
S
S
K
K
K
N
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R
L
Y
V
P
L
Y
S
S
K
Site 293
Y2777
S
R
L
Y
V
P
L
Y
S
S
K
Q
I
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation