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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRSS23
Full Name:
Serine protease 23
Alias:
Putative secreted protein Zsig13
Type:
Mass (Da):
43001
Number AA:
383
UniProt ID:
O95084
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
A
V
G
Q
V
S
P
Y
S
A
P
W
K
P
T
Site 2
S25
V
G
Q
V
S
P
Y
S
A
P
W
K
P
T
W
Site 3
Y35
W
K
P
T
W
P
A
Y
R
L
P
V
V
L
P
Site 4
S63
E
A
K
L
E
V
S
S
S
C
G
P
Q
C
H
Site 5
S64
A
K
L
E
V
S
S
S
C
G
P
Q
C
H
K
Site 6
T73
G
P
Q
C
H
K
G
T
P
L
P
T
Y
E
E
Site 7
Y78
K
G
T
P
L
P
T
Y
E
E
A
K
Q
Y
L
Site 8
Y84
T
Y
E
E
A
K
Q
Y
L
S
Y
E
T
L
Y
Site 9
S86
E
E
A
K
Q
Y
L
S
Y
E
T
L
Y
A
N
Site 10
Y91
Y
L
S
Y
E
T
L
Y
A
N
G
S
R
T
E
Site 11
S95
E
T
L
Y
A
N
G
S
R
T
E
T
Q
V
G
Site 12
T99
A
N
G
S
R
T
E
T
Q
V
G
I
Y
I
L
Site 13
Y104
T
E
T
Q
V
G
I
Y
I
L
S
S
S
G
D
Site 14
S109
G
I
Y
I
L
S
S
S
G
D
G
A
Q
H
R
Site 15
S118
D
G
A
Q
H
R
D
S
G
S
S
G
K
S
R
Site 16
S120
A
Q
H
R
D
S
G
S
S
G
K
S
R
R
K
Site 17
S121
Q
H
R
D
S
G
S
S
G
K
S
R
R
K
R
Site 18
S124
D
S
G
S
S
G
K
S
R
R
K
R
Q
I
Y
Site 19
Y131
S
R
R
K
R
Q
I
Y
G
Y
D
S
R
F
S
Site 20
Y133
R
K
R
Q
I
Y
G
Y
D
S
R
F
S
I
F
Site 21
S138
Y
G
Y
D
S
R
F
S
I
F
G
K
D
F
L
Site 22
Y148
G
K
D
F
L
L
N
Y
P
F
S
T
S
V
K
Site 23
S153
L
N
Y
P
F
S
T
S
V
K
L
S
T
G
C
Site 24
T182
H
C
I
H
D
G
K
T
Y
V
K
G
T
Q
K
Site 25
Y183
C
I
H
D
G
K
T
Y
V
K
G
T
Q
K
L
Site 26
S209
G
G
R
G
A
N
D
S
T
S
A
M
P
E
Q
Site 27
T210
G
R
G
A
N
D
S
T
S
A
M
P
E
Q
M
Site 28
S211
R
G
A
N
D
S
T
S
A
M
P
E
Q
M
K
Site 29
Y247
D
I
G
M
D
Y
D
Y
A
L
L
E
L
K
K
Site 30
S266
K
F
M
K
I
G
V
S
P
P
A
K
Q
L
P
Site 31
Y282
G
R
I
H
F
S
G
Y
D
N
D
R
P
G
N
Site 32
T301
F
C
D
V
K
D
E
T
Y
D
L
L
Y
Q
Q
Site 33
Y302
C
D
V
K
D
E
T
Y
D
L
L
Y
Q
Q
C
Site 34
Y306
D
E
T
Y
D
L
L
Y
Q
Q
C
D
A
Q
P
Site 35
S318
A
Q
P
G
A
S
G
S
G
V
Y
V
R
M
W
Site 36
Y321
G
A
S
G
S
G
V
Y
V
R
M
W
K
R
Q
Site 37
Y371
L
K
Y
A
Q
I
C
Y
W
I
K
G
N
Y
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation