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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SFRS15
Full Name:
Splicing factor, arginine/serine-rich 15
Alias:
CTD-binding SR-like protein RA4; DKFZp434E098; KIAA1172; SCAF4; SFR15; SRA4
Type:
RNA binding protein; RNA processing
Mass (Da):
125869
Number AA:
1147
UniProt ID:
O95104
International Prot ID:
IPI00181702
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
F
N
Q
E
L
F
S
L
M
D
M
K
P
P
Site 2
Y58
I
K
K
C
K
P
E
Y
K
V
P
G
L
Y
V
Site 3
Y64
E
Y
K
V
P
G
L
Y
V
I
D
S
I
V
R
Site 4
S68
P
G
L
Y
V
I
D
S
I
V
R
Q
S
R
H
Site 5
S73
I
D
S
I
V
R
Q
S
R
H
Q
F
G
T
D
Site 6
T79
Q
S
R
H
Q
F
G
T
D
K
D
V
F
G
P
Site 7
S89
D
V
F
G
P
R
F
S
K
N
I
T
A
T
F
Site 8
T93
P
R
F
S
K
N
I
T
A
T
F
Q
Y
L
Y
Site 9
Y100
T
A
T
F
Q
Y
L
Y
L
C
P
S
E
D
K
Site 10
S104
Q
Y
L
Y
L
C
P
S
E
D
K
S
K
I
V
Site 11
S108
L
C
P
S
E
D
K
S
K
I
V
R
V
L
N
Site 12
T149
A
P
V
A
E
N
V
T
N
N
E
G
S
P
P
Site 13
S154
N
V
T
N
N
E
G
S
P
P
P
P
V
K
V
Site 14
S162
P
P
P
P
V
K
V
S
S
E
P
P
T
Q
A
Site 15
S163
P
P
P
V
K
V
S
S
E
P
P
T
Q
A
T
Site 16
T167
K
V
S
S
E
P
P
T
Q
A
T
P
N
S
V
Site 17
T170
S
E
P
P
T
Q
A
T
P
N
S
V
P
A
V
Site 18
S173
P
T
Q
A
T
P
N
S
V
P
A
V
P
Q
L
Site 19
T207
Q
L
Q
Q
I
L
Q
T
F
Q
Q
P
P
K
P
Site 20
S216
Q
Q
P
P
K
P
Q
S
P
A
L
D
N
A
V
Site 21
T236
A
I
T
A
Q
L
K
T
T
P
T
Q
P
S
E
Site 22
T237
I
T
A
Q
L
K
T
T
P
T
Q
P
S
E
Q
Site 23
T239
A
Q
L
K
T
T
P
T
Q
P
S
E
Q
K
A
Site 24
Y267
K
L
L
D
R
F
D
Y
D
D
E
P
E
A
V
Site 25
T282
E
E
S
K
K
E
D
T
T
A
V
T
T
T
A
Site 26
S312
A
A
A
P
A
A
A
S
P
P
P
P
Q
A
P
Site 27
Y332
D
G
M
Q
Q
P
A
Y
T
Q
H
Q
N
M
D
Site 28
T387
A
Q
P
V
I
P
P
T
P
P
V
Q
Q
P
F
Site 29
S397
V
Q
Q
P
F
Q
A
S
F
Q
A
Q
N
E
P
Site 30
T406
Q
A
Q
N
E
P
L
T
Q
K
P
H
Q
Q
E
Site 31
S429
Q
E
V
K
R
H
M
S
D
N
R
K
S
R
S
Site 32
S434
H
M
S
D
N
R
K
S
R
S
R
S
A
S
R
Site 33
S436
S
D
N
R
K
S
R
S
R
S
A
S
R
S
P
Site 34
S438
N
R
K
S
R
S
R
S
A
S
R
S
P
K
R
Site 35
S440
K
S
R
S
R
S
A
S
R
S
P
K
R
R
R
Site 36
S442
R
S
R
S
A
S
R
S
P
K
R
R
R
S
R
Site 37
S448
R
S
P
K
R
R
R
S
R
S
G
S
R
S
R
Site 38
S450
P
K
R
R
R
S
R
S
G
S
R
S
R
R
S
Site 39
S452
R
R
R
S
R
S
G
S
R
S
R
R
S
R
H
Site 40
S454
R
S
R
S
G
S
R
S
R
R
S
R
H
R
R
Site 41
S457
S
G
S
R
S
R
R
S
R
H
R
R
S
R
S
Site 42
S462
R
R
S
R
H
R
R
S
R
S
R
S
R
D
R
Site 43
S464
S
R
H
R
R
S
R
S
R
S
R
D
R
R
R
Site 44
S466
H
R
R
S
R
S
R
S
R
D
R
R
R
H
S
Site 45
S473
S
R
D
R
R
R
H
S
P
R
S
R
S
Q
E
Site 46
S476
R
R
R
H
S
P
R
S
R
S
Q
E
R
R
D
Site 47
S478
R
H
S
P
R
S
R
S
Q
E
R
R
D
R
E
Site 48
T502
L
P
Q
V
K
P
E
T
A
S
V
C
S
T
T
Site 49
S504
Q
V
K
P
E
T
A
S
V
C
S
T
T
L
W
Site 50
T520
G
Q
L
D
K
R
T
T
Q
Q
D
V
A
S
L
Site 51
S536
E
E
F
G
P
I
E
S
I
N
M
I
P
P
R
Site 52
Y557
M
V
H
R
Q
D
A
Y
R
A
L
Q
K
L
S
Site 53
Y568
Q
K
L
S
R
G
N
Y
K
V
N
Q
K
S
I
Site 54
Y589
N
K
G
I
K
A
D
Y
K
Q
Y
W
D
V
E
Site 55
Y592
I
K
A
D
Y
K
Q
Y
W
D
V
E
L
G
V
Site 56
S614
V
K
P
E
E
L
E
S
F
C
E
G
G
M
L
Site 57
S623
C
E
G
G
M
L
D
S
D
T
L
N
P
D
W
Site 58
T625
G
G
M
L
D
S
D
T
L
N
P
D
W
K
G
Site 59
T652
G
G
A
E
T
S
H
T
E
P
V
S
P
I
P
Site 60
S656
T
S
H
T
E
P
V
S
P
I
P
K
P
L
P
Site 61
T748
P
G
P
P
P
P
I
T
P
P
V
S
I
P
P
Site 62
S752
P
P
I
T
P
P
V
S
I
P
P
P
H
T
P
Site 63
T758
V
S
I
P
P
P
H
T
P
P
I
S
I
P
N
Site 64
S762
P
P
H
T
P
P
I
S
I
P
N
S
T
I
A
Site 65
S766
P
P
I
S
I
P
N
S
T
I
A
G
I
N
E
Site 66
T775
I
A
G
I
N
E
D
T
T
K
D
L
S
I
G
Site 67
T776
A
G
I
N
E
D
T
T
K
D
L
S
I
G
N
Site 68
S780
E
D
T
T
K
D
L
S
I
G
N
P
I
P
T
Site 69
S798
G
A
R
G
N
A
E
S
G
D
S
V
K
M
Y
Site 70
S801
G
N
A
E
S
G
D
S
V
K
M
Y
G
S
A
Site 71
Y805
S
G
D
S
V
K
M
Y
G
S
A
V
P
P
A
Site 72
S807
D
S
V
K
M
Y
G
S
A
V
P
P
A
A
P
Site 73
T819
A
A
P
T
N
L
P
T
P
P
V
T
Q
P
V
Site 74
S970
Q
Q
Q
Q
P
P
P
S
Q
Q
P
P
P
T
Q
Site 75
T976
P
S
Q
Q
P
P
P
T
Q
Q
Q
P
Q
Q
F
Site 76
S993
D
N
R
Q
Q
F
N
S
G
R
D
Q
E
R
F
Site 77
S1004
Q
E
R
F
G
R
R
S
F
G
N
R
V
E
N
Site 78
Y1016
V
E
N
D
R
E
R
Y
G
N
R
N
D
D
R
Site 79
S1026
R
N
D
D
R
D
N
S
N
R
D
R
R
E
W
Site 80
S1037
R
R
E
W
G
R
R
S
P
D
R
D
R
H
R
Site 81
S1053
L
E
E
R
N
R
R
S
S
G
H
R
D
R
E
Site 82
S1054
E
E
R
N
R
R
S
S
G
H
R
D
R
E
R
Site 83
S1063
H
R
D
R
E
R
D
S
R
D
R
E
S
R
R
Site 84
S1068
R
D
S
R
D
R
E
S
R
R
E
K
E
E
A
Site 85
T1084
G
K
E
K
P
E
V
T
D
R
A
G
G
N
K
Site 86
T1092
D
R
A
G
G
N
K
T
V
E
P
P
I
S
Q
Site 87
S1098
K
T
V
E
P
P
I
S
Q
V
G
N
V
D
T
Site 88
T1105
S
Q
V
G
N
V
D
T
A
S
E
L
E
K
G
Site 89
S1107
V
G
N
V
D
T
A
S
E
L
E
K
G
V
S
Site 90
S1114
S
E
L
E
K
G
V
S
E
A
A
V
L
K
P
Site 91
T1130
E
E
L
P
A
E
A
T
S
S
V
E
P
E
K
Site 92
S1131
E
L
P
A
E
A
T
S
S
V
E
P
E
K
D
Site 93
S1132
L
P
A
E
A
T
S
S
V
E
P
E
K
D
S
Site 94
S1139
S
V
E
P
E
K
D
S
G
S
A
A
E
A
P
Site 95
S1141
E
P
E
K
D
S
G
S
A
A
E
A
P
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation