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Updated November 2019
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Protein Info
Short Name:
UBE4B
Full Name:
Ubiquitin conjugation factor E4 B
Alias:
HDNB1; Homozygously deleted in neuroblastoma-1; KIAA0684; UB4B; Ubiquitin fusion degradation protein 2; Ubiquitin-fusion degradation protein 2; UFD2
Type:
Ubiquitin ligase complex
Mass (Da):
146185
Number AA:
1302
UniProt ID:
O95155
International Prot ID:
IPI00005715
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000151
Uniprot
OncoNet
Molecular Function:
GO:0019899
GO:0051082
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0042787
GO:0009411
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
A
R
L
A
G
G
Q
T
S
Q
P
T
T
P
L
Site 2
S23
R
L
A
G
G
Q
T
S
Q
P
T
T
P
L
T
Site 3
T26
G
G
Q
T
S
Q
P
T
T
P
L
T
S
P
Q
Site 4
T27
G
Q
T
S
Q
P
T
T
P
L
T
S
P
Q
R
Site 5
T30
S
Q
P
T
T
P
L
T
S
P
Q
R
E
N
P
Site 6
S31
Q
P
T
T
P
L
T
S
P
Q
R
E
N
P
P
Site 7
S45
P
G
P
P
I
A
A
S
A
P
G
P
S
Q
S
Site 8
S52
S
A
P
G
P
S
Q
S
L
G
L
N
V
H
N
Site 9
T61
G
L
N
V
H
N
M
T
P
A
T
S
P
I
G
Site 10
S65
H
N
M
T
P
A
T
S
P
I
G
A
S
G
V
Site 11
S76
A
S
G
V
A
H
R
S
Q
S
S
E
G
V
S
Site 12
S78
G
V
A
H
R
S
Q
S
S
E
G
V
S
S
L
Site 13
S79
V
A
H
R
S
Q
S
S
E
G
V
S
S
L
S
Site 14
S83
S
Q
S
S
E
G
V
S
S
L
S
S
S
P
S
Site 15
S84
Q
S
S
E
G
V
S
S
L
S
S
S
P
S
N
Site 16
S86
S
E
G
V
S
S
L
S
S
S
P
S
N
S
L
Site 17
S87
E
G
V
S
S
L
S
S
S
P
S
N
S
L
E
Site 18
S88
G
V
S
S
L
S
S
S
P
S
N
S
L
E
T
Site 19
S90
S
S
L
S
S
S
P
S
N
S
L
E
T
Q
S
Site 20
S92
L
S
S
S
P
S
N
S
L
E
T
Q
S
Q
S
Site 21
T95
S
P
S
N
S
L
E
T
Q
S
Q
S
L
S
R
Site 22
S97
S
N
S
L
E
T
Q
S
Q
S
L
S
R
S
Q
Site 23
S99
S
L
E
T
Q
S
Q
S
L
S
R
S
Q
S
M
Site 24
S101
E
T
Q
S
Q
S
L
S
R
S
Q
S
M
D
I
Site 25
S103
Q
S
Q
S
L
S
R
S
Q
S
M
D
I
D
G
Site 26
S105
Q
S
L
S
R
S
Q
S
M
D
I
D
G
V
S
Site 27
S112
S
M
D
I
D
G
V
S
C
E
K
S
M
S
Q
Site 28
S116
D
G
V
S
C
E
K
S
M
S
Q
V
D
V
D
Site 29
S118
V
S
C
E
K
S
M
S
Q
V
D
V
D
S
G
Site 30
S124
M
S
Q
V
D
V
D
S
G
I
E
N
M
E
V
Site 31
S141
N
D
R
R
E
K
R
S
L
S
D
K
E
P
S
Site 32
S143
R
R
E
K
R
S
L
S
D
K
E
P
S
S
G
Site 33
S148
S
L
S
D
K
E
P
S
S
G
P
E
V
S
E
Site 34
S149
L
S
D
K
E
P
S
S
G
P
E
V
S
E
E
Site 35
S154
P
S
S
G
P
E
V
S
E
E
Q
A
L
Q
L
Site 36
S181
D
R
D
V
I
F
L
S
S
L
S
A
Q
F
K
Site 37
S182
R
D
V
I
F
L
S
S
L
S
A
Q
F
K
Q
Site 38
S196
Q
N
P
K
E
V
F
S
D
F
K
D
L
I
G
Site 39
S224
R
D
E
N
P
F
A
S
L
T
A
T
S
Q
P
Site 40
T226
E
N
P
F
A
S
L
T
A
T
S
Q
P
I
A
Site 41
S249
N
L
L
L
N
T
G
S
N
P
G
T
S
P
M
Site 42
T253
N
T
G
S
N
P
G
T
S
P
M
F
C
S
V
Site 43
S254
T
G
S
N
P
G
T
S
P
M
F
C
S
V
A
Site 44
S262
P
M
F
C
S
V
A
S
F
G
A
S
S
L
S
Site 45
S269
S
F
G
A
S
S
L
S
S
L
Y
E
S
S
P
Site 46
S270
F
G
A
S
S
L
S
S
L
Y
E
S
S
P
A
Site 47
Y272
A
S
S
L
S
S
L
Y
E
S
S
P
A
P
T
Site 48
S274
S
L
S
S
L
Y
E
S
S
P
A
P
T
P
S
Site 49
S275
L
S
S
L
Y
E
S
S
P
A
P
T
P
S
F
Site 50
T279
Y
E
S
S
P
A
P
T
P
S
F
W
S
S
V
Site 51
S281
S
S
P
A
P
T
P
S
F
W
S
S
V
P
V
Site 52
S285
P
T
P
S
F
W
S
S
V
P
V
M
G
P
S
Site 53
S295
V
M
G
P
S
L
A
S
P
S
R
A
A
S
Q
Site 54
S297
G
P
S
L
A
S
P
S
R
A
A
S
Q
L
A
Site 55
S301
A
S
P
S
R
A
A
S
Q
L
A
V
P
S
T
Site 56
S307
A
S
Q
L
A
V
P
S
T
P
L
S
P
H
S
Site 57
T308
S
Q
L
A
V
P
S
T
P
L
S
P
H
S
A
Site 58
S311
A
V
P
S
T
P
L
S
P
H
S
A
A
S
G
Site 59
S314
S
T
P
L
S
P
H
S
A
A
S
G
T
A
A
Site 60
S317
L
S
P
H
S
A
A
S
G
T
A
A
G
S
Q
Site 61
T319
P
H
S
A
A
S
G
T
A
A
G
S
Q
P
S
Site 62
S323
A
S
G
T
A
A
G
S
Q
P
S
S
P
R
Y
Site 63
S326
T
A
A
G
S
Q
P
S
S
P
R
Y
R
P
Y
Site 64
S327
A
A
G
S
Q
P
S
S
P
R
Y
R
P
Y
T
Site 65
Y330
S
Q
P
S
S
P
R
Y
R
P
Y
T
V
T
H
Site 66
Y333
S
S
P
R
Y
R
P
Y
T
V
T
H
P
W
A
Site 67
T334
S
P
R
Y
R
P
Y
T
V
T
H
P
W
A
S
Site 68
T336
R
Y
R
P
Y
T
V
T
H
P
W
A
S
S
G
Site 69
S345
P
W
A
S
S
G
V
S
I
L
S
S
S
P
S
Site 70
S348
S
S
G
V
S
I
L
S
S
S
P
S
P
P
A
Site 71
S352
S
I
L
S
S
S
P
S
P
P
A
L
A
S
S
Site 72
S358
P
S
P
P
A
L
A
S
S
P
Q
A
V
P
A
Site 73
S359
S
P
P
A
L
A
S
S
P
Q
A
V
P
A
S
Site 74
S366
S
P
Q
A
V
P
A
S
S
S
R
Q
R
P
S
Site 75
S367
P
Q
A
V
P
A
S
S
S
R
Q
R
P
S
S
Site 76
S368
Q
A
V
P
A
S
S
S
R
Q
R
P
S
S
T
Site 77
S373
S
S
S
R
Q
R
P
S
S
T
G
P
P
L
P
Site 78
S374
S
S
R
Q
R
P
S
S
T
G
P
P
L
P
P
Site 79
T375
S
R
Q
R
P
S
S
T
G
P
P
L
P
P
A
Site 80
S383
G
P
P
L
P
P
A
S
P
S
A
T
S
R
R
Site 81
S385
P
L
P
P
A
S
P
S
A
T
S
R
R
P
S
Site 82
T387
P
P
A
S
P
S
A
T
S
R
R
P
S
S
L
Site 83
S388
P
A
S
P
S
A
T
S
R
R
P
S
S
L
R
Site 84
S392
S
A
T
S
R
R
P
S
S
L
R
I
S
P
S
Site 85
S393
A
T
S
R
R
P
S
S
L
R
I
S
P
S
L
Site 86
S397
R
P
S
S
L
R
I
S
P
S
L
G
A
S
G
Site 87
S399
S
S
L
R
I
S
P
S
L
G
A
S
G
G
A
Site 88
S403
I
S
P
S
L
G
A
S
G
G
A
S
N
W
D
Site 89
S407
L
G
A
S
G
G
A
S
N
W
D
S
Y
S
D
Site 90
S411
G
G
A
S
N
W
D
S
Y
S
D
H
F
T
I
Site 91
Y412
G
A
S
N
W
D
S
Y
S
D
H
F
T
I
E
Site 92
T417
D
S
Y
S
D
H
F
T
I
E
T
C
K
E
T
Site 93
S449
K
K
A
P
K
M
C
S
Q
P
A
V
S
Q
L
Site 94
S462
Q
L
L
S
N
I
R
S
Q
C
I
S
H
T
A
Site 95
T477
L
V
L
Q
G
S
L
T
Q
P
R
S
L
Q
Q
Site 96
S481
G
S
L
T
Q
P
R
S
L
Q
Q
P
S
F
L
Site 97
S486
P
R
S
L
Q
Q
P
S
F
L
V
P
Y
M
L
Site 98
T508
F
I
Q
E
L
V
R
T
T
H
Q
D
E
E
V
Site 99
T509
I
Q
E
L
V
R
T
T
H
Q
D
E
E
V
F
Site 100
S535
A
L
A
A
K
E
C
S
L
D
S
D
Y
F
K
Site 101
S538
A
K
E
C
S
L
D
S
D
Y
F
K
Y
P
L
Site 102
Y540
E
C
S
L
D
S
D
Y
F
K
Y
P
L
M
A
Site 103
Y543
L
D
S
D
Y
F
K
Y
P
L
M
A
L
G
E
Site 104
T554
A
L
G
E
L
C
E
T
K
F
G
K
T
H
P
Site 105
S576
L
R
L
W
L
P
K
S
L
S
P
G
C
G
R
Site 106
S578
L
W
L
P
K
S
L
S
P
G
C
G
R
E
L
Site 107
S589
G
R
E
L
Q
R
L
S
Y
L
G
A
F
F
S
Site 108
S626
L
E
N
T
R
V
V
S
Q
S
L
Q
H
Y
L
Site 109
S628
N
T
R
V
V
S
Q
S
L
Q
H
Y
L
E
L
Site 110
Y632
V
S
Q
S
L
Q
H
Y
L
E
L
G
R
Q
E
Site 111
T653
S
I
L
L
N
G
E
T
R
E
A
A
L
S
Y
Site 112
S682
Q
T
D
D
R
L
V
S
T
D
G
F
M
L
N
Site 113
T705
S
T
K
I
K
L
E
T
V
D
P
T
Y
I
F
Site 114
T709
K
L
E
T
V
D
P
T
Y
I
F
H
P
R
C
Site 115
Y710
L
E
T
V
D
P
T
Y
I
F
H
P
R
C
R
Site 116
T719
F
H
P
R
C
R
I
T
L
P
N
D
E
T
R
Site 117
T725
I
T
L
P
N
D
E
T
R
V
N
A
T
M
E
Site 118
T739
E
D
V
N
D
W
L
T
E
L
Y
G
D
Q
P
Site 119
Y742
N
D
W
L
T
E
L
Y
G
D
Q
P
P
F
S
Site 120
S749
Y
G
D
Q
P
P
F
S
E
P
K
F
P
T
E
Site 121
S768
T
L
H
A
H
H
L
S
I
L
P
S
C
R
R
Site 122
S772
H
H
L
S
I
L
P
S
C
R
R
Y
I
R
R
Site 123
Y776
I
L
P
S
C
R
R
Y
I
R
R
L
R
A
I
Site 124
T789
A
I
R
E
L
N
R
T
V
E
D
L
K
N
N
Site 125
S798
E
D
L
K
N
N
E
S
Q
W
K
D
S
P
L
Site 126
S803
N
E
S
Q
W
K
D
S
P
L
A
T
R
H
R
Site 127
T807
W
K
D
S
P
L
A
T
R
H
R
E
M
L
K
Site 128
T818
E
M
L
K
R
C
K
T
Q
L
K
K
L
V
R
Site 129
S838
D
A
G
L
L
D
E
S
F
L
R
R
C
L
N
Site 130
T866
D
P
A
Y
P
D
I
T
L
P
L
N
S
D
V
Site 131
Y904
Q
Y
S
P
Q
A
L
Y
E
P
C
T
Q
D
I
Site 132
Y929
Q
N
Y
I
R
N
P
Y
L
V
A
K
L
V
E
Site 133
S969
S
T
K
L
L
V
P
S
L
M
K
F
Y
T
D
Site 134
T975
P
S
L
M
K
F
Y
T
D
V
E
H
T
G
A
Site 135
Y987
T
G
A
T
S
E
F
Y
D
K
F
T
I
R
Y
Site 136
T998
T
I
R
Y
H
I
S
T
I
F
K
S
L
W
Q
Site 137
Y1026
S
G
K
Q
F
V
R
Y
I
N
M
L
I
N
D
Site 138
S1041
T
T
F
L
L
D
E
S
L
E
S
L
K
R
I
Site 139
S1044
L
L
D
E
S
L
E
S
L
K
R
I
H
E
V
Site 140
S1074
D
Q
Q
Q
A
R
Q
S
Q
L
A
Q
D
E
R
Site 141
S1083
L
A
Q
D
E
R
V
S
R
S
Y
L
A
L
A
Site 142
Y1086
D
E
R
V
S
R
S
Y
L
A
L
A
T
E
T
Site 143
T1156
K
K
L
L
D
Q
L
T
D
I
Y
L
Q
L
D
Site 144
Y1159
L
D
Q
L
T
D
I
Y
L
Q
L
D
C
A
R
Site 145
S1177
A
I
A
D
D
Q
R
S
Y
S
K
E
L
F
E
Site 146
Y1178
I
A
D
D
Q
R
S
Y
S
K
E
L
F
E
E
Site 147
S1179
A
D
D
Q
R
S
Y
S
K
E
L
F
E
E
V
Site 148
S1188
E
L
F
E
E
V
I
S
K
M
R
K
A
G
I
Site 149
Y1225
N
A
R
A
E
I
D
Y
S
D
A
P
D
E
F
Site 150
S1226
A
R
A
E
I
D
Y
S
D
A
P
D
E
F
R
Site 151
T1239
F
R
D
P
L
M
D
T
L
M
T
D
P
V
R
Site 152
T1242
P
L
M
D
T
L
M
T
D
P
V
R
L
P
S
Site 153
S1249
T
D
P
V
R
L
P
S
G
T
I
M
D
R
S
Site 154
S1256
S
G
T
I
M
D
R
S
I
I
L
R
H
L
L
Site 155
S1265
I
L
R
H
L
L
N
S
P
T
D
P
F
N
R
Site 156
T1267
R
H
L
L
N
S
P
T
D
P
F
N
R
Q
T
Site 157
T1274
T
D
P
F
N
R
Q
T
L
T
E
S
M
L
E
Site 158
T1276
P
F
N
R
Q
T
L
T
E
S
M
L
E
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation