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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IKBKAP
Full Name:
Elongator complex protein 1
Alias:
DYS; elongator complex 1; ELP1; IKAP; ikappaB kinase complex-associated; IKI3; IKK complex-associated; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; p150; TOT1
Type:
Transcription regulation; Protein kinase, regulatory subunit
Mass (Da):
150190
Number AA:
UniProt ID:
O95163
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016591
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0008607
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0006461
GO:0006357
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
R
N
L
K
L
F
R
T
L
E
F
R
D
I
Q
Site 2
S25
P
G
N
P
Q
C
F
S
L
R
T
E
Q
G
T
Site 3
T32
S
L
R
T
E
Q
G
T
V
L
I
G
S
E
H
Site 4
S48
L
I
E
V
D
P
V
S
R
E
V
K
N
E
V
Site 5
S56
R
E
V
K
N
E
V
S
L
V
A
E
G
F
L
Site 6
S68
G
F
L
P
E
D
G
S
G
R
I
V
G
V
Q
Site 7
S116
A
S
G
I
S
V
M
S
W
S
P
D
Q
E
L
Site 8
T160
F
G
E
S
K
F
I
T
V
G
W
G
R
K
E
Site 9
T168
V
G
W
G
R
K
E
T
Q
F
H
G
S
E
G
Site 10
T199
D
D
H
R
P
Q
V
T
W
R
G
D
G
Q
F
Site 11
S232
N
R
E
F
A
L
Q
S
T
S
E
P
V
A
G
Site 12
S251
L
A
W
K
P
S
G
S
L
I
A
S
T
Q
D
Site 13
S255
P
S
G
S
L
I
A
S
T
Q
D
K
P
N
Q
Site 14
T256
S
G
S
L
I
A
S
T
Q
D
K
P
N
Q
Q
Site 15
T279
G
L
L
H
G
H
F
T
L
P
F
L
K
D
E
Site 16
S313
E
D
L
Q
R
E
E
S
S
I
P
K
T
C
V
Site 17
T318
E
E
S
S
I
P
K
T
C
V
Q
L
W
T
V
Site 18
Y331
T
V
G
N
Y
H
W
Y
L
K
Q
S
L
S
F
Site 19
S337
W
Y
L
K
Q
S
L
S
F
S
T
C
G
K
S
Site 20
S339
L
K
Q
S
L
S
F
S
T
C
G
K
S
K
I
Site 21
S385
D
R
S
V
G
D
N
S
S
D
L
S
N
V
A
Site 22
S386
R
S
V
G
D
N
S
S
D
L
S
N
V
A
V
Site 23
S389
G
D
N
S
S
D
L
S
N
V
A
V
I
D
G
Site 24
T428
P
H
P
V
N
Q
V
T
F
L
A
H
P
Q
K
Site 25
Y451
A
S
N
Q
I
S
V
Y
K
C
G
D
C
P
S
Site 26
S458
Y
K
C
G
D
C
P
S
A
D
P
T
V
K
L
Site 27
S471
K
L
G
A
V
G
G
S
G
F
K
V
C
L
R
Site 28
T479
G
F
K
V
C
L
R
T
P
H
L
E
K
R
Y
Site 29
S518
E
D
V
F
L
A
V
S
H
S
E
F
S
P
R
Site 30
S523
A
V
S
H
S
E
F
S
P
R
S
V
I
H
H
Site 31
S526
H
S
E
F
S
P
R
S
V
I
H
H
L
T
A
Site 32
T532
R
S
V
I
H
H
L
T
A
A
S
S
E
M
D
Site 33
S536
H
H
L
T
A
A
S
S
E
M
D
E
E
H
G
Site 34
Y581
A
D
G
Q
I
F
K
Y
L
W
E
S
P
S
L
Site 35
S587
K
Y
L
W
E
S
P
S
L
A
I
K
P
W
K
Site 36
Y605
G
F
P
V
R
F
P
Y
P
C
T
Q
T
E
L
Site 37
T672
L
R
D
A
S
F
K
T
L
Q
A
G
L
S
S
Site 38
S678
K
T
L
Q
A
G
L
S
S
N
H
V
S
H
G
Site 39
S679
T
L
Q
A
G
L
S
S
N
H
V
S
H
G
E
Site 40
S683
G
L
S
S
N
H
V
S
H
G
E
V
L
R
K
Site 41
S695
L
R
K
V
E
R
G
S
R
I
V
T
V
V
P
Site 42
T699
E
R
G
S
R
I
V
T
V
V
P
Q
D
T
K
Site 43
T705
V
T
V
V
P
Q
D
T
K
L
V
L
Q
M
P
Site 44
Y756
R
I
N
L
N
L
I
Y
D
H
N
P
K
V
F
Site 45
T793
E
L
K
E
E
D
V
T
K
T
M
Y
P
A
P
Site 46
T795
K
E
E
D
V
T
K
T
M
Y
P
A
P
V
T
Site 47
Y797
E
D
V
T
K
T
M
Y
P
A
P
V
T
S
S
Site 48
T802
T
M
Y
P
A
P
V
T
S
S
V
Y
L
S
R
Site 49
S803
M
Y
P
A
P
V
T
S
S
V
Y
L
S
R
D
Site 50
S804
Y
P
A
P
V
T
S
S
V
Y
L
S
R
D
P
Site 51
Y806
A
P
V
T
S
S
V
Y
L
S
R
D
P
D
G
Site 52
S808
V
T
S
S
V
Y
L
S
R
D
P
D
G
N
K
Site 53
Y835
E
S
I
N
P
H
K
Y
C
L
S
I
L
T
S
Site 54
S838
N
P
H
K
Y
C
L
S
I
L
T
S
H
V
K
Site 55
S842
Y
C
L
S
I
L
T
S
H
V
K
K
T
T
P
Site 56
T848
T
S
H
V
K
K
T
T
P
E
L
E
I
V
L
Site 57
S867
E
L
Q
G
N
A
P
S
D
P
D
A
V
S
A
Site 58
S873
P
S
D
P
D
A
V
S
A
E
E
A
L
K
Y
Site 59
Y891
L
V
D
V
N
E
L
Y
D
H
S
L
G
T
Y
Site 60
S910
V
L
M
V
A
E
K
S
Q
K
D
P
K
E
Y
Site 61
Y917
S
Q
K
D
P
K
E
Y
L
P
F
L
N
T
L
Site 62
T923
E
Y
L
P
F
L
N
T
L
K
K
M
E
T
N
Site 63
Y931
L
K
K
M
E
T
N
Y
Q
R
F
T
I
D
K
Site 64
T935
E
T
N
Y
Q
R
F
T
I
D
K
Y
L
K
R
Site 65
Y939
Q
R
F
T
I
D
K
Y
L
K
R
Y
E
K
A
Site 66
Y943
I
D
K
Y
L
K
R
Y
E
K
A
I
G
H
L
Site 67
S951
E
K
A
I
G
H
L
S
K
C
G
P
E
Y
F
Site 68
Y957
L
S
K
C
G
P
E
Y
F
P
E
C
L
N
L
Site 69
Y971
L
I
K
D
K
N
L
Y
N
E
A
L
K
L
Y
Site 70
Y978
Y
N
E
A
L
K
L
Y
S
P
S
S
Q
Q
Y
Site 71
S979
N
E
A
L
K
L
Y
S
P
S
S
Q
Q
Y
Q
Site 72
S982
L
K
L
Y
S
P
S
S
Q
Q
Y
Q
D
I
S
Site 73
Y985
Y
S
P
S
S
Q
Q
Y
Q
D
I
S
I
A
Y
Site 74
S989
S
Q
Q
Y
Q
D
I
S
I
A
Y
G
E
H
L
Site 75
Y1002
H
L
M
Q
E
H
M
Y
E
P
A
G
L
M
F
Site 76
T1024
K
A
L
S
A
F
L
T
C
G
N
W
K
Q
A
Site 77
Y1097
E
E
A
L
R
L
V
Y
K
Y
N
R
L
D
I
Site 78
Y1099
A
L
R
L
V
Y
K
Y
N
R
L
D
I
I
E
Site 79
S1126
N
Y
M
A
F
L
D
S
Q
T
A
T
F
S
R
Site 80
T1128
M
A
F
L
D
S
Q
T
A
T
F
S
R
H
K
Site 81
T1130
F
L
D
S
Q
T
A
T
F
S
R
H
K
K
R
Site 82
S1132
D
S
Q
T
A
T
F
S
R
H
K
K
R
L
L
Site 83
S1163
E
V
P
H
G
Q
E
S
D
L
F
S
E
T
S
Site 84
S1167
G
Q
E
S
D
L
F
S
E
T
S
S
V
V
S
Site 85
T1169
E
S
D
L
F
S
E
T
S
S
V
V
S
G
S
Site 86
S1170
S
D
L
F
S
E
T
S
S
V
V
S
G
S
E
Site 87
S1171
D
L
F
S
E
T
S
S
V
V
S
G
S
E
M
Site 88
S1174
S
E
T
S
S
V
V
S
G
S
E
M
S
G
K
Site 89
S1176
T
S
S
V
V
S
G
S
E
M
S
G
K
Y
S
Site 90
S1179
V
V
S
G
S
E
M
S
G
K
Y
S
H
S
N
Site 91
S1183
S
E
M
S
G
K
Y
S
H
S
N
S
R
I
S
Site 92
S1185
M
S
G
K
Y
S
H
S
N
S
R
I
S
A
R
Site 93
S1187
G
K
Y
S
H
S
N
S
R
I
S
A
R
S
S
Site 94
S1190
S
H
S
N
S
R
I
S
A
R
S
S
K
N
R
Site 95
S1193
N
S
R
I
S
A
R
S
S
K
N
R
R
K
A
Site 96
S1194
S
R
I
S
A
R
S
S
K
N
R
R
K
A
E
Site 97
S1206
K
A
E
R
K
K
H
S
L
K
E
G
S
P
L
Site 98
S1211
K
H
S
L
K
E
G
S
P
L
E
D
L
A
L
Site 99
T1275
R
S
L
P
E
I
W
T
L
T
Y
Q
Q
N
S
Site 100
T1277
L
P
E
I
W
T
L
T
Y
Q
Q
N
S
A
T
Site 101
Y1278
P
E
I
W
T
L
T
Y
Q
Q
N
S
A
T
P
Site 102
T1284
T
Y
Q
Q
N
S
A
T
P
V
L
G
P
N
S
Site 103
S1295
G
P
N
S
T
A
N
S
I
M
A
S
Y
Q
Q
Site 104
S1299
T
A
N
S
I
M
A
S
Y
Q
Q
Q
K
T
S
Site 105
T1305
A
S
Y
Q
Q
Q
K
T
S
V
P
V
L
D
A
Site 106
T1324
P
P
K
I
N
R
R
T
Q
W
K
L
S
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation