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Updated November 2019
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Protein Info
Short Name:
RTN3
Full Name:
Reticulon-3
Alias:
ASY interacting protein; ASYIP; HAP; Isoforme III; Neuroendocrine-specific protein-like 2; NSPL2; NSPLII; NSP-like protein II; Of ASY protein; Reticulon 3; Reticulon-3; RTN3-A1
Type:
Endoplasmic reticulum
Mass (Da):
112611
Number AA:
1032
UniProt ID:
O95197
International Prot ID:
IPI00028946
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005783
GO:0005615
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0044419
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
E
P
S
A
A
T
Q
S
H
S
Site 2
T8
M
A
E
P
S
A
A
T
Q
S
H
S
I
S
S
Site 3
S10
E
P
S
A
A
T
Q
S
H
S
I
S
S
S
S
Site 4
S12
S
A
A
T
Q
S
H
S
I
S
S
S
S
F
G
Site 5
S14
A
T
Q
S
H
S
I
S
S
S
S
F
G
A
E
Site 6
S15
T
Q
S
H
S
I
S
S
S
S
F
G
A
E
P
Site 7
S16
Q
S
H
S
I
S
S
S
S
F
G
A
E
P
S
Site 8
S17
S
H
S
I
S
S
S
S
F
G
A
E
P
S
A
Site 9
S23
S
S
F
G
A
E
P
S
A
P
G
G
G
G
S
Site 10
S30
S
A
P
G
G
G
G
S
P
G
A
C
P
A
L
Site 11
T39
G
A
C
P
A
L
G
T
K
S
C
S
S
S
C
Site 12
S41
C
P
A
L
G
T
K
S
C
S
S
S
C
A
D
Site 13
S43
A
L
G
T
K
S
C
S
S
S
C
A
D
S
F
Site 14
S45
G
T
K
S
C
S
S
S
C
A
D
S
F
V
S
Site 15
S49
C
S
S
S
C
A
D
S
F
V
S
S
S
S
S
Site 16
S52
S
C
A
D
S
F
V
S
S
S
S
S
Q
P
V
Site 17
S53
C
A
D
S
F
V
S
S
S
S
S
Q
P
V
S
Site 18
S54
A
D
S
F
V
S
S
S
S
S
Q
P
V
S
L
Site 19
S55
D
S
F
V
S
S
S
S
S
Q
P
V
S
L
F
Site 20
S56
S
F
V
S
S
S
S
S
Q
P
V
S
L
F
S
Site 21
S60
S
S
S
S
Q
P
V
S
L
F
S
T
S
Q
E
Site 22
S63
S
Q
P
V
S
L
F
S
T
S
Q
E
G
L
S
Site 23
T64
Q
P
V
S
L
F
S
T
S
Q
E
G
L
S
S
Site 24
S70
S
T
S
Q
E
G
L
S
S
L
C
S
D
E
P
Site 25
S71
T
S
Q
E
G
L
S
S
L
C
S
D
E
P
S
Site 26
S74
E
G
L
S
S
L
C
S
D
E
P
S
S
E
I
Site 27
S78
S
L
C
S
D
E
P
S
S
E
I
M
T
S
S
Site 28
S79
L
C
S
D
E
P
S
S
E
I
M
T
S
S
F
Site 29
T83
E
P
S
S
E
I
M
T
S
S
F
L
S
S
S
Site 30
S84
P
S
S
E
I
M
T
S
S
F
L
S
S
S
E
Site 31
S85
S
S
E
I
M
T
S
S
F
L
S
S
S
E
I
Site 32
S88
I
M
T
S
S
F
L
S
S
S
E
I
H
N
T
Site 33
S89
M
T
S
S
F
L
S
S
S
E
I
H
N
T
G
Site 34
S90
T
S
S
F
L
S
S
S
E
I
H
N
T
G
L
Site 35
T95
S
S
S
E
I
H
N
T
G
L
T
I
L
H
G
Site 36
S105
T
I
L
H
G
E
K
S
H
V
L
G
S
Q
P
Site 37
S110
E
K
S
H
V
L
G
S
Q
P
I
L
A
K
E
Site 38
S137
M
E
K
P
Q
G
T
S
N
N
V
S
D
S
S
Site 39
S141
Q
G
T
S
N
N
V
S
D
S
S
V
S
L
A
Site 40
S143
T
S
N
N
V
S
D
S
S
V
S
L
A
A
G
Site 41
S157
G
V
H
C
D
R
P
S
I
P
A
S
F
P
E
Site 42
S161
D
R
P
S
I
P
A
S
F
P
E
H
P
A
F
Site 43
T184
E
E
Q
I
D
K
E
T
K
N
P
N
G
V
S
Site 44
T206
L
D
A
D
D
R
F
T
L
L
T
A
Q
K
P
Site 45
T209
D
D
R
F
T
L
L
T
A
Q
K
P
P
T
E
Site 46
T215
L
T
A
Q
K
P
P
T
E
Y
S
K
V
E
G
Site 47
Y217
A
Q
K
P
P
T
E
Y
S
K
V
E
G
I
Y
Site 48
T225
S
K
V
E
G
I
Y
T
Y
S
L
S
P
S
K
Site 49
S227
V
E
G
I
Y
T
Y
S
L
S
P
S
K
V
S
Site 50
S229
G
I
Y
T
Y
S
L
S
P
S
K
V
S
G
D
Site 51
S231
Y
T
Y
S
L
S
P
S
K
V
S
G
D
D
V
Site 52
S243
D
D
V
I
E
K
D
S
P
E
S
P
F
E
V
Site 53
S246
I
E
K
D
S
P
E
S
P
F
E
V
I
I
D
Site 54
S264
F
D
K
E
F
K
D
S
Y
K
E
S
T
D
D
Site 55
Y265
D
K
E
F
K
D
S
Y
K
E
S
T
D
D
F
Site 56
S268
F
K
D
S
Y
K
E
S
T
D
D
F
G
S
W
Site 57
T269
K
D
S
Y
K
E
S
T
D
D
F
G
S
W
S
Site 58
S274
E
S
T
D
D
F
G
S
W
S
V
H
T
D
K
Site 59
S276
T
D
D
F
G
S
W
S
V
H
T
D
K
E
S
Site 60
T279
F
G
S
W
S
V
H
T
D
K
E
S
S
E
D
Site 61
S283
S
V
H
T
D
K
E
S
S
E
D
I
S
E
T
Site 62
S284
V
H
T
D
K
E
S
S
E
D
I
S
E
T
N
Site 63
S288
K
E
S
S
E
D
I
S
E
T
N
D
K
L
F
Site 64
Y305
R
N
K
E
A
G
R
Y
P
M
S
A
L
L
S
Site 65
S308
E
A
G
R
Y
P
M
S
A
L
L
S
R
Q
F
Site 66
S312
Y
P
M
S
A
L
L
S
R
Q
F
S
H
T
N
Site 67
S316
A
L
L
S
R
Q
F
S
H
T
N
A
A
L
E
Site 68
T318
L
S
R
Q
F
S
H
T
N
A
A
L
E
E
V
Site 69
T352
V
P
Q
V
K
Q
Q
T
D
K
S
S
D
C
I
Site 70
S355
V
K
Q
Q
T
D
K
S
S
D
C
I
T
K
T
Site 71
S356
K
Q
Q
T
D
K
S
S
D
C
I
T
K
T
T
Site 72
T360
D
K
S
S
D
C
I
T
K
T
T
G
L
D
M
Site 73
T362
S
S
D
C
I
T
K
T
T
G
L
D
M
S
E
Site 74
S368
K
T
T
G
L
D
M
S
E
Y
N
S
E
I
P
Site 75
Y370
T
G
L
D
M
S
E
Y
N
S
E
I
P
V
V
Site 76
S372
L
D
M
S
E
Y
N
S
E
I
P
V
V
N
L
Site 77
T387
K
T
S
T
H
Q
K
T
P
V
C
S
I
D
G
Site 78
S391
H
Q
K
T
P
V
C
S
I
D
G
S
T
P
I
Site 79
S395
P
V
C
S
I
D
G
S
T
P
I
T
K
S
T
Site 80
T396
V
C
S
I
D
G
S
T
P
I
T
K
S
T
G
Site 81
T399
I
D
G
S
T
P
I
T
K
S
T
G
D
W
A
Site 82
S401
G
S
T
P
I
T
K
S
T
G
D
W
A
E
A
Site 83
S409
T
G
D
W
A
E
A
S
L
Q
Q
E
N
A
I
Site 84
T417
L
Q
Q
E
N
A
I
T
G
K
P
V
P
D
S
Site 85
S424
T
G
K
P
V
P
D
S
L
N
S
T
K
E
F
Site 86
S427
P
V
P
D
S
L
N
S
T
K
E
F
S
I
K
Site 87
T428
V
P
D
S
L
N
S
T
K
E
F
S
I
K
G
Site 88
S432
L
N
S
T
K
E
F
S
I
K
G
V
Q
G
N
Site 89
T446
N
M
Q
K
Q
D
D
T
L
A
E
L
P
G
S
Site 90
S453
T
L
A
E
L
P
G
S
P
P
E
K
C
D
S
Site 91
S460
S
P
P
E
K
C
D
S
L
G
S
G
V
A
T
Site 92
S485
K
D
E
M
D
W
Q
S
S
A
L
G
E
I
T
Site 93
T492
S
S
A
L
G
E
I
T
E
A
D
S
S
G
E
Site 94
S496
G
E
I
T
E
A
D
S
S
G
E
S
D
D
T
Site 95
S497
E
I
T
E
A
D
S
S
G
E
S
D
D
T
V
Site 96
S500
E
A
D
S
S
G
E
S
D
D
T
V
I
E
D
Site 97
T503
S
S
G
E
S
D
D
T
V
I
E
D
I
T
A
Site 98
T509
D
T
V
I
E
D
I
T
A
D
T
S
F
E
N
Site 99
S513
E
D
I
T
A
D
T
S
F
E
N
N
K
I
Q
Site 100
S544
R
E
I
K
E
I
P
S
C
E
R
E
E
K
T
Site 101
S552
C
E
R
E
E
K
T
S
K
N
F
E
E
L
V
Site 102
S560
K
N
F
E
E
L
V
S
D
S
E
L
H
Q
D
Site 103
S575
Q
P
D
I
L
G
R
S
P
A
S
E
A
A
C
Site 104
S583
P
A
S
E
A
A
C
S
K
V
P
D
T
N
V
Site 105
T588
A
C
S
K
V
P
D
T
N
V
S
L
E
D
V
Site 106
S591
K
V
P
D
T
N
V
S
L
E
D
V
S
E
V
Site 107
T605
V
A
P
E
K
P
I
T
T
E
N
P
K
L
P
Site 108
T606
A
P
E
K
P
I
T
T
E
N
P
K
L
P
S
Site 109
S613
T
E
N
P
K
L
P
S
T
V
S
P
N
V
F
Site 110
T614
E
N
P
K
L
P
S
T
V
S
P
N
V
F
N
Site 111
S616
P
K
L
P
S
T
V
S
P
N
V
F
N
E
T
Site 112
S626
V
F
N
E
T
E
F
S
L
N
V
T
T
S
A
Site 113
T630
T
E
F
S
L
N
V
T
T
S
A
Y
L
E
S
Site 114
Y634
L
N
V
T
T
S
A
Y
L
E
S
L
H
G
K
Site 115
S649
N
V
K
H
I
D
D
S
S
P
E
D
L
I
A
Site 116
S650
V
K
H
I
D
D
S
S
P
E
D
L
I
A
A
Site 117
S669
R
D
K
G
I
V
D
S
E
R
N
A
F
K
A
Site 118
T682
K
A
I
S
E
K
M
T
D
F
K
T
T
P
P
Site 119
T686
E
K
M
T
D
F
K
T
T
P
P
V
E
V
L
Site 120
T687
K
M
T
D
F
K
T
T
P
P
V
E
V
L
H
Site 121
S698
E
V
L
H
E
N
E
S
G
G
S
E
I
K
D
Site 122
S701
H
E
N
E
S
G
G
S
E
I
K
D
I
G
S
Site 123
S708
S
E
I
K
D
I
G
S
K
Y
S
E
Q
S
K
Site 124
Y710
I
K
D
I
G
S
K
Y
S
E
Q
S
K
E
T
Site 125
S714
G
S
K
Y
S
E
Q
S
K
E
T
N
G
S
E
Site 126
S720
Q
S
K
E
T
N
G
S
E
P
L
G
V
F
P
Site 127
S735
T
Q
G
T
P
V
A
S
L
D
L
E
Q
E
Q
Site 128
S759
G
E
R
Q
V
E
K
S
T
S
A
Q
R
D
A
Site 129
T777
S
E
E
V
L
K
Q
T
F
T
F
A
P
E
S
Site 130
T779
E
V
L
K
Q
T
F
T
F
A
P
E
S
W
P
Site 131
S784
T
F
T
F
A
P
E
S
W
P
Q
R
S
Y
D
Site 132
S789
P
E
S
W
P
Q
R
S
Y
D
I
L
E
R
N
Site 133
Y790
E
S
W
P
Q
R
S
Y
D
I
L
E
R
N
V
Site 134
S801
E
R
N
V
K
N
G
S
D
L
G
I
S
Q
K
Site 135
S806
N
G
S
D
L
G
I
S
Q
K
P
I
T
I
R
Site 136
T811
G
I
S
Q
K
P
I
T
I
R
E
T
T
R
V
Site 137
T815
K
P
I
T
I
R
E
T
T
R
V
D
A
V
S
Site 138
T816
P
I
T
I
R
E
T
T
R
V
D
A
V
S
S
Site 139
S822
T
T
R
V
D
A
V
S
S
L
S
K
T
E
L
Site 140
S823
T
R
V
D
A
V
S
S
L
S
K
T
E
L
V
Site 141
T827
A
V
S
S
L
S
K
T
E
L
V
K
K
H
V
Site 142
S906
V
I
Q
A
V
Q
K
S
E
E
G
H
P
F
K
Site 143
Y915
E
G
H
P
F
K
A
Y
L
D
V
D
I
T
L
Site 144
S923
L
D
V
D
I
T
L
S
S
E
A
F
H
N
Y
Site 145
Y930
S
S
E
A
F
H
N
Y
M
N
A
A
M
V
H
Site 146
Y969
V
F
M
W
L
M
T
Y
V
G
A
V
F
N
G
Site 147
Y997
V
P
I
V
Y
E
K
Y
K
T
Q
I
D
H
Y
Site 148
T999
I
V
Y
E
K
Y
K
T
Q
I
D
H
Y
V
G
Site 149
Y1004
Y
K
T
Q
I
D
H
Y
V
G
I
A
R
D
Q
Site 150
T1012
V
G
I
A
R
D
Q
T
K
S
I
V
E
K
I
Site 151
S1014
I
A
R
D
Q
T
K
S
I
V
E
K
I
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation