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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL2
Full Name:
Kelch-like protein 2
Alias:
ABP-KELCH; actin-binding protein Mayven; kelch-like 2; kelch-like 2, Mayven; MAV; MAYVEN
Type:
Mass (Da):
65970
Number AA:
UniProt ID:
O95198
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
G
H
Q
K
P
L
D
S
K
D
D
N
T
E
K
Site 2
T26
L
D
S
K
D
D
N
T
E
K
H
C
P
V
T
Site 3
S51
K
V
M
N
E
L
R
S
Q
N
L
L
C
D
V
Site 4
Y80
V
L
A
A
C
S
P
Y
F
H
A
M
F
T
G
Site 5
T86
P
Y
F
H
A
M
F
T
G
E
M
S
E
S
R
Site 6
S92
F
T
G
E
M
S
E
S
R
A
K
R
V
R
I
Site 7
T106
I
K
E
V
D
G
W
T
L
R
M
L
I
D
Y
Site 8
T122
Y
T
A
E
I
Q
V
T
E
E
N
V
Q
V
L
Site 9
T144
Q
L
Q
D
V
K
K
T
C
C
E
F
L
E
S
Site 10
T212
L
I
S
S
D
K
L
T
I
S
S
E
E
K
V
Site 11
S214
S
S
D
K
L
T
I
S
S
E
E
K
V
F
E
Site 12
Y254
L
P
L
L
P
R
E
Y
L
V
Q
R
V
E
E
Site 13
S269
E
A
L
V
K
N
S
S
A
C
K
D
Y
L
I
Site 14
Y274
N
S
S
A
C
K
D
Y
L
I
E
A
M
K
Y
Site 15
Y281
Y
L
I
E
A
M
K
Y
H
L
L
P
T
E
Q
Site 16
T286
M
K
Y
H
L
L
P
T
E
Q
R
I
L
M
K
Site 17
S294
E
Q
R
I
L
M
K
S
V
R
T
R
L
R
T
Site 18
T301
S
V
R
T
R
L
R
T
P
M
N
L
P
K
L
Site 19
Y326
A
I
R
S
V
E
C
Y
D
F
K
E
E
R
W
Site 20
S341
H
Q
V
A
E
L
P
S
R
R
C
R
A
G
M
Site 21
T369
N
G
S
L
R
V
R
T
V
D
S
Y
D
P
V
Site 22
S372
L
R
V
R
T
V
D
S
Y
D
P
V
K
D
Q
Site 23
Y373
R
V
R
T
V
D
S
Y
D
P
V
K
D
Q
W
Site 24
S382
P
V
K
D
Q
W
T
S
V
A
N
M
R
D
R
Site 25
S391
A
N
M
R
D
R
R
S
T
L
G
A
A
V
L
Site 26
T392
N
M
R
D
R
R
S
T
L
G
A
A
V
L
N
Site 27
S415
F
D
G
S
T
G
L
S
S
V
E
A
Y
N
I
Site 28
S416
D
G
S
T
G
L
S
S
V
E
A
Y
N
I
K
Site 29
Y420
G
L
S
S
V
E
A
Y
N
I
K
S
N
E
W
Site 30
T435
F
H
V
A
P
M
N
T
R
R
S
S
V
G
V
Site 31
S439
P
M
N
T
R
R
S
S
V
G
V
G
V
V
G
Site 32
S459
V
G
G
Y
D
G
A
S
R
Q
C
L
S
T
V
Site 33
S464
G
A
S
R
Q
C
L
S
T
V
E
C
Y
N
A
Site 34
T465
A
S
R
Q
C
L
S
T
V
E
C
Y
N
A
T
Site 35
S483
W
T
Y
I
A
E
M
S
T
R
R
S
G
A
G
Site 36
S487
A
E
M
S
T
R
R
S
G
A
G
V
G
V
L
Site 37
S512
D
G
P
L
V
R
K
S
V
E
V
Y
D
P
T
Site 38
Y516
V
R
K
S
V
E
V
Y
D
P
T
T
N
A
W
Site 39
T519
S
V
E
V
Y
D
P
T
T
N
A
W
R
Q
V
Site 40
T520
V
E
V
Y
D
P
T
T
N
A
W
R
Q
V
A
Site 41
S559
D
G
S
C
N
L
A
S
V
E
Y
Y
N
P
T
Site 42
Y562
C
N
L
A
S
V
E
Y
Y
N
P
T
T
D
K
Site 43
Y563
N
L
A
S
V
E
Y
Y
N
P
T
T
D
K
W
Site 44
T571
N
P
T
T
D
K
W
T
V
V
S
S
C
M
S
Site 45
S574
T
D
K
W
T
V
V
S
S
C
M
S
T
G
R
Site 46
S575
D
K
W
T
V
V
S
S
C
M
S
T
G
R
S
Site 47
S578
T
V
V
S
S
C
M
S
T
G
R
S
Y
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation