PhosphoNET

           
Protein Info 
   
Short Name:  ABCC6
Full Name:  Multidrug resistance-associated protein 6
Alias:  ATP-binding cassette sub-family C member 6;Anthracycline resistance-associated protein;Multi-specific organic anion transporter E
Type: 
Mass (Da):  164906
Number AA:  1503
UniProt ID:  O95255
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S66GRGYLWMSPLFKAKM
Site 2T98LWKIQQGTPEAPEFL
Site 3T124FAVFLIHTERKKGVQ
Site 4S132ERKKGVQSSGVLFGY
Site 5S133RKKGVQSSGVLFGYW
Site 6S162ASGAGFQSDPVRHLS
Site 7T206QSNPCPETGAAFPSK
Site 8Y227SGLVWRGYRRPLRPK
Site 9S238LRPKDLWSLGRENSS
Site 10S244WSLGRENSSEELVSR
Site 11S245SLGRENSSEELVSRL
Site 12S250NSSEELVSRLEKEWM
Site 13S261KEWMRNRSAARRHNK
Site 14S278AFKRKGGSGMKAPET
Site 15T285SGMKAPETEPFLRQE
Site 16S294PFLRQEGSQWRPLLK
Site 17Y372LFEQQNMYRLKVLQM
Site 18S397YRKVLALSSGSRKAS
Site 19S398RKVLALSSGSRKASA
Site 20S404SSGSRKASAVGDVVN
Site 21T421SVDVQRLTESVLYLN
Site 22S486EQMRQKDSRARLTSS
Site 23T491KDSRARLTSSILRNS
Site 24S492DSRARLTSSILRNSK
Site 25S493SRARLTSSILRNSKT
Site 26S498TSSILRNSKTIKFHG
Site 27T500SILRNSKTIKFHGWE
Site 28S528ELGALRTSGLLFSVS
Site 29S617VDPGVVDSSSSGSAA
Site 30S618DPGVVDSSSSGSAAG
Site 31S619PGVVDSSSSGSAAGK
Site 32S620GVVDSSSSGSAAGKD
Site 33S622VDSSSSGSAAGKDCI
Site 34S639HSATFAWSQESPPCL
Site 35S642TFAWSQESPPCLHRI
Site 36T652CLHRINLTVPQGCLL
Site 37S737ALQPDVDSFPEGIHT
Site 38T744SFPEGIHTSIGEQGM
Site 39S745FPEGIHTSIGEQGMN
Site 40S754GEQGMNLSGGQKQRL
Site 41S762GGQKQRLSLARAVYR
Site 42S836GAIAEMGSYQELLQR
Site 43Y837AIAEMGSYQELLQRK
Site 44T865GDRGEGETEPGTSTK
Site 45T869EGETEPGTSTKDPRG
Site 46S870GETEPGTSTKDPRGT
Site 47T871ETEPGTSTKDPRGTS
Site 48T877STKDPRGTSAGRRPE
Site 49S878TKDPRGTSAGRRPEL
Site 50S890PELRRERSIKSVPEK
Site 51S893RRERSIKSVPEKDRT
Site 52T900SVPEKDRTTSEAQTE
Site 53T901VPEKDRTTSEAQTEV
Site 54S902PEKDRTTSEAQTEVP
Site 55T906RTTSEAQTEVPLDDP
Site 56Y927AGKDSIQYGRVKATV
Site 57S1034DVVRSPISFFERTPI
Site 58S1049GHLLNRFSKETDTVD
Site 59T1054RFSKETDTVDVDIPD
Site 60S1117CQLRRLESASYSSVC
Site 61S1119LRRLESASYSSVCSH
Site 62Y1120RRLESASYSSVCSHM
Site 63S1121RLESASYSSVCSHMA
Site 64S1122LESASYSSVCSHMAE
Site 65S1125ASYSSVCSHMAETFQ
Site 66S1134MAETFQGSTVVRAFR
Site 67S1157NNARVDESQRISFPR
Site 68S1161VDESQRISFPRLVAD
Site 69S1232DLENSIVSVERMQDY
Site 70Y1239SVERMQDYAWTPKEA
Site 71T1252EAPWRLPTCAAQPPW
Site 72S1306GRTGAGKSSLASGLL
Site 73S1307RTGAGKSSLASGLLR
Site 74S1310AGKSSLASGLLRLQE
Site 75S1343HTLRSRISIIPQDPI
Site 76S1367LDLLQEHSDEAIWAA
Site 77S1403ADRGEDLSVGQKQLL
Site 78T1436TAAVDPGTELQMQAM
Site 79S1480DKGQVAESGSPAQLL
Site 80S1482GQVAESGSPAQLLAQ
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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