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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCC6
Full Name:
Multidrug resistance-associated protein 6
Alias:
ATP-binding cassette sub-family C member 6;Anthracycline resistance-associated protein;Multi-specific organic anion transporter E
Type:
Mass (Da):
164906
Number AA:
1503
UniProt ID:
O95255
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S66
G
R
G
Y
L
W
M
S
P
L
F
K
A
K
M
Site 2
T98
L
W
K
I
Q
Q
G
T
P
E
A
P
E
F
L
Site 3
T124
F
A
V
F
L
I
H
T
E
R
K
K
G
V
Q
Site 4
S132
E
R
K
K
G
V
Q
S
S
G
V
L
F
G
Y
Site 5
S133
R
K
K
G
V
Q
S
S
G
V
L
F
G
Y
W
Site 6
S162
A
S
G
A
G
F
Q
S
D
P
V
R
H
L
S
Site 7
T206
Q
S
N
P
C
P
E
T
G
A
A
F
P
S
K
Site 8
Y227
S
G
L
V
W
R
G
Y
R
R
P
L
R
P
K
Site 9
S238
L
R
P
K
D
L
W
S
L
G
R
E
N
S
S
Site 10
S244
W
S
L
G
R
E
N
S
S
E
E
L
V
S
R
Site 11
S245
S
L
G
R
E
N
S
S
E
E
L
V
S
R
L
Site 12
S250
N
S
S
E
E
L
V
S
R
L
E
K
E
W
M
Site 13
S261
K
E
W
M
R
N
R
S
A
A
R
R
H
N
K
Site 14
S278
A
F
K
R
K
G
G
S
G
M
K
A
P
E
T
Site 15
T285
S
G
M
K
A
P
E
T
E
P
F
L
R
Q
E
Site 16
S294
P
F
L
R
Q
E
G
S
Q
W
R
P
L
L
K
Site 17
Y372
L
F
E
Q
Q
N
M
Y
R
L
K
V
L
Q
M
Site 18
S397
Y
R
K
V
L
A
L
S
S
G
S
R
K
A
S
Site 19
S398
R
K
V
L
A
L
S
S
G
S
R
K
A
S
A
Site 20
S404
S
S
G
S
R
K
A
S
A
V
G
D
V
V
N
Site 21
T421
S
V
D
V
Q
R
L
T
E
S
V
L
Y
L
N
Site 22
S486
E
Q
M
R
Q
K
D
S
R
A
R
L
T
S
S
Site 23
T491
K
D
S
R
A
R
L
T
S
S
I
L
R
N
S
Site 24
S492
D
S
R
A
R
L
T
S
S
I
L
R
N
S
K
Site 25
S493
S
R
A
R
L
T
S
S
I
L
R
N
S
K
T
Site 26
S498
T
S
S
I
L
R
N
S
K
T
I
K
F
H
G
Site 27
T500
S
I
L
R
N
S
K
T
I
K
F
H
G
W
E
Site 28
S528
E
L
G
A
L
R
T
S
G
L
L
F
S
V
S
Site 29
S617
V
D
P
G
V
V
D
S
S
S
S
G
S
A
A
Site 30
S618
D
P
G
V
V
D
S
S
S
S
G
S
A
A
G
Site 31
S619
P
G
V
V
D
S
S
S
S
G
S
A
A
G
K
Site 32
S620
G
V
V
D
S
S
S
S
G
S
A
A
G
K
D
Site 33
S622
V
D
S
S
S
S
G
S
A
A
G
K
D
C
I
Site 34
S639
H
S
A
T
F
A
W
S
Q
E
S
P
P
C
L
Site 35
S642
T
F
A
W
S
Q
E
S
P
P
C
L
H
R
I
Site 36
T652
C
L
H
R
I
N
L
T
V
P
Q
G
C
L
L
Site 37
S737
A
L
Q
P
D
V
D
S
F
P
E
G
I
H
T
Site 38
T744
S
F
P
E
G
I
H
T
S
I
G
E
Q
G
M
Site 39
S745
F
P
E
G
I
H
T
S
I
G
E
Q
G
M
N
Site 40
S754
G
E
Q
G
M
N
L
S
G
G
Q
K
Q
R
L
Site 41
S762
G
G
Q
K
Q
R
L
S
L
A
R
A
V
Y
R
Site 42
S836
G
A
I
A
E
M
G
S
Y
Q
E
L
L
Q
R
Site 43
Y837
A
I
A
E
M
G
S
Y
Q
E
L
L
Q
R
K
Site 44
T865
G
D
R
G
E
G
E
T
E
P
G
T
S
T
K
Site 45
T869
E
G
E
T
E
P
G
T
S
T
K
D
P
R
G
Site 46
S870
G
E
T
E
P
G
T
S
T
K
D
P
R
G
T
Site 47
T871
E
T
E
P
G
T
S
T
K
D
P
R
G
T
S
Site 48
T877
S
T
K
D
P
R
G
T
S
A
G
R
R
P
E
Site 49
S878
T
K
D
P
R
G
T
S
A
G
R
R
P
E
L
Site 50
S890
P
E
L
R
R
E
R
S
I
K
S
V
P
E
K
Site 51
S893
R
R
E
R
S
I
K
S
V
P
E
K
D
R
T
Site 52
T900
S
V
P
E
K
D
R
T
T
S
E
A
Q
T
E
Site 53
T901
V
P
E
K
D
R
T
T
S
E
A
Q
T
E
V
Site 54
S902
P
E
K
D
R
T
T
S
E
A
Q
T
E
V
P
Site 55
T906
R
T
T
S
E
A
Q
T
E
V
P
L
D
D
P
Site 56
Y927
A
G
K
D
S
I
Q
Y
G
R
V
K
A
T
V
Site 57
S1034
D
V
V
R
S
P
I
S
F
F
E
R
T
P
I
Site 58
S1049
G
H
L
L
N
R
F
S
K
E
T
D
T
V
D
Site 59
T1054
R
F
S
K
E
T
D
T
V
D
V
D
I
P
D
Site 60
S1117
C
Q
L
R
R
L
E
S
A
S
Y
S
S
V
C
Site 61
S1119
L
R
R
L
E
S
A
S
Y
S
S
V
C
S
H
Site 62
Y1120
R
R
L
E
S
A
S
Y
S
S
V
C
S
H
M
Site 63
S1121
R
L
E
S
A
S
Y
S
S
V
C
S
H
M
A
Site 64
S1122
L
E
S
A
S
Y
S
S
V
C
S
H
M
A
E
Site 65
S1125
A
S
Y
S
S
V
C
S
H
M
A
E
T
F
Q
Site 66
S1134
M
A
E
T
F
Q
G
S
T
V
V
R
A
F
R
Site 67
S1157
N
N
A
R
V
D
E
S
Q
R
I
S
F
P
R
Site 68
S1161
V
D
E
S
Q
R
I
S
F
P
R
L
V
A
D
Site 69
S1232
D
L
E
N
S
I
V
S
V
E
R
M
Q
D
Y
Site 70
Y1239
S
V
E
R
M
Q
D
Y
A
W
T
P
K
E
A
Site 71
T1252
E
A
P
W
R
L
P
T
C
A
A
Q
P
P
W
Site 72
S1306
G
R
T
G
A
G
K
S
S
L
A
S
G
L
L
Site 73
S1307
R
T
G
A
G
K
S
S
L
A
S
G
L
L
R
Site 74
S1310
A
G
K
S
S
L
A
S
G
L
L
R
L
Q
E
Site 75
S1343
H
T
L
R
S
R
I
S
I
I
P
Q
D
P
I
Site 76
S1367
L
D
L
L
Q
E
H
S
D
E
A
I
W
A
A
Site 77
S1403
A
D
R
G
E
D
L
S
V
G
Q
K
Q
L
L
Site 78
T1436
T
A
A
V
D
P
G
T
E
L
Q
M
Q
A
M
Site 79
S1480
D
K
G
Q
V
A
E
S
G
S
P
A
Q
L
L
Site 80
S1482
G
Q
V
A
E
S
G
S
P
A
Q
L
L
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation