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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE8B
Full Name:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Alias:
EC 3.1.4.17; Phosphodiesterase 8B
Type:
Enzyme, phosphodiesterase, nucleotide metabolism
Mass (Da):
98979
Number AA:
885
UniProt ID:
O95263
International Prot ID:
IPI00294049
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0000156
GO:0000287
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0000160
GO:0006139
GO:0006198
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
S
I
H
V
S
Q
S
G
V
I
Y
C
R
D
Site 2
Y16
V
S
Q
S
G
V
I
Y
C
R
D
S
D
E
S
Site 3
S20
G
V
I
Y
C
R
D
S
D
E
S
S
S
P
R
Site 4
S23
Y
C
R
D
S
D
E
S
S
S
P
R
Q
T
T
Site 5
S24
C
R
D
S
D
E
S
S
S
P
R
Q
T
T
S
Site 6
S25
R
D
S
D
E
S
S
S
P
R
Q
T
T
S
V
Site 7
T29
E
S
S
S
P
R
Q
T
T
S
V
S
Q
G
P
Site 8
T30
S
S
S
P
R
Q
T
T
S
V
S
Q
G
P
A
Site 9
S31
S
S
P
R
Q
T
T
S
V
S
Q
G
P
A
A
Site 10
S33
P
R
Q
T
T
S
V
S
Q
G
P
A
A
P
L
Site 11
S56
A
A
D
A
I
P
P
S
R
A
S
G
P
P
S
Site 12
S59
A
I
P
P
S
R
A
S
G
P
P
S
V
A
R
Site 13
S63
S
R
A
S
G
P
P
S
V
A
R
V
R
R
A
Site 14
T72
A
R
V
R
R
A
R
T
E
L
G
S
G
S
S
Site 15
S76
R
A
R
T
E
L
G
S
G
S
S
A
G
S
A
Site 16
S78
R
T
E
L
G
S
G
S
S
A
G
S
A
A
P
Site 17
S82
G
S
G
S
S
A
G
S
A
A
P
A
A
T
T
Site 18
S90
A
A
P
A
A
T
T
S
R
G
R
R
R
H
C
Site 19
S99
G
R
R
R
H
C
C
S
S
A
E
A
E
T
Q
Site 20
S100
R
R
R
H
C
C
S
S
A
E
A
E
T
Q
T
Site 21
Y109
E
A
E
T
Q
T
C
Y
T
S
V
K
Q
V
S
Site 22
S111
E
T
Q
T
C
Y
T
S
V
K
Q
V
S
S
A
Site 23
T128
R
I
G
P
M
R
L
T
Q
D
P
I
Q
V
L
Site 24
S143
L
I
F
A
K
E
D
S
Q
S
D
G
F
W
W
Site 25
Y157
W
A
C
D
R
A
G
Y
R
C
N
I
A
R
T
Site 26
T164
Y
R
C
N
I
A
R
T
P
E
S
A
L
E
C
Site 27
S167
N
I
A
R
T
P
E
S
A
L
E
C
F
L
D
Site 28
T187
I
V
I
D
H
R
Q
T
Q
N
F
D
A
E
A
Site 29
S198
D
A
E
A
V
C
R
S
I
R
A
T
N
P
S
Site 30
T202
V
C
R
S
I
R
A
T
N
P
S
E
H
T
V
Site 31
S205
S
I
R
A
T
N
P
S
E
H
T
V
I
L
A
Site 32
S218
L
A
V
V
S
R
V
S
D
D
H
E
E
A
S
Site 33
S225
S
D
D
H
E
E
A
S
V
L
P
L
L
H
A
Site 34
Y248
N
S
S
I
I
A
C
Y
N
E
L
I
Q
I
E
Site 35
Y293
S
D
D
H
V
I
Q
Y
V
N
P
A
F
E
R
Site 36
Y304
A
F
E
R
M
M
G
Y
H
K
G
E
L
L
G
Site 37
S320
E
L
A
D
L
P
K
S
D
K
N
R
A
D
L
Site 38
Y345
G
K
E
W
Q
G
V
Y
Y
A
R
R
K
S
G
Site 39
Y346
K
E
W
Q
G
V
Y
Y
A
R
R
K
S
G
D
Site 40
S351
V
Y
Y
A
R
R
K
S
G
D
S
I
Q
Q
H
Site 41
S354
A
R
R
K
S
G
D
S
I
Q
Q
H
V
K
I
Site 42
T362
I
Q
Q
H
V
K
I
T
P
V
I
G
Q
G
G
Site 43
S397
I
H
K
I
H
R
D
S
G
D
N
S
Q
T
E
Site 44
S401
H
R
D
S
G
D
N
S
Q
T
E
P
H
S
F
Site 45
T403
D
S
G
D
N
S
Q
T
E
P
H
S
F
R
Y
Site 46
S407
N
S
Q
T
E
P
H
S
F
R
Y
K
N
R
R
Site 47
S417
Y
K
N
R
R
K
E
S
I
D
V
K
S
I
S
Site 48
S422
K
E
S
I
D
V
K
S
I
S
S
R
G
S
D
Site 49
S424
S
I
D
V
K
S
I
S
S
R
G
S
D
A
P
Site 50
S428
K
S
I
S
S
R
G
S
D
A
P
S
L
Q
N
Site 51
S432
S
R
G
S
D
A
P
S
L
Q
N
R
R
Y
P
Site 52
Y438
P
S
L
Q
N
R
R
Y
P
S
M
A
R
I
H
Site 53
S440
L
Q
N
R
R
Y
P
S
M
A
R
I
H
S
M
Site 54
S446
P
S
M
A
R
I
H
S
M
T
I
E
A
P
I
Site 55
S467
I
N
A
A
Q
E
N
S
P
V
T
V
A
E
A
Site 56
T470
A
Q
E
N
S
P
V
T
V
A
E
A
L
D
R
Site 57
T484
R
V
L
E
I
L
R
T
T
E
L
Y
S
P
Q
Site 58
Y488
I
L
R
T
T
E
L
Y
S
P
Q
L
G
T
K
Site 59
S489
L
R
T
T
E
L
Y
S
P
Q
L
G
T
K
D
Site 60
T501
T
K
D
E
D
P
H
T
S
D
L
V
G
G
L
Site 61
S502
K
D
E
D
P
H
T
S
D
L
V
G
G
L
M
Site 62
S517
T
D
G
L
R
R
L
S
G
N
E
Y
V
F
T
Site 63
Y521
R
R
L
S
G
N
E
Y
V
F
T
K
N
V
H
Site 64
T524
S
G
N
E
Y
V
F
T
K
N
V
H
Q
S
H
Site 65
Y614
N
Y
H
S
S
N
A
Y
H
N
S
T
H
A
A
Site 66
S639
G
K
E
R
V
K
G
S
L
D
Q
L
D
E
V
Site 67
S665
D
H
P
G
R
T
N
S
F
L
C
N
A
G
S
Site 68
T696
T
A
L
A
F
Q
L
T
V
K
D
T
K
C
N
Site 69
Y713
K
N
I
D
R
N
H
Y
R
T
L
R
Q
A
I
Site 70
T715
I
D
R
N
H
Y
R
T
L
R
Q
A
I
I
D
Site 71
S754
M
A
A
E
I
E
G
S
D
C
E
C
N
P
A
Site 72
Y803
A
G
R
I
S
E
E
Y
F
A
Q
T
D
E
E
Site 73
T826
M
P
V
F
D
R
N
T
C
S
I
P
K
S
Q
Site 74
S828
V
F
D
R
N
T
C
S
I
P
K
S
Q
I
S
Site 75
Y865
M
Q
H
L
A
D
N
Y
K
H
W
K
T
L
D
Site 76
S878
L
D
D
L
K
C
K
S
L
R
L
P
S
D
S
Site 77
S883
C
K
S
L
R
L
P
S
D
S
_
_
_
_
_
Site 78
S885
S
L
R
L
P
S
D
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation