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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAPSS2
Full Name:
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Alias:
3'- phosphoadenosine-5'-phosphosulfate synthetase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase; APS kinase; ATPSK2; ATP-sulfurylase; Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2; PAPS synthethase 2; PAPS2; PAPSS 2; PPS2; SAT; SK 2; SK2; Sulfate adenylate transferase; Sulfurylase kinase 2
Type:
Nucleotide Metabolism - purine; Transferase; EC 2.7.1.25; Other Amino Acids Metabolism - selenoamino acid; Energy Metabolism - sulfur; EC 2.7.7.4
Mass (Da):
69501
Number AA:
614
UniProt ID:
O95340
International Prot ID:
IPI00030009
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004020
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0001501
GO:0000103
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
S
G
I
K
K
Q
K
T
E
N
Q
Q
K
S
T
Site 2
S15
K
T
E
N
Q
Q
K
S
T
N
V
V
Y
Q
A
Site 3
Y20
Q
K
S
T
N
V
V
Y
Q
A
H
H
V
S
R
Site 4
S26
V
Y
Q
A
H
H
V
S
R
N
K
R
G
Q
V
Site 5
S92
L
N
R
N
L
G
F
S
P
G
D
R
E
E
N
Site 6
S138
N
A
R
K
I
H
E
S
A
G
L
P
F
F
E
Site 7
S157
A
P
L
N
I
C
E
S
R
D
V
K
G
L
Y
Site 8
Y164
S
R
D
V
K
G
L
Y
K
R
A
R
A
G
E
Site 9
S180
K
G
F
T
G
I
D
S
D
Y
E
K
P
E
T
Site 10
Y182
F
T
G
I
D
S
D
Y
E
K
P
E
T
P
E
Site 11
T187
S
D
Y
E
K
P
E
T
P
E
R
V
L
K
T
Site 12
T194
T
P
E
R
V
L
K
T
N
L
S
T
V
S
D
Site 13
S197
R
V
L
K
T
N
L
S
T
V
S
D
C
V
H
Site 14
T198
V
L
K
T
N
L
S
T
V
S
D
C
V
H
Q
Site 15
T219
E
Q
N
I
V
P
Y
T
I
I
K
D
I
H
E
Site 16
T243
H
V
R
A
E
A
E
T
L
P
S
L
S
I
T
Site 17
S246
A
E
A
E
T
L
P
S
L
S
I
T
K
L
D
Site 18
Y277
G
F
M
R
E
K
E
Y
L
Q
V
M
H
F
D
Site 19
T308
P
V
S
A
E
D
K
T
R
L
E
G
C
S
K
Site 20
S314
K
T
R
L
E
G
C
S
K
F
V
L
A
H
G
Site 21
Y334
I
L
R
D
A
E
F
Y
E
H
R
K
E
E
R
Site 22
T349
C
S
R
V
W
G
T
T
C
T
K
H
P
H
I
Site 23
T351
R
V
W
G
T
T
C
T
K
H
P
H
I
K
M
Site 24
Y386
W
N
D
G
L
D
Q
Y
R
L
T
P
L
E
L
Site 25
T389
G
L
D
Q
Y
R
L
T
P
L
E
L
K
Q
K
Site 26
T425
H
A
L
L
M
Q
D
T
R
R
R
L
L
E
R
Site 27
Y434
R
R
L
L
E
R
G
Y
K
H
P
V
L
L
L
Site 28
T522
A
G
M
P
H
P
E
T
K
K
D
L
Y
E
P
Site 29
Y527
P
E
T
K
K
D
L
Y
E
P
T
H
G
G
K
Site 30
Y565
A
K
K
A
M
D
F
Y
D
P
A
R
H
N
E
Site 31
S577
H
N
E
F
D
F
I
S
G
T
R
M
R
K
L
Site 32
T579
E
F
D
F
I
S
G
T
R
M
R
K
L
A
R
Site 33
T605
P
K
A
W
K
V
L
T
D
Y
Y
R
S
L
E
Site 34
Y607
A
W
K
V
L
T
D
Y
Y
R
S
L
E
K
N
Site 35
Y608
W
K
V
L
T
D
Y
Y
R
S
L
E
K
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation