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Updated November 2019
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Protein Info
Short Name:
TACC2
Full Name:
Transforming acidic coiled-coil-containing protein 2
Alias:
Anti zuai-1; Anti Zuai-1; AZU-1; ECTACC; Transforming acidic coiled-coil-containing protein 2; Transforming, acidic coiled-coil containing protein 2
Type:
Cell cycle regulation
Mass (Da):
309427
Number AA:
2948
UniProt ID:
O95359
International Prot ID:
IPI00030033
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0035257
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
G
N
E
N
S
T
S
D
N
Q
R
T
L
S
Site 2
T13
S
T
S
D
N
Q
R
T
L
S
A
Q
T
P
R
Site 3
S15
S
D
N
Q
R
T
L
S
A
Q
T
P
R
S
A
Site 4
T18
Q
R
T
L
S
A
Q
T
P
R
S
A
Q
P
P
Site 5
S21
L
S
A
Q
T
P
R
S
A
Q
P
P
G
N
S
Site 6
S28
S
A
Q
P
P
G
N
S
Q
N
I
K
R
K
Q
Site 7
T38
I
K
R
K
Q
Q
D
T
P
G
S
P
D
H
R
Site 8
S41
K
Q
Q
D
T
P
G
S
P
D
H
R
D
A
S
Site 9
S48
S
P
D
H
R
D
A
S
S
I
G
S
V
G
L
Site 10
S49
P
D
H
R
D
A
S
S
I
G
S
V
G
L
G
Site 11
S64
G
F
C
T
A
S
E
S
S
A
S
L
D
P
C
Site 12
S74
S
L
D
P
C
L
V
S
P
E
V
T
E
P
R
Site 13
T78
C
L
V
S
P
E
V
T
E
P
R
K
D
P
Q
Site 14
S93
G
A
R
G
P
E
G
S
L
L
P
S
P
P
P
Site 15
S97
P
E
G
S
L
L
P
S
P
P
P
S
Q
E
R
Site 16
S101
L
L
P
S
P
P
P
S
Q
E
R
E
H
P
S
Site 17
S109
Q
E
R
E
H
P
S
S
S
M
P
F
A
E
C
Site 18
S110
E
R
E
H
P
S
S
S
M
P
F
A
E
C
P
Site 19
S124
P
P
E
G
C
L
A
S
P
A
A
A
P
E
D
Site 20
T135
A
P
E
D
G
P
Q
T
Q
S
P
R
R
E
P
Site 21
S137
E
D
G
P
Q
T
Q
S
P
R
R
E
P
A
P
Site 22
S160
A
F
P
A
E
R
D
S
S
T
P
Y
Q
E
I
Site 23
S161
F
P
A
E
R
D
S
S
T
P
Y
Q
E
I
A
Site 24
T162
P
A
E
R
D
S
S
T
P
Y
Q
E
I
A
A
Site 25
Y164
E
R
D
S
S
T
P
Y
Q
E
I
A
A
V
P
Site 26
S186
P
K
E
E
G
Q
K
S
S
F
S
F
S
S
G
Site 27
S187
K
E
E
G
Q
K
S
S
F
S
F
S
S
G
I
Site 28
S189
E
G
Q
K
S
S
F
S
F
S
S
G
I
D
Q
Site 29
S191
Q
K
S
S
F
S
F
S
S
G
I
D
Q
S
P
Site 30
S192
K
S
S
F
S
F
S
S
G
I
D
Q
S
P
G
Site 31
S197
F
S
S
G
I
D
Q
S
P
G
M
S
P
V
P
Site 32
S201
I
D
Q
S
P
G
M
S
P
V
P
L
R
E
P
Site 33
S225
D
Q
P
G
G
F
E
S
Q
E
K
E
A
A
G
Site 34
S239
G
G
F
P
P
A
E
S
R
Q
G
V
A
S
V
Site 35
S245
E
S
R
Q
G
V
A
S
V
Q
V
T
P
E
A
Site 36
T249
G
V
A
S
V
Q
V
T
P
E
A
P
A
A
A
Site 37
S269
S
S
A
V
L
E
K
S
P
L
K
P
M
A
P
Site 38
S286
Q
D
P
A
P
R
A
S
D
R
E
R
G
Q
G
Site 39
Y299
Q
G
E
A
P
P
Q
Y
L
T
D
D
L
E
F
Site 40
S315
R
A
C
H
L
P
R
S
N
S
G
A
A
P
E
Site 41
S317
C
H
L
P
R
S
N
S
G
A
A
P
E
A
E
Site 42
S329
E
A
E
V
N
A
A
S
Q
E
S
C
Q
Q
P
Site 43
S362
L
V
P
E
A
G
G
S
G
K
E
A
L
D
T
Site 44
T369
S
G
K
E
A
L
D
T
I
D
V
Q
G
H
P
Site 45
T378
D
V
Q
G
H
P
Q
T
G
M
R
G
T
K
P
Site 46
T383
P
Q
T
G
M
R
G
T
K
P
N
Q
V
V
C
Site 47
S404
P
E
G
G
L
P
V
S
P
E
P
S
L
L
T
Site 48
S408
L
P
V
S
P
E
P
S
L
L
T
P
T
E
E
Site 49
T411
S
P
E
P
S
L
L
T
P
T
E
E
A
H
P
Site 50
S420
T
E
E
A
H
P
A
S
S
L
A
S
F
P
A
Site 51
S421
E
E
A
H
P
A
S
S
L
A
S
F
P
A
A
Site 52
S439
I
A
V
E
E
P
G
S
S
S
R
E
S
V
S
Site 53
S440
A
V
E
E
P
G
S
S
S
R
E
S
V
S
K
Site 54
S441
V
E
E
P
G
S
S
S
R
E
S
V
S
K
A
Site 55
S444
P
G
S
S
S
R
E
S
V
S
K
A
G
M
P
Site 56
S446
S
S
S
R
E
S
V
S
K
A
G
M
P
V
S
Site 57
S453
S
K
A
G
M
P
V
S
A
D
A
A
K
E
V
Site 58
S473
V
G
L
E
R
Q
V
S
D
L
G
S
K
G
E
Site 59
S477
R
Q
V
S
D
L
G
S
K
G
E
H
P
E
G
Site 60
S493
P
G
E
V
P
A
P
S
P
Q
E
R
G
E
H
Site 61
T503
E
R
G
E
H
L
N
T
E
Q
S
H
E
V
Q
Site 62
S506
E
H
L
N
T
E
Q
S
H
E
V
Q
P
G
V
Site 63
S523
P
P
L
P
K
E
Q
S
H
E
V
Q
P
G
A
Site 64
S540
P
P
L
P
K
A
P
S
E
S
A
R
G
P
P
Site 65
S542
L
P
K
A
P
S
E
S
A
R
G
P
P
G
P
Site 66
S561
K
V
H
E
D
S
T
S
P
A
V
A
K
E
G
Site 67
S569
P
A
V
A
K
E
G
S
R
S
P
G
D
S
P
Site 68
S571
V
A
K
E
G
S
R
S
P
G
D
S
P
G
G
Site 69
S575
G
S
R
S
P
G
D
S
P
G
G
K
E
E
A
Site 70
S599
G
N
L
Q
G
E
D
S
Q
A
F
S
S
K
R
Site 71
S603
G
E
D
S
Q
A
F
S
S
K
R
D
P
E
V
Site 72
S604
E
D
S
Q
A
F
S
S
K
R
D
P
E
V
G
Site 73
S616
E
V
G
K
D
E
L
S
K
P
S
S
D
A
E
Site 74
S620
D
E
L
S
K
P
S
S
D
A
E
S
R
D
H
Site 75
S624
K
P
S
S
D
A
E
S
R
D
H
P
S
S
H
Site 76
S629
A
E
S
R
D
H
P
S
S
H
S
A
Q
P
P
Site 77
S630
E
S
R
D
H
P
S
S
H
S
A
Q
P
P
R
Site 78
T644
R
K
G
G
A
G
H
T
D
G
P
H
S
Q
T
Site 79
S649
G
H
T
D
G
P
H
S
Q
T
A
E
A
D
A
Site 80
S657
Q
T
A
E
A
D
A
S
G
L
P
H
K
L
G
Site 81
T681
P
D
G
A
G
E
P
T
V
P
E
G
A
I
W
Site 82
T700
L
Q
P
K
C
P
D
T
L
Q
S
R
E
G
L
Site 83
S712
E
G
L
G
R
M
E
S
F
L
T
L
E
S
E
Site 84
T715
G
R
M
E
S
F
L
T
L
E
S
E
K
S
D
Site 85
S718
E
S
F
L
T
L
E
S
E
K
S
D
F
P
P
Site 86
S721
L
T
L
E
S
E
K
S
D
F
P
P
T
P
V
Site 87
T726
E
K
S
D
F
P
P
T
P
V
A
E
V
A
P
Site 88
T741
K
A
Q
E
G
E
S
T
L
E
I
R
K
M
G
Site 89
S749
L
E
I
R
K
M
G
S
C
D
G
E
G
L
L
Site 90
T757
C
D
G
E
G
L
L
T
S
P
D
Q
P
R
G
Site 91
S758
D
G
E
G
L
L
T
S
P
D
Q
P
R
G
P
Site 92
S770
R
G
P
A
C
D
A
S
R
Q
E
F
H
A
G
Site 93
S819
G
W
I
R
G
A
A
S
E
W
P
L
L
S
S
Site 94
S825
A
S
E
W
P
L
L
S
S
E
K
H
L
Q
P
Site 95
S833
S
E
K
H
L
Q
P
S
Q
A
Q
P
E
T
S
Site 96
S859
P
E
N
G
K
E
T
S
P
S
H
P
G
F
K
Site 97
S861
N
G
K
E
T
S
P
S
H
P
G
F
K
D
Q
Site 98
S872
F
K
D
Q
G
A
D
S
S
Q
I
H
V
P
V
Site 99
S873
K
D
Q
G
A
D
S
S
Q
I
H
V
P
V
E
Site 100
S903
A
L
G
S
E
L
Q
S
Q
L
P
K
G
T
L
Site 101
T909
Q
S
Q
L
P
K
G
T
L
S
D
T
P
T
S
Site 102
S911
Q
L
P
K
G
T
L
S
D
T
P
T
S
S
P
Site 103
T913
P
K
G
T
L
S
D
T
P
T
S
S
P
T
D
Site 104
T915
G
T
L
S
D
T
P
T
S
S
P
T
D
M
V
Site 105
S916
T
L
S
D
T
P
T
S
S
P
T
D
M
V
W
Site 106
S917
L
S
D
T
P
T
S
S
P
T
D
M
V
W
E
Site 107
S926
T
D
M
V
W
E
S
S
L
T
E
E
S
E
L
Site 108
T928
M
V
W
E
S
S
L
T
E
E
S
E
L
S
A
Site 109
S931
E
S
S
L
T
E
E
S
E
L
S
A
P
T
R
Site 110
S934
L
T
E
E
S
E
L
S
A
P
T
R
Q
K
L
Site 111
S958
G
A
C
G
D
G
Q
S
S
R
V
S
P
P
A
Site 112
S959
A
C
G
D
G
Q
S
S
R
V
S
P
P
A
A
Site 113
S962
D
G
Q
S
S
R
V
S
P
P
A
A
D
V
L
Site 114
S973
A
D
V
L
K
D
F
S
L
A
G
N
F
S
R
Site 115
T983
G
N
F
S
R
K
E
T
C
C
T
G
Q
G
P
Site 116
T986
S
R
K
E
T
C
C
T
G
Q
G
P
N
K
S
Site 117
S993
T
G
Q
G
P
N
K
S
Q
Q
A
L
A
D
A
Site 118
S1018
C
Q
R
H
P
G
A
S
E
A
A
D
G
C
S
Site 119
S1025
S
E
A
A
D
G
C
S
P
L
W
G
L
S
K
Site 120
S1031
C
S
P
L
W
G
L
S
K
R
E
M
A
S
G
Site 121
T1071
A
P
A
S
P
G
V
T
P
T
Q
D
A
P
E
Site 122
T1085
E
T
E
A
C
D
E
T
Q
E
G
R
Q
Q
P
Site 123
T1105
Q
K
M
E
C
W
A
T
S
D
A
E
S
P
K
Site 124
S1106
K
M
E
C
W
A
T
S
D
A
E
S
P
K
L
Site 125
S1110
W
A
T
S
D
A
E
S
P
K
L
L
A
S
F
Site 126
S1116
E
S
P
K
L
L
A
S
F
P
S
A
G
E
Q
Site 127
S1119
K
L
L
A
S
F
P
S
A
G
E
Q
G
G
E
Site 128
S1135
G
A
A
E
T
G
G
S
A
G
A
G
D
P
G
Site 129
T1154
P
E
K
P
G
E
A
T
L
S
C
G
L
L
Q
Site 130
S1156
K
P
G
E
A
T
L
S
C
G
L
L
Q
T
E
Site 131
T1167
L
Q
T
E
H
C
L
T
S
G
E
E
A
S
T
Site 132
T1174
T
S
G
E
E
A
S
T
S
A
L
R
E
S
C
Site 133
S1175
S
G
E
E
A
S
T
S
A
L
R
E
S
C
Q
Site 134
S1180
S
T
S
A
L
R
E
S
C
Q
A
E
H
P
M
Site 135
S1206
E
L
G
G
I
P
R
S
T
M
D
F
S
T
H
Site 136
T1207
L
G
G
I
P
R
S
T
M
D
F
S
T
H
Q
Site 137
T1212
R
S
T
M
D
F
S
T
H
Q
A
V
P
D
P
Site 138
S1225
D
P
K
E
L
L
L
S
G
P
P
E
V
A
A
Site 139
T1235
P
E
V
A
A
P
D
T
P
Y
L
H
V
D
S
Site 140
Y1237
V
A
A
P
D
T
P
Y
L
H
V
D
S
A
A
Site 141
S1242
T
P
Y
L
H
V
D
S
A
A
Q
R
G
A
E
Site 142
S1251
A
Q
R
G
A
E
D
S
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V
K
K
S
P
K
R
S
P
L
S
Site 295
S2440
V
K
K
S
P
K
R
S
P
L
S
D
P
P
S
Site 296
S2443
S
P
K
R
S
P
L
S
D
P
P
S
Q
D
P
Site 297
S2447
S
P
L
S
D
P
P
S
Q
D
P
T
P
A
A
Site 298
T2451
D
P
P
S
Q
D
P
T
P
A
A
T
P
E
T
Site 299
T2455
Q
D
P
T
P
A
A
T
P
E
T
P
P
V
I
Site 300
T2458
T
P
A
A
T
P
E
T
P
P
V
I
S
A
V
Site 301
Y2495
L
E
A
D
K
Q
D
Y
P
Q
P
S
D
L
S
Site 302
S2499
K
Q
D
Y
P
Q
P
S
D
L
S
T
F
V
N
Site 303
T2503
P
Q
P
S
D
L
S
T
F
V
N
E
T
K
F
Site 304
T2508
L
S
T
F
V
N
E
T
K
F
S
S
P
T
E
Site 305
S2511
F
V
N
E
T
K
F
S
S
P
T
E
E
L
D
Site 306
S2512
V
N
E
T
K
F
S
S
P
T
E
E
L
D
Y
Site 307
Y2519
S
P
T
E
E
L
D
Y
R
N
S
Y
E
I
E
Site 308
S2522
E
E
L
D
Y
R
N
S
Y
E
I
E
Y
M
E
Site 309
Y2523
E
L
D
Y
R
N
S
Y
E
I
E
Y
M
E
K
Site 310
Y2527
R
N
S
Y
E
I
E
Y
M
E
K
I
G
S
S
Site 311
S2533
E
Y
M
E
K
I
G
S
S
L
P
Q
D
D
D
Site 312
Y2548
A
P
K
K
Q
A
L
Y
L
M
F
D
T
S
Q
Site 313
T2553
A
L
Y
L
M
F
D
T
S
Q
E
S
P
V
K
Site 314
S2554
L
Y
L
M
F
D
T
S
Q
E
S
P
V
K
S
Site 315
S2557
M
F
D
T
S
Q
E
S
P
V
K
S
S
P
V
Site 316
S2561
S
Q
E
S
P
V
K
S
S
P
V
R
M
S
E
Site 317
S2562
Q
E
S
P
V
K
S
S
P
V
R
M
S
E
S
Site 318
S2567
K
S
S
P
V
R
M
S
E
S
P
T
P
C
S
Site 319
S2569
S
P
V
R
M
S
E
S
P
T
P
C
S
G
S
Site 320
T2571
V
R
M
S
E
S
P
T
P
C
S
G
S
S
F
Site 321
S2574
S
E
S
P
T
P
C
S
G
S
S
F
E
E
T
Site 322
S2576
S
P
T
P
C
S
G
S
S
F
E
E
T
E
A
Site 323
S2577
P
T
P
C
S
G
S
S
F
E
E
T
E
A
L
Site 324
T2581
S
G
S
S
F
E
E
T
E
A
L
V
N
T
A
Site 325
S2613
H
L
Q
V
P
E
K
S
S
Q
K
E
L
E
A
Site 326
S2641
A
P
E
G
S
F
A
S
A
D
A
L
L
S
R
Site 327
S2719
A
A
H
P
T
D
V
S
I
S
K
T
A
L
Y
Site 328
T2723
T
D
V
S
I
S
K
T
A
L
Y
S
R
I
G
Site 329
Y2726
S
I
S
K
T
A
L
Y
S
R
I
G
T
A
E
Site 330
T2731
A
L
Y
S
R
I
G
T
A
E
V
E
K
P
A
Site 331
S2749
F
Q
Q
P
D
L
D
S
A
L
Q
I
A
R
A
Site 332
T2760
I
A
R
A
E
I
I
T
K
E
R
E
V
S
E
Site 333
S2766
I
T
K
E
R
E
V
S
E
W
K
D
K
Y
E
Site 334
Y2772
V
S
E
W
K
D
K
Y
E
E
S
R
R
E
V
Site 335
T2792
I
V
A
E
Y
E
K
T
I
A
Q
M
I
E
D
Site 336
S2805
E
D
E
Q
R
E
K
S
V
S
H
Q
T
V
Q
Site 337
S2807
E
Q
R
E
K
S
V
S
H
Q
T
V
Q
Q
L
Site 338
S2827
Q
A
L
A
D
L
N
S
V
E
K
S
L
A
D
Site 339
S2831
D
L
N
S
V
E
K
S
L
A
D
L
F
R
R
Site 340
Y2839
L
A
D
L
F
R
R
Y
E
K
M
K
E
V
L
Site 341
Y2863
L
K
R
C
A
Q
E
Y
L
S
R
V
K
K
E
Site 342
Y2874
V
K
K
E
E
Q
R
Y
Q
A
L
K
V
H
A
Site 343
S2909
E
Q
A
A
H
Q
A
S
L
R
K
E
Q
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation