PhosphoNET

           
Protein Info 
   
Short Name:  Rapgef3
Full Name:  Rap guanine nucleotide exchange factor 3
Alias:  Bcm910; Camp-gefi; CAMP-regulated guanine nucleotide exchange factor I; Epac; Epac 1; Epac1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; Hsu79275; Mgc21410; Rap guanine nucleotide exchange factor (gef) 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
Type: 
Mass (Da):  103633
Number AA:  923
UniProt ID:  O95398
International Prot ID:  IPI00329727
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005952  GO:0012505  GO:0016020 Uniprot OncoNet
Molecular Function:  GO:0030552  GO:0008603  GO:0005085 PhosphoSite+ KinaseNET
Biological Process:  GO:0008283  GO:0001932  GO:0051056 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S53RRMHRPRSCSYQLLL
Site 2S55MHRPRSCSYQLLLEH
Site 3S66LLEHQRPSCIQGLRW
Site 4T74CIQGLRWTPLTNSEE
Site 5T77GLRWTPLTNSEESLD
Site 6S79RWTPLTNSEESLDFS
Site 7S82PLTNSEESLDFSESL
Site 8S86SEESLDFSESLEQAS
Site 9S88ESLDFSESLEQASTE
Site 10T94ESLEQASTERVLRAG
Site 11T111LHRHLLATCPNLIRD
Site 12Y121NLIRDRKYHLRLYRQ
Site 13Y126RKYHLRLYRQCCSGR
Site 14S131RLYRQCCSGRELVDG
Site 15Y182QDRDAQFYRFPGPEP
Site 16T194PEPEPVGTHEMEEEL
Site 17T218RGPDALLTVALRKPP
Site 18S250IKAVAHLSNSVKREL
Site 19T271EPHSKAGTVLFSQGD
Site 20S275KAGTVLFSQGDKGTS
Site 21Y284GDKGTSWYIIWKGSV
Site 22T324NDAPRAATIILREDN
Site 23T353IKDVEAKTMRLEEHG
Site 24S370VLVLERASQGAGPSR
Site 25S376ASQGAGPSRPPTPGR
Site 26T380AGPSRPPTPGRNRYT
Site 27Y386PTPGRNRYTVMSGTP
Site 28T387TPGRNRYTVMSGTPE
Site 29S390RNRYTVMSGTPEKIL
Site 30T392RYTVMSGTPEKILEL
Site 31S408LEAMGPDSSAHDPTE
Site 32S409EAMGPDSSAHDPTET
Site 33T416SAHDPTETFLSDFLL
Site 34S419DPTETFLSDFLLTHR
Site 35S455GGSEQERSTYVCNKR
Site 36T456GSEQERSTYVCNKRQ
Site 37Y457SEQERSTYVCNKRQQ
Site 38S488HTDPVATSFLQKLSD
Site 39T501SDLVGRDTRLSNLLR
Site 40S504VGRDTRLSNLLREQW
Site 41S528ENGCGNASPQMKARN
Site 42S550QDEPLPGSSCAIQVG
Site 43Y562QVGDKVPYDICRPDH
Site 44S570DICRPDHSVLTLQLP
Site 45T596LAQEDGWTKGQVLVK
Site 46S623DARGVATSLGLNERL
Site 47T651HPDQLGPTVGSAEGL
Site 48T671KDLAGQLTDHDWSLF
Site 49T700PQHLRDVTTANLERF
Site 50T701QHLRDVTTANLERFM
Site 51Y716RRFNELQYWVATELC
Site 52S753KEQKNLNSFFAVMFG
Site 53T772AISRLAHTWERLPHK
Site 54Y784PHKVRKLYSALERLL
Site 55S794LERLLDPSWNHRVYR
Site 56Y800PSWNHRVYRLALAKL
Site 57T823PLLLKDMTFIHEGNH
Site 58T831FIHEGNHTLVENLIN
Site 59S857RMLHHCRSHNPVPLS
Site 60S864SHNPVPLSPLRSRVS
Site 61S868VPLSPLRSRVSHLHE
Site 62S871SPLRSRVSHLHEDSQ
Site 63S877VSHLHEDSQVARIST
Site 64S883DSQVARISTCSEQSL
Site 65T884SQVARISTCSEQSLS
Site 66S886VARISTCSEQSLSTR
Site 67S889ISTCSEQSLSTRSPA
Site 68S891TCSEQSLSTRSPAST
Site 69T892CSEQSLSTRSPASTW
Site 70S894EQSLSTRSPASTWAY
Site 71S897LSTRSPASTWAYVQQ
Site 72T898STRSPASTWAYVQQL
Site 73S915IDNQRELSRLSRELE
Site 74S918QRELSRLSRELEP__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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