KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Rapgef3
Full Name:
Rap guanine nucleotide exchange factor 3
Alias:
Bcm910; Camp-gefi; CAMP-regulated guanine nucleotide exchange factor I; Epac; Epac 1; Epac1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; Hsu79275; Mgc21410; Rap guanine nucleotide exchange factor (gef) 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
Type:
Mass (Da):
103633
Number AA:
923
UniProt ID:
O95398
International Prot ID:
IPI00329727
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005952
GO:0012505
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0030552
GO:0008603
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0001932
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S53
R
R
M
H
R
P
R
S
C
S
Y
Q
L
L
L
Site 2
S55
M
H
R
P
R
S
C
S
Y
Q
L
L
L
E
H
Site 3
S66
L
L
E
H
Q
R
P
S
C
I
Q
G
L
R
W
Site 4
T74
C
I
Q
G
L
R
W
T
P
L
T
N
S
E
E
Site 5
T77
G
L
R
W
T
P
L
T
N
S
E
E
S
L
D
Site 6
S79
R
W
T
P
L
T
N
S
E
E
S
L
D
F
S
Site 7
S82
P
L
T
N
S
E
E
S
L
D
F
S
E
S
L
Site 8
S86
S
E
E
S
L
D
F
S
E
S
L
E
Q
A
S
Site 9
S88
E
S
L
D
F
S
E
S
L
E
Q
A
S
T
E
Site 10
T94
E
S
L
E
Q
A
S
T
E
R
V
L
R
A
G
Site 11
T111
L
H
R
H
L
L
A
T
C
P
N
L
I
R
D
Site 12
Y121
N
L
I
R
D
R
K
Y
H
L
R
L
Y
R
Q
Site 13
Y126
R
K
Y
H
L
R
L
Y
R
Q
C
C
S
G
R
Site 14
S131
R
L
Y
R
Q
C
C
S
G
R
E
L
V
D
G
Site 15
Y182
Q
D
R
D
A
Q
F
Y
R
F
P
G
P
E
P
Site 16
T194
P
E
P
E
P
V
G
T
H
E
M
E
E
E
L
Site 17
T218
R
G
P
D
A
L
L
T
V
A
L
R
K
P
P
Site 18
S250
I
K
A
V
A
H
L
S
N
S
V
K
R
E
L
Site 19
T271
E
P
H
S
K
A
G
T
V
L
F
S
Q
G
D
Site 20
S275
K
A
G
T
V
L
F
S
Q
G
D
K
G
T
S
Site 21
Y284
G
D
K
G
T
S
W
Y
I
I
W
K
G
S
V
Site 22
T324
N
D
A
P
R
A
A
T
I
I
L
R
E
D
N
Site 23
T353
I
K
D
V
E
A
K
T
M
R
L
E
E
H
G
Site 24
S370
V
L
V
L
E
R
A
S
Q
G
A
G
P
S
R
Site 25
S376
A
S
Q
G
A
G
P
S
R
P
P
T
P
G
R
Site 26
T380
A
G
P
S
R
P
P
T
P
G
R
N
R
Y
T
Site 27
Y386
P
T
P
G
R
N
R
Y
T
V
M
S
G
T
P
Site 28
T387
T
P
G
R
N
R
Y
T
V
M
S
G
T
P
E
Site 29
S390
R
N
R
Y
T
V
M
S
G
T
P
E
K
I
L
Site 30
T392
R
Y
T
V
M
S
G
T
P
E
K
I
L
E
L
Site 31
S408
L
E
A
M
G
P
D
S
S
A
H
D
P
T
E
Site 32
S409
E
A
M
G
P
D
S
S
A
H
D
P
T
E
T
Site 33
T416
S
A
H
D
P
T
E
T
F
L
S
D
F
L
L
Site 34
S419
D
P
T
E
T
F
L
S
D
F
L
L
T
H
R
Site 35
S455
G
G
S
E
Q
E
R
S
T
Y
V
C
N
K
R
Site 36
T456
G
S
E
Q
E
R
S
T
Y
V
C
N
K
R
Q
Site 37
Y457
S
E
Q
E
R
S
T
Y
V
C
N
K
R
Q
Q
Site 38
S488
H
T
D
P
V
A
T
S
F
L
Q
K
L
S
D
Site 39
T501
S
D
L
V
G
R
D
T
R
L
S
N
L
L
R
Site 40
S504
V
G
R
D
T
R
L
S
N
L
L
R
E
Q
W
Site 41
S528
E
N
G
C
G
N
A
S
P
Q
M
K
A
R
N
Site 42
S550
Q
D
E
P
L
P
G
S
S
C
A
I
Q
V
G
Site 43
Y562
Q
V
G
D
K
V
P
Y
D
I
C
R
P
D
H
Site 44
S570
D
I
C
R
P
D
H
S
V
L
T
L
Q
L
P
Site 45
T596
L
A
Q
E
D
G
W
T
K
G
Q
V
L
V
K
Site 46
S623
D
A
R
G
V
A
T
S
L
G
L
N
E
R
L
Site 47
T651
H
P
D
Q
L
G
P
T
V
G
S
A
E
G
L
Site 48
T671
K
D
L
A
G
Q
L
T
D
H
D
W
S
L
F
Site 49
T700
P
Q
H
L
R
D
V
T
T
A
N
L
E
R
F
Site 50
T701
Q
H
L
R
D
V
T
T
A
N
L
E
R
F
M
Site 51
Y716
R
R
F
N
E
L
Q
Y
W
V
A
T
E
L
C
Site 52
S753
K
E
Q
K
N
L
N
S
F
F
A
V
M
F
G
Site 53
T772
A
I
S
R
L
A
H
T
W
E
R
L
P
H
K
Site 54
Y784
P
H
K
V
R
K
L
Y
S
A
L
E
R
L
L
Site 55
S794
L
E
R
L
L
D
P
S
W
N
H
R
V
Y
R
Site 56
Y800
P
S
W
N
H
R
V
Y
R
L
A
L
A
K
L
Site 57
T823
P
L
L
L
K
D
M
T
F
I
H
E
G
N
H
Site 58
T831
F
I
H
E
G
N
H
T
L
V
E
N
L
I
N
Site 59
S857
R
M
L
H
H
C
R
S
H
N
P
V
P
L
S
Site 60
S864
S
H
N
P
V
P
L
S
P
L
R
S
R
V
S
Site 61
S868
V
P
L
S
P
L
R
S
R
V
S
H
L
H
E
Site 62
S871
S
P
L
R
S
R
V
S
H
L
H
E
D
S
Q
Site 63
S877
V
S
H
L
H
E
D
S
Q
V
A
R
I
S
T
Site 64
S883
D
S
Q
V
A
R
I
S
T
C
S
E
Q
S
L
Site 65
T884
S
Q
V
A
R
I
S
T
C
S
E
Q
S
L
S
Site 66
S886
V
A
R
I
S
T
C
S
E
Q
S
L
S
T
R
Site 67
S889
I
S
T
C
S
E
Q
S
L
S
T
R
S
P
A
Site 68
S891
T
C
S
E
Q
S
L
S
T
R
S
P
A
S
T
Site 69
T892
C
S
E
Q
S
L
S
T
R
S
P
A
S
T
W
Site 70
S894
E
Q
S
L
S
T
R
S
P
A
S
T
W
A
Y
Site 71
S897
L
S
T
R
S
P
A
S
T
W
A
Y
V
Q
Q
Site 72
T898
S
T
R
S
P
A
S
T
W
A
Y
V
Q
Q
L
Site 73
S915
I
D
N
Q
R
E
L
S
R
L
S
R
E
L
E
Site 74
S918
Q
R
E
L
S
R
L
S
R
E
L
E
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation