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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZFYVE9
Full Name:
Zinc finger FYVE domain-containing protein 9
Alias:
Madh-interacting; MADHIP; Mothers against decapentaplegic homolog-interacting; SARA; Smad anchor for receptor activation; SMADIP; Zinc finger FYVE domain-containing 9; Zinc finger, FYVE domain containing 9
Type:
Adapter/scaffold protein
Mass (Da):
156403
Number AA:
1425
UniProt ID:
O95405
International Prot ID:
IPI00480079
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031901
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004872
GO:0008236
PhosphoSite+
KinaseNET
Biological Process:
GO:0007183
GO:0007184
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
F
E
Q
N
E
D
E
T
V
S
S
T
L
L
D
Site 2
S29
N
E
D
E
T
V
S
S
T
L
L
D
T
K
W
Site 3
T34
V
S
S
T
L
L
D
T
K
W
N
K
I
L
D
Site 4
S44
N
K
I
L
D
P
P
S
H
R
L
S
F
N
P
Site 5
S48
D
P
P
S
H
R
L
S
F
N
P
T
L
A
S
Site 6
T52
H
R
L
S
F
N
P
T
L
A
S
V
N
E
S
Site 7
S55
S
F
N
P
T
L
A
S
V
N
E
S
A
V
S
Site 8
S59
T
L
A
S
V
N
E
S
A
V
S
N
E
S
Q
Site 9
S62
S
V
N
E
S
A
V
S
N
E
S
Q
P
Q
L
Site 10
S77
K
V
F
S
L
A
H
S
A
P
L
T
T
E
E
Site 11
T81
L
A
H
S
A
P
L
T
T
E
E
E
D
H
C
Site 12
Y120
D
Q
L
I
K
R
N
Y
S
W
D
D
Q
C
S
Site 13
S121
Q
L
I
K
R
N
Y
S
W
D
D
Q
C
S
A
Site 14
S127
Y
S
W
D
D
Q
C
S
A
V
E
V
G
E
K
Site 15
Y172
D
L
Q
D
C
N
N
Y
N
S
Q
S
L
M
D
Site 16
S182
Q
S
L
M
D
A
F
S
C
S
L
D
N
E
N
Site 17
S184
L
M
D
A
F
S
C
S
L
D
N
E
N
R
Q
Site 18
T192
L
D
N
E
N
R
Q
T
D
Q
F
S
F
S
I
Site 19
S196
N
R
Q
T
D
Q
F
S
F
S
I
N
E
S
T
Site 20
S198
Q
T
D
Q
F
S
F
S
I
N
E
S
T
E
K
Site 21
S202
F
S
F
S
I
N
E
S
T
E
K
D
M
N
S
Site 22
S209
S
T
E
K
D
M
N
S
E
K
Q
M
D
P
L
Site 23
T221
D
P
L
N
R
P
K
T
E
G
R
S
V
N
H
Site 24
S225
R
P
K
T
E
G
R
S
V
N
H
L
C
P
T
Site 25
T232
S
V
N
H
L
C
P
T
S
S
D
S
L
A
S
Site 26
S234
N
H
L
C
P
T
S
S
D
S
L
A
S
V
C
Site 27
S239
T
S
S
D
S
L
A
S
V
C
S
P
S
Q
L
Site 28
S242
D
S
L
A
S
V
C
S
P
S
Q
L
K
D
D
Site 29
S244
L
A
S
V
C
S
P
S
Q
L
K
D
D
G
S
Site 30
S251
S
Q
L
K
D
D
G
S
I
G
R
D
P
S
M
Site 31
S257
G
S
I
G
R
D
P
S
M
S
A
I
T
S
L
Site 32
S272
T
V
D
S
V
I
S
S
Q
G
T
D
G
C
P
Site 33
T294
Y
I
P
D
E
D
L
T
G
K
I
S
S
P
R
Site 34
S298
E
D
L
T
G
K
I
S
S
P
R
T
D
L
G
Site 35
S299
D
L
T
G
K
I
S
S
P
R
T
D
L
G
S
Site 36
T302
G
K
I
S
S
P
R
T
D
L
G
S
P
N
S
Site 37
S306
S
P
R
T
D
L
G
S
P
N
S
F
S
H
M
Site 38
S309
T
D
L
G
S
P
N
S
F
S
H
M
S
E
G
Site 39
S311
L
G
S
P
N
S
F
S
H
M
S
E
G
I
L
Site 40
S327
K
K
E
P
A
E
E
S
T
T
E
E
S
L
R
Site 41
T329
E
P
A
E
E
S
T
T
E
E
S
L
R
S
G
Site 42
S332
E
E
S
T
T
E
E
S
L
R
S
G
L
P
L
Site 43
S335
T
T
E
E
S
L
R
S
G
L
P
L
L
L
K
Site 44
S349
K
P
D
M
P
N
G
S
G
R
N
N
D
C
E
Site 45
Y375
R
A
D
E
N
E
G
Y
E
H
E
E
T
L
G
Site 46
T380
E
G
Y
E
H
E
E
T
L
G
T
T
E
F
L
Site 47
T383
E
H
E
E
T
L
G
T
T
E
F
L
N
M
T
Site 48
T390
T
T
E
F
L
N
M
T
E
H
F
S
E
S
Q
Site 49
T400
F
S
E
S
Q
D
M
T
N
W
K
L
T
K
L
Site 50
S413
K
L
N
E
M
N
D
S
Q
V
N
E
E
K
E
Site 51
S426
K
E
K
F
L
Q
I
S
Q
P
E
D
T
N
G
Site 52
T431
Q
I
S
Q
P
E
D
T
N
G
D
S
G
G
Q
Site 53
S435
P
E
D
T
N
G
D
S
G
G
Q
C
V
G
L
Site 54
T452
A
G
L
D
L
K
G
T
C
I
S
E
S
E
E
Site 55
S455
D
L
K
G
T
C
I
S
E
S
E
E
C
D
F
Site 56
S457
K
G
T
C
I
S
E
S
E
E
C
D
F
S
T
Site 57
S463
E
S
E
E
C
D
F
S
T
V
I
D
T
P
A
Site 58
T464
S
E
E
C
D
F
S
T
V
I
D
T
P
A
A
Site 59
Y473
I
D
T
P
A
A
N
Y
L
S
N
G
C
D
S
Site 60
S475
T
P
A
A
N
Y
L
S
N
G
C
D
S
Y
G
Site 61
S480
Y
L
S
N
G
C
D
S
Y
G
M
Q
D
P
G
Site 62
Y481
L
S
N
G
C
D
S
Y
G
M
Q
D
P
G
V
Site 63
S489
G
M
Q
D
P
G
V
S
F
V
P
K
T
L
P
Site 64
T494
G
V
S
F
V
P
K
T
L
P
S
K
E
D
S
Site 65
S497
F
V
P
K
T
L
P
S
K
E
D
S
V
T
E
Site 66
S501
T
L
P
S
K
E
D
S
V
T
E
E
K
E
I
Site 67
T503
P
S
K
E
D
S
V
T
E
E
K
E
I
E
E
Site 68
S511
E
E
K
E
I
E
E
S
K
S
E
C
Y
S
N
Site 69
S513
K
E
I
E
E
S
K
S
E
C
Y
S
N
I
Y
Site 70
Y516
E
E
S
K
S
E
C
Y
S
N
I
Y
E
Q
R
Site 71
S517
E
S
K
S
E
C
Y
S
N
I
Y
E
Q
R
G
Site 72
Y520
S
E
C
Y
S
N
I
Y
E
Q
R
G
N
E
A
Site 73
T528
E
Q
R
G
N
E
A
T
E
G
S
G
L
L
L
Site 74
S537
G
S
G
L
L
L
N
S
T
G
D
L
M
K
K
Site 75
T538
S
G
L
L
L
N
S
T
G
D
L
M
K
K
N
Site 76
Y546
G
D
L
M
K
K
N
Y
L
H
N
F
C
S
Q
Site 77
S556
N
F
C
S
Q
V
P
S
V
L
G
Q
S
S
P
Site 78
S585
G
A
R
P
K
Q
P
S
N
L
K
L
Q
I
P
Site 79
S596
L
Q
I
P
K
P
L
S
D
H
L
Q
N
D
F
Site 80
T611
P
A
N
S
G
N
N
T
K
N
K
N
D
I
L
Site 81
T629
K
L
G
E
N
S
A
T
N
V
C
S
P
S
L
Site 82
S633
N
S
A
T
N
V
C
S
P
S
L
G
N
I
S
Site 83
S635
A
T
N
V
C
S
P
S
L
G
N
I
S
N
V
Site 84
T644
G
N
I
S
N
V
D
T
N
G
E
H
L
E
S
Site 85
S651
T
N
G
E
H
L
E
S
Y
E
A
E
I
S
T
Site 86
Y652
N
G
E
H
L
E
S
Y
E
A
E
I
S
T
R
Site 87
S657
E
S
Y
E
A
E
I
S
T
R
P
C
L
A
L
Site 88
S668
C
L
A
L
A
P
D
S
P
D
N
D
L
R
A
Site 89
S681
R
A
G
Q
F
G
I
S
A
R
K
P
F
T
T
Site 90
T688
S
A
R
K
P
F
T
T
L
G
E
V
A
P
V
Site 91
Y741
S
L
K
C
K
L
L
Y
M
D
R
K
E
A
R
Site 92
S768
Q
A
W
E
N
M
M
S
A
S
S
Q
S
P
N
Site 93
S771
E
N
M
M
S
A
S
S
Q
S
P
N
P
N
N
Site 94
S773
M
M
S
A
S
S
Q
S
P
N
P
N
N
P
A
Site 95
Y782
N
P
N
N
P
A
E
Y
C
S
T
I
P
P
L
Site 96
T785
N
P
A
E
Y
C
S
T
I
P
P
L
Q
Q
A
Site 97
S795
P
L
Q
Q
A
Q
A
S
G
A
L
S
S
P
P
Site 98
T856
N
G
T
S
S
A
G
T
L
A
V
S
H
D
P
Site 99
T868
H
D
P
V
K
P
V
T
T
S
P
L
P
A
E
Site 100
S870
P
V
K
P
V
T
T
S
P
L
P
A
E
T
D
Site 101
S884
D
I
C
L
F
S
G
S
I
T
Q
V
G
S
P
Site 102
Y917
S
T
G
V
K
G
D
Y
A
V
E
E
K
P
S
Site 103
S924
Y
A
V
E
E
K
P
S
Q
I
S
V
M
Q
Q
Site 104
S927
E
E
K
P
S
Q
I
S
V
M
Q
Q
L
E
D
Site 105
Y1003
F
N
H
F
V
Q
L
Y
R
D
A
L
A
G
N
Site 106
S1021
N
L
G
H
S
F
F
S
Q
S
F
L
G
S
K
Site 107
S1023
G
H
S
F
F
S
Q
S
F
L
G
S
K
E
H
Site 108
S1027
F
S
Q
S
F
L
G
S
K
E
H
G
G
F
L
Site 109
Y1035
K
E
H
G
G
F
L
Y
V
T
S
T
Y
Q
S
Site 110
T1037
H
G
G
F
L
Y
V
T
S
T
Y
Q
S
L
Q
Site 111
S1038
G
G
F
L
Y
V
T
S
T
Y
Q
S
L
Q
D
Site 112
T1039
G
F
L
Y
V
T
S
T
Y
Q
S
L
Q
D
L
Site 113
S1042
Y
V
T
S
T
Y
Q
S
L
Q
D
L
V
L
P
Site 114
Y1118
A
D
F
R
N
Y
Q
Y
T
L
P
V
V
Q
G
Site 115
T1119
D
F
R
N
Y
Q
Y
T
L
P
V
V
Q
G
L
Site 116
T1135
V
D
M
E
V
R
K
T
S
I
K
I
P
S
N
Site 117
S1136
D
M
E
V
R
K
T
S
I
K
I
P
S
N
R
Site 118
Y1183
V
Q
N
D
D
G
N
Y
Q
T
Q
A
I
S
I
Site 119
T1198
H
N
Q
P
R
K
V
T
G
A
S
F
F
V
F
Site 120
S1213
S
G
A
L
K
S
S
S
G
Y
L
A
K
S
S
Site 121
S1219
S
S
G
Y
L
A
K
S
S
I
V
E
D
G
V
Site 122
S1237
I
T
A
E
N
M
D
S
L
R
Q
A
L
R
E
Site 123
T1249
L
R
E
M
K
D
F
T
I
T
C
G
K
A
D
Site 124
S1281
N
V
S
K
G
V
V
S
P
I
D
G
K
S
M
Site 125
S1287
V
S
P
I
D
G
K
S
M
E
T
I
T
N
V
Site 126
T1292
G
K
S
M
E
T
I
T
N
V
K
I
F
H
G
Site 127
Y1302
K
I
F
H
G
S
E
Y
K
A
N
G
K
V
I
Site 128
S1327
D
D
Q
H
N
C
L
S
D
P
A
D
H
S
R
Site 129
T1336
P
A
D
H
S
R
L
T
E
H
V
A
K
A
F
Site 130
T1360
L
L
K
E
D
G
M
T
K
L
G
L
R
V
T
Site 131
T1367
T
K
L
G
L
R
V
T
L
D
S
D
Q
V
G
Site 132
S1370
G
L
R
V
T
L
D
S
D
Q
V
G
Y
Q
A
Site 133
Y1375
L
D
S
D
Q
V
G
Y
Q
A
G
S
N
G
Q
Site 134
S1386
S
N
G
Q
P
L
P
S
Q
Y
M
N
D
L
D
Site 135
Y1388
G
Q
P
L
P
S
Q
Y
M
N
D
L
D
S
A
Site 136
S1408
H
G
G
A
C
Q
L
S
E
G
P
V
V
M
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation