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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SVIL
Full Name:
Supervillin
Alias:
Archvillin; P205/p250
Type:
Actin binding protein; Nuclear receptor co-regulator
Mass (Da):
247746
Number AA:
2214
UniProt ID:
O95425
International Prot ID:
IPI00412650
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042995
GO:0043034
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0007010
GO:0007519
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
L
E
G
I
E
N
D
T
Q
P
I
L
L
Q
S
Site 2
S25
T
Q
P
I
L
L
Q
S
C
T
G
L
V
T
H
Site 3
T39
H
R
L
L
E
E
D
T
P
R
Y
M
R
A
S
Site 4
Y42
L
E
E
D
T
P
R
Y
M
R
A
S
D
P
A
Site 5
S46
T
P
R
Y
M
R
A
S
D
P
A
S
P
H
I
Site 6
S50
M
R
A
S
D
P
A
S
P
H
I
G
R
S
N
Site 7
S56
A
S
P
H
I
G
R
S
N
E
E
E
E
T
S
Site 8
T62
R
S
N
E
E
E
E
T
S
D
S
S
L
E
K
Site 9
S63
S
N
E
E
E
E
T
S
D
S
S
L
E
K
Q
Site 10
S65
E
E
E
E
T
S
D
S
S
L
E
K
Q
T
R
Site 11
S66
E
E
E
T
S
D
S
S
L
E
K
Q
T
R
S
Site 12
Y75
E
K
Q
T
R
S
K
Y
C
T
E
T
S
G
V
Site 13
T77
Q
T
R
S
K
Y
C
T
E
T
S
G
V
H
G
Site 14
S80
S
K
Y
C
T
E
T
S
G
V
H
G
D
S
P
Site 15
S86
T
S
G
V
H
G
D
S
P
Y
G
S
G
T
M
Site 16
Y88
G
V
H
G
D
S
P
Y
G
S
G
T
M
D
T
Site 17
S90
H
G
D
S
P
Y
G
S
G
T
M
D
T
H
S
Site 18
T95
Y
G
S
G
T
M
D
T
H
S
L
E
S
K
A
Site 19
S97
S
G
T
M
D
T
H
S
L
E
S
K
A
E
R
Site 20
Y120
R
R
Q
L
A
E
K
Y
G
L
T
L
D
P
E
Site 21
T123
L
A
E
K
Y
G
L
T
L
D
P
E
A
D
S
Site 22
S130
T
L
D
P
E
A
D
S
E
Y
L
S
R
Y
T
Site 23
Y132
D
P
E
A
D
S
E
Y
L
S
R
Y
T
K
S
Site 24
S134
E
A
D
S
E
Y
L
S
R
Y
T
K
S
R
K
Site 25
Y136
D
S
E
Y
L
S
R
Y
T
K
S
R
K
E
P
Site 26
T137
S
E
Y
L
S
R
Y
T
K
S
R
K
E
P
D
Site 27
S139
Y
L
S
R
Y
T
K
S
R
K
E
P
D
A
V
Site 28
S153
V
E
K
R
G
G
K
S
D
K
Q
E
E
S
S
Site 29
S159
K
S
D
K
Q
E
E
S
S
R
D
A
S
S
L
Site 30
S160
S
D
K
Q
E
E
S
S
R
D
A
S
S
L
Y
Site 31
S164
E
E
S
S
R
D
A
S
S
L
Y
P
G
T
E
Site 32
S165
E
S
S
R
D
A
S
S
L
Y
P
G
T
E
T
Site 33
Y167
S
R
D
A
S
S
L
Y
P
G
T
E
T
M
G
Site 34
T170
A
S
S
L
Y
P
G
T
E
T
M
G
L
R
T
Site 35
Y185
C
A
G
E
S
K
D
Y
A
L
H
V
G
D
G
Site 36
S194
L
H
V
G
D
G
S
S
D
P
E
V
L
L
N
Site 37
S212
Q
R
R
G
Q
E
L
S
A
T
R
Q
A
H
D
Site 38
T214
R
G
Q
E
L
S
A
T
R
Q
A
H
D
L
S
Site 39
S221
T
R
Q
A
H
D
L
S
P
A
A
E
S
S
S
Site 40
S226
D
L
S
P
A
A
E
S
S
S
T
F
S
F
S
Site 41
S227
L
S
P
A
A
E
S
S
S
T
F
S
F
S
G
Site 42
S228
S
P
A
A
E
S
S
S
T
F
S
F
S
G
R
Site 43
T229
P
A
A
E
S
S
S
T
F
S
F
S
G
R
D
Site 44
S231
A
E
S
S
S
T
F
S
F
S
G
R
D
S
S
Site 45
S233
S
S
S
T
F
S
F
S
G
R
D
S
S
F
T
Site 46
S237
F
S
F
S
G
R
D
S
S
F
T
E
V
P
R
Site 47
S238
S
F
S
G
R
D
S
S
F
T
E
V
P
R
S
Site 48
T240
S
G
R
D
S
S
F
T
E
V
P
R
S
P
K
Site 49
S245
S
F
T
E
V
P
R
S
P
K
H
A
H
S
S
Site 50
S251
R
S
P
K
H
A
H
S
S
S
L
Q
Q
A
A
Site 51
S252
S
P
K
H
A
H
S
S
S
L
Q
Q
A
A
S
Site 52
S253
P
K
H
A
H
S
S
S
L
Q
Q
A
A
S
R
Site 53
S259
S
S
L
Q
Q
A
A
S
R
S
P
S
F
G
D
Site 54
S261
L
Q
Q
A
A
S
R
S
P
S
F
G
D
P
Q
Site 55
S263
Q
A
A
S
R
S
P
S
F
G
D
P
Q
L
S
Site 56
S270
S
F
G
D
P
Q
L
S
P
E
A
R
P
S
T
Site 57
S276
L
S
P
E
A
R
P
S
T
G
K
P
K
H
E
Site 58
T277
S
P
E
A
R
P
S
T
G
K
P
K
H
E
W
Site 59
S290
E
W
F
L
Q
K
D
S
E
G
D
T
P
S
L
Site 60
T294
Q
K
D
S
E
G
D
T
P
S
L
I
N
W
P
Site 61
S296
D
S
E
G
D
T
P
S
L
I
N
W
P
S
R
Site 62
S302
P
S
L
I
N
W
P
S
R
V
K
V
R
E
K
Site 63
S315
E
K
L
V
K
E
E
S
A
R
N
S
P
E
L
Site 64
S319
K
E
E
S
A
R
N
S
P
E
L
A
S
E
S
Site 65
S324
R
N
S
P
E
L
A
S
E
S
V
T
Q
R
R
Site 66
S326
S
P
E
L
A
S
E
S
V
T
Q
R
R
H
Q
Site 67
T328
E
L
A
S
E
S
V
T
Q
R
R
H
Q
P
A
Site 68
Y339
H
Q
P
A
P
V
H
Y
V
S
F
Q
S
E
H
Site 69
S341
P
A
P
V
H
Y
V
S
F
Q
S
E
H
S
A
Site 70
S354
S
A
F
D
R
V
P
S
K
A
A
G
S
T
R
Site 71
S359
V
P
S
K
A
A
G
S
T
R
Q
P
I
R
G
Site 72
Y367
T
R
Q
P
I
R
G
Y
V
Q
P
A
D
T
G
Site 73
T381
G
H
T
A
K
L
V
T
P
E
T
P
E
N
A
Site 74
T384
A
K
L
V
T
P
E
T
P
E
N
A
S
E
C
Site 75
S389
P
E
T
P
E
N
A
S
E
C
S
W
V
A
S
Site 76
S392
P
E
N
A
S
E
C
S
W
V
A
S
A
T
Q
Site 77
S396
S
E
C
S
W
V
A
S
A
T
Q
N
V
P
K
Site 78
S406
Q
N
V
P
K
P
P
S
L
T
V
L
E
G
D
Site 79
T408
V
P
K
P
P
S
L
T
V
L
E
G
D
G
R
Site 80
S417
L
E
G
D
G
R
D
S
P
V
L
H
V
C
E
Site 81
S425
P
V
L
H
V
C
E
S
K
A
E
E
E
E
G
Site 82
S467
E
G
D
G
L
V
R
S
P
E
D
P
S
R
N
Site 83
S472
V
R
S
P
E
D
P
S
R
N
E
D
F
G
K
Site 84
S483
D
F
G
K
P
A
V
S
T
V
T
L
E
H
Q
Site 85
T484
F
G
K
P
A
V
S
T
V
T
L
E
H
Q
K
Site 86
T507
P
Q
A
P
H
Q
P
T
E
R
T
G
R
S
E
Site 87
S513
P
T
E
R
T
G
R
S
E
M
V
L
Y
I
Q
Site 88
Y518
G
R
S
E
M
V
L
Y
I
Q
S
E
P
V
S
Site 89
S521
E
M
V
L
Y
I
Q
S
E
P
V
S
Q
D
A
Site 90
S525
Y
I
Q
S
E
P
V
S
Q
D
A
K
P
T
G
Site 91
S538
T
G
H
N
R
E
A
S
K
K
R
K
V
R
T
Site 92
T545
S
K
K
R
K
V
R
T
R
S
L
S
D
F
T
Site 93
S547
K
R
K
V
R
T
R
S
L
S
D
F
T
G
P
Site 94
S549
K
V
R
T
R
S
L
S
D
F
T
G
P
P
Q
Site 95
T552
T
R
S
L
S
D
F
T
G
P
P
Q
L
Q
A
Site 96
Y562
P
Q
L
Q
A
L
K
Y
K
D
P
A
S
R
R
Site 97
S567
L
K
Y
K
D
P
A
S
R
R
E
L
E
L
P
Site 98
S575
R
R
E
L
E
L
P
S
S
K
T
E
G
P
Y
Site 99
S576
R
E
L
E
L
P
S
S
K
T
E
G
P
Y
G
Site 100
T578
L
E
L
P
S
S
K
T
E
G
P
Y
G
E
I
Site 101
Y582
S
S
K
T
E
G
P
Y
G
E
I
S
M
L
D
Site 102
S586
E
G
P
Y
G
E
I
S
M
L
D
T
K
V
S
Site 103
S615
C
R
R
P
E
L
K
S
R
V
E
R
S
A
E
Site 104
S620
L
K
S
R
V
E
R
S
A
E
G
P
G
L
P
Site 105
T628
A
E
G
P
G
L
P
T
G
V
E
R
E
R
G
Site 106
S636
G
V
E
R
E
R
G
S
R
K
P
R
R
Y
F
Site 107
Y642
G
S
R
K
P
R
R
Y
F
S
P
G
E
S
R
Site 108
S644
R
K
P
R
R
Y
F
S
P
G
E
S
R
K
T
Site 109
S648
R
Y
F
S
P
G
E
S
R
K
T
S
E
R
F
Site 110
T651
S
P
G
E
S
R
K
T
S
E
R
F
R
T
Q
Site 111
S652
P
G
E
S
R
K
T
S
E
R
F
R
T
Q
P
Site 112
T657
K
T
S
E
R
F
R
T
Q
P
I
T
S
A
E
Site 113
T661
R
F
R
T
Q
P
I
T
S
A
E
R
K
E
S
Site 114
S668
T
S
A
E
R
K
E
S
D
R
C
T
S
H
S
Site 115
T672
R
K
E
S
D
R
C
T
S
H
S
E
T
P
T
Site 116
S673
K
E
S
D
R
C
T
S
H
S
E
T
P
T
V
Site 117
S675
S
D
R
C
T
S
H
S
E
T
P
T
V
D
D
Site 118
T677
R
C
T
S
H
S
E
T
P
T
V
D
D
E
E
Site 119
T679
T
S
H
S
E
T
P
T
V
D
D
E
E
K
V
Site 120
S693
V
D
E
R
A
K
L
S
V
A
A
K
R
L
L
Site 121
S707
L
F
R
E
M
E
K
S
F
D
E
Q
N
V
P
Site 122
S718
Q
N
V
P
K
R
R
S
R
N
T
A
V
E
Q
Site 123
T721
P
K
R
R
S
R
N
T
A
V
E
Q
R
L
R
Site 124
S734
L
R
R
L
Q
D
R
S
L
T
Q
P
I
T
T
Site 125
T736
R
L
Q
D
R
S
L
T
Q
P
I
T
T
E
E
Site 126
T749
E
E
V
V
I
A
A
T
E
P
I
P
A
S
C
Site 127
S755
A
T
E
P
I
P
A
S
C
S
G
G
T
H
P
Site 128
T771
M
A
R
L
P
S
P
T
V
A
R
S
A
V
Q
Site 129
S775
P
S
P
T
V
A
R
S
A
V
Q
P
A
R
L
Site 130
T796
K
A
L
A
K
D
Q
T
N
E
G
K
E
L
A
Site 131
S810
A
E
Q
G
E
P
D
S
S
T
L
S
L
A
E
Site 132
S811
E
Q
G
E
P
D
S
S
T
L
S
L
A
E
K
Site 133
T812
Q
G
E
P
D
S
S
T
L
S
L
A
E
K
L
Site 134
S814
E
P
D
S
S
T
L
S
L
A
E
K
L
A
L
Site 135
S830
N
K
L
S
Q
P
V
S
K
A
I
S
T
R
N
Site 136
S834
Q
P
V
S
K
A
I
S
T
R
N
R
I
D
T
Site 137
T841
S
T
R
N
R
I
D
T
R
Q
R
R
M
N
A
Site 138
Y850
Q
R
R
M
N
A
R
Y
Q
T
Q
P
V
T
L
Site 139
T852
R
M
N
A
R
Y
Q
T
Q
P
V
T
L
G
E
Site 140
T856
R
Y
Q
T
Q
P
V
T
L
G
E
V
E
Q
V
Site 141
Y890
A
S
T
V
A
P
M
Y
A
G
D
L
R
T
K
Site 142
T896
M
Y
A
G
D
L
R
T
K
P
P
L
D
H
N
Site 143
S905
P
P
L
D
H
N
A
S
A
T
D
Y
K
F
S
Site 144
Y909
H
N
A
S
A
T
D
Y
K
F
S
S
S
I
E
Site 145
S914
T
D
Y
K
F
S
S
S
I
E
N
S
D
S
P
Site 146
S918
F
S
S
S
I
E
N
S
D
S
P
V
R
S
I
Site 147
S920
S
S
I
E
N
S
D
S
P
V
R
S
I
L
K
Site 148
S924
N
S
D
S
P
V
R
S
I
L
K
S
Q
A
W
Site 149
S928
P
V
R
S
I
L
K
S
Q
A
W
Q
P
L
V
Site 150
S938
W
Q
P
L
V
E
G
S
E
N
K
G
M
L
R
Site 151
Y947
N
K
G
M
L
R
E
Y
G
E
T
E
S
K
R
Site 152
T950
M
L
R
E
Y
G
E
T
E
S
K
R
A
L
T
Site 153
S952
R
E
Y
G
E
T
E
S
K
R
A
L
T
G
R
Site 154
T957
T
E
S
K
R
A
L
T
G
R
D
S
G
M
E
Site 155
S961
R
A
L
T
G
R
D
S
G
M
E
K
Y
G
S
Site 156
Y966
R
D
S
G
M
E
K
Y
G
S
F
E
E
A
E
Site 157
S968
S
G
M
E
K
Y
G
S
F
E
E
A
E
A
S
Site 158
S975
S
F
E
E
A
E
A
S
Y
P
I
L
N
R
A
Site 159
Y976
F
E
E
A
E
A
S
Y
P
I
L
N
R
A
R
Site 160
S987
N
R
A
R
E
G
D
S
H
K
E
S
K
Y
A
Site 161
S991
E
G
D
S
H
K
E
S
K
Y
A
V
P
R
R
Site 162
Y993
D
S
H
K
E
S
K
Y
A
V
P
R
R
G
S
Site 163
S1000
Y
A
V
P
R
R
G
S
L
E
R
A
N
P
P
Site 164
S1052
N
V
M
K
R
K
F
S
L
R
A
A
E
F
G
Site 165
S1063
A
E
F
G
E
P
T
S
E
Q
T
G
T
A
A
Site 166
T1068
P
T
S
E
Q
T
G
T
A
A
G
K
T
I
A
Site 167
T1077
A
G
K
T
I
A
Q
T
T
A
P
V
S
W
K
Site 168
T1078
G
K
T
I
A
Q
T
T
A
P
V
S
W
K
P
Site 169
S1082
A
Q
T
T
A
P
V
S
W
K
P
Q
D
S
S
Site 170
S1089
S
W
K
P
Q
D
S
S
E
Q
P
Q
E
K
L
Site 171
T1111
F
A
A
G
E
I
K
T
P
T
G
E
G
L
L
Site 172
T1113
A
G
E
I
K
T
P
T
G
E
G
L
L
D
S
Site 173
S1120
T
G
E
G
L
L
D
S
P
S
K
T
M
S
I
Site 174
S1122
E
G
L
L
D
S
P
S
K
T
M
S
I
K
E
Site 175
T1124
L
L
D
S
P
S
K
T
M
S
I
K
E
R
L
Site 176
S1126
D
S
P
S
K
T
M
S
I
K
E
R
L
A
L
Site 177
S1137
R
L
A
L
L
K
K
S
G
E
E
D
W
R
N
Site 178
S1147
E
D
W
R
N
R
L
S
R
R
Q
E
G
G
K
Site 179
S1158
E
G
G
K
A
P
A
S
S
L
H
T
Q
E
A
Site 180
S1159
G
G
K
A
P
A
S
S
L
H
T
Q
E
A
G
Site 181
T1162
A
P
A
S
S
L
H
T
Q
E
A
G
R
S
L
Site 182
S1168
H
T
Q
E
A
G
R
S
L
I
K
K
R
V
T
Site 183
T1175
S
L
I
K
K
R
V
T
E
S
R
E
S
Q
M
Site 184
S1177
I
K
K
R
V
T
E
S
R
E
S
Q
M
T
I
Site 185
S1180
R
V
T
E
S
R
E
S
Q
M
T
I
E
E
R
Site 186
T1183
E
S
R
E
S
Q
M
T
I
E
E
R
K
Q
L
Site 187
T1192
E
E
R
K
Q
L
I
T
V
R
E
E
A
W
K
Site 188
T1200
V
R
E
E
A
W
K
T
R
G
R
G
A
A
N
Site 189
S1209
G
R
G
A
A
N
D
S
T
Q
F
T
V
A
G
Site 190
T1210
R
G
A
A
N
D
S
T
Q
F
T
V
A
G
R
Site 191
T1213
A
N
D
S
T
Q
F
T
V
A
G
R
M
V
K
Site 192
S1225
M
V
K
K
G
L
A
S
P
T
A
I
T
P
V
Site 193
T1227
K
K
G
L
A
S
P
T
A
I
T
P
V
A
S
Site 194
T1230
L
A
S
P
T
A
I
T
P
V
A
S
P
I
C
Site 195
T1240
A
S
P
I
C
G
K
T
R
G
T
T
P
V
S
Site 196
T1243
I
C
G
K
T
R
G
T
T
P
V
S
K
P
L
Site 197
T1244
C
G
K
T
R
G
T
T
P
V
S
K
P
L
E
Site 198
S1247
T
R
G
T
T
P
V
S
K
P
L
E
D
I
E
Site 199
S1263
R
P
D
M
Q
L
E
S
D
L
K
L
D
R
L
Site 200
T1272
L
K
L
D
R
L
E
T
F
L
R
R
L
N
N
Site 201
T1287
K
V
G
G
M
H
E
T
V
L
T
V
T
G
K
Site 202
T1290
G
M
H
E
T
V
L
T
V
T
G
K
S
V
K
Site 203
T1307
M
K
P
D
D
D
E
T
F
A
K
F
Y
R
S
Site 204
S1314
T
F
A
K
F
Y
R
S
V
D
Y
N
M
P
R
Site 205
Y1317
K
F
Y
R
S
V
D
Y
N
M
P
R
S
P
V
Site 206
S1322
V
D
Y
N
M
P
R
S
P
V
E
M
D
E
D
Site 207
Y1337
F
D
V
I
F
D
P
Y
A
P
K
L
T
S
S
Site 208
S1344
Y
A
P
K
L
T
S
S
V
A
E
H
K
R
A
Site 209
S1361
P
K
R
R
V
Q
A
S
K
N
P
L
K
M
L
Site 210
Y1378
R
E
D
L
L
Q
E
Y
T
E
Q
R
L
N
V
Site 211
S1390
L
N
V
A
F
M
E
S
K
R
M
K
V
E
K
Site 212
S1400
M
K
V
E
K
M
S
S
N
S
N
F
S
E
V
Site 213
S1419
L
A
S
K
E
N
F
S
N
V
S
L
R
S
V
Site 214
S1422
K
E
N
F
S
N
V
S
L
R
S
V
N
L
T
Site 215
T1429
S
L
R
S
V
N
L
T
E
Q
N
S
N
N
S
Site 216
S1433
V
N
L
T
E
Q
N
S
N
N
S
A
V
P
Y
Site 217
Y1440
S
N
N
S
A
V
P
Y
K
R
L
M
L
L
Q
Site 218
T1456
K
G
R
R
H
V
Q
T
R
L
V
E
P
R
A
Site 219
S1464
R
L
V
E
P
R
A
S
A
L
N
S
G
D
C
Site 220
S1476
G
D
C
F
L
L
L
S
P
H
C
C
F
L
W
Site 221
T1501
A
K
A
S
E
L
A
T
L
I
Q
T
K
R
E
Site 222
T1505
E
L
A
T
L
I
Q
T
K
R
E
L
G
C
R
Site 223
T1514
R
E
L
G
C
R
A
T
Y
I
Q
T
I
E
E
Site 224
Y1515
E
L
G
C
R
A
T
Y
I
Q
T
I
E
E
G
Site 225
T1525
T
I
E
E
G
I
N
T
H
T
H
A
A
K
D
Site 226
S1542
K
L
L
G
G
Q
T
S
Y
Q
S
A
G
D
P
Site 227
Y1543
L
L
G
G
Q
T
S
Y
Q
S
A
G
D
P
K
Site 228
S1545
G
G
Q
T
S
Y
Q
S
A
G
D
P
K
E
D
Site 229
Y1555
D
P
K
E
D
E
L
Y
E
A
A
I
I
E
T
Site 230
Y1579
K
L
V
P
D
D
D
Y
W
G
K
I
P
K
C
Site 231
Y1604
F
D
F
G
S
E
V
Y
V
W
H
G
K
E
V
Site 232
Y1633
L
W
N
G
T
F
D
Y
E
N
C
D
I
N
P
Site 233
T1672
R
L
T
E
H
N
E
T
I
L
F
K
E
K
F
Site 234
T1683
K
E
K
F
L
D
W
T
E
L
K
R
S
N
E
Site 235
S1688
D
W
T
E
L
K
R
S
N
E
K
N
P
G
E
Site 236
T1705
Q
H
K
E
D
P
R
T
D
V
K
A
Y
D
V
Site 237
Y1710
P
R
T
D
V
K
A
Y
D
V
T
R
M
V
S
Site 238
T1713
D
V
K
A
Y
D
V
T
R
M
V
S
M
P
Q
Site 239
S1717
Y
D
V
T
R
M
V
S
M
P
Q
T
T
A
G
Site 240
Y1736
G
V
N
V
G
R
G
Y
G
L
V
E
G
H
D
Site 241
T1750
D
R
R
Q
F
E
I
T
S
V
S
V
D
V
W
Site 242
S1751
R
R
Q
F
E
I
T
S
V
S
V
D
V
W
H
Site 243
Y1764
W
H
I
L
E
F
D
Y
S
R
L
P
K
Q
S
Site 244
S1765
H
I
L
E
F
D
Y
S
R
L
P
K
Q
S
I
Site 245
S1771
Y
S
R
L
P
K
Q
S
I
G
Q
F
H
E
G
Site 246
Y1781
Q
F
H
E
G
D
A
Y
V
V
K
W
K
F
M
Site 247
S1790
V
K
W
K
F
M
V
S
T
A
V
G
S
R
Q
Site 248
T1791
K
W
K
F
M
V
S
T
A
V
G
S
R
Q
K
Site 249
S1795
M
V
S
T
A
V
G
S
R
Q
K
G
E
H
S
Site 250
S1802
S
R
Q
K
G
E
H
S
V
R
A
A
G
K
E
Site 251
Y1813
A
G
K
E
K
C
V
Y
F
F
W
Q
G
R
H
Site 252
S1821
F
F
W
Q
G
R
H
S
T
V
S
E
K
G
T
Site 253
T1822
F
W
Q
G
R
H
S
T
V
S
E
K
G
T
S
Site 254
S1824
Q
G
R
H
S
T
V
S
E
K
G
T
S
A
L
Site 255
T1833
K
G
T
S
A
L
M
T
V
E
L
D
E
E
R
Site 256
S1867
Q
G
G
M
V
V
H
S
G
R
R
E
E
E
E
Site 257
Y1884
V
Q
S
E
W
R
L
Y
C
V
R
G
E
V
P
Site 258
S1904
L
E
V
A
C
H
C
S
S
L
R
S
R
T
S
Site 259
S1905
E
V
A
C
H
C
S
S
L
R
S
R
T
S
M
Site 260
S1911
S
S
L
R
S
R
T
S
M
V
V
L
N
V
N
Site 261
S1957
P
L
E
A
G
L
H
S
S
S
K
V
T
I
H
Site 262
S1958
L
E
A
G
L
H
S
S
S
K
V
T
I
H
E
Site 263
S1959
E
A
G
L
H
S
S
S
K
V
T
I
H
E
C
Site 264
Y1987
G
R
R
D
R
K
A
Y
D
C
M
L
Q
D
P
Site 265
S1996
C
M
L
Q
D
P
G
S
F
N
F
A
P
R
L
Site 266
T2016
S
S
G
D
F
A
A
T
E
F
V
Y
P
A
R
Site 267
S2030
R
A
P
S
V
V
S
S
M
P
F
L
Q
E
D
Site 268
Y2039
P
F
L
Q
E
D
L
Y
S
A
P
Q
P
A
L
Site 269
S2040
F
L
Q
E
D
L
Y
S
A
P
Q
P
A
L
F
Site 270
S2071
I
E
N
K
I
T
G
S
A
R
I
R
W
A
S
Site 271
S2078
S
A
R
I
R
W
A
S
D
R
K
S
A
M
E
Site 272
S2082
R
W
A
S
D
R
K
S
A
M
E
T
V
L
Q
Site 273
T2086
D
R
K
S
A
M
E
T
V
L
Q
Y
C
K
G
Site 274
S2103
L
K
K
P
A
P
K
S
Y
L
I
H
A
G
L
Site 275
T2114
H
A
G
L
E
P
L
T
F
T
N
M
F
P
S
Site 276
Y2179
D
P
L
K
L
E
I
Y
L
T
D
E
D
F
E
Site 277
T2181
L
K
L
E
I
Y
L
T
D
E
D
F
E
F
A
Site 278
Y2196
L
D
M
T
R
D
E
Y
N
A
L
P
A
W
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation