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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIGN
Full Name:
GPI ethanolamine phosphate transferase 1
Alias:
MCD4 homolog;Phosphatidylinositol-glycan biosynthesis class N protein
Type:
Mass (Da):
105810
Number AA:
931
UniProt ID:
O95427
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
S
P
L
V
H
G
M
T
P
Q
F
T
P
L
P
Site 2
T37
H
G
M
T
P
Q
F
T
P
L
P
P
P
A
R
Site 3
Y60
G
L
R
A
D
A
L
Y
E
L
D
E
N
G
N
Site 4
S68
E
L
D
E
N
G
N
S
R
A
P
F
I
R
N
Site 5
S86
H
E
G
S
W
G
I
S
H
T
R
V
P
T
E
Site 6
T88
G
S
W
G
I
S
H
T
R
V
P
T
E
S
R
Site 7
T92
I
S
H
T
R
V
P
T
E
S
R
P
G
H
V
Site 8
S94
H
T
R
V
P
T
E
S
R
P
G
H
V
A
L
Site 9
S110
A
G
F
Y
E
D
V
S
A
V
A
K
G
W
K
Site 10
S125
E
N
P
V
E
F
D
S
L
F
N
E
S
K
Y
Site 11
Y132
S
L
F
N
E
S
K
Y
T
W
S
W
G
S
P
Site 12
S135
N
E
S
K
Y
T
W
S
W
G
S
P
D
I
L
Site 13
Y155
G
A
S
G
D
H
V
Y
T
Y
S
Y
D
A
K
Site 14
Y157
S
G
D
H
V
Y
T
Y
S
Y
D
A
K
R
E
Site 15
S158
G
D
H
V
Y
T
Y
S
Y
D
A
K
R
E
D
Site 16
T215
L
H
L
L
G
I
D
T
N
G
H
A
H
R
P
Site 17
S223
N
G
H
A
H
R
P
S
S
R
D
Y
K
H
N
Site 18
S224
G
H
A
H
R
P
S
S
R
D
Y
K
H
N
I
Site 19
Y227
H
R
P
S
S
R
D
Y
K
H
N
I
K
K
V
Site 20
Y249
V
S
M
F
N
H
F
Y
G
N
D
G
K
T
T
Site 21
S277
S
H
G
A
G
H
P
S
E
T
L
T
P
L
V
Site 22
T281
G
H
P
S
E
T
L
T
P
L
V
T
W
G
A
Site 23
Y292
T
W
G
A
G
I
K
Y
P
Q
R
V
S
A
Q
Site 24
S297
I
K
Y
P
Q
R
V
S
A
Q
Q
F
D
D
A
Site 25
S394
F
T
P
F
K
L
L
S
D
S
K
Q
F
N
I
Site 26
S396
P
F
K
L
L
S
D
S
K
Q
F
N
I
L
R
Site 27
S407
N
I
L
R
K
A
R
S
Y
I
K
H
R
K
F
Site 28
Y408
I
L
R
K
A
R
S
Y
I
K
H
R
K
F
D
Site 29
S419
R
K
F
D
E
V
V
S
L
C
K
E
L
I
H
Site 30
Y435
A
L
K
G
L
S
Y
Y
H
T
Y
D
R
F
F
Site 31
T437
K
G
L
S
Y
Y
H
T
Y
D
R
F
F
L
G
Site 32
Y438
G
L
S
Y
Y
H
T
Y
D
R
F
F
L
G
V
Site 33
S474
S
N
L
I
K
G
V
S
K
E
V
K
K
P
S
Site 34
S481
S
K
E
V
K
K
P
S
H
L
L
P
C
S
F
Site 35
T586
P
F
L
T
R
L
W
T
R
A
K
M
T
S
L
Site 36
S644
S
L
M
K
R
K
D
S
F
I
K
E
E
L
L
Site 37
T670
S
M
Y
V
V
Y
S
T
Q
S
S
L
L
R
K
Site 38
S673
V
V
Y
S
T
Q
S
S
L
L
R
K
Q
G
L
Site 39
T750
W
I
N
I
E
Q
E
T
L
Q
Q
S
G
V
C
Site 40
S768
K
L
T
S
I
Q
F
S
Y
N
T
D
I
T
Q
Site 41
Y780
I
T
Q
F
R
Q
L
Y
L
D
D
I
R
R
A
Site 42
T852
A
F
E
A
V
Q
L
T
T
Q
L
S
S
K
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation