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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAPLN
Full Name:
Papilin
Alias:
Type:
Mass (Da):
137700
Number AA:
1278
UniProt ID:
O95428
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
L
A
P
A
P
G
S
S
A
P
K
V
R
R
Site 2
S26
A
P
K
V
R
R
Q
S
D
T
W
G
P
W
S
Site 3
S47
R
T
C
G
G
G
V
S
F
R
E
R
P
C
Y
Site 4
Y54
S
F
R
E
R
P
C
Y
S
Q
R
R
D
G
G
Site 5
S55
F
R
E
R
P
C
Y
S
Q
R
R
D
G
G
S
Site 6
S62
S
Q
R
R
D
G
G
S
S
C
V
G
P
A
R
Site 7
S63
Q
R
R
D
G
G
S
S
C
V
G
P
A
R
S
Site 8
S70
S
C
V
G
P
A
R
S
H
R
S
C
R
T
E
Site 9
S73
G
P
A
R
S
H
R
S
C
R
T
E
S
C
P
Site 10
S78
H
R
S
C
R
T
E
S
C
P
D
G
A
R
D
Site 11
Y104
A
E
F
Q
G
R
R
Y
R
W
L
P
Y
Y
S
Site 12
Y109
R
R
Y
R
W
L
P
Y
Y
S
A
P
N
K
C
Site 13
Y110
R
Y
R
W
L
P
Y
Y
S
A
P
N
K
C
E
Site 14
Y129
P
K
G
E
N
F
Y
Y
K
H
R
E
A
V
V
Site 15
T139
R
E
A
V
V
D
G
T
P
C
E
P
G
K
R
Site 16
S165
G
C
D
H
E
L
D
S
S
K
Q
E
D
K
C
Site 17
S166
C
D
H
E
L
D
S
S
K
Q
E
D
K
C
L
Site 18
T181
R
C
G
G
D
G
T
T
C
Y
P
V
A
G
T
Site 19
Y183
G
G
D
G
T
T
C
Y
P
V
A
G
T
F
D
Site 20
Y198
A
N
D
L
S
R
G
Y
N
Q
I
L
I
V
P
Site 21
Y232
V
K
N
V
R
G
E
Y
Y
L
N
G
H
W
T
Site 22
Y233
K
N
V
R
G
E
Y
Y
L
N
G
H
W
T
I
Site 23
Y255
A
A
S
T
I
L
H
Y
E
R
G
A
E
G
D
Site 24
T274
R
L
H
A
R
G
P
T
S
E
P
L
V
I
E
Site 25
Y293
E
P
N
P
G
V
H
Y
E
Y
H
L
P
L
R
Site 26
Y295
N
P
G
V
H
Y
E
Y
H
L
P
L
R
R
P
Site 27
S303
H
L
P
L
R
R
P
S
P
G
F
S
W
S
H
Site 28
S307
R
R
P
S
P
G
F
S
W
S
H
G
S
W
S
Site 29
S309
P
S
P
G
F
S
W
S
H
G
S
W
S
D
C
Site 30
S312
G
F
S
W
S
H
G
S
W
S
D
C
S
A
E
Site 31
T332
Q
S
R
L
V
F
C
T
I
D
H
E
A
Y
P
Site 32
S354
P
R
P
A
D
R
R
S
C
N
L
H
P
C
P
Site 33
T363
N
L
H
P
C
P
E
T
K
R
W
K
A
G
P
Site 34
S375
A
G
P
W
A
P
C
S
A
S
C
G
G
G
S
Site 35
S377
P
W
A
P
C
S
A
S
C
G
G
G
S
Q
S
Site 36
S382
S
A
S
C
G
G
G
S
Q
S
R
S
V
Y
C
Site 37
S384
S
C
G
G
G
S
Q
S
R
S
V
Y
C
I
S
Site 38
S386
G
G
G
S
Q
S
R
S
V
Y
C
I
S
S
D
Site 39
Y388
G
S
Q
S
R
S
V
Y
C
I
S
S
D
G
A
Site 40
S438
P
W
G
E
C
S
V
S
C
G
V
G
V
R
K
Site 41
S447
G
V
G
V
R
K
R
S
V
T
C
R
G
E
R
Site 42
T449
G
V
R
K
R
S
V
T
C
R
G
E
R
G
S
Site 43
S456
T
C
R
G
E
R
G
S
L
L
H
T
A
A
C
Site 44
T460
E
R
G
S
L
L
H
T
A
A
C
S
L
E
D
Site 45
T472
L
E
D
R
P
P
L
T
E
P
C
V
H
E
D
Site 46
S497
V
G
T
W
G
L
C
S
K
S
C
S
S
G
T
Site 47
S499
T
W
G
L
C
S
K
S
C
S
S
G
T
R
R
Site 48
S501
G
L
C
S
K
S
C
S
S
G
T
R
R
R
Q
Site 49
S502
L
C
S
K
S
C
S
S
G
T
R
R
R
Q
V
Site 50
T504
S
K
S
C
S
S
G
T
R
R
R
Q
V
I
C
Site 51
S521
G
P
P
S
H
C
G
S
L
Q
H
S
K
P
V
Site 52
S525
H
C
G
S
L
Q
H
S
K
P
V
D
V
E
P
Site 53
T552
P
S
M
Q
D
V
H
T
P
A
S
N
P
W
M
Site 54
S566
M
P
L
G
P
Q
E
S
P
A
S
D
S
R
G
Site 55
S569
G
P
Q
E
S
P
A
S
D
S
R
G
Q
W
W
Site 56
S583
W
A
A
Q
E
H
P
S
A
R
G
D
H
R
G
Site 57
T601
D
P
R
G
D
Q
G
T
H
L
S
A
L
G
P
Site 58
S604
G
D
Q
G
T
H
L
S
A
L
G
P
A
P
S
Site 59
S611
S
A
L
G
P
A
P
S
L
Q
Q
P
P
Y
Q
Site 60
Y617
P
S
L
Q
Q
P
P
Y
Q
Q
P
L
R
S
G
Site 61
S623
P
Y
Q
Q
P
L
R
S
G
S
G
P
H
D
C
Site 62
S625
Q
Q
P
L
R
S
G
S
G
P
H
D
C
R
H
Site 63
T643
G
C
C
P
D
G
H
T
A
S
L
G
P
Q
W
Site 64
S645
C
P
D
G
H
T
A
S
L
G
P
Q
W
Q
G
Site 65
S671
G
C
C
P
D
R
V
S
V
A
E
G
P
H
H
Site 66
S684
H
H
A
G
C
T
K
S
Y
G
G
D
S
T
G
Site 67
Y685
H
A
G
C
T
K
S
Y
G
G
D
S
T
G
G
Site 68
S689
T
K
S
Y
G
G
D
S
T
G
G
M
P
R
S
Site 69
S696
S
T
G
G
M
P
R
S
R
A
V
A
S
T
V
Site 70
S701
P
R
S
R
A
V
A
S
T
V
H
N
T
H
Q
Site 71
T702
R
S
R
A
V
A
S
T
V
H
N
T
H
Q
P
Site 72
S717
Q
A
Q
Q
N
E
P
S
E
C
R
G
S
Q
F
Site 73
S762
L
L
P
S
A
H
G
S
C
A
D
W
A
A
R
Site 74
S803
S
E
Q
E
C
M
S
S
C
Q
G
S
L
H
G
Site 75
S807
C
M
S
S
C
Q
G
S
L
H
G
P
R
R
P
Site 76
S819
R
R
P
Q
P
G
A
S
G
R
S
T
H
T
D
Site 77
T823
P
G
A
S
G
R
S
T
H
T
D
G
G
G
S
Site 78
T825
A
S
G
R
S
T
H
T
D
G
G
G
S
S
P
Site 79
S831
H
T
D
G
G
G
S
S
P
A
G
E
Q
E
P
Site 80
S839
P
A
G
E
Q
E
P
S
Q
H
R
T
G
A
A
Site 81
T843
Q
E
P
S
Q
H
R
T
G
A
A
V
Q
R
K
Site 82
S854
V
Q
R
K
P
W
P
S
G
G
L
W
R
Q
D
Site 83
T872
G
P
G
E
A
P
H
T
Q
A
F
G
E
W
P
Site 84
S886
P
W
G
Q
E
L
G
S
R
A
P
G
L
G
G
Site 85
S897
G
L
G
G
D
A
G
S
P
A
P
P
F
H
S
Site 86
S904
S
P
A
P
P
F
H
S
S
S
Y
R
I
S
L
Site 87
S905
P
A
P
P
F
H
S
S
S
Y
R
I
S
L
A
Site 88
S906
A
P
P
F
H
S
S
S
Y
R
I
S
L
A
G
Site 89
S910
H
S
S
S
Y
R
I
S
L
A
G
V
E
P
S
Site 90
S930
L
G
Q
L
V
R
L
S
C
S
D
D
T
A
P
Site 91
S932
Q
L
V
R
L
S
C
S
D
D
T
A
P
E
S
Site 92
T935
R
L
S
C
S
D
D
T
A
P
E
S
Q
A
A
Site 93
S939
S
D
D
T
A
P
E
S
Q
A
A
W
Q
K
D
Site 94
S951
Q
K
D
G
Q
P
I
S
S
D
R
H
R
L
Q
Site 95
S952
K
D
G
Q
P
I
S
S
D
R
H
R
L
Q
F
Site 96
S962
H
R
L
Q
F
D
G
S
L
I
I
H
P
L
Q
Site 97
T975
L
Q
A
E
D
A
G
T
Y
S
C
G
S
T
R
Site 98
S977
A
E
D
A
G
T
Y
S
C
G
S
T
R
P
G
Site 99
S980
A
G
T
Y
S
C
G
S
T
R
P
G
R
D
S
Site 100
T981
G
T
Y
S
C
G
S
T
R
P
G
R
D
S
Q
Site 101
S987
S
T
R
P
G
R
D
S
Q
K
I
Q
L
R
I
Site 102
S1008
V
L
S
E
A
E
L
S
R
F
P
Q
P
R
D
Site 103
S1034
G
P
L
G
A
I
P
S
S
H
P
Q
P
A
N
Site 104
S1035
P
L
G
A
I
P
S
S
H
P
Q
P
A
N
R
Site 105
S1056
Q
P
R
V
V
D
A
S
P
G
Q
R
I
R
M
Site 106
T1064
P
G
Q
R
I
R
M
T
C
R
A
E
G
F
P
Site 107
S1085
Q
R
D
G
Q
P
V
S
S
P
R
H
Q
L
Q
Site 108
S1086
R
D
G
Q
P
V
S
S
P
R
H
Q
L
Q
P
Site 109
S1096
H
Q
L
Q
P
D
G
S
L
V
I
S
R
V
A
Site 110
T1141
T
I
S
G
L
P
P
T
V
T
V
P
E
G
D
Site 111
T1143
S
G
L
P
P
T
V
T
V
P
E
G
D
T
A
Site 112
S1160
L
C
V
V
A
G
E
S
V
N
I
R
W
S
R
Site 113
S1166
E
S
V
N
I
R
W
S
R
N
G
L
P
V
Q
Site 114
S1182
D
G
H
R
V
H
Q
S
P
D
G
T
L
L
I
Site 115
T1186
V
H
Q
S
P
D
G
T
L
L
I
Y
N
L
R
Site 116
Y1190
P
D
G
T
L
L
I
Y
N
L
R
A
R
D
E
Site 117
S1199
L
R
A
R
D
E
G
S
Y
T
C
S
A
Y
Q
Site 118
Y1200
R
A
R
D
E
G
S
Y
T
C
S
A
Y
Q
G
Site 119
T1201
A
R
D
E
G
S
Y
T
C
S
A
Y
Q
G
S
Site 120
S1203
D
E
G
S
Y
T
C
S
A
Y
Q
G
S
Q
A
Site 121
S1208
T
C
S
A
Y
Q
G
S
Q
A
V
S
R
S
T
Site 122
S1212
Y
Q
G
S
Q
A
V
S
R
S
T
E
V
K
V
Site 123
T1215
S
Q
A
V
S
R
S
T
E
V
K
V
V
S
P
Site 124
S1221
S
T
E
V
K
V
V
S
P
A
P
T
A
Q
P
Site 125
T1225
K
V
V
S
P
A
P
T
A
Q
P
R
D
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation