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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARN
Full Name:
Poly(A)-specific ribonuclease PARN
Alias:
DAN; Deadenylating nuclease; Deadenylation nuclease; Poly (A)-specific ribonuclease; Poly(A)-specific ribonuclease (deadenylation nuclease); Polyadenylate-specific ribonuclease
Type:
Ribonuclease; EC 3.1.13.4; RNA binding protein
Mass (Da):
73451
Number AA:
639
UniProt ID:
O95453
International Prot ID:
IPI00294744
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003730
GO:0000287
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0009451
GO:0007292
GO:0000184
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
K
S
N
L
H
K
V
Y
Q
A
I
E
E
A
D
Site 2
S35
D
G
E
F
S
G
I
S
D
G
P
S
V
S
A
Site 3
S39
S
G
I
S
D
G
P
S
V
S
A
L
T
N
G
Site 4
T49
A
L
T
N
G
F
D
T
P
E
E
R
Y
Q
K
Site 5
Y76
F
G
L
C
T
F
K
Y
D
Y
T
D
S
K
Y
Site 6
Y78
L
C
T
F
K
Y
D
Y
T
D
S
K
Y
I
T
Site 7
Y83
Y
D
Y
T
D
S
K
Y
I
T
K
S
F
N
F
Site 8
Y91
I
T
K
S
F
N
F
Y
V
F
P
K
P
F
N
Site 9
S101
P
K
P
F
N
R
S
S
P
D
V
K
F
V
C
Site 10
S118
S
S
I
D
F
L
A
S
Q
G
F
D
F
N
K
Site 11
Y133
V
F
R
N
G
I
P
Y
L
N
Q
E
E
E
R
Site 12
Y146
E
R
Q
L
R
E
Q
Y
D
E
K
R
S
Q
A
Site 13
S151
E
Q
Y
D
E
K
R
S
Q
A
N
G
A
G
A
Site 14
S160
A
N
G
A
G
A
L
S
Y
V
S
P
N
T
S
Site 15
Y161
N
G
A
G
A
L
S
Y
V
S
P
N
T
S
K
Site 16
S163
A
G
A
L
S
Y
V
S
P
N
T
S
K
C
P
Site 17
T166
L
S
Y
V
S
P
N
T
S
K
C
P
V
T
I
Site 18
S167
S
Y
V
S
P
N
T
S
K
C
P
V
T
I
P
Site 19
T172
N
T
S
K
C
P
V
T
I
P
E
D
Q
K
K
Site 20
S194
K
I
E
D
L
L
Q
S
E
E
N
K
N
L
D
Site 21
Y214
G
F
Q
R
K
L
I
Y
Q
T
L
S
W
K
Y
Site 22
T216
Q
R
K
L
I
Y
Q
T
L
S
W
K
Y
P
K
Site 23
T232
I
H
V
E
T
L
E
T
E
K
K
E
R
Y
I
Site 24
Y238
E
T
E
K
K
E
R
Y
I
V
I
S
K
V
D
Site 25
S242
K
E
R
Y
I
V
I
S
K
V
D
E
E
E
R
Site 26
S309
C
P
L
P
A
D
L
S
E
F
K
E
M
T
T
Site 27
T353
L
E
K
R
L
K
E
T
P
F
N
P
P
K
V
Site 28
S362
F
N
P
P
K
V
E
S
A
E
G
F
P
S
Y
Site 29
S368
E
S
A
E
G
F
P
S
Y
D
T
A
S
E
Q
Site 30
Y369
S
A
E
G
F
P
S
Y
D
T
A
S
E
Q
L
Site 31
T371
E
G
F
P
S
Y
D
T
A
S
E
Q
L
H
E
Site 32
S373
F
P
S
Y
D
T
A
S
E
Q
L
H
E
A
G
Site 33
Y381
E
Q
L
H
E
A
G
Y
D
A
Y
I
T
G
L
Site 34
S402
N
Y
L
G
S
F
L
S
P
P
K
I
H
V
S
Site 35
S409
S
P
P
K
I
H
V
S
A
R
S
K
L
I
E
Site 36
Y432
M
R
V
M
D
I
P
Y
L
N
L
E
G
P
D
Site 37
T451
R
D
H
V
L
H
V
T
F
P
K
E
W
K
T
Site 38
S459
F
P
K
E
W
K
T
S
D
L
Y
Q
L
F
S
Site 39
Y462
E
W
K
T
S
D
L
Y
Q
L
F
S
A
F
G
Site 40
S484
D
D
T
S
A
F
V
S
L
S
Q
P
E
Q
V
Site 41
S486
T
S
A
F
V
S
L
S
Q
P
E
Q
V
K
I
Site 42
S498
V
K
I
A
V
N
T
S
K
Y
A
E
S
Y
R
Site 43
Y500
I
A
V
N
T
S
K
Y
A
E
S
Y
R
I
Q
Site 44
S503
N
T
S
K
Y
A
E
S
Y
R
I
Q
T
Y
A
Site 45
T508
A
E
S
Y
R
I
Q
T
Y
A
E
Y
M
G
R
Site 46
Y509
E
S
Y
R
I
Q
T
Y
A
E
Y
M
G
R
K
Site 47
Y512
R
I
Q
T
Y
A
E
Y
M
G
R
K
Q
E
E
Site 48
T527
K
Q
I
K
R
K
W
T
E
D
S
W
K
E
A
Site 49
S530
K
R
K
W
T
E
D
S
W
K
E
A
D
S
K
Site 50
S536
D
S
W
K
E
A
D
S
K
R
L
N
P
Q
C
Site 51
Y546
L
N
P
Q
C
I
P
Y
T
L
Q
N
H
Y
Y
Site 52
Y552
P
Y
T
L
Q
N
H
Y
Y
R
N
N
S
F
T
Site 53
Y553
Y
T
L
Q
N
H
Y
Y
R
N
N
S
F
T
A
Site 54
S557
N
H
Y
Y
R
N
N
S
F
T
A
P
S
T
V
Site 55
T559
Y
Y
R
N
N
S
F
T
A
P
S
T
V
G
K
Site 56
T563
N
S
F
T
A
P
S
T
V
G
K
R
N
L
S
Site 57
S570
T
V
G
K
R
N
L
S
P
S
Q
E
E
A
G
Site 58
S572
G
K
R
N
L
S
P
S
Q
E
E
A
G
L
E
Site 59
S583
A
G
L
E
D
G
V
S
G
E
I
S
D
T
E
Site 60
S587
D
G
V
S
G
E
I
S
D
T
E
L
E
Q
T
Site 61
T589
V
S
G
E
I
S
D
T
E
L
E
Q
T
D
S
Site 62
T594
S
D
T
E
L
E
Q
T
D
S
C
A
E
P
L
Site 63
S596
T
E
L
E
Q
T
D
S
C
A
E
P
L
S
E
Site 64
S602
D
S
C
A
E
P
L
S
E
G
R
K
K
A
K
Site 65
S619
K
R
M
K
K
E
L
S
P
A
G
S
I
S
K
Site 66
S623
K
E
L
S
P
A
G
S
I
S
K
N
S
P
A
Site 67
S625
L
S
P
A
G
S
I
S
K
N
S
P
A
T
L
Site 68
S628
A
G
S
I
S
K
N
S
P
A
T
L
F
E
V
Site 69
T631
I
S
K
N
S
P
A
T
L
F
E
V
P
D
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation